Patents by Inventor Karen Robins

Karen Robins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of optically active chiral amines
    Patent number: 9551018
    Abstract: The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: January 24, 2017
    Assignee: LONZA AG
    Inventors: Karen Robins, Uwe Scheuer, Matthias Hohne
  • PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE CHIRAL AMINES
    Publication number: 20150284752
    Abstract: The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
    Type: Application
    Filed: June 16, 2015
    Publication date: October 8, 2015
    Inventors: Karen ROBINS, Uwe SCHEUER, Matthias HOHNE
  • Process for the preparation of optically active chiral amines
    Patent number: 9074228
    Abstract: The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: July 7, 2015
    Assignee: LONZA AG
    Inventors: Karen Robins, Uwe Bornscheuer, Matthias Höhne
  • Process for preparation of optically active N-protected 3-aminopyrrolidine or optically active N-protected 3-aminopiperidine and the corresponding ketones by optical resolution of the racemic amine mixtures employing a bacterial omega-transaminase
    Patent number: 8728750
    Abstract: The present invention relates to the production of optically active amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: May 20, 2014
    Assignee: Lonza AG
    Inventors: Karen Robins, Uwe Bornscheuer, Matthias Höhne
  • Process for the identification and preparation of a (R)-specific omega-transaminase
    Patent number: 8577622
    Abstract: The present invention relates to processes for the screening, preparation and characterization of (R)-selective ?-transaminases, to transaminases obtained thereby and their uses in various transamination processes.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: November 5, 2013
    Assignee: Lonza AG
    Inventors: Matthias Hoehne, Uwe Bornscheuer, Karen Robins, Sebastian Schaetzle
  • PROCESS FOR THE IDENTIFICATION AND PREPARATION OF A (R)-SPECIFIC OMEGA-TRANSAMINASE
    Publication number: 20120156706
    Abstract: The present invention relates to processes for the screening, preparation and characterization of (R)-selective ?-transaminases, to transaminases obtained thereby and their uses in various transamination processes.
    Type: Application
    Filed: August 13, 2010
    Publication date: June 21, 2012
    Applicant: LONZA AG
    Inventors: Matthias Hoehne, Uwe Bornscheuer, Karen Robins, Sebastian Schaetzle
  • PROCESS FOR PREPARATION OF OPTICALLY ACTIVE N-PROTECTED 3-AMINOPYRROLIDINE OR OPTICALLY ACTIVE N-PROTECTED 3-AMINOPIPERIDINE AND THE CORRESPONDING KETONES BY OPTICAL RESOLUTION OF THE RACEMIC AMINE MIXTURES EMPLOYING A BACTERIAL OMEGA-TRANSAMINASE
    Publication number: 20090325224
    Abstract: The present invention relates to the production of optically active amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
    Type: Application
    Filed: September 6, 2007
    Publication date: December 31, 2009
    Applicant: LONZA AG
    Inventors: Karen Robins, Uwe Bornscheuer, Matthias Höhne
  • Process for The Preparation of Optically Active Chiral Amines
    Publication number: 20090246837
    Abstract: The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
    Type: Application
    Filed: February 13, 2007
    Publication date: October 1, 2009
    Inventors: Karen Robins, Uwe Bornscheuer, Matthias Höhne
  • Process for the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid
    Patent number: 7553652
    Abstract: The present invention relates to a novel process for the preparation of (S)— or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: June 30, 2009
    Assignee: Lonza AG
    Inventors: Walter Brieden, Andrew Naughton, Karen Robins, Nicholas Shaw, Andreas Tinschert, Thomas Zimmermann
  • Process for the Preparation of Amides
    Publication number: 20080057550
    Abstract: A novel biotechnological process for the preparation of nitrites, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 6, 2008
    Inventors: Karen Robins, Toru Nagasawa
  • Enzymes for the preparation of amides
    Publication number: 20080050798
    Abstract: A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Microorganisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.
    Type: Application
    Filed: October 31, 2007
    Publication date: February 28, 2008
    Inventors: Karen Robins, Toru Nagasawa
  • Process for the Preparation of Amides
    Publication number: 20080050789
    Abstract: A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.
    Type: Application
    Filed: October 31, 2007
    Publication date: February 28, 2008
    Inventors: KAREN ROBINS, Toru Nagasawa
  • Polyacryamide beads containing encapsulated cells
    Publication number: 20070259415
    Abstract: Polyacrylamide beads containing encapsulated cells were prepared by a process comprising the steps of (i) providing an aqueous solution of a mixture of acrylic monomers, (ii) providing a suspension of cells in an aqueous solution of a persulfate (iii) providing an emulsion of an aqueous solution of a tertiary amine in a water-immiscible liquid, which liquid optionally contains a surfactant, (iv) mixing the solution provided in step (i) and the suspension provided in step (ii) (v) adding the mixture obtained in step (iv) to the stirred emulsion provided in step (iii) (vi) polymerizing the mixture of acrylic monomers and simultaneously encapsulating the cells to form polyacrylamide beads containing encapsulated cells.
    Type: Application
    Filed: July 11, 2007
    Publication date: November 8, 2007
    Applicant: LONZA Ltd.
    Inventors: Jana Zigova, Karen Robins, Johannes Bartek
  • Microbiological method for producing amides
    Publication number: 20070148743
    Abstract: The present invention provides for microorganisms capable of tolerating acetonitrile concentrations of at least 3 M, enzyme extracts obtainable from these microorganisms, a nitrile hydratase obtainable from these microorganisms, a method for preparing amides using these microorganisms, the enzyme extracts or the nitrile hydratase obtainable therefrom, and a method for removing acetonitrile from solutions using these microorganisms, the enzyme extracts or the nitrile hydratase obtainable therefrom.
    Type: Application
    Filed: February 27, 2007
    Publication date: June 28, 2007
    Applicant: LONZA AG
    Inventors: Karen Robins, Toru Nagasawa
  • Process for the preparation of amides
    Publication number: 20070031949
    Abstract: A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.
    Type: Application
    Filed: July 28, 2006
    Publication date: February 8, 2007
    Inventors: Karen Robins, Toru Nagasawa
  • Process for the preparation of (S) - or (R) -3,3,3- trifluoro-2-hydroxy-2-methylpropionic acid
    Publication number: 20060177919
    Abstract: The present invention relates to a novel process for the preparation of (S)— or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.
    Type: Application
    Filed: August 10, 2005
    Publication date: August 10, 2006
    Applicant: LONZA AG.
    Inventors: Walter Brieden, Andrew Naughton, Karen Robins, Nicholas Shaw, Andreas Tinschert, Thomas Zimmermann
  • Process for the preparation of (S) - or (R) -3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid
    Patent number: 7074606
    Abstract: The present invention relates to a novel process for the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: July 11, 2006
    Assignee: Lonza AG
    Inventors: Walter Brieden, Andrew Naughton, Karen Robins, Nicholas Shaw, Andreas Tinschert, Thomas Zimmermann
  • Polyacryamide beads containing encapsulated cells
    Publication number: 20050089987
    Abstract: Polyacrylamide beads containing encapsulated cells were prepared by a process comprising the steps of (i) providing an aqueous solution of a mixture of acrylic monomers, (ii) providing a suspension of cells in an aqueous solution of a persulfate (iii) providing an emulsion of an aqueous solution of a tertiary amine in a water-immiscible liquid, which liquid optionally contains a surfactant, (iv) mixing the solution provided in step (i) and the suspension provided in step (ii) (v) adding the mixture obtained in step (iv) to the stirred emulsion provided in step (iii) (vi) polymerizing the mixture of acrylic monomers and simultaneously encapsulating the cells to form polyacrylamide beads containing encapsulated cells.
    Type: Application
    Filed: June 22, 2004
    Publication date: April 28, 2005
    Applicant: LONZA Ltd.
    Inventors: Jana Zigova, Karen Robins, Johannes Bartek
  • Method of preparing (S)- or (R) -3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid
    Patent number: 6773910
    Abstract: Described are new micro-organisms and a new enzyme capable of using as sole source of nitrogen the propionic acid amide of formula (VI), in racemate form or as optically active isomers. Described also is a method of preparing (S)- or (R)-3,3,2-trifluoro-2-hydroxy-2-methylpropionic acid of formulas (I) and (II) starting from trifluoroaceto-acetic ester. The first three process steps are chemical, the fourth process step microbiological.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: August 10, 2004
    Inventors: Walter Brieden, Andrew Naughton, Karen Robins, Nicholas Shaw, Andreas Tinschert, Thomas Zimmermann
  • Process for the preparation of (S) - or (R) -3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid
    Publication number: 20030087402
    Abstract: The present invention relates to a novel process for the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula 1
    Type: Application
    Filed: February 28, 2002
    Publication date: May 8, 2003
    Inventors: Walter Brieden, Andrew Naughton, Karen Robins, Nicholas Shaw, Andreas Tinschert, Thomas Zimmermann