Abstract: The invention intends to provide a method for preventing deterioration in quality of the primer layer resulting from spinning-off and reattachment of a primer liquid on forming a polyurethane primer layer on a substrate for an eyeglass lens or the like using a coating composition containing a moisture-curing polyurethane resin. The method for producing a laminate according to the present invention comprises performing spin-coating while a spin-coating apparatus is forcefully evacuated through the side wall and/or the bottom thereof, on producing a laminate by spin-coating the surface of a substrate with a coating composition containing a moisture-curing polyurethane resin.

Abstract: A primer coating composition is provided for an optical article capable of forming a coating layer having excellent impact resistance, abrasion resistance, and adhesion to various kinds of plastic materials without occurring of appearance faulty for an optical base material, for example, a plastic lens for an eyeglass. A primer composition for an optical article comprises; (A) aqueous dispersion of urethane resin having a polycarbonate-derived skeleton and the elongation of 200˜1000%; (B) an organic solvent having 3˜9 carbon atoms and having an ether bond or carbonyl bond and one hydroxyl group in a molecule; and (C) lower alcohol having 1˜4 carbon atoms, wherein the weight ratio of said organic solvent to said lower alcohol is from 0.01 to less than 2.00.

Abstract: In a semiconductor memory device which uses a same pad for an address input and data input/output, and has an input circuit and data output circuit connected to the pad, an output of the data output circuit is turned to a high impedance state in accordance with a chip enable signal, output enable signal, and address capture signal, at a stand-by time, output disable time, and address capture period, and thereby, it becomes possible to start an internal read operation even before the address capture period is finished, and a high-speed operation becomes possible.

Abstract: To provide a coating apparatus capable of automatically executing a series of steps of measuring the shape of a lens and applying a primer solution thereon, drying the primer solution and applying a photochromic coating solution thereon, and curing the coated solutions by the UV irradiation, liberating the operator from the work of setting the lenses piece by piece. A lens-feeding portion 2 is arranged upstream of the series of steps, the lens-feeding portion 2 having lens-holding units 22 in which a plurality of lenses are arranged straight in the horizontal direction and/or in the up-and-down direction, and a first lens sub-carrier means 31 for carrying the lenses held therein to the lens-measuring portion 3.

Abstract: [Problems] A coating composition preferably used for forming a hard coating by being applied and cured on a light-transmitting member such as a highly refractive plastic lens or a highly refractive photochromic plastic lens having a function for developing a color, the coating composition markedly improving weather resistance (preventing discoloration) while sustaining high refractive index, scratch resistance and excellent adhesion to the optical material. [Means for Solution] The coating composition comprises (A) a fine granular metal oxide containing titanium oxide and (B) a fine granular metal oxide containing titanium oxide having dissimilar properties as selected by a specific light irradiation test and, further, contains (C) an epoxy group-containing organosilicon compound such as ?-glycidoxypropyltrimethoxysilane, (D) water, (E) an organic solvent such as methyl alcohol, and (F) a curing catalyst such as aluminum acetyl acetonato or magnesium perchlorate at specific ratios.

Abstract: [Problem] To provide a coating composition for forming a hard coating which, by itself, favorably adheres to a plastic optical substrate, and effectively prevents the occurrence of cracks caused by the thermal hysteresis at the time of curing. [Means for Solution] The coating composition for forming a hard coating, contains a fine inorganic oxide particle, a hydrolyzable organosilicon compound, water, a curing catalyst and an organic solvent, wherein cyclic ketone is contained in an amount of 0.10 parts by mass to 30.00 parts by mass per 100 parts by mass of the total of the fine inorganic oxide particle and the hydrolyzable organosilicon compound.

Abstract: To provide a coating composition capable of forming a hard coat layer having excellent transparency and scratch resistance on the surface of an optical resin substrate such as a plastic lens, and exhibiting long-term storage stability. [Means for Solution] The coating composition comprises (A) a fine particulate composite metal oxide, (B?) a hydrolyzed product obtained by the hydrolysis of (B) a hydrolyzable organosilicon compound containing (B1) an organosilicon compound that has an epoxy group, such as ?-glycidoxypropyltrimethoxysilane, (C) water, (D1) a low-boiling lowly viscous alcohol having not more than 3 carbon atoms, such as methanol or ethanol, (D2) a low-boiling highly viscous alcohol such as t-butanol, (D3) a high-boiling organic solvent having a boiling point of 150° C. to 200° C., such as diacetone alcohol, and (E) a curing catalyst such as tris(2,4-pentanedionato)aluminum(III), the mass ratio (D1/C) of the component (D1) and the component (C) being in a range of 1.80 to 7.

Abstract: A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plant or the progenies thereof, in which genome is modified so as to have a decreased or deleted activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body; a process for producing an antibody composition from the animal or plant; and a medicament comprising the antibody composition.

Abstract: [Problems] To prevent or reduce the problem wherein color development and fading in expected color tones do not occur in an optical element that includes a photochromic coat layer containing alkylamino group-containing photochromic compounds and/or dialkylamino group-containing photochromic compounds in a high concentration and a hard coat layer formed on the photochromic coat layer. [Means for Solving Problems] A photochromic optical element comprising an optical substrate, a photochromic coat layer, and a hard coat layer that are laminated in this order, wherein (I) the photochromic coat layer comprising an alkylamino group-containing photochromic compound and/or a dialkylamino group-containing photochromic compound in a total amount of 0.1 to 10.

Abstract: [Problem] To form a coating film without developing stripes by spin-coating relying on a simple control and using a coating solution in small amounts.

Abstract: A curable composition comprising (1) 0.1 to 20 parts by weight of a silicon compound having a silanol group or a functional group for forming a silanol group upon hydrolysis and no radically polymerizable group, such as ?-glycidoxypropyltrimethoxysilane, (2) 100 parts by weight of radically polymerizable monomers and (3) 0.01 to 20 parts by weight of a photochromic compound, wherein the radically polymerizable monomers include a radically polymerizable monomer having an epoxy group in the molecule, such as glycidyl methacrylate. This curable composition is capable of forming a photochromic coating layer which shows excellent photochromic properties such as high color development density and fast fading rate, is free from the dissolution of the photochromic compound, exhibits high adhesion to a substrate through a simple pre-treatment and has excellent hard coating applicability.

Abstract: The present invention provides a monoclonal antibody which specifically recognizes CD27 containing an O-linked sugar chain to which galactose is not bound and binds to its extracellular region, or a method for using the same. The present invention can provide a monoclonal antibody or an antibody fragment thereof, which specifically recognizes a polypeptide encoded by CD27 gene containing an O-linked sugar chain to which galactose is not bound, and binds to its extracellular region; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtainable by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

Abstract: A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plant or the progenies thereof, in which genome is modified so as to have a decreased or deleted activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body; a process for producing an antibody composition from the animal or plant; and a medicament comprising the antibody composition.

Abstract: [Problem] To provide a coating composition capable of forming a hard coating on the surfaces of an optical base member such as a plastic lens featuring highly closely adhering property, excellent transparency and excellent scratch resistance. [Means for Solution] The coating composition comprise (a) a fine granular silica having a grain size of not larger than 30 nm; (b) organosilicon compound components containing an epoxy group-containing organosilicon compound (b1) and tetraalkoxysilane (b2) at a mass ratio (b1/b2) of 0.25 to 4.0; (c) water; and (d) a curing catalyst comprising a complex containing aluminum as a core metal, wherein the fine granular silica (a) is contained in an amount of 15 to 55 parts by mass, the water (c) is contained in an amount of 30 to 200 parts by mass and the curing catalyst (d) is contained in an amount of 0.1 to 5.0 parts by mass per the total amount of the fine granular silica (a) and the organosilicon compound components (b) of 100 parts by mass.

Abstract: [Problem] To provide a coating apparatus capable of automatically executing a series of steps of measuring the shape of a lens and applying a primer solution thereon, drying the primer solution and applying a photochromic coating solution thereon, and curing the coated solutions by the UV irradiation, liberating the operator from the work of setting the lenses piece by piece. [Means for Solution] A lens-feeding portion 2 is arranged upstream of the series of steps, the lens-feeding portion 2 having lens-holding units 22 in which a plurality of lenses are arranged straight in the horizontal direction and/or in the up-and-down direction, and a first lens sub-carrier means 31 for carrying the lenses held therein to the lens-measuring portion 3.

Abstract: A method of coating without permitting the coating solution to flow onto the side surfaces or the back surfaces of the lenses in the operation for applying the coating solution onto the lenses. A lens 15 is spin-coated with the coating solution having a particular viscosity. A side edge portion 121 of a spatula 119 is brought into contact with an upper edge portion of a side surface 15a of the lens 15 before the coating solution fed onto the surface of the lens arrives at the peripheral edge portion of the lens. The side edge portion 121 of the spatula 119 is so arranged that the upper end side of the spatula is tilted toward the center side of the lens 15 at an angle of 5 to 35 degrees with the vertical line as a reference. The coating solution applied onto the lens 15 that is rotating adheres onto the spatula 119 but does not adhere onto the side surface of the lens 15.

Abstract: A semiconductor memory device which has a normal memory cell array and a redundant memory cell array for replacing a failure bit in the normal memory cell array, having: a memory cell array having a plurality of word lines, a plurality of bit line pairs crossing the word lines, and a plurality of memory cells placed at the crossing positions; and a plurality of sense amplifier circuits which are placed between adjacent memory cell arrays and are shared by bit line pairs of memory cell arrays on both sides. And a current interrupting circuit for disconnecting the sense amplifier and the bit line pairs in a column having a failure is formed respectively between the sense amplifier circuit and the bit line pairs on both sides. By this current interrupting circuit, short-circuit current from the sense amplifier circuit to the shorted area can be suppressed.

Abstract: It is an objective of the present invention to reduce or prevent incorporation of bubbles into a coating film formed by spin coating a surface of a substrate with a coating liquid having a high viscosity at a relatively high discharging velocity. The spin coating method relating to the present invention comprises the steps of discharging a coating liquid from the tip of a nozzle and dropping onto a surface of a rotating substrate to form a uniform coating film on the surface of the substrate, characterized in that the distance between the tip of the nozzle and the surface of the substrate during discharging the coating liquid is 2.5 mm or less.

Abstract: A process is provided whereby a photocurable coating agent is applied to a surface of a plastic lens having a central area less than 2 mm in thickness and thinner than the peripheral area, and the coating agent is cured to produce an objective coated plastic lens without any special cooling apparatus, with high productivity and without deforming the lens. The process for producing a lens includes: holding a lens on a lens holder, the lens having an uncured coating of a photocurable composition on its surface, the lens holder having a lens-contact member composed of an elastic material, the lens-contact member having a surface configuration substantially conforming with a back surface of the lens, the lens being held such that the back surface of the lens is in close contact with the lens-contact part; and curing the uncured coating by irradiation.

Abstract: The invention intends to provide a method for preventing deterioration in quality of the primer layer resulting from spinning-off and reattachment of a primer liquid on forming a polyurethane primer layer on a substrate for an eyeglass lens or the like using a coating composition containing a moisture-curing polyurethane resin. The method for producing a laminate according to the present invention comprises performing spin-coating while a spin-coating apparatus is forcefully evacuated through the side wall and/or the bottom thereof, on producing a laminate by spin-coating the surface of a substrate with a coating composition containing a moisture-curing polyurethane resin.