Abstract: A method for self-administrated surveillance of use of addictive-stimulus for an individual comprises providing (S10) of a body-measurement schedule for the individual. The individual is requested (S20) to perform measurements of bodily conditions, comprising eye conditions analysable from camera recordings, within each of multiple measurement time-slots. Data of the measurements a respective measurement time are collected (S30) in a handheld user interaction device. The collected data is transmitting (S40) from the user interaction device and is stored (S50) in a central server. Likelihood information of that the individual was exposed to an addictive stimulus is estimated (S60), based on the collected data. The estimating comprises comparison with individualized baseline data associated with the individual. An addictive-stimulus use-discouraging action is initiated (S70) as a response to likelihood information being larger than a predetermined threshold.

Abstract: Methods and devices enabling the study of the pupil of an eye are presented. In particular, the methods and devices relate to estimating the pupil size and its reaction to changes in light. The invention is particularly suited for dark eyes, where the contrast between pupil and iris is low. At least one eye image is acquired (110). Each acquired eye image is processed (120). The processing comprises estimation of a pupil size in the acquired image. It is furthermore determined (130) that the pupil size estimation has been completed.

Abstract: A screw joint arrangement that allows a second member to be fixed or movable relative to a first member. The first member includes at least one screw-receiving opening. The second member includes a bore having, in order from the first member side, a first threaded section, a non-threaded section, and a second threaded section. A screw with a head and a shaft carrying a threaded portion cooperates with these features to provide two selectable states. In the fixed state, a screw-receiving opening is aligned with the bore and the screw's threaded portion engages the second threaded section, clamping the first member between the screw head and the second member. In the movable state, rotation advances the screw until its threaded portion lies within the non-threaded section while the shaft passes through the first threaded section, thereby releasing the clamp and retaining engagement between the members for adjustment.

Abstract: A method (100) and a system for management of medical care resources are provided. The method comprises the steps of collecting (110) statistical information (120) associated with screening tests (130) for a disease, wherein the statistical information is associated with at least one classification (150) of an individual of a group of individuals, defining (160) a group of persons having an estimated need for one of the screening tests according to the classification, establishing (170) a first level of availability of the at least one treatment resource, selecting (180) a screening test to be used for the defined group of persons based on the statistical information under a boundary condition that the average of the estimated need of the at least one treatment resource is not allowed to exceed the first level of availability of the at least one treatment resource.

Abstract: The present invention relates to methods of determining an appropriate time interval for further diagnostic testing for prostate cancer in an individual having low total blood prostate specific antigen (PSA) levels.

Abstract: Methods for providing medical conclusions and support therefore comprises measuring of quantities related to concentrations of at least three different biomarkers of control samples, sending, receiving and storing the same in an archive memory. Stored data is retrieved as a response to a sending and receiving of a request for an adapted medical conclusion model and is processed into the certainty deduction model. The adapted medical conclusion model is processed based on the certainty deduction model, and is outputted and received and medical conclusions made from measurements of samples together with the control samples is provided based on the received adapted medical conclusion model. The certainty deduction model comprises a group model, determined for all control samples, and measurement entity performance characteristics, determined for measurements related to the first measurement entity that are performed less than a predetermined time ago.

Abstract: Methods for providing certainty estimation support and certainty estimations, respectively, in medical conclusions comprises measuring of quantities related to concentrations of at least three different biomarkers of control samples, sending, receiving and storing the same in an archive memory. Stored data is retrieved as a response to a sending and receiving of a request for a certainty deduction model and is processed into the certainty deduction model. The certainty deduction model is outputted and received and a certainty estimate for medical conclusions made from measurements of samples together with the control samples is provided based on the received certainty deduction model. The certainty deduction model comprises a group model, determined for all control samples, and measurement entity performance characteristics, determined for measurements related to the first measurement entity that are performed less than a predetermined time ago.

Abstract: Methods for harmonization of test results from a biological sample in a multiplexed biochemical assay, wherein presence and/or concentration of multiple biomarkers are determined at the same time in the same sample, making test results obtained in different laboratories comparable comprise: quantifying a presence or concentration of at least two different biomarkers in a biological sample and in a harmonization standard sample, independently in each sample, by means of a defined multiplexed biochemical assay implemented in a defined type of analytical instrument; receiving the test results from the samples into a computer-based decision engine for harmonization of test results from biological samples; and transforming the test results received from the biological sample, which includes transforming the test results from the harmonization standard sample into generalized units and adjusting the test results of the biological sample into the generalized units, GE.

Abstract: Disclosed is a solid support suitable for improving the detection of how different species interact with each other. The solid support has multiple defined areas divided by low dividers, and optionally independent containers divided by high dividers, each container having at least two defined areas. The solid support is typically used in measurements where the total amount of liquid is temporarily reduced during measurement. The solid support extends the possibilities of the measurement system.

Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.