Abstract: The present invention provides a device for communicating with a voice-disabled person. The device includes, generally, a housing, a plurality of means for receiving physical input, each physical input receiving means generating a specified response signal upon being physically manipulated, a display means, and means for receiving the response signals and converting the response signals into a corresponding visual representation on the display means.

Abstract: The present invention provides a device for communicating with a voice-disabled person. The device includes, generally, a housing, a plurality of means for receiving physical input, each physical input receiving means generating a specified response signal upon being physically manipulated, a display means, and means for receiving the response signals and converting the response signals into a corresponding visual representation on the display means.

Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.

Abstract: An energy-absorbing pad structure includes an energy-absorbing pad that is encapsulated by a polymeric film. The polymeric film is sufficiently air-permeable to permit air to escape during rapid compression of the pad structure, such as from a high-speed dynamic impact, but nonetheless is water resistant under ordinary conditions. It is desirable that the polymeric film is made from an elastic polymer. The air-permeability can be provided from a series of perforations such that the film's elastic quality tends to contract the perforations thereby impeding the progress of water through them under normal conditions. The energy-absorbing pad can be a semi-rigid viscoelastic foam.

Abstract: The present invention provides a device for communicating with a voice-disabled person. The device includes, generally, a housing, a plurality of means for receiving physical input, each physical input receiving means generating a specified response signal upon being physically manipulated, a display means, and means for receiving the response signals and converting the response signals into a corresponding visual representation on the display means.

Abstract: A helmet liner that is custom-fitted to a wearer's head, and methods of making the liner, are provided. To make the liner, scanning equipment directly scans the person's head to generate computer-readable data containing a surface map of the head. This data then is used by suitable machining equipment to machine a custom-fitted liner from a universal liner blank, whose resulting convex surface will substantially conform to the shape and contour of the person's head. The scanning equipment desirably is or includes one or a plurality of lasers. A mobile platform including both the scanning and the machining equipment also is provided.

Abstract: A helmet that is custom-fitted to a wearer's head, and methods of making the helmet, are provided A method includes the steps of positioning a shape-forming means over the wearer's head, and hardening the shape-forming means to provide a hardened headform that substantially conforms to the shape of the wearer's head. The shape-forming means can be a stretchable beanie cap that is coated or impregnated with a curable polymeric material, a heat-softenable plastic sheet, or a strip or plurality of strips of curable tape that are wrapped about the wearer's head to provide a headwrap. Once the hardened headform has been made, it can be used to cast a hardened plaster fixture for use as the “male” member in a mold for casting an energy absorbing foam liner for a helmet which has an inner surface substantially conforming to the shape of the wearer's head. Alternatively, the hardened headform can itself be used as the “male” member of the liner casting mold.

Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.