Patents by Inventor Kaushal Rege

Kaushal Rege has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11931460
    Abstract: The instant disclosure is directed to compositions comprising an encapsulated spheroid, and methods of making and using the same. A composition may comprise a spheroid comprising a plurality of cells and aminoglycoside antibiotic-derived hydrogel beads, wherein the spheroid is encapsulated by the aminoglycoside antibiotic-derived hydrogel beads to form an encapsulated spheroid. A method may comprise administering the composition to a subject in need thereof. Another method may comprise administering a compound to the encapsulated spheroid. A method of creating an encapsulated spheroid may comprise coating a surface with an aminoglycoside antibiotic-derived hydrogel, culturing a plurality of cells on the surface, thereby creating a spheroid, and encapsulating the spheroid with a plurality of aminoglycoside antibiotic-derived hydrogel beads.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: March 19, 2024
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Kaushal Rege, Rajeshwar Nitiyanandan, Tanya Nanda
  • Patent number: 11896724
    Abstract: A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: February 13, 2024
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Kaushal Rege, Deepanjan Ghosh
  • Publication number: 20220411360
    Abstract: The present invention provides polymers, particles, and compositions thereof that selectively and efficiently deliver various therapeutic agents, such as metabolites, to a cell. The present invention further relates to methods relating to the said polymers, particles, and compositions for enhancing biological tissue growth (e.g. biological tissue regeneration in wound healing) in a subject. The present invention additionally provides kits that find use in the practice of the methods of the invention.
    Type: Application
    Filed: November 9, 2020
    Publication date: December 29, 2022
    Inventors: Abhinav Acharya, Kaushal Rege
  • Publication number: 20220273365
    Abstract: The present invention provides a method of nerve repair using localized delivery of heat. The method involves localized induction of hyperthermia for end-to-end attachment of severed peripheral nerves by delivering stimulus responsive materials and exposing them to an excitation source under conditions wherein they emit heat. The generation of heat effects the joining of the nerve ends.
    Type: Application
    Filed: August 27, 2020
    Publication date: September 1, 2022
    Inventors: Kaushal Rege, Inam Ridha, Russell Urie, Pelagia Kouloumberis, Shelley Noland
  • Publication number: 20220151927
    Abstract: The instant disclosure is directed to compositions comprising an encapsulated spheroid, and methods of making and using the same. A composition may comprise a spheroid comprising a plurality of cells and aminoglycoside antibiotic-derived hydrogel beads, wherein the spheroid is encapsulated by the aminoglycoside antibiotic-derived hydrogel beads to form an encapsulated spheroid. A method may comprise administering the composition to a subject in need thereof. Another method may comprise administering a compound to the encapsulated spheroid. A method of creating an encapsulated spheroid may comprise coating a surface with an aminoglycoside antibiotic-derived hydrogel, culturing a plurality of cells on the surface, thereby creating a spheroid, and encapsulating the spheroid with a plurality of aminoglycoside antibiotic-derived hydrogel beads.
    Type: Application
    Filed: November 18, 2021
    Publication date: May 19, 2022
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Kaushal Rege, Rajeshwar Nitiyanandan, Tanya Nanda
  • Patent number: 11317968
    Abstract: Disclosed herein are methods of connecting disrupted tissue, tissue repair, treating colorectal disorder and tissue welding. The methods comprise using a bioadhesive composition comprising ELP and light absorbing chromophores and irradiating the bioadhesive tissue.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: May 3, 2022
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Kaushal Rege, Huang-Chiao Huang
  • Publication number: 20220071613
    Abstract: A method of closing an opening in a tissue comprises providing a light absorbing material, introducing the light absorbing material into a tissue opening, and irradiating the light absorbing material with at least one light source so as to increase a temperature of the light absorbing material, causing the tissue edges of the tissue opening adhere to the light absorbing material and/or to each other. A kit comprising a light absorbing material and a light emitting device is also described.
    Type: Application
    Filed: December 19, 2019
    Publication date: March 10, 2022
    Inventors: Kaushal Rege, Ridha Inam, Yu Yao
  • Publication number: 20220018826
    Abstract: An apparatus includes a solution including a metallic compound, a surfactant, and an acid. The solution is substantially colorless. A container holds the solution.
    Type: Application
    Filed: June 24, 2021
    Publication date: January 20, 2022
    Applicants: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, BANNER HEALTH
    Inventors: Kaushal Rege, Karthik Subramaniam Pushpavanam, Eshwaran Narayanan, Stephen Sapareto, John C. Chang
  • Publication number: 20210100927
    Abstract: A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent is in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.
    Type: Application
    Filed: October 7, 2020
    Publication date: April 8, 2021
    Inventors: Kaushal Rege, Deepanjan Ghosh
  • Patent number: 10907145
    Abstract: Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: February 2, 2021
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Kaushal Rege, Kevin Lin, Sudhakar Godeshala, Taraka Sai Pavan Grandhi
  • Publication number: 20200165572
    Abstract: Methods to form a novel aminoglycoside based hydrogel for high-throughput generation of 3D dormant, relapsed and micrometastatic tumor microenvironments are disclosed. In addition, methods of screening agents against tumor cells grown in the 3D environments disclosed herein that include, for example, screening of lead drugs and therapies for an effect on dormant, relapsed and/or micrometastatic tumor cells.
    Type: Application
    Filed: December 9, 2019
    Publication date: May 28, 2020
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Kaushal Rege, Taraka Sai Pavan Grandhi, Thrimoorthy Potta
  • Publication number: 20200061163
    Abstract: A method for inhibiting and/or treating cancer in a subject in need thereof is disclosed. The method can include administering to a subject an effective amount of an HSP90 inhibitor; and administering to the subject an effective amount of Granzyme A, thereby treating and/or inhibiting the cancer in the subject in need thereof. A composition including an effective amount of an HSP90 inhibitor and an effective amount of Granzyme A is also disclosed.
    Type: Application
    Filed: August 20, 2019
    Publication date: February 27, 2020
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Kaushal REGE, Rajeshwar NITIYANANDAN
  • Patent number: 10428160
    Abstract: An apparatus includes a hydrogel including a metallic compound, a surfactant, an acid, agarose and water. The hydrogel is substantially colorless. A radiated hydrogel having a color is formed when the hydrogel receives a low dose of ionizing radiation.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: October 1, 2019
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, BANNER HEALTH—An Arizona Nonprofit Corporation
    Inventors: Kaushal Rege, Karthik Subramaniam Pushpavanam, Stephen Sapareto
  • Publication number: 20190133685
    Abstract: Disclosed herein are methods of connecting disrupted tissue, tissue repair, treating colorectal disorder and tissue welding. The methods comprise using a bioadhesive composition comprising ELP and light absorbing chromophores and irradiating the bioadhesive tissue.
    Type: Application
    Filed: November 19, 2018
    Publication date: May 9, 2019
    Inventors: Kaushal Rege, Huang-Chiao Huang
  • Patent number: 10232345
    Abstract: Methods and materials for the generation of amikacin antibiotic-derived microbeads, (FIG. 3). These beads may function as anion-exchange resins for use in pDNA purification as well as in situ capture of DNA from mammalian cells. New microresin and macroporous monolith based materials also are disclosed and may function for plasmid DNA binding and purification, mammalian whole cell genomic DNA extraction, and in-vitro cell culture.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: March 19, 2019
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Kaushal Rege, Taraka Sai Pavan Grandhi, Thrimoorthy Potta
  • Publication number: 20190078052
    Abstract: Methods and compositions involving hydrogel compositions utilized for growing, separating, isolating, and/or screening cancer cells for resistance to one or more anti-cancer cell agents, such as a drug or biologic. Some hydrogel compositions utilize the monomer aminoglycoside amikacin AM1 or aminoglycoside amikacin AM3 in combination with a variety of crosslinkers.
    Type: Application
    Filed: March 16, 2017
    Publication date: March 14, 2019
    Inventors: Kaushal Rege, Taraka Sai Pavan Grandhi
  • Patent number: 10154881
    Abstract: Disclosed herein are methods of connecting disrupted tissue, tissue repair, treating colorectal disorder and tissue welding. The methods comprise using a bioadhesive composition comprising ELP and light absorbing chromophores and irradiating the bioadhesive tissue.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: December 18, 2018
    Assignee: Arizona Board of Regents for and on behalf of Arizona State University
    Inventors: Kaushal Rege, Huang-Chiao Huang
  • Publication number: 20180258416
    Abstract: Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.
    Type: Application
    Filed: March 8, 2018
    Publication date: September 13, 2018
    Inventors: Kaushal Rege, Kevin Lin, Sudhakar Godeshala Godeshala, Taraka Sai Pavan Grandhi
  • Publication number: 20180066074
    Abstract: An apparatus includes a hydrogel including a metallic compound, a surfactant, an acid, agarose and water. The hydrogel is substantially colorless. A radiated hydrogel having a color is formed when the hydrogel receives a low dose of ionizing radiation.
    Type: Application
    Filed: July 10, 2017
    Publication date: March 8, 2018
    Inventor: Kaushal Rege
  • Publication number: 20180021753
    Abstract: Methods and materials for the generation of amikacin antibiotic-derived microbeads, (FIG. 3). These beads may function as anion-exchange resins for use in pDNA purification as well as in situ capture of DNA from mammalian cells. New microresin and macroporous monolith based materials also are disclosed and may function for plasmid DNA binding and purification, mammalian whole cell genomic DNA extraction, and in-vitro cell culture.
    Type: Application
    Filed: February 12, 2016
    Publication date: January 25, 2018
    Inventors: Kaushal Rege, Taraka Sai Pavan Grandhi, Thrimoorthy Potta