Patents by Inventor Karsten Matthias
Karsten Matthias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9370193Abstract: The present invention relates to the modification of lipids in lipid-containing plant material, such as cereal bran for the generation of functional lipids. The present invention further relates to the preparation of compositions comprising such functional lipids as well as the use of these compositions comprising functional lipids and other functional compounds derived from the action of lipid modifying enzymes for the preparation of composition suitable for the preparation of bio-ethanol as well as food products, such as bread.Type: GrantFiled: January 15, 2010Date of Patent: June 21, 2016Assignee: DUPONT NUTRITION BIOSCIENCES APSInventors: Jens Frisbaek Sørensen, René Mikkelsen, Charlotte Horsmans Poulsen, Karsten Matthias Kragh
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Patent number: 9045514Abstract: A method of preparing a compound of formula (I): wherein: a first group selected from R1, R2 and R3 is an amino- or N-acylamino monosaccharide moiety, the acyl group having 1 to 6 carbon atoms, or an oligosaccharide chain comprising 2 to 4 monosaccharide moieties, at least one of which is an amino- or N-acylamino monosaccharide moiety; a second group selected from R1, R2 and R3 is a alkanoyl and alkenoyl acyl group having 3 to 40 carbon atoms; and a third group selected from R1, R2 and R3 is hydrogen, the method comprising contacting a monoacylglycerol, the acyl moiety thereof being a saturated or unsaturated acyl group having 3 to 40 carbon atoms, or an activated derivative thereof, with a source of amino- or N-acylamino monosaccharide moiety, or an activated derivative thereof, and, if required, a source of unsubstituted monosaccharide moiety, or an activated derivative thereof, optionally in the presence of a suitable catalyst or activating agent, is described.Type: GrantFiled: January 20, 2011Date of Patent: June 2, 2015Assignee: DuPont Nutrition Biosciences ApSInventors: Flemming Vang Sparsø, Karsten Matthias Kragh, Lars Wiebe, Rene Mikkelsen, Anne Katherine Kjærsgaard Laursen
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Publication number: 20140363478Abstract: There is provided an anti-fouling composition comprising (i) a surface coating material; (ii) an enzyme obtained or obtainable from a marine organism; and (iii)(a) a substrate for the enzyme; and/or (b) a precursor enzyme and a precursor substrate, wherein the precursor enzyme and the precursor substrate are selected such that a substrate for the enzyme is generatable by action of the precursor enzyme on the precursor substrate; wherein the enzyme and the substrate are selected such that an anti-foulant compound is generatable by action of the enzyme on the substrate.Type: ApplicationFiled: March 21, 2014Publication date: December 11, 2014Applicant: DUPONT NUTRITION BIOSCIENCES APSInventors: Charlotte Horsmans Poulsen, Karsten Matthias Kragh
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Patent number: 8809032Abstract: This invention relates to amylase polypeptides, and nucleic acids encoding the polypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically the amylases of the current invention show an altered exospecifity.Type: GrantFiled: February 1, 2008Date of Patent: August 19, 2014Assignee: Dupont Nutrition Biosciences ApsInventors: Casper Tune Berg, Kirsten Bojsen, Patrick M. F. Derkx, Carol Fioresi, Gijsbert Gerritse, Karsten Matthias Kragh, Wei Liu, Andrew Shaw, Charlotte Refdahl Thoudahl, Anja Hemmingsen Kellett-Smith
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Patent number: 8802398Abstract: A method of oxidizing a saccharide, by contacting the saccharide with an alcohol dehydrogenase (ADH) enzyme selected from a quinone redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide (NAD+) redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide phosphate (NADP+) redox cofactor-dependent ADH, and any combination thereof is described. An oxidized saccharide obtainable by the method and products, in particular food products and paper products, containing the oxidized saccharide, are also described.Type: GrantFiled: October 29, 2010Date of Patent: August 12, 2014Assignee: Dupont Nutrition Biosciences ApsInventors: Jorn Dalgaard Mikkelsen, Karsten Matthias Kragh, Rene Mikkelsen, Patrick Maria Franciscus Derkx, Shukun Yu, Harm Mulder, Igor Nikolaev
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Patent number: 8753859Abstract: This invention relates to polypeptides, more specifically amylase polypeptides and nucleic acids encoding these, and their uses e.g. as non-maltogenic exoamylases in producing food or feed products.Type: GrantFiled: November 2, 2011Date of Patent: June 17, 2014Assignee: Dupont Nutrition Biosciences APSInventors: Karsten Matthias Kragh, Anja Hemmingsen Kellet-Smith, René Mikkelsen, Rie Mejldal, Rikke L. Bundgaard Jenner
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Patent number: 8663966Abstract: We disclose a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises substitutions at the following positions: G121D, 134, 141, 157, 223, 307 and 334 with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1.Type: GrantFiled: September 19, 2007Date of Patent: March 4, 2014Assignee: Dupont Nutrition Biosciences APSInventors: Karsten Matthias Kragh, Bo Spange Sørensen
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Publication number: 20130224820Abstract: There is provided an anti-fouling composition comprising (i) a surface coating material; (ii) an enzyme obtained or obtainable from a marine organism; and (iii)(a) a substrate for the enzyme; and/or (b) a precursor enzyme and a precursor substrate, wherein the precursor enzyme and the precursor substrate are selected such that a substrate for the enzyme is generatable by action of the precursor enzyme on the precursor substrate; wherein the enzyme and the substrate are selected such that an anti-foulant compound is generatable by action of the enzyme on the substrate.Type: ApplicationFiled: April 20, 2012Publication date: August 29, 2013Inventors: Charlotte Horsmans Poulsen, Karsten Matthias Kragh
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Publication number: 20120315373Abstract: A method of preparing a compound of formula (I): wherein: a first group selected from R1, R2 and R3 is an amino- or N-acylamino monosaccharide moiety, the acyl group having 1 to 6 carbon atoms, or an oligosaccharide chain comprising 2 to 4 monosaccharide moieties, at least one of which is an amino- or N-acylamino monosaccharide moiety; a second group selected from R1, R2 and R3 is a saturated or unsaturated acyi group having 3 to 40 carbon atoms; and a third group selected from R1, R2 and R3 is hydrogen, the method comprising contacting a monoacylglycerol, the acyl moiety thereof being a saturated or unsaturated acyl group having 3 to 40 carbon atoms, or an activated derivative thereof, with a source of amino- or N-acylamino monosaccharide moiety, or an activated derivative thereof, and, if required, a source of unsubstituted monosaccharide moiety, or an activated derivative thereof, optionally in the presence of a suitable catalyst or activating agent, is described.Type: ApplicationFiled: January 20, 2011Publication date: December 13, 2012Applicant: DUPONT NUTRITION BIOSCIENCES APSInventors: Flemming Vang Sparsø, Karsten Matthias Kragh, Lars Wiebe, Rene Mikkelsen, Anne Katherine Kjærsgaard Laursen
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Publication number: 20120190075Abstract: This invention relates to polypeptides, more specifically amylase polypeptides and nucleic acids encoding these, and their uses e.g. as non-maltogenic exoamylases in producing food or feed products.Type: ApplicationFiled: November 2, 2011Publication date: July 26, 2012Inventors: Karsten Matthias Kragh, Anja Hemmingsen Kellet-Smith, René Mikkelsen, Rie Mejldal, Rikke L. Bundgaard Jenner
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Patent number: 8178090Abstract: Use of a preparation as an antimicrobial agent or as an anti-oxidant; wherein said preparation comprises a polypeptide having hexose oxidase activity, the polypeptide being in a substantially pure form, and said polypeptide comprises at least one amino acid sequence selected from the group consisting of (i) (SEQ?ID?NO:?1) Tyr-Glu-Pro-Tyr-Gly-Gly-Val-Pro (ii) (SEQ?ID?NO:?2) Ala-Ile-Ile-Asn-Val-Thr-Gly-Leu-Val-Glu-Ser-Gly- Tyr-Asp-X-X-X-Gly-Tyr-X-Val-Ser-Ser- (iii) (SEQ?ID?NO:?3) Asp-Leu-Pro-Met-Ser-Pro-Arg-Gly-Val-Ile-Ala-Ser- Asn-Leu-X-Phe- (iv) (SEQ?ID?NO:?4) Asp-Ser-Glu-Gly-Asn-Asp-Gly-Glu-Leu-Phe-X-Ala-His- Thr (v) (SEQ?ID?NO:?5) Tyr-Tyr-Phe-Lys (vi) (SEQ?ID?NO:?6) Asp-Pro-Gly-Tyr-Ile-Val-Ile-Asp-Val-Asn-Ala-Gly- Thr-X-Asp (vii) (SEQ?ID?NO:?7) Leu-Gln-Tyr-Gln-Thr-Tyr-Trp-Gln-Glu-Glu-Asp (viii) (SEQ?ID?NO:?8) X-Ile-Arg-Asp-Phe-Tyr-Glu-GluType: GrantFiled: March 3, 2009Date of Patent: May 15, 2012Assignee: Danisco A/SInventors: Peter Stougaard, Ole Cai Hansen, Charlotte Horsmans Poulsen, Karsten Matthias Kragh
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Patent number: 8178336Abstract: We describe a PS4 variant polypeptide derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises an amino acid substitution at position 307 to lysine (K) or arginine (R), with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1. Preferably, the PS4 variant polypeptide further comprises an amino acid substitution at position 70, preferably G70D. The amino acid at positions 272 and 303 of the sequence of the are preferably histidine (H) and glycine (G).Type: GrantFiled: December 19, 2008Date of Patent: May 15, 2012Assignee: Danisco A/SInventors: Patrick Maria Franciscus Derkx, Anja Kellet-Smith Hemmingen, Rie Mejldal, Bo Spange Sørensen, Karsten Matthias Kragh
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Patent number: 8143048Abstract: This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exospecifity.Type: GrantFiled: July 7, 2004Date of Patent: March 27, 2012Assignee: Danisco A/SInventors: Karsten Matthias Kragh, Kirsten Bojsen, Casper Tune Berg, Patrick M. F. Derkx, Anja H. Kellett-Smith, Charlotte Refdahl Thoudahl, Carol Fioresi, Wei Liu, Andrew Shaw, Gijsbert Gerritse
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Patent number: 8137944Abstract: Variant polypeptides derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the variant polypeptides comprise an amino acid mutation at one or more positions selected from the group consisting of: 121, 161, 223, 146, 157, 158, 198, 229, 303, 306, 309, 316, 353, 26, 70, 145, 188, 272, 339, with reference to the position numbering of a Pseudomonas saccharophila exoamylase sequence shown as SEQ ID NO: 1.Type: GrantFiled: July 7, 2005Date of Patent: March 20, 2012Assignee: Danisco A/SInventors: Casper Tune Berg, Patrick M. F. Derkx, Carol Fioresi, Gijsbert Gerritse, Anja Hemmingen Kellet-Smith, Karsten Matthias Kragh, Wei Liu, Andrew Shaw, Bo Spange Sørensen, Charlotte Refdahl Thoudahl
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Publication number: 20120058222Abstract: The present invention relates to the use of an amylase and a lipolytic enzyme in combination to improve the stackability of bread, methods of preparing dough and baked products having a combination of such enzymes, as well as bread having particular bread stackability profiles.Type: ApplicationFiled: May 19, 2010Publication date: March 8, 2012Applicant: Danisco A/SInventors: Bo Spange Sorensen, Inge Lise Povlsen, Rie Mejldal, Karsten Matthias Kragh, Anja Hemmingsen Kellett-Smith, Rene Mikkelsen, Rikke L. Bundgaard Jenner
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Patent number: 8129511Abstract: This invention relates to nucleic acids encoding amylase polypeptides, the encoded polypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exo-specificity and/or thermostability. Some embodiments of the invention relate to said polypeptides and nucleic acids and their uses as non-maltogenic exoamylases in producing food products.Type: GrantFiled: February 8, 2011Date of Patent: March 6, 2012Assignee: Danisco A/SInventors: Karsten Matthias Kragh, Bo Spange Sørensen, Casper Tune Berg, Kirsten Bojsen, Patrick M. F. Derkx, Carol Fioresi, Anja H. Kellett-Smith, Charlotte Refdahl Thoudahl, Oene R. Veltman, Gijsbert Gerritse, Wei Liu, Andrew Shaw
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Publication number: 20120003690Abstract: The present invention relates to the modification of lipids in lipid-containing plant material, such as cereal bran for the generation of functional lipids. The present invention further relates to the preparation of compositions comprising such functional lipids as well as the use of these compositions comprising functional lipids and other functional compounds derived from the action of lipid modifying enzymes for the preparation of composition suitable for the preparation of bio-ethanol as well as food products, such as bread.Type: ApplicationFiled: January 15, 2010Publication date: January 5, 2012Applicant: Danisco A/SInventors: Jens Frisbaek Sorensen, René Mikkelsen, Charlotte Horsmans Poulsen, Karsten Matthias Kragh
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Publication number: 20110293591Abstract: The present invention provides a composition, and a process for preparing and method for using such a composition. The composition comprises (i) a surface coating material; and (ii) (ii) a cross-linked enzyme crystal or cross-linked enzyme aggregate wherein the enzyme is cross-linked with a multifunctional cross-linking agent and wherein the cross-linked enzyme crystal or cross-linked enzyme aggregate has an antifouling activity or generates an antifouling compound. Suitably the composition may be used to inhibit biofilm formation.Type: ApplicationFiled: February 4, 2010Publication date: December 1, 2011Inventors: Brian Søgaard Lauresen, Jakob Broberg Kristensen, Flemming Basenbacher, Stepan Shipovskov, Duncan Sutherland, Karsten Matthias Kragh
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Publication number: 20110274786Abstract: The present invention relates to the solubilisation of cereal bran, for preparing compositions comprising soluble fractions of cereal bran and the use of these compositions comprising solubilised cereal bran for the preparation of food products, such as bread.Type: ApplicationFiled: January 15, 2010Publication date: November 10, 2011Applicant: Danisco A/SInventors: Jens Frisbaek Sørensen, René Mikkelsen, Charlotte Horsmans Poulsen, Karsten Matthias Kragh
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Patent number: 8030050Abstract: The invention describes a PS4 variant polypeptide derivable from a parent polypeptide having amylase activity selected from the group consisting of: (a) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 161, 178, 179, 223, 229, 272, 303, 307, 309 and 334; (b) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 145, 146, 157, 178, 179, 223, 229, 272, 303, 307 and 334; (c) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; and (d) a polypeptide comprising an amino acid mutation at each of positions 3, 33, 34, 70, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1, uses of such a polypeptide as a food or feed additive, and nucleic acids encoding such.Type: GrantFiled: September 22, 2006Date of Patent: October 4, 2011Assignee: Danisco A/SInventors: Casper Tune Berg, Patrick Maria Franciscus Derkx, Carol Fioresi, Gijsbert Gerritse, Anja Hemmingen Kellet-Smith, Karsten Matthias Kragh, Wei Liu, Andrew Shaw, Bo Spange Sørensen, Charlotte Refdahl Thoudahl