Patents by Inventor Katsushige Ikai
Katsushige Ikai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20010034335Abstract: Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.Type: ApplicationFiled: January 29, 2001Publication date: October 25, 2001Inventors: Takeshi Sakai, Hideo Kitano, Fu-Gong Yu, Shinji Nakayama, Kaoru Kojima, Hitomi Kimura, Yoshikuni Nakanishi, Kaoru Katayama, Takanari Tominaga, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Patent number: 6277616Abstract: An isolated endo-fucoidan-lyase is described. The enzyme acts on fucoidan, has a pH optimum from 6 to 10, and has an optimum pH from 30 to 40° C. The enzyme can be isolated from Flavobacterium sp. FERM BP-5402. The enzyme is used to obtain sugar compounds which are useful in the study on carbohydrates.Type: GrantFiled: March 3, 2000Date of Patent: August 21, 2001Assignees: Takara Shuzo Co. Ltd., Research Institute for GlycotechnologyInventors: Takeshi Sakai, Hitomi Kimura, Kaoru Kojima, Katsushige Ikai, Sumiko Akiyoshi, Yoshikuni Nakanishi, Ikunoshin Kato
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Patent number: 6207652Abstract: Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.Type: GrantFiled: April 9, 1998Date of Patent: March 27, 2001Assignees: Takara Shuzo Co., Ltd., Research Institute for GlycotechnologyInventors: Takeshi Sakai, Hideo Kitano, Fu-Gong Yu, Shinji Nakayama, Kaoru Kojima, Hitomi Kimura, Yoshikuni Nakanishi, Kaoru Katayama, Takanari Tominaga, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Patent number: 6177592Abstract: A compound represented by the following formula [I] or an optically active substance or a salt thereof. (In the formula, a bond shown by a dotted line in the five-membered ring means that said five-membered ring may be any of a cyclopentene ring having a double bond and a cyclopentane ring where said bond is saturated and, in the case of a cyclopentene ring, X is OH, Y is ═O and Z is H while, in the case of a cyclopentane ring, X is ═O, Y is OH and Z is OH. R is a residue after removal of an SH group from the SH-containing compound.Type: GrantFiled: July 16, 1999Date of Patent: January 23, 2001Assignee: Takara Shuzo Co., Ltd.Inventors: Nobuto Koyama, Tatsuji Enoki, Katsushige Ikai, Hua-Kang Wu, Hiromu Ohnogi, Takanari Tominaga, Eiji Nishiyama, Michio Hagiya, Hiroaki Sagawa, Hideto Chono, Ikunoshin Kato
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Patent number: 6166091Abstract: 2,3,4-trihydroxycyclopentanone represented by the following formula [I], its optically active substance or salt thereof.Type: GrantFiled: September 29, 1999Date of Patent: December 26, 2000Assignee: Takara Shuzo Co., Ltd.Inventors: Kaoru Kojima, Katsushige Ikai, Tatsuji Enoki, Nobuto Koyama, Ikunoshin Kato
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Patent number: 6136854Abstract: Cyclopentenone derivative having a structure of 5-(R.sub.1 COO--)-4-(R.sub.2 COO--)--substituted 2-cyclopenten-1-one (R.sub.1 and R.sub.2 are some or different and each is alkyl group, alkenyl group or aryl group) or an optically active substance thereof; a method for the manufacture of the cyclopentenone derivative by the reaction of 4,5-dihydroxy-2-cyclopenten-1-one with the corresponding carboxylic acid or a reactive derivative thereof; and anticancer agent, apoptosis-inducing agent and antibacterial agent containing said derivative.Type: GrantFiled: July 21, 1999Date of Patent: October 24, 2000Assignee: Takara Shuzo Co.Inventors: Nobuto Koyama, Katsushige Ikai, Eiji Kobayashi, Ikunoshin Kato
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Patent number: 6133238Abstract: 2,5-dihydroxytetrahydro-2-furancarboxylic acid represented by the following formula [I], its optically active substance or salt thereof.Type: GrantFiled: July 2, 1999Date of Patent: October 17, 2000Assignee: Takara Shuzo Co., Ltd.Inventors: Hiroaki Sagawa, Shinji Okuda, Nobuko Muraki, Nobuto Koyama, Katsushige Ikai, Ikunoshin Kato
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Patent number: 6087401Abstract: There is disclosed a method of manufacturing 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [1] which is characterized in that at least one substance selected from the following (a), (b) and (c) is heated.(a): uronic acid or uronic acid derivative(s);(b): a saccharide compound which contains uronic acid and/or uronic acid derivative(s); and(c): a substance containing a saccharide compound which contains uronic acid and/or uronic acid derivative(s).Type: GrantFiled: February 2, 1999Date of Patent: July 11, 2000Assignee: Takara Shuzo Co., Ltd.Inventors: Nobuto Koyama, Hiroaki Sagawa, Eiji Kobayashi, Tatsuji Enoki, Hua-Kang Wu, Eiji Nishiyama, Katsushige Ikai, Ikunoshin Kato
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Patent number: 6054577Abstract: A novel endo-fucoidan-lyase and a novel microorganism useful in the production of sugar compounds. Sugar compounds represented by the following general formula (1), wherein at least one of alcoholic hydroxyl group has been sulfated, or salts thereof: ##STR1## wherein Y represents hydrogen or a group represented by the following formula (2).Type: GrantFiled: September 26, 1997Date of Patent: April 25, 2000Assignees: Takara Shuzo Co., Ltd., Research Institute For GlycotechnologyInventors: Takeshi Sakai, Hitomi Kimura, Kaoru Kojima, Katsushige Ikai, Sumiko Akiyoshi, Yoshikuni Nakanishi, Ikunoshin Kato
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Patent number: 5260214Abstract: An antibiotic R106 represented by the general formula I): ##STR1## wherein: R is methyl or ethyl;X.sub.1 is MePhe, .beta.-HOMePhe or Phe;X.sub.2 is allo-Ile, Val or Leu;X.sub.3 is MeVal or Val;X.sub.4 is .beta.-HOMeVal, .gamma.-HOMeVal, MeVal, Val, N,.beta.-MeAsp, .beta.-HOMePhe, MePhe, MeDH.sub.2,3 Val or MeDH.sub.3,4 Valis produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.Type: GrantFiled: March 30, 1992Date of Patent: November 9, 1993Assignee: Takara Shuzo Co.Inventors: Kazutoh Takesako, Katsushige Ikai, Kazuo Shimanaka, Junko Yamamoto, Fumiyo Haruna, Teruya Nakamura, Hideyo Yamaguchi, Katsuhisa Uchida
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Patent number: 5200505Abstract: There are provided R106 compounds represented by the following general formula (I): ##STR1## wherein: A.sub.1 is Phe, o-FPhe, m-FPhe, or Tyr;A.sub.2 is MePhe, o-FMePhe, m-FMePhe, MeTyr, Sar, MeSery, or .beta.-oxoMePhe;A.sub.3 is Pro, 4Hyp, or SPro;A.sub.4 is allo-Ile or Nle;A.sub.5 is Leu or Nva;A.sub.6 is .beta.-HOMeVal or Sar;excluding those wherein A.sub.1 is Phe and A.sub.2 is MePhe and A.sub.3 is Pro and A.sub.4 is allo-Ile and A.sub.5 is Leu and A.sub.6 is .beta.-HOMeVal (SEQ ID No. 4), which are useful as therapeutic agents for fungal infection.Type: GrantFiled: January 22, 1991Date of Patent: April 6, 1993Assignee: Takara Shuzo Co., Ltd.Inventors: Kazutoh Takesako, Katsushige Ikai, Kazuo Shimanaka, Junko Yamamoto, Fumiyo Haruna, Teruya Nakamura, Hideyo Yamaguchi, Katsuhisa Uchida
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Patent number: 5162581Abstract: The invention provides crystalline deoxyspergualin trihydrochloride, a process for the preparation of the same and a suppository composition containing the same. The compound and composition has antitumor and immunosuppressive activity.Type: GrantFiled: July 29, 1991Date of Patent: November 10, 1992Assignees: Takaru Shuzo Co., Ltd., Nippon Kayaku Kabushiki KaishaInventors: Katsushige Ikai, Makoto Moriguchi, Yoshihisa Umeda, Ikunoshin Kato, Tetsushi Saino, Hironobu Hiraga, Takaaki Ohkuma
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Patent number: 5158876Abstract: An antibiotic R106 represented by the general formula (I): ##STR1## wherein: R is methyl or ethyl;X.sub.1 is MePhe, .beta.-HOMePhe or Phe;X.sub.2 is allo-Ile, Val or Leu;X.sub.3 is MeVal or Val;X.sub.4 is .beta.-HOMeVal, .gamma.HOMeVal, MeVal, Val, N,.beta.-MeAsp, .beta.-HOMePhe, MePhe, MeDH.sub.2,3 Val or MeDH.sub.3,4 Valis produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.Type: GrantFiled: February 2, 1991Date of Patent: October 27, 1992Assignee: Takara Shuzo Co., Ltd.Inventors: Kazutoh Takesako, Katsushige Ikai, Kazuo Shimanaka, Junko Yamamoto, Fumiyo Haruna, Teruya Nakamura, Hideyo Yamaguchi, Katsuhisa Uchida
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Patent number: 5057493Abstract: An antibiotic R106 represented by the general formula (I): ##STR1## wherein: R is methyl or ethyl;X.sub.1 is MePhe, .beta.-HOMePhe or Phe;X.sub.2 is allo-Ile, Val or Leu;X.sub.3 is MeVal or Val;X.sub.4 is .beta.-HOMeVal, .gamma.-HOMeVal, MeVal, Val, N,.beta.-MeAsp, .beta.-HOMePhe, MePhe, MeDH.sub.2,3 Val or MeDH.sub.3,4 Valis produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.Type: GrantFiled: July 13, 1989Date of Patent: October 15, 1991Assignee: Takara Shuzo Co., Ltd.Inventors: Kazutoh Takesako, Katsushige Ikai, Kazuo Shimanaka, Junko Yamamoto, Fumiyo Haruna, Teruya Nakamura, Hideyo Yamaguchi, Katsuhisa Uchida
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Patent number: 4554289Abstract: Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 is hydrogen, alkyl of 1 to 10 carbon atoms or acyl of 1 to 6 carbon atoms; R.sup.2 is hydrogen or halo; R.sup.3 is hydrogen, alkyl of 1 to 6 carbon atoms or acyl of 1 to 6 carbon atoms; R.sup.4 is hydrogen or alkyl of 1 to 6 carbon atoms; R.sup.5 is hydrogen or acyl of 1 to 6 carbon atoms; X is CONH.sub.2, hydroxyalkyl of 1 to 4 carbon atoms or COOR.sup.6 wherein R.sup.6 is hydrogen or alkyl of 1 to 4 carbon atoms; and Y is CONH.sub.2, hydroxyalkyl of 1 to 4 carbon atoms or COOR.sup.7 wherein R.sup.7 is hydrogen, alkyl of 1 to 10 carbon atoms or benzyl are useful for inhibiting the activity of amino-peptidase B, exhibit immunomodulating action against living organisms and exhibit anti-inflammatory activity.Type: GrantFiled: December 23, 1983Date of Patent: November 19, 1985Assignees: Takara Shuzo Co., Ltd., Nippon Shinyaku Co., Ltd.Inventors: Susumu Sano, Katsushige Ikai, Hiroyuki Kuroda, Teruya Nakamura, Hiroshi Enomoto, Yoji Ezure