Patents by Inventor Kazuhiko Maekawa

Kazuhiko Maekawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10865246
    Abstract: The present invention provides an anti-PD-L1 antibody capable of staining tumor cells such as melanoma cells. An anti-PD-L1 antibody comprising (a) a light chain comprising CDR1 having the amino acid sequence of KSISKY (SEQ ID NO: 1), CDR2 having the amino acid sequence of SGS and CDR3 having the amino acid sequence of QQHNEYPLT (SEQ ID NO: 2) and (b) a heavy chain comprising CDR1 having the amino acid sequence of GYTFTDYI (SEQ ID NO: 3), CDR2 having the amino acid sequence of INPDSGGN (SEQ ID NO: 4) and CDR3 having the amino acid sequence of ARGITMMVVISHWKFDF (SEQ ID NO: 5). A composition for detecting PD-L1, comprising the above antibody as an active ingredient. A method for preparing the above antibody is also provided.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: December 15, 2020
    Assignees: Fuso Pharmaceutical Industries, Ltd., National University Corporation Hokkaido University
    Inventors: Satoru Konnai, Kazuhiko Ohashi, Shiro Murata, Tomohiro Okagawa, Asami Nishimori, Naoya Maekawa, Satoshi Takagi, Yumiko Kagawa, Yasuhiko Suzuki, Chie Nakajima
  • Publication number: 20200362078
    Abstract: The invention relates to particles with an average particle size of 300 to 1000 ?m, comprising a modified polyvinyl alcohol having vinyl alcohol units and structural units represented by formula (1), wherein a content of the vinyl alcohol units is 60 to 90 mol % based on the total structural units: wherein R1 represents a hydrogen atom or a methyl group. Thus, the present invention provides particles containing a modified polyvinyl alcohol having high water solubility and high affinity for a photosensitive monomer, which are highly photosensitive.
    Type: Application
    Filed: February 18, 2019
    Publication date: November 19, 2020
    Applicant: KURARAY CO., LTD.
    Inventors: Yusuke AMANO, Yuki TACHIBANA, Yuki SHIMIZU, Kazuhiko MAEKAWA
  • Publication number: 20200355486
    Abstract: A bend sensor comprising a sensor section in which a polymer electrolyte film is sandwiched between a pair of electrode films, wherein each of the electrode films contains: a block copolymer (Z) having a polymer block (S) composed of a structural unit derived from an aromatic vinyl compound, and containing an ion-conducting group, and an amorphous polymer block (T) composed of a structural unit derived from an unsaturated aliphatic hydrocarbon; and a conducting particle; which block copolymer (Z) forms a lamellar structure, which bend sensor therefore allows generation of enhanced voltage between the electrode films when deformation of the sensor occurs as it follows movement of an object, is provided.
    Type: Application
    Filed: May 26, 2020
    Publication date: November 12, 2020
    Applicant: NIPPON NEKTRON, LTD.T
    Inventors: Mikiya MATSUURA, Katsuei Takahashi, Naoki Chikugo, Kazuhiko Maekawa, Kenji Shachi
  • Publication number: 20200324629
    Abstract: A striker mounting structure is configured to mount a striker on a vehicle body. A hook fixed to a door is hooked to the striker. A reinforcement formed with an insertion hole may be attached to the vehicle body. An outer panel covering a reinforcement may include a striker mounting surface spaced from the reinforcement. A reinforcement member may be fixed to the striker and the striker mounting surface. Two or more connecting rods may extend from the reinforcement member. Each of the connecting rods may include locking portions, which are inserted in the insertion hole formed in the reinforcement.
    Type: Application
    Filed: April 3, 2020
    Publication date: October 15, 2020
    Applicants: KABUSHIKI KAISHA TOYOTA JIDOSHOKKI, TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Shu NAKAMURA, Hironori TAJIMA, Kazuhiko SATO, Mikio NAKASHIMA, Hiroki KAWAMURA, Tsuyoshi KATO, Satoshi MAEKAWA, Hirokazu SHIROUZU, Kanichi SAITO
  • Publication number: 20200325707
    Abstract: A striker mounting structure is designed to mount a striker on a vehicle body and prevent a door from entering a passenger compartment. A reinforcement provided on the vehicle body is covered by an outer panel. A striker mounting surface is arranged to be spaced away from the reinforcement in a front/backward direction of the vehicle body. The reinforcement is provided with an insertion hole opening toward a direction away from the passenger compartment. The striker and a reinforcement member are fixed to opposite sides of the striker mounting surface. A connecting rod is fixed to the reinforcement member and is formed with a locking portion extending into the insertion hole in a direction toward the passenger compartment and formed with an abutment portion. A distance between an end of the abutment portion and the passenger compartment is smaller than a distance between the striker and the passenger compartment.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 15, 2020
    Applicants: KABUSHIKI KAISHA TOYOTA JIDOSHOKKI, TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Shu Nakamura, Hironori Tajima, Kazuhiko Sato, Mikio Nakashima, Hiroki Kawamura, Tsuyoshi Kato, Satoshi Maekawa, Hirokazu Shirouzu, Kanichi Saito
  • Patent number: 10766495
    Abstract: An onboard apparatus comprises a controller configured to execute acquisition of information regarding a driving environment on a route from a riding point of a passenger riding on a vehicle to an alighting point where the passenger alights; and calculation of points given to a driver who drives the vehicle along the route according to the information regarding the driving environment.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: September 8, 2020
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Masayuki Matsuda, Kazuhiko Nakanishi, Yuko Mizuno, Satoshi Shimada, Takuya Maekawa, Yorichika Ishiyama
  • Patent number: 10766978
    Abstract: A polyvinyl alcohol is produced in a method comprising: a polymerization step comprising polymerizing vinyl ester monomers by controlled radical polymerization in the presence of a radical initiator and an organic cobalt complex to obtain a polymer solution containing a polyvinyl ester; an extraction step comprising extracting a cobalt complex from the polymer solution by contacting an aqueous solution containing a water-soluble ligand with the polymer solution; and a saponification step comprising saponifying the polyvinyl ester after the extraction step to obtain a polyvinyl alcohol. A method for producing a polyvinyl alcohol is thus provided that has a narrow molecular weight distribution and a high number-average molecular weight with good hue and further good solubility in water.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: September 8, 2020
    Assignees: KURARAY CO., LTD., UNIVERSITE DE LIEGE
    Inventors: Takumi Takayama, Yusuke Amano, Kazuhiko Maekawa, Christophe Detrembleur, Antoine Debuigne, Christine Jerome
  • Publication number: 20200265535
    Abstract: According to one embodiment, a skill platform system includes a data acquisition unit, a model creation unit and a skill provision unit. The data acquisition unit is configured to acquire data on work of a skilled worker at a first site. The model creation unit is configured to perform modeling a skill of the skilled worker using the data acquired by the data acquisition unit. The skill provision unit is configured to provide the skill of the skilled worker to a second site by using the model created by the model creation unit.
    Type: Application
    Filed: May 8, 2020
    Publication date: August 20, 2020
    Applicants: KABUSHIKI KAISHA TOSHIBA, TOSHIBA DIGITAL SOLUTIONS CORPORATION
    Inventors: Koji OKADA, Kazuhiko NISHIKAWA, Yoshikatsu MAEKAWA, Noboru FUJIMAKI, Takashi IWASAKI, Tadayuki NAKAMURA
  • Patent number: 10745491
    Abstract: Provided is a monoclonal antibody or a fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: August 18, 2020
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Shoichi Naito, Junji Onoda, Tasuku Tsukamoto, Katsutoshi Yamada, Shoji Yamane, Yoshito Numata, Kazuhiko Maekawa, Tatsuya Takahashi
  • Publication number: 20200216584
    Abstract: A polyvinyl alcohol has a number-average molecular weight (Mn) from 4,400 to 440,000, a molecular weight distribution (Mw/Mn) from 1.05 to 1.70, a degree of saponification from 80 to 99.99 mol %, wherein the polyvinyl alcohol contains an end group represented by a formula (I) below, and a molar ratio (X) of the end group based on total monomer units and the number-average molecular weight (Mn) satisfy a formula (1) below. Such a polyvinyl alcohol has a narrow molecular weight distribution and a high number-average molecular weight with hue good. (In the formula, R1 denotes an optionally substituted aromatic group having a carbon number from 6 to 20, and R2 denotes a hydrogen atom, an alkyl group having a carbon number from 1 to 20, or an optionally substituted aromatic group having a carbon number from 6 to 20.) X·Mn/44?0.
    Type: Application
    Filed: July 11, 2018
    Publication date: July 9, 2020
    Applicants: KURARAY CO., LTD., UNIVERSITE DE LIEGE
    Inventors: Takumi TAKAYAMA, Kazuhiko MAEKAWA, Christophe DETREMBLEUR, Antoine DEBUIGNE, Christine JEROME
  • Publication number: 20200157255
    Abstract: There is provided a vinyl alcohol-based polymer having an olefin in side chain, comprising 0.001 to 10 mol % of a structural unit represented by Formula (1) based on the total amount of structural units, wherein the total carbon number of X, R1, R2, R3 and R4 is 2 or more. The vinyl alcohol-based polymer having an olefin in side chain has excellent storage stability, good solubility in water or an organic solvent even after thermal treatment, and excellent reactivity to high energy beam.
    Type: Application
    Filed: June 5, 2018
    Publication date: May 21, 2020
    Applicant: KURARAYCO., LTD.
    Inventors: Yuki TACHIBANA, Yusuke AMANO, Kazuhiko MAEKAWA
  • Publication number: 20200131270
    Abstract: The present invention provides a novel therapeutic strategy using an inhibitor targeting PD-1/PD-L1. A pharmaceutical composition which comprises a COX-2 inhibitor and is administered before, after or simultaneously with the administration of an inhibitor targeting PD-1/PD-L1. A potentiator for the immunostimulatory effect of an inhibitor targeting PD-1/PD-L1, which comprises a COX-2 inhibitor.
    Type: Application
    Filed: July 19, 2018
    Publication date: April 30, 2020
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, FUSO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Satoru KONNAI, Kazuhiko OHASHI, Shiro MURATA, Tomohiro OKAGAWA, Naoya MAEKAWA, Asami NISHIMORI, Shinya GOTO, Yasuhiko SUZUKI, Chie NAKAJIMA, Yamato SAJIKI
  • Publication number: 20200123296
    Abstract: The present invention provides a resin composition satisfying both high crystallinity and excellent flexibility while ensuring desirable workability. The present invention relates to a resin composition comprising a vinyl alcohol polymer (A) and a copolymer (B), wherein the copolymer (B) comprises a vinyl alcohol polymer (B-1) and a diene polymer (B-2), and has a content ratio of 10 to 70 mass % with respect to a total mass of the vinyl alcohol polymer (A) and the copolymer (B), the resin composition having a powder or pellet form, and an average particle diameter of 50 to 4,000 ?m.
    Type: Application
    Filed: June 29, 2018
    Publication date: April 23, 2020
    Applicant: KURARAY CO., LTD.
    Inventors: Yusuke AMANO, Eiichi ISHIDA, Kazuhiko MAEKAWA
  • Publication number: 20200031932
    Abstract: The present invention provides an anti-PD-L1 antibody capable of staining tumor cells such as melanoma cells. An anti-PD-L1 antibody comprising (a) a light chain comprising CDR1 having the amino acid sequence of KSISKY (SEQ ID NO: 1), CDR2 having the amino acid sequence of SGS and CDR3 having the amino acid sequence of QQHNEYPLT (SEQ ID NO: 2) and (b) a heavy chain comprising CDR1 having the amino acid sequence of GYTFTDYI (SEQ ID NO: 3), CDR2 having the amino acid sequence of INPDSGGN (SEQ ID NO: 4) and CDR3 having the amino acid sequence of ARGITMMVVISHWKFDF (SEQ ID NO: 5). A composition for detecting PD-L1, comprising the above antibody as an active ingredient. A method for preparing the above antibody is also provided.
    Type: Application
    Filed: March 23, 2018
    Publication date: January 30, 2020
    Inventors: Satoru Konnai, Kazuhiko Ohashi, Shiro Murata, Tomohiro Okagawa, Asami Nishimori, Naoya Maekawa, Satoshi Takagi, Yumiko Kagawa, Yasuhiko Suzuki, Chie Nakajima
  • Publication number: 20200027291
    Abstract: An onboard apparatus comprises a communication unit; and a controller configured to execute: detecting start of running of a vehicle provided for sharing a ride, detecting a driver at the start of running, detecting change of the driver after the start of running and measuring passage information including at least one of running time and running distance from the start of running until the change of the driver, and transmitting the measured passage information to an information processing apparatus via the communication unit along with identification information for identifying the driver detected before the change of the driver.
    Type: Application
    Filed: July 3, 2019
    Publication date: January 23, 2020
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Yuko MIZUNO, Kazuhiko NAKANISHI, Masayuki MATSUDA, Satoshi SHIMADA, Takuya MAEKAWA, Yorichika ISHIYAMA
  • Publication number: 20200025580
    Abstract: An information processing apparatus comprising a processor configured to transmit, through a communicator, a notification that a carpool passenger is recruited, according to a request from a planner who planned ride-sharing, and acquire information on a carpool demander who demands carpooling for the ride-sharing in response to the notification, the carpool demander satisfying a condition related to a distance from a reference position.
    Type: Application
    Filed: July 8, 2019
    Publication date: January 23, 2020
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Masayuki MATSUDA, Kazuhiko NAKANISHI, Yuko MIZUNO, Satoshi SHIMADA, Takuya MAEKAWA, Yorichika ISHIYAMA
  • Publication number: 20200010090
    Abstract: An onboard apparatus comprises a controller configured to execute acquisition of information regarding a driving environment on a route from a riding point of a passenger riding on a vehicle to an alighting point where the passenger alights; and calculation of points given to a driver who drives the vehicle along the route according to the information regarding the driving environment.
    Type: Application
    Filed: July 2, 2019
    Publication date: January 9, 2020
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Masayuki MATSUDA, Kazuhiko NAKANISHI, Yuko MIZUNO, Satoshi SHIMADA, Takuya MAEKAWA, Yorichika ISHIYAMA
  • Publication number: 20200011686
    Abstract: An information processing apparatus comprises a controller configured to acquire information for identifying a vehicle conducting ride-sharing; and instruct a management apparatus of a toll road to apply preferential treatment when the vehicle conducting the ride-sharing travels along the toll road.
    Type: Application
    Filed: June 26, 2019
    Publication date: January 9, 2020
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Satoshi SHIMADA, Kazuhiko NAKANISHI, Yuko MIZUNO, Masayuki MATSUDA, Takuya MAEKAWA, Yorichika ISHIYAMA
  • Publication number: 20200011679
    Abstract: An information processing apparatus comprises a controller configured to acquire sponsor information including information on a facility available as a getting-in place or getting-off place for ride sharing, information on a time period during which the facility is available as the getting-in place or getting-off place for ride sharing, and information on a privilege when the facility is used as the getting-in place or getting-off place for ride sharing; and provide the acquired sponsor information to a ride sharing coordinator.
    Type: Application
    Filed: June 12, 2019
    Publication date: January 9, 2020
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Kazuhiko NAKANISHI, Yuko MIZUNO, Masayuki MATSUDA, Satoshi SHIMADA, Takuya MAEKAWA, Yorichika ISHIYAMA
  • Publication number: 20190345279
    Abstract: The present invention relates to a vinyl alcohol-based polymer having an olefin in side chain, comprising a vinyl alcohol unit and a structural unit represented by Formula (I), wherein X represents a divalent saturated hydrocarbon group with 1 to 6 carbon atoms, optionally having a branched structure; Y represents a hydrogen atom or a saturated hydrocarbon group with 1 to 6 carbon atoms, optionally having a branched structure; and Z represents a hydrogen atom or a methyl group. Thus, there is provided a vinyl alcohol-based polymer having an olefin in side chain exhibiting higher water solubility even after thermal treatment, higher storage stability, and higher reactivity to high energy beam, and a method for producing it.
    Type: Application
    Filed: December 26, 2017
    Publication date: November 14, 2019
    Applicant: KURARAY CO., LTD.
    Inventors: Yusuke AMANO, Yuki TACHIBANA, Yuki KOSAKA, Kazuhiko MAEKAWA