Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: A multi-electron beam image acquiring apparatus includes a stage configured to mount thereon a substrate, an illumination optical system configured to apply multiple primary electron beams to the substrate, a plurality of multipole lenses including at least two stages of multipole lenses, arranged at positions common to a trajectory of the multiple primary electron beams and a trajectory of multiple secondary electron beams which are emitted because the substrate is irradiated with the multiple primary electron beams and each configured to include at least four electrodes and at least four magnetic poles, and a multi-detector configured to detect the multiple secondary electron beams separated from the trajectory of the multiple primary electron beams, wherein one of the plurality of multipole lenses separates the multiple secondary electron beams from the trajectory of the multiple primary electron beams.

Abstract: A conduction inspection method for a multipole aberration corrector according to one aspect of the present invention includes applying, in a state where a predetermined potential has been applied to each shield electrode, an inspection charged particle beam to pass through a first opening, a second opening, and a third opening, using a multipole aberration corrector which includes an upper-stage substrate where the first opening is formed and a shield electrode is arranged around the first opening, a middle-stage substrate where the second opening is formed, a plurality of control electrodes are disposed to be opposite each other across the second opening, and a plurality of wirings are arranged to be individually connected to one of the plurality of control electrodes which are different from each other, and a lower-stage substrate where the third opening is formed and a shield electrode is arranged around the third opening, and which corrects aberration of a correction charged particle beam passing through

Abstract: The purpose of the present invention is to provide a current collector that has high strength and is easily impregnated with an electrolyte. This current collector is provided with an opening formation portion provided with a plurality of openings, the current collector being characterized in that a protruding portion is formed at the tip of each opening, and only partial locations of the opening formation portion reach an end surface of the current collector and the other locations thereof do not reach the end surface.

Abstract: An electromagnetic lens includes a coil, and a pole piece configured to include an upper wall, a lower wall, an outer peripheral wall and an inner peripheral wall which are formed using a conductive magnetic material, to surround the coil by the upper wall, the lower wall, the outer peripheral wall and the inner peripheral wall, one of opposite facing surfaces of an upper part and a lower part of the inner peripheral wall and opposite facing surfaces of the upper wall and the inner peripheral wall being insulated electrically, the outer peripheral wall including a laminated structure where a magnetic material and an insulator are alternately laminated in a direction of a central axis of a trajectory of a passing electron beam, and to be covered at least the laminated structure of the outer peripheral wall with an insulator.

Abstract: According to one aspect of the present invention, an aberration corrector includes a first electrode substrate provided with first passage holes through which multiple electron beams pass; a second electrode substrate disposed below the first electrode substrate and provided with second passage holes through which the multiple electron beams pass, first electrodes of four or more poles being disposed individually on each top surface region of top surface regions around some second passage holes among the second passage holes; and a third electrode substrate disposed below the second electrode substrate and provided with third passage holes through which the multiple electron beams pass, second electrodes of four or more poles being disposed individually on each of top surface region of top surface regions around some third passage holes corresponding to remaining second passage holes in which the first electrodes are not disposed, among the third passage holes.

Abstract: Deterioration in cycle characteristics and battery swelling are improved. The lithium ion secondary battery of the present invention is characterized in comprising an electrolyte solution comprising a multifunctional monomer comprising two or more epoxy groups and a negative electrode comprising a binder comprising a polymer comprising a monomer unit comprising a functional group selected from the group consisting of —OH, —OM, —COOH, —COOM and —COOCnH2n+1, wherein M is a metal element, and n is an integer of 1 to 5.

Abstract: A carboxymethylated cellulose having a carboxymethyl substitution of no more than 0.50 and a cellulose I type crystallization of at least 50%. Ideally, the anionization is 0.00-1.00 meq/g. The Schopper-Riegler freeness is ideally at least 60.0° SR. Ideally the ratio of filtration residue is 0%-30% by mass. The viscosity (30 rpm, 25° C.) for an aqueous dispersion having a 1% solid content (w/v) is ideally no more than 10.0 mPa·s.

Abstract: Provided is a novel manufacturing method whereby a carboxymethylated cellulose nanofiber dispersion having high tarnasparency can be obtained economically. In carboxymethylation of cellulose in the present invention, mercerization is performed in water as the main solvent, after which carboxymethylation is performed in a solvent mixture of water and an organic solvent, By defibrating the resultant carboxymethylated cellulose, a carboxymethylated cellulose nanofiber dispersion having high transparency can be obtained economically.

Abstract: According to one aspect of the present invention, a multi-beam image acquisition apparatus, includes: an objective lens configured to image multiple primary electron beams on a substrate by using the multiple primary electron beams; a separator configured to have two or more electrodes for forming an electric field and two or more magnetic poles for forming a magnetic field and configured to separate multiple secondary electron beams emitted due to the substrate being irradiated with the multiple primary electron beams from trajectories of the multiple primary electron beams by the electric field and the magnetic field formed; a deflector configured to deflect the multiple secondary electron beams separated; a lens arranged between the objective lens and the deflector and configured to image the multiple secondary electron beams at a deflection point of the deflector; and a detector configured to detect the deflected multiple secondary electron beams.

Abstract: The lithium ion secondary battery is a secondary battery in which a positive electrode 30 and a negative electrode 40 are stacked alternatively via a separator 25, wherein the separator 25 is a single layer and is not melted or softened at least 200° C., a thermal shrinkage ratio of the separator being 3% or below, wherein an insulating layer 70 is formed on a surface of the positive electrode 30, the surface facing to the separator 25.

Abstract: A multi-electron beam image acquisition apparatus includes: a first electromagnetic lens configured to focus the multiple primary electron beams to form an image on the substrate; and a second electromagnetic lens configured to be able to variably adjust a peak position of a magnetic field distribution in a direction of a trajectory central axis of the multiple secondary electron beams, and to focus the multiple secondary electron beams to form an image on either one of a detection surface of the detector and a position conjugate to the detection surface, wherein the first electromagnetic lens focuses, to form an image, the multiple secondary electron beams in a state before being separated from the multiple primary electron beams, and the second electromagnetic lens is arranged between the separator and an image forming point on which the multiple secondary electron beams are focused by the first electromagnetic lens.

Abstract: According to the present invention, a desired one of multiple beams can be aligned with a small-diameter aperture quickly. A multi-electron beam inspection apparatus includes a beam selection aperture substrate including a first passage hole that passes all the multiple electron beams, a second passage hole through which one of the multiple electron beams is able to pass, a first slit, and a second slit not parallel to the first slit, an aperture moving unit moving the beam selection aperture substrate, a first detector detecting a current of a beam having passed through the first slit and a current of a beam having passed through the second slit, of the multiple electron beams, and a second detector detecting multiple secondary electron beams including reflected electrons, discharged from a substrate, due to application of the multiple electron beams, having passed through the first passage hole, to the substrate. The substrate is inspected based on an output signal from the second detector.

Abstract: A multi-electron beam image acquisition apparatus includes a multiple-beam forming mechanism to form multiple primary electron beams, a primary-electron optical system to irradiate 1a sample with the multiple primary electron beams, a beam separator, arranged at a position conjugate to an image plane of each of the multiple primary electron beams, to form an electric field and a magnetic field to be mutually perpendicular, to separate multiple secondary electron beams, emitted from the sample due to irradiation with the multiple primary electron beams, from the multiple primary electron beams by using actions of the electric field and the magnetic field, and to have a lens action on the multiple secondary electron beams in at least one of the electric field and the magnetic field, a multi-detector to detect the multiple secondary electron beams, and a secondary-electron optical system to lead the multiple secondary electron beams to the multi-detector.

Abstract: Aberration corrector includes a lower electrode substrate to be formed therein with plural first passage holes having a first hole diameter and making multiple electron beams pass therethrough, and to be arranged thereon plural electrode sets each being plural electrodes of four or more poles, surrounding a first passage hole, for each of the plural first passage holes, and an upper electrode substrate above the lower one, to be formed therein with plural second passage holes making multiple electron beams pass therethrough, whose size from the top of the upper electrode substrate to the middle of way to the back side of the upper electrode substrate is a second hole diameter, and whose size from the middle to the back side is a third hole diameter larger than each of the first and second hole diameters, wherein a shield electrode is on inner walls of plural second passage holes.

Abstract: A problem to be solved is to provide a packaging method suitable for transporting a cellulosic polymer, and another problem to be solved is to provide a packaging method suitable for transportation while suppressing the viscosity reduction of the cellulosic polymer. The cellulosic polymer is packaged so as to meet the following conditions (1), (2), and (3): (1) the packaging bag having a gas barrier property is filled with a cellulosic polymer; (2) an oxygen concentration in the packaging bag is adjusted to 0.8% or less and the packaging bag was sealed; and (3) when the packaging bag filled with the cellulosic polymer is placed such that the longest long side L is horizontal, the depth D of the packaging bag from the horizontal plane and the long side L satisfy the relational expression of 6.1?L/D?10.

Abstract: Carboxymethylated cellulose nanofibers in which the cellulose type I crystallinity is 60% or higher, the aspect ratio is 350 or lower, and the transmittance of light having a wavelength of 660 nm when the carboxymethylated cellulose nanofibers are made into an aqueous dispersion having a solids fraction of 1% (w/v) is 60% or higher.

Abstract: Component A: a carboxymethyl cellulose having a degree of carboxymethyl substitution per anhydroglucose unit of 0.45 or more or a salt thereof and Component B: a saturated carboxylic acid having 6 or less carbon atoms or a salt thereof are contained.

Abstract: One of the objects of the present invention is to suppress a short circuit due to metal deposition in an insulating layer in a secondary battery in which a positive electrode and a negative electrode are disposed to face each other via the insulating layer. The secondary battery comprises a battery element including at least one positive electrode 11 and at least one negative electrode 12, and a casing that seals the battery element together with an electrolyte. At least one of the positive electrode 11 and the negative electrode 12 comprises a current collector, an active material layer formed on at least one surface of the current collector, and an insulating layer 112 formed on the surface of the active material layer. The electrolyte comprises an electrolyte component and a crosslinked gelling agent.

Abstract: Aberration corrector includes a lower electrode substrate to be formed therein with plural first passage holes having a first hole diameter and making multiple electron beams pass therethrough, and to be arranged thereon plural electrode sets each being plural electrodes of four or more poles, surrounding a first passage hole, for each of the plural first passage holes, and an upper electrode substrate above the lower one, to be formed therein with plural second passage holes making multiple electron beams pass therethrough, whose size from the top of the upper electrode substrate to the middle of way to the back side of the upper electrode substrate is a second hole diameter, and whose size from the middle to the back side is a third hole diameter larger than each of the first and second hole diameters, wherein a shield electrode is on inner walls of plural second passage holes.