Patents by Inventor Karl Kolter

Karl Kolter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210387156
    Abstract: The present invention relates to processes for producing microparticles having, in their interior, at least one cavity which is connected via pores to the surface of the microparticles and which have been laden with at least one organic active of low molecular weight. The invention especially relates to a process for loading microparticles with at least one organic active of low molecular weight, wherein the active has been embedded in a matrix and/or the pores of the microparticles have been closed by means of a substance applied to the surface of the microparticles. The invention additionally relates to a process for sealing microparticles laden with at least one organic active of low molecular weight. The invention also relates to compositions of microparticles laden with at least one active of low molecular weight and to the use thereof.
    Type: Application
    Filed: October 29, 2019
    Publication date: December 16, 2021
    Inventors: Bernd Dieter OSCHMANN, Kerstin MUELHEIMS, Wolfgang KRAUSE, Patrick LEIBACH, Roland Hinrich STAFF, Dieter FLICK, Lukas MAYR, Stephanie RENZ, Felicitas GUTH, Klaus KAHLE, Stephan HUEFFER, Tobias Maximilian MERKEL, Axel BINDER, Karl KOLTER, Yean Yik GEOERG, Regina VOGELSANG, Antoine Maxime Charles Jos BEZIAU
  • Patent number: 11154508
    Abstract: A finely divided binder in powder form consisting of a polyethylene glycol-polyvinyl alcohol graft polymer particles, wherein the particles have an average particle size D[4,3] in the range of from 10 to 70 ?m.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: October 26, 2021
    Assignee: BASF SE
    Inventors: Bernhard Fussnegger, Silke Gebert, Felicitas Guth, Karl Kolter
  • Patent number: 11123282
    Abstract: An odorant and flavoring formulation for topical application comprising, as matrix former, a mixture of at least one water-insoluble polymer from the group of homo- or co-polymers of C1-C4-carboxylic acid vinyl esters and at least one water-soluble polymer from the group of homo- or copolymers of N-vinyllactams.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: September 21, 2021
    Assignee: BASF SE
    Inventors: Karl Kolter, Ralf Pelzer, Marion Bendel, Matthias Karl
  • Publication number: 20210251905
    Abstract: The use of powder-form, crosslinked, water-insoluble, low-swelling polyacrylates as disintegrants for solid pharmaceutical dosage forms.
    Type: Application
    Filed: May 15, 2019
    Publication date: August 19, 2021
    Inventors: Theo SMIT, Matthias KARL, Felicitas GUTH, Maximilian ANGEL, Karl KOLTER, Frank SCHMIDT, Maximilian BLOCHBERGER-CLAUS
  • Publication number: 20210163879
    Abstract: A method for stabilizing cells in cell culture production, the method comprising culturing a cell line capable of expressing proteins in cell culture media, and supplementing said cell culture media with a graft polymer in which N-vinyl caprolactam and vinyl acetate moieties are grafted on a polyethylene glycol backbone.
    Type: Application
    Filed: December 7, 2018
    Publication date: June 3, 2021
    Inventors: Felicitas Guth, Karl Kolter, Nigel A. Langley, Kerri Gaumer Freidl, Kristina Brueggemann
  • Publication number: 20210153540
    Abstract: The present invention relates to dust-free preparations dispersible in cold water. These preparations consist of particles comprising water-insoluble or only sparingly water-soluble active substance(s), said particles being coated with one or more layers, the outermost layer comprising as principal component one or more hydrophobic powdering agents on which at least one dispersant is absorbed. The invention also relates to a process for producing these particles and to the use thereof in food supplements, foodstuffs, animal feeds, personal-care products, and medicaments.
    Type: Application
    Filed: May 29, 2019
    Publication date: May 27, 2021
    Inventors: Kathrin MEYER-BOEHM, Andreas HABICH, Daniel WAGNER, Wolf PELLETIER, Walter DOBLER, Peter SCHORDING, Karl KOLTER
  • Publication number: 20210069112
    Abstract: Terpolymer, wherein 20 to 35% by weight of the structural units are derived from acrylic acid, 45 to 60% by weight of the structural units from a hydrophobic methacrylate selected from a group consisting of isopropyl methacrylate, tert-butyl methacrylate and cyclohexyl methacrylate and 15 to 40% by weight of the structural units from a third olefinic monomer selected from the group consisting of N-vinyl lactam, hydroxy ethyl methacrylate and phenoxyethyl acrylate with the proviso that the total amount of structural units derived from the three monomer groups adds up to 100% by weight, and the use of the terpolymers as crystallization inhibitors in pharmaceutical dosage forms for inhibiting the recrystallization in an aqueous environment of a human or animal body of an active ingredient.
    Type: Application
    Filed: December 7, 2018
    Publication date: March 11, 2021
    Inventors: Ferdinand Paul Brandl, Theo Smit, Felicitas Guth, Karl Kolter, Maximilian Angel, Frank Schmidt
  • Patent number: 10912835
    Abstract: Pharmaceutical coatings obtained from coating compositions based on film-forming copolymers of N,N-diethylaminoethyl methacrylate (DEAEMA) and methyl methacrylate (MMA) comprising a weight ratio of DEAEMA:MMA in the range of 35:65 to 55:45, where the copolymers are present partially neutralized with C3-C10-dicarboxylic acids.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: February 9, 2021
    Assignee: BASF SE
    Inventors: Karl Kolter, Silke Gebert, Michael Klemens Müller, Maximilian Angel
  • Patent number: 10835456
    Abstract: The present invention relates to a pulverulent vitamin formulation in which the vitamin essentially has a particle size of less than 0.7 ?m and which comprises an effective amount of propyl gallate, and also to processes for producing this formulation, and to formulations obtainable by these processes and to the use thereof as animal feed, food, food supplement, personal care product or pharmaceutical composition. The formulations of the invention have improved stability compared to the prior art.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: November 17, 2020
    Assignee: BASF SE
    Inventors: Kathrin Meyer-Boehm, Thrandur Helgason, Raajvinder Singh, Walter Dobler, Peter Schording, Christof Wilhelm Wigbers, Karl Kolter, Stefan Bruhns, Wolf Pelletier, Daniel Wagner
  • Patent number: 10668156
    Abstract: Described are solid dispersions of hydrophobic active ingredients and cationic copolymers of N,N-diethylaminoethyl methacrylate and methyl methacrylate in a weight ratio of the monomers of from 35:65 to 55:45. Also described are the preparation and use of such solid dispersions for pharmaceutical dosage forms.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: June 2, 2020
    Assignee: BASF SE
    Inventors: Karl Kolter, Maximilian Angel, Matthias Karl, Silke Gebert, Michael Klemens Mueller
  • Publication number: 20200129437
    Abstract: A finely divided binder in powder form consisting of a polyethylene glycol-polyvinyl alcohol graft polymer particles, wherein the particles have an average particle size D[4,3] in the range of from 10 to 70 ?m.
    Type: Application
    Filed: June 5, 2018
    Publication date: April 30, 2020
    Inventors: Bernhard Fussnegger, Silke Gebert, Felicitas Guth, Karl Kolter
  • Patent number: 10610487
    Abstract: Water-soluble polymeric salts of medicaments sparingly soluble in water consisting of a cationogenic medicament which, in uncharged form or as hydrochloride, has a solubility of less than 0.1% (m/m) in water, artificial intestinal juice or gastric juice, and an anionogenic water-soluble polymer having a solubility in water of at least 5% (m/m) in the pH range of 1 to 13 and which is obtained by free-radically initiated polymerization of a monomer mixture of i) 70 to 90% by weight N-vinylpyrrolidone and ii) 10 to 30% by weight acrylic acid, wherein the sum total of i) and ii) corresponds to 100% by weight.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: April 7, 2020
    Assignee: BASF SE
    Inventors: Heiko Alexander Schiffter, Maximilian Angel, Karl Kolter, Felicitas Guth
  • Patent number: 10406105
    Abstract: Pharmaceutical formulation in the form of agglomerates comprising A) an excipient content composed of a) 60-97% by weight of sugar or sugar alcohols, b) 1-25% by weight of a disintegrant, c) 1-15% by weight of water-insoluble, film-forming polymers d) 0-15% by weight of water-soluble polymers and e) 0-15% by weight of further pharmaceutically customary excipients the total of the components a) to e) being 100% by weight, and B) at least one active ingredient.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: September 10, 2019
    Assignee: BASF SE
    Inventors: Karl Kolter, Michael Schönherr, Silke Gebert, Kathrin Meyer-Böhm, Angelika Maschke
  • Publication number: 20190240119
    Abstract: The present invention relates to a pulverulent vitamin formulation in which the vitamin essentially has a particle size of less than 0.7 ?m and which comprises an effective amount of propyl gallate, and also to processes for producing this formulation, and to formulations obtainable by these processes and to the use thereof as animal feed, food, food supplement, personal care product or pharmaceutical composition. The formulations of the invention have improved stability compared to the prior art.
    Type: Application
    Filed: July 17, 2017
    Publication date: August 8, 2019
    Inventors: KATHRIN MEYER-BOEHM, Thrandur HELGASON, Raajvinder SINGH, Walter DOBLER, Peter SCHORDING, Christof Wilhelm WIGBERS, Karl KOLTER, Stefan BRUHNS, Wolf PELLETIER, Daniel WAGNER
  • Publication number: 20190231659
    Abstract: The present invention relates to compositions of spherical microparticles composed of a wall material and at least one cavity that comprises a gas and/or a liquid, which have pores on the surface thereof, wherein the spherical microparticles have a mean particle diameter of 10-600 ?m and wherein at least 80% of those microparticles, the particle diameter of which does not deviate from the mean particle diameter of the microparticles of the composition by more than 20%, each have on average at least 10 pores, the diameter of which is in the range from 1/5000 to ? of the mean particle diameter, and, furthermore, the diameter of each of these pores is at least 20 nm, wherein the wall material consists of a composition comprising at least one aliphatic-aromatic polyester, and the wall material has a solubility at 25° C. of at least 50 g/l in dichloromethane, a method for the preparation thereof and also the use thereof.
    Type: Application
    Filed: October 4, 2017
    Publication date: August 1, 2019
    Inventors: Ewelina BURAKOWSKA-MEISE, Wolfgang KRAUSE, Patrick LEIBACH, Karl KOLTER
  • Patent number: 10328150
    Abstract: Dosage forms comprising preparations of slightly water-soluble active substances in a polymer matrix of polyether copolymers, the polyether copolymers being obtained by free radical polymerization of a mixture of from 30 to 80% by weight of N-vinyllactam, from 10 to 50% by weight of vinyl acetate and from 10 to 50% by weight of a polyether, and of at least one slightly water-soluble polymer in which the slightly water-soluble active substance is present in amorphous form in the polymer matrix.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: June 25, 2019
    Assignee: BASF SE
    Inventors: Karl Kolter, Dejan Djuric, Stefan Fischer
  • Publication number: 20190090529
    Abstract: The present invention relates to a method for producing particles containing carotenoid and/or vitamin and/or omega-3 fatty acids and/or phytosterols and/or conjugated linoleic acids, having a narrow particle size distribution and uniform spherical shape and density, and also to particles obtainable by this method and use thereof as food supplements, foodstuffs, feedstuffs, body care products and medicaments. The particles according to the invention exhibit improved storage stability compared to the prior art.
    Type: Application
    Filed: February 28, 2017
    Publication date: March 28, 2019
    Inventors: Kathrin MEYER-BOEHM, Thrandur HELGASON, Karl KOLTER, Walter DOBLER, Christol STADAGER, MIchael SCHOENHERR, Katja KESTEN, Nikolaus NESTLE
  • Publication number: 20190060209
    Abstract: An odorant and flavoring formulation for topical application comprising, as matrix former, a mixture of at least one water-insoluble polymer from the group of homo- or co-polymers of C1-C4-carboxylic acid vinyl esters and at least one water-soluble polymer from the group of homo- or copolymers of N-vinyllactams.
    Type: Application
    Filed: October 13, 2016
    Publication date: February 28, 2019
    Inventors: Karl Kolter, Ralf Pelzer, Marion Bendel, Matthias Karl
  • Publication number: 20180305636
    Abstract: An optically clear, solid water-soluble formulation of odorants and flavorings comprising at least one synthetically prepared odorant and flavoring, in which the odorants and flavorings are embedded homogeneously in a polymer matrix based on polyvinyllactams.
    Type: Application
    Filed: October 13, 2016
    Publication date: October 25, 2018
    Inventors: Karl Kolter, Ralf Pelzer, Matthias Karl
  • Publication number: 20180235885
    Abstract: Water-soluble polymeric salts of medicaments sparingly soluble in water consisting of a cationogenic medicament which, in uncharged form or as hydrochloride, has a solubility of less than 0.1% (m/m) in water, artificial intestinal juice or gastric juice, and an anionogenic water-soluble polymer having a solubility in water of at least 5% (m/m) in the pH range of 1 to 13 and which is obtained by free-radically initiated polymerization of a monomer mixture of i) 70 to 90% by weight N-vinylpyrrolidone and ii) 10 to 30% by weight acrylic acid, wherein the sum total of i) and ii) corresponds to 100% by weight.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 23, 2018
    Inventors: Heiko Alexander Schiffter, Maximilian Angel, Karl Kolter, Felicitas Guth