Patents by Inventor Karl G. Metzger

Karl G. Metzger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5631291
    Abstract: The invention relates to cyclopentane- and -pentene-.beta.-amino acids, processes for their preparation and their use as medicaments.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: May 20, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Joachim Mittendorf, Franz Kunisch, Michael Matzke, Hans-Christian Militzer, Rainer Endermann, Karl G. Metzger, Klaus-Dieter Bremm, Manfred Plempel
  • Patent number: 5621105
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: April 15, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Klaus Grohe, Klaus-Dieter Bremm, Rainer Endermann, Karl G. Metzger
  • Patent number: 5607942
    Abstract: 7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen,X.sup.2 is hydrogen, halogen, amino or other radical,R.sup.1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical,R.sup.2 is hydrogen, alkyl or a dioxolylmethyl radical,R.sup.3 is ##STR2## and A is N, CH, C-halogen, or the like, or forms a bridge with R.sup.1,and addition products thereof.
    Type: Grant
    Filed: March 20, 1995
    Date of Patent: March 4, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Andreas Krebs, Klaus Grohe, Michael Schriewer, Ingo Haller, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler
  • Patent number: 5605910
    Abstract: The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a tricyclic amine radical, their salts, processes for their preparation and antibacterial compositions comprising these compounds.
    Type: Grant
    Filed: July 28, 1995
    Date of Patent: February 25, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Thomas Jaetsch, Stephan Bartel, Klaus D. Bremm, Rainer Endermann, Karl G. Metzger
  • Patent number: 5574161
    Abstract: The invention relates to novel derivatives of quinolone-carboxylic acid and naphthyridonecarboxylic acid which are substituted in the 7 position by a 1- (or 5-)amino-methyl-2- (or 3-)oxa-7-aza-bicyclo[3.3.0]oct-7-yl residue, their salts, processes for their preparation and antibacterial agents containing these compounds.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: November 12, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Klaus Grohe, Klaus-Dieter Bremm, Rainer Endermann, Karl G. Metzger
  • Patent number: 5571812
    Abstract: The invention is related to 7-amino-1-cyclopropyl-6,8- dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxylic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.
    Type: Grant
    Filed: April 27, 1992
    Date of Patent: November 5, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Klaus Grohe, Hans-Joachim Zeiler, Karl G. Metzger
  • Patent number: 5556979
    Abstract: The invention relates to novel quinolone derivatives and naphthyridone derivatives which are substituted in the 7-position by a partially hydrogenated isoindolinyl ring, to processes for their preparation and to antibacterial agents and feed additives containing them.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: September 17, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Philipps, Stephan Bartel, Andreas Krebs, Uwe Petersen, Thomas Schenke, Klaus-Dieter Bremm, Rainer Endermann, Karl G. Metzger, Burkhard Mielke
  • Patent number: 5545642
    Abstract: The invention relates to novel derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)-naphthyridonecarboxylic acid which are substituted in the 7 position by a 2,3,4,5,6,7-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl or 1,2,3,4,5,6-hexahydropyrrolo[3,4-c]pyrrol-2-yl residue, to their salts, to a process for their preparation and to antibacterial agents containing these derivatives.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: August 13, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Stefan B ohm, Rolf Grosser, Klaus D. Bremm, Rainer Endermann, Karl G. Metzger
  • Patent number: 5508278
    Abstract: Novel bactericidal pyrido[1,2,3-d,e,][1,3,4]benzoxadiazine derivatives of the formula (I) ##STR1## in which R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl optionally substituted by hydroxyl or halogen,R.sup.2 independently of R.sup.1 is hydrogen or methyl,R.sup.3 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl optionally substituted by hydroxyl, methoxy, amino, methylamino or dimethylamino, or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl,X.sup.
    Type: Grant
    Filed: August 26, 1994
    Date of Patent: April 16, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Jaetsch, Burkhard Mielke, Uwe Petersen, Thomas Philipps, Thomas Schenke, Klaus D. Bremm, Rainer Endermann, Karl G. Metzger, Martin Scheer, Michael Stegemann, Heinz-Georg Wetzstein
  • Patent number: 5468861
    Abstract: The invention is related to 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxy lic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: November 21, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Klaus Grobe, Hans-Joachim Zeiler, Karl G. Metzger
  • Patent number: 5468742
    Abstract: The invention relates to new 8-vinyl- and 8-ethinylquinolonecarboxylic acids, process for their preparation, and antibacterial agents and feed additives containing them.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: November 21, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Himmler, Thomas Schenke, Andreas Krebs, Klaus Grohe, Klaus-Dieter Bremm, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler
  • Patent number: 5453422
    Abstract: An antibacterially active quinolone or naphthyridonecarboxylic acid derivative of the formula ##STR1## in which R.sup.1 stands for various organic radical,R.sup.2 stands for hydrogen, alkyl having 1 to 4 carbon atoms or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl,R.sup.3 stands for hydrogen or amino,R.sup.4 stands for a radical of the formula ##STR2## A stands for N or C--R.sup.5, whereinR.sup.5 stands for hydrogen, halogen methyl, cyano or nitro or else together with R.sup.1 can form a bridge of the structure ##STR3## or a pharmaceutically utilizable hydrate, acid addition salt, alkali metal salt, alkaline earth metal salt, silver salt or guanidinium salt of the carboxylic acid when R.sup.2 is hydrogen.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: September 26, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Klaus Grohe, Michael Schriewer, Ingo Haller, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler
  • Patent number: 5416096
    Abstract: 7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen,X.sup.2 is hydrogen, halogen, amino or other radical,R.sup.1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical,R.sup.2 is hydrogen, alkyl or a dioxolylmethyl radical,R.sup.3 is ##STR2## and A is N, CH, C-halogen, or the like, or forms a bridge with R.sup.1,and addition products thereof.
    Type: Grant
    Filed: July 30, 1991
    Date of Patent: May 16, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Andreas Krebs, Klaus Grohe, Michael Schriewer, Ingo Haller, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler
  • Patent number: 5395944
    Abstract: 7-(Aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)quinolonecarboxylic acid and 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)naphthyridonecarboxyli c acid derivatives The invention relates to novel derivatives of quinolonecarboxylic acid and naphthyridonecarboxylic acid which are substituted in the 7 position by a 1- (or 5-)aminomethyl-2- (or 3-)oxa-7-aza-bicyclo[3.3.0]oct-7-yl residue, their salts, processes for their preparation and antibacterial agents containing these compounds.
    Type: Grant
    Filed: September 20, 1993
    Date of Patent: March 7, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Klaus Grohe, Klaus-Dieter Bremm, Rainer Endermann, Karl G. Metzger
  • Patent number: 5284855
    Abstract: The invention relates to new 7-(2,7-Diazabicyclo[3.3.0]octyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives, processes for their preparation, and anti-bacterial agents and feed additives containing them.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: February 8, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Michael Schriewer, Klaus Grohe, Andreas Krebs, Ingo Haller, Karl G. Metzger, Klaus-Dieter Bremm, Rainer Endermann, Hans-Joachim Zeiler
  • Patent number: 5284842
    Abstract: An antibacterially active quinolone or naphthyridonecarboxylic acid derivative of the formula ##STR1## in which R.sup.1 stands for various organic radical,R.sup.2 stands for hydrogen, alkyl having 1 to 4 carbon atoms or (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl,R.sup.3 stands for hydrogen or amino,R.sup.4 stands for a radical of the formula ##STR2## A stands for N or C--R.sup.5, whereinR.sup.5 stands for hydrogen, halogen methyl, cyano or nitro or else together with R.sup.1 can form a bridge of the structure ##STR3## or a pharmaceutically utilizable hydrate, acid addition salt, alkali metal salt, alkaline earth metal salt, silver salt or guanidinium salt of the carboxylic acid when R.sup.2 is hydrogen.
    Type: Grant
    Filed: August 18, 1992
    Date of Patent: February 8, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Klaus Grohe, Michael Schriewer, Ingo Haller, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler
  • Patent number: 5276024
    Abstract: The invention relates to new 3-substituted cephalosporins, to a process for their preparation and to their use as medicaments, in particular as medicaments having antibacterial activity.The invention relates to compounds of the general formula (I) ##STR1## in which X, Y, R.sup.1 and R.sup.2 have the meaning indicated in the description.
    Type: Grant
    Filed: November 21, 1991
    Date of Patent: January 4, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Stephan Schneider, Rainer Endermann, Karl G. Metzger, Klaus-Dieter Bremm
  • Patent number: 5252734
    Abstract: Antibacterial 5-alkylquinolonecarboxylic acids of the formula ##STR1## in which R.sup.3 is C.sub.1 -C.sub.4 - alkyl,R.sup.1 is optionally substituted alkyl or cycloalkyl, alkenyl, alkoxy, amino or alkylamino or optionally substituted phenyl,R.sup.2 is hydrogen or optionally substituted alkyl,R.sup.4 is a nitrogen-containing heterocyclic radical, andA is hydrogen, halogen, methyl, cyano or nitro, or forms a bridge with R.sup.1.and hydrates and salts thereof.
    Type: Grant
    Filed: February 5, 1992
    Date of Patent: October 12, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Schriewer, Klaus Grohe, Andreas Krebs, Uwe Petersen, Thomas Schenke, Ingo Haller, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler
  • Patent number: 5202337
    Abstract: The invention relates to new 7-(2,7-Diazabicyclo[3.3.0]octyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives, processes for their preparation, and antibacterial agents and feed additives containing them.
    Type: Grant
    Filed: October 3, 1991
    Date of Patent: April 13, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Michael Schriewer, Klaus Grohe, Andreas Krebs, Ingo Haller, Karl G. Metzger, Klaus-Dieter Bremm, Rainer Endermann, Hans-Joachim Zeiler
  • Patent number: 5190955
    Abstract: Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxlyic acid derivatives of the formula ##STR1## in which Y represents a carboxyl group, a nitrile group, an ester group --COOR.sup.1 or an acid amide group --CONR.sup.2 R.sup.3,X.sup.1 represents hydrogen nitro, alkyl or halogenX.sup.4 can be hydrogen or halogen, or alkyl,R.sup.4 and R.sup.5, together with the nitrogen atom to which they are bonded, form a 5- or 6-membered heterocyclic ring which can additionally contain the atoms or groups --O--, --S--, --SO--, --SO.sub.2 --, ##STR2## as ring members or the group ##STR3## can also represent a ring system of the structure ##STR4## which can optionally be substituted on the ring carbons by methyl and pharmaceutically usable hydrates, salts or esters thereof.These compounds have a high antibacterial activity and are therefore suitable as active compounds for human and veterinary medicine.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: March 2, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Schriewer, Klaus Grohe, Uwe Petersen, Ingo Haller, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler