Patents by Inventor Karen E. Linder

Karen E. Linder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rhenium tris dioxime complexes
    Patent number: 5118797
    Abstract: Rhenium tris dioxime complexes are useful in the synthesis of boronic acid adducts of rhenium dioxime complexes which are useful as radiotherapeutic agents.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: June 2, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Silvia Jurisson, Karen E. Linder, Lynn C. Francesconi
  • Boronic acid adducts of technetium-.sup.99m dioxime-imine complexes
    Patent number: 5069900
    Abstract: Boronic acid adducts of technetium-.sup.99m imine-dioxime complexes are useful for imaging the myocardium, hepatobiliary system, brain and blood pool in humans and other mammalian species.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: December 3, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karen E. Linder
  • Metal-isonitrile adducts for preparing radionuclide complexes
    Patent number: 4894445
    Abstract: A method for preparing a coordination complex of an isonitrile ligand and a radioisotope of Tc, Ru, Co, Pt, Re, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Nb and Ta from a non-radioactive metal adduct of the isonitrile.
    Type: Grant
    Filed: June 25, 1986
    Date of Patent: January 16, 1990
    Assignee: E. I. Du Pont De Nemours and Company
    Inventors: Alan P. Carpenter, Jr., Leo J. Maheu, Michael A. Patz, Thomas H. Tulip, Karen E. Linder, Vinayakam Subramanyam, Jeffery S. Thompson
  • Neutral technetium 99-m complexes useful as radiodiagnostic agents
    Patent number: 4789543
    Abstract: An hepatobiliary imaging agent is disclosed which is a neutral complex of Tc-99m, a complexing ion, SO.sub.2, and a mono or polydentate organic ligand having one or more donor atoms for complexing with TC-99m to form the neutral complex.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: December 6, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Karen E. Linder
  • Cationic technetium complexes useful as radiodiagnostic agents
    Patent number: 4512967
    Abstract: A cationic lipophilic complex of technetium is disclosed wherein all of the coordination positions of the technetium atom are filled with a neutral donor atom having a pair of electrons available for forming a coordinate bond with technetium. The donor atoms are provided by target-seeking ligands or salts thereof, said ligands having the following structure of one of formulas I, II or III. Such complexes are useful for imaging heart and hepatobiliary tissues.
    Type: Grant
    Filed: August 2, 1982
    Date of Patent: April 23, 1985
    Assignee: E. I. Du Pont de Nemours and Compamy
    Inventor: Karen E. Linder
  • Cationic technetium complexes useful as radiodiagnostic agents
    Patent number: RE32826
    Abstract: A cationic lipophilic complex of technetium is disclosed wherein all of the coordination positions of the technetium atom are filled with a neutral donor atom having a pair of electrons available for forming a coordinate bond with technetium. The donor atoms are provided by target-seeking ligands or salts thereof, said ligands having the following structure of one of formulas I, II or III. Such complexes are useful for imaging heart and hepatobiliary tissues.
    Type: Grant
    Filed: February 6, 1987
    Date of Patent: January 10, 1989
    Assignee: E. I Du Pont de Nemours and Company
    Inventor: Karen E. Linder