Patents by Inventor Karl G. Metzger

Karl G. Metzger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinolone acids and antibacterial agents containing these compounds
    Patent number: 4559342
    Abstract: The invention relates to quinolone carboxylic acids of the formula (I) as defined herein, pharmaceutical compositions containing said quinolone carboxylic acids and the use of said compounds and compositions for treatment of bacterial infection. Also included in the invention are process for the manufacture of the active quinolone carboxylic acids.
    Type: Grant
    Filed: February 3, 1984
    Date of Patent: December 17, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Klaus Grohe, Hans-Joachim Zeiler, Karl G. Metzger
  • Quinolonecarboxylic acids and antibacterial agents containing these compounds
    Patent number: 4559341
    Abstract: The invention relates to quinolone carboxylic acids, pharmaceutical compositions containing said quinolone carboxylic acids and the use of said compounds and compositions for treatment of bacterial infection. Also included in the invention are process for the manufacture of the active quinolone carboxylic acids.
    Type: Grant
    Filed: February 3, 1984
    Date of Patent: December 17, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Klaus Grohe, Engelbert Kuhle, Hans-Joachim Zeiler, Karl G. Metzger
  • 7-Amino-1-cyclopropyl-6,8-difluoro-1,4-di hydro-4-oxo-quinoline-3-carboxylic acids and antibacterial agents containing these compounds
    Patent number: 4556658
    Abstract: The invention relates to 7-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxyli c acids, processes for their preparation and compositions containing them as antibacterial agents. Also included in the invention are methods for treating bacterial infection using the compounds and compositions of the invention.
    Type: Grant
    Filed: April 24, 1984
    Date of Patent: December 3, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Grohe, Uwe Petersen, Hans-Joachim Zeiler, Karl G. Metzger
  • 2-Amino-8-cyclopropyl-5-oxo-5,8-dihydro-pyrido[2,3-d]-pyrimidin e-6-carboxylic acid compounds
    Patent number: 4556709
    Abstract: The invention relates to 2-amino-8-cyclopropyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxyli c acid compounds, processes for their preparation and their use as antibacterial agents, and also as feed additives.
    Type: Grant
    Filed: July 26, 1982
    Date of Patent: December 3, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Grohe, Hans-Joachim Zeiler, Karl G. Metzger
  • 4H-1,4-Benzothiazine derivatives
    Patent number: 4548934
    Abstract: The present invention relates to novel 4H-1,4-benzothiazine derivatives and a method for their synthesis. The invention also relates to the pharmaceutical use of said derivatives, in particular their use as anti-infective agents, as agents for promoting growth and for improving feed stuff utilization in animals, and as preservations.
    Type: Grant
    Filed: August 1, 1983
    Date of Patent: October 22, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerd Fengler, Dieter Arlt, Klaus Grohe, Hans-Joachim Zeiler, Karl G. Metzger
  • 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(oxo-alkyl)-1-piperazinyl ]quinoline-3-carboxylic acids and their derivatives, and antibacterial agents containing them
    Patent number: 4547503
    Abstract: The invention relates to 1-cyclopropyl-6-fluoro-1,4 dihydro-4-oxo-7-[4-(oxo-(alkyl)-1-piperazinyl]-quinoline-3-carboxylic acids of Formula (I), processes for their manufacture, compositions containing them and use of said compounds and compositions as antibacterial and/or feedstuff additives.
    Type: Grant
    Filed: December 9, 1983
    Date of Patent: October 15, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Klaus Grohe, Hans-Joachim Zeiler, Karl G. Metzger
  • Streptomyces species and process for producing antibiotic
    Patent number: 4546079
    Abstract: An antibiotic compound which can be in the iron-free or iron-containing form and has the structural formula (B) as described herein. The compound possesses antimicrobial activity. Also fermentation processes for preparation of the above-mentioned antibiotic compound. In addition, pharmaceutical compositions containing said antibiotic compound and the use of said antibiotic compound and compositions for combating bacterial infection.
    Type: Grant
    Filed: May 31, 1983
    Date of Patent: October 8, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl G. Metzger, Jorg Pfitzner, Delf Schmidt, Horst Weyland, Gunter Benz, Theo Schroder
  • 1-Cyclopropyl-6-fluoro-1,4-dih ydro-4-oxo-7-(alkyl-1-piperazinyl)quinoline-3-carboxylic acids, processes for their preparation and antibacterial agents containing them
    Patent number: 4544658
    Abstract: The invention relates to 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(alkyl-1-piperazinyl)quinoline- 3-carboxylic acids of Formula (I), processes for their manufacture, compositions containing them and use of said compounds and compositions as antibacterial and/or feedstuff additives.
    Type: Grant
    Filed: December 9, 1983
    Date of Patent: October 1, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Klaus Grohe, Hans-Joachim Zeiler, Karl G. Metzger
  • Cleavage products of 4',6'-didesoxy-4'-thio-,6'-amino-hepturonic acid nucleosides
    Patent number: 4535083
    Abstract: The invention relates to compounds of the formula ##STR1## said compounds being obtainable by cleavage of compounds of formula ##STR2## The compounds of the invention as well as compositions and medicaments containing a compound of the invention are useful as antimicrobial agents.
    Type: Grant
    Filed: September 9, 1983
    Date of Patent: August 13, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Benz, Karl G. Metzger, Hans-Joachim Zeiler
  • Synergistic mixtures of penicillins
    Patent number: 4529591
    Abstract: Synergistic anti-bacterial compositions comprising (A) D-.alpha.-[(imidazolidin-2-on-1-yl)-carbonylamino]-benzylpenicillin or D-.alpha.-[(3-methylsulphonyl-imidazolidin-2-on-1-yl)-carbonylamino]-benzy lpenicillin, and (B) 3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolylpenicillin, 3-(2-chloro-6-fluo rophenyl)-5-methyl-4-isoxazolylpenicillin, 3-(2-chlorophenyl)-5-methyl-4-isoxazolylpenicillin, 3-phenyl-5-methyl-4-isoxazolylpenicillin, or 2,6-dimethoxyphenylpenicillin, or salts thereof. They can be used to fight infection, as additives to animal feeds to promote growth, and as a preservative for polymers.
    Type: Grant
    Filed: March 1, 1982
    Date of Patent: July 16, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventor: Karl G. Metzger
  • .beta.-Lactam antibiotics
    Patent number: 4515789
    Abstract: A 3-.beta.-(vic-dihydroxyphenylmethyleneamino-2-oxo-imidazolidine)- or 3-.beta.-(vic-dihydroxyphenyl-methyleneamino-2,3-dioxo-piperazine)-1-carbo nylamino-acetamidoazetidin-2-one having an acidic grouping on .sub.1 N, e.g. of the formula ##STR1## The compounds are antibiotically active, especially against Pseudomonas bacteria and can be used in combating bacterial infection, as a preservative and as a growth promoting agent in animal feeds.
    Type: Grant
    Filed: April 7, 1983
    Date of Patent: May 7, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl G. Metzger, Wilfried Schrock, Dieter Habich, Paul Naab, Hans-Joachim Zeiler
  • Cephalosporins
    Patent number: 4489076
    Abstract: Antibacterially active cephalosporins of the formula ##STR1## in which R.sup.1 denotes C.sub.1 -C.sub.6 -alkyl, phenyl or halogen-substituted phenyl, andR.sup.2 and R.sup.3, which can be identical or different, denote H, C.sub.1 -C.sub.4 -alkyl, chlorine, bromine, carbamoyl or N-C.sub.1 -C.sub.4 -alkylcarbamoyl.
    Type: Grant
    Filed: October 17, 1983
    Date of Patent: December 18, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunther Kinast, Michael Boberg, Karl G. Metzger, Hans-Joachim Zeiler
  • Antibiotic compounds, their production and their medicinal use
    Patent number: 4474762
    Abstract: The invention relates to antimicrobial compounds of Formula (I) and semi-synthetic methods for their production. Also included in the invention are compositions containing said antimicrobial compounds and methods for the use of said compound and compositions.
    Type: Grant
    Filed: June 14, 1982
    Date of Patent: October 2, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Benz, Karl G. Metzger, Jorg Pfitzner, Delf Schmidt, Hans-Joachim Zeiler
  • .beta.-Lactam antibiotics
    Patent number: 4438114
    Abstract: A .beta.-lactam of the formula ##STR1## or a hydrate thereof, in whichR represents a hydrogen atom or a methoxy group,n is 1 or 2,Z represents a group of the formula ##STR2## wherein R.sup.
    Type: Grant
    Filed: September 7, 1982
    Date of Patent: March 20, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Boberg, Dieter Habich, Karl G. Metzger, Paul Naab
  • Sisomicin compounds
    Patent number: 4438260
    Abstract: The invention relates to sisomicin derivatives of formula (I) and methods for their preparation. Also included in the invention are compositions containing said sisomicin derivatives and the use of said derivatives and compositions for the treatment of bacterial infections.
    Type: Grant
    Filed: December 24, 1981
    Date of Patent: March 20, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Peter Stadler, Oswald Lockhoff, Hans-Joachim Zeiler, Karl G. Metzger
  • .beta.-Lactam antibiotics and compositions containing the same
    Patent number: 4416880
    Abstract: .beta.-Lactam antibiotics of the formula ##STR1## in which A is a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl group, a substituted or unsubstituted phenyl ring, a polycyclic aromatic ring or an optionally substituted heterocyclic 5-membered or 6-membered ring with 1 to 4 hetero-atoms,Y is ##STR2## X is a sulphur or oxygen atom, T is an organic radical, andZ is a hydrogen atom or a C.sub.1 to C.sub.6 alkoxy group, or an ester or salt thereof.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: November 22, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Boberg, Karl G. Metzger
  • Antibiotic compound, its production and its medicinal use
    Patent number: 4416870
    Abstract: The invention relates to an antibiotic compound which can be in the iron-free or iron-containing form and has the structural formula (A) as described herein. The compound possesses antimicrobial activity. Also included in the invention are fermentation processes for preparation of the above-mentioned antibiotic compound. In addition, the invention includes pharmaceutical compositions containing said antibiotic compound and the use of said antibiotic compound and compositions for combating bacterial infections.
    Type: Grant
    Filed: January 18, 1982
    Date of Patent: November 22, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl G. Metzger, Jorg Pfitzner, Delf Schmidt, Horst Weyland, Gunter Benz, Theo Schroder
  • Antibiotic compound, its production and its medicinal use
    Patent number: 4415557
    Abstract: The invention relates to an antibiotic compound which can be in the iron-free or iron-containing form and has the structural formula (B) as described herein. The compound posesses antimicrobial activity. Also included in the invention are fermentation processes for preparation of the above-mentioned antibiotic compound. In addition, the invention includes pharmaceutical compositions containing said antibiotic compound and the use of said antibiotic compound and compositions for combating bacterial infection.
    Type: Grant
    Filed: January 18, 1982
    Date of Patent: November 15, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl G. Metzger, Jorg Pfitzner, Delf Schmidt, Horst Weyland, Gunter Benz, Theo Schroder
  • 1-N(Aminopolyhydroxyalkyl)aminoglycoside antibiotics and method of use
    Patent number: 4393051
    Abstract: The invention relates to pseudotrisaccharides of Formula (I) as defined above, methods for preparing them, compositions containing them and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: June 2, 1980
    Date of Patent: July 12, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Stadler, Karl G. Metzger, Eckart Voss, Uwe Petersen, Hans-Joachim Zeiler
  • Pseudotrissaccharides, a process for their production and their use as medicaments
    Patent number: RE31512
    Abstract: Pseudotrisaccharides of the sisomycin type are provided which are effective an antibacterial agents, particularly against gram-negative microorganisms. The invention also includes methods for the manufacture of the pseudotrisaccharides, compositions containing said pseudotrisaccharides and methods for the treatment of warm-blooded animals using said compounds and compositions.
    Type: Grant
    Filed: May 6, 1981
    Date of Patent: January 31, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Stadler, Karl G. Metzger, Eckart Voss, Uwe Petersen, Hans-Joachim Zeiler, Hans-Joachim Kabbe