Patents by Inventor Karen J. McGovern

Karen J. McGovern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of use of cyclopamine analogs
    Patent number: 8227509
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: July 24, 2012
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, William Matsui, Karen J. McGovern, Martin R. Tremblay
  • Methods of Use of Cyclopamine Analogs
    Publication number: 20120077834
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: July 27, 2011
    Publication date: March 29, 2012
    Inventors: Alfredo C. Castro, Michael J. Grogan, William Matsui, Karen J. McGovern, Martin R. Tremblay
  • THERAPEUTIC REGIMENS FOR HEDGEHOG-ASSOCIATED CANCERS
    Publication number: 20120010229
    Abstract: Provided herein are methods, therapeutic regimens, and kits that optimize the benefits of hedgehog inhibition for cancer therapy.
    Type: Application
    Filed: July 8, 2011
    Publication date: January 12, 2012
    Inventors: John R. MacDougall, Karen J. McGovern
  • METHODS AND COMPOSITIONS FOR IDENTIFICATION, ASSESSMENT AND TREATMENT OF CANCERS ASSOCIATED WITH HEDGEHOG SIGNALING
    Publication number: 20120010230
    Abstract: Provided herein are methods, assays and kits for evaluating a sample, e.g., a sample obtained from a cancer patient, to detect one or more hedgehog biomarkers and/or one or more cilium markers. Thus, the invention can be used, inter alia, as a means to identify patients likely to benefit from administration of one or more hedgehog inhibitors, alone or in combination with therapeutic agents; to predict a time course of disease or a probability of a significant event in the disease of a cancer patient; to stratify patient populations; and/or to more effectively treat or prevent a cancer or a tumor associated with hedgehog signaling.
    Type: Application
    Filed: July 8, 2011
    Publication date: January 12, 2012
    Inventors: John R. MacDougall, Juan Guillermo Paez, Karen J. McGovern, Jeffery L. Kutok, Georgios Skliris, Kerry White, Kerrie L. Faia, Marisa Osswalt Peluso, Veronica Travaglione Campbell
  • METHODS OF USE FOR CYCLOPAMINE ANALOGS
    Publication number: 20110230509
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: April 20, 2011
    Publication date: September 22, 2011
    Inventors: Alfredo C. Castro, Michael J. Grogan, William Matsui, Karen J. McGovern, Martin R. Tremblay
  • Methods of use of cyclopamine analogs
    Patent number: 8017648
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: September 13, 2011
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Karen J. McGovern, Martin Tremblay
  • DOSING REGIMENS FOR THE TREATMENT OF CANCER
    Publication number: 20110034498
    Abstract: The invention relates to a method of treating cancer. The method includes administering systemically a therapeutically effective amount of a small molecule hedgehog pathway inhibitor, such that the concentration of the inhibitor in the blood does not vary by more than about ±30% from the average concentration, and such that the concentration remains at or below the maximum tolerated dose of the inhibitor for a time period of at least about one day.
    Type: Application
    Filed: March 24, 2006
    Publication date: February 10, 2011
    Inventors: Karen J. Mcgovern, Christine S. Pien, James L. Wright
  • METHODS OF USE OF CYCLOPAMINE ANALOGS
    Publication number: 20100286180
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: December 27, 2007
    Publication date: November 11, 2010
    Applicants: Infinity Pharmaceuticals, Inc., Johns Hopkins University
    Inventors: Alfredo C. Castro, Michael J. Grogan, William Matsui, Karen J. McGovern, Martin Tremblay
  • Therapeutic Cancer Treatments
    Publication number: 20100222287
    Abstract: Provided are methods for treating prostate cancer by administering a therapeutically effective amount of a hedgehog inhibitor.
    Type: Application
    Filed: September 25, 2009
    Publication date: September 2, 2010
    Inventors: Karen J. McGovern, Margaret Read, Robert W. Ross
  • Methods for controlling GGT-positive bacteria
    Patent number: 6380217
    Abstract: Methods and compositions useful for controlling GGT positive bacteria have been identified.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: April 30, 2002
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Karen J. McGovern