Patents by Inventor Kazuhiko Maekawa

Kazuhiko Maekawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220227871
    Abstract: The present invention provides an anti-PD-L1 antibody capable of repeated administration even to animals other than rat. An anti-PD-L1 antibody comprising (a) a light chain comprising a light chain variable region containing CDR1 having the amino acid sequence of QSLLYSENQKDY (SEQ ID NO: 37), CDR2 having the amino acid sequence of WAT and CDR3 having the amino acid sequence of GQYLVYPFT (SEQ ID NO: 38) and the light chain constant region of an antibody of an animal other than rat; and (b) a heavy chain comprising a heavy chain variable region containing CDR1 having the amino acid sequence of GYTFTSNF (SEQ ID NO: 39), CDR2 having the amino acid sequence of IYPEYGNT (SEQ ID NO: 40) and CDR3 having the amino acid sequence of ASEEAVISLVY (SEQ ID NO: 41) and the heavy chain constant region of an antibody of an animal other than rat. A pharmaceutical composition comprising the above anti-PD-L1 antibody as an active ingredient. A method for preparing the above anti-PD-L1 antibody is also provided.
    Type: Application
    Filed: January 19, 2022
    Publication date: July 21, 2022
    Inventors: Satoru Konnai, Kazuhiko Ohashi, Shiro Murata, Tomohiro Okagawa, Asami Nishimori, Naoya Maekawa, Yasuhiko Suzuki, Chie Nakajima
  • Publication number: 20220220332
    Abstract: A coating composition may include a modified polyvinyl alcohol resin (A) having an ethylene unsaturated group in a side chain thereof. Examples of the modified polyvinyl alcohol resin (A) include those including a structural unit represented by formula (II) or (III). Substrates in various technical fields such as the resin molding field, automobile/railway/aircraft/ships-related field, medical product field, food field, agriculture/gardening field, electrical field, and construction field can be coated with such a coating composition.
    Type: Application
    Filed: April 24, 2020
    Publication date: July 14, 2022
    Applicant: Kuraray Co., Ltd.
    Inventors: Yuki TACHIBANA, Yusuke AMANO, Kazuhiko MAEKAWA
  • Publication number: 20220144977
    Abstract: A method of producing modified vinyl alcohol-based polymer particles, includes mixing vinyl alcohol-based polymer particles with a mixed medium containing unsaturated carboxylic acid, an acid catalyst, and water, wherein, by mixing the vinyl alcohol-based polymer particles with the mixed medium, the vinyl alcohol-based polymer particles are reacted with the unsaturated carboxylic acid to obtain modified vinyl alcohol-based polymer particles containing a vinyl ester unit represented by a formula (2) below, having a vinyl alcohol unit content based on the total constitutional units from 95 to 99.99 mol %, and having an average particle diameter from 50 to 2000 ?m. The production method does not cause the problem of the residual sulfur content derived from a liquid medium used for reaction and is also capable of modifying the vinyl alcohol-based polymer particles while maintaining the particle shape.
    Type: Application
    Filed: March 12, 2020
    Publication date: May 12, 2022
    Applicant: KURARAY CO., LTD.
    Inventors: Yuki TACHIBANA, Yusuke AMANO, Yuki SHIMIZU, Kazuhiko MAEKAWA
  • Publication number: 20220089793
    Abstract: A method of producing modified vinyl alcohol-based polymer particles, includes mixing vinyl alcohol-based polymer particles with a mixed medium containing unsaturated carboxylic acid, an acid catalyst, and water, wherein, by mixing the vinyl alcohol-based polymer particles with the mixed medium, the vinyl alcohol-based polymer particles are reacted with the unsaturated carboxylic acid to obtain modified vinyl alcohol-based polymer particles containing a vinyl ester unit represented by a formula (2) below, having a vinyl alcohol unit content based on the total constitutional units of 60 mol % or more and less than 95 mol %, and having an average particle diameter from 50 to 2000 ?m. The production method is capable of controlling the particle shape and does not cause the problem of the residual sulfur content, and is further convenient and economically advantageous.
    Type: Application
    Filed: December 26, 2019
    Publication date: March 24, 2022
    Applicant: KURARAY CO., LTD.
    Inventors: Yuki TACHIBANA, Yusuke AMANO, Yuki SHIMIZU, Kazuhiko MAEKAWA
  • Patent number: 11261270
    Abstract: A polyvinyl alcohol has a number-average molecular weight (Mn) from 4,400 to 440,000, a molecular weight distribution (Mw/Mn) from 1.05 to 1.70, a degree of saponification from 80 to 99.99 mol %, wherein the polyvinyl alcohol contains an end group represented by a formula (I) below, and a molar ratio (X) of the end group based on total monomer units and the number-average molecular weight (Mn) satisfy a formula (1) below. Such a polyvinyl alcohol has a narrow molecular weight distribution and a high number-average molecular weight with hue good. (In the formula, R1 denotes an optionally substituted aromatic group having a carbon number from 6 to 20, and R2 denotes a hydrogen atom, an alkyl group having a carbon number from 1 to 20, or an optionally substituted aromatic group having a carbon number from 6 to 20.) X·Mn/44?0.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: March 1, 2022
    Assignees: KURARAY CO., LTD., UNIVERSITE DE LIEGE
    Inventors: Takumi Takayama, Kazuhiko Maekawa, Christophe Detrembleur, Antoine Debuigne, Christine Jerome
  • Publication number: 20220049082
    Abstract: The present invention provides a resin composition having superior flexibility and that exhibits excellent durability in thermal molding, and a molded body of such a resin composition. The present invention relates to a resin composition comprising: a copolymer (B) constituted of a vinyl alcohol polymer (B-1) region and a diene polymer (B-2) region; and at least one compound selected from the group consisting of a phenol-based compound (C), an amine-based compound (D), and a phosphorus-based compound (E).
    Type: Application
    Filed: September 12, 2019
    Publication date: February 17, 2022
    Applicant: KURARAYCO., LTD.
    Inventors: Yusuke AMANO, Eiichi ISHIDA, Masayoshi YAMANAKA, Kazuhiko MAEKAWA
  • Patent number: 11111319
    Abstract: A polyvinyl alcohol has a number-average molecular weight (Mn) from 4,400 to 440,000, a molecular weight distribution (Mw/Mn) from 1.05 to 1.70, a degree of saponification from 80 to 99.99 mol %, and a carbon-carbon double bond content (X) of 0.1 mol % or less based on total monomer units, and satisfying a formula (1) below. A polyvinyl alcohol, having a narrow molecular weight distribution and a high number-average molecular weight with good hue, and a method for producing the same are thus provided.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: September 7, 2021
    Assignee: KURARAY CO., LTD.
    Inventors: Yusuke Amano, Takumi Takayama, Kazuhiko Maekawa
  • Publication number: 20210246299
    Abstract: The present invention provides a rubber composition having superior moldability, wear resistance, and grip performance, and tires therewith. The present invention relates to a rubber composition comprising: a copolymer (B) constituted of a vinyl alcohol polymer (B-1) region and a diene polymer (B-2) region; and a rubber component (C), wherein the rubber composition comprises 1 to 20 parts by mass of the copolymer (B) relative to 100 parts by mass of the rubber component (C).
    Type: Application
    Filed: June 7, 2019
    Publication date: August 12, 2021
    Applicant: KURARAYCO., LTD.
    Inventors: Yusuke AMANO, Eiichi ISHIDA, Kazuhiko MAEKAWA, Daisuke KODA, Hiroshi KANBARA
  • Patent number: 11078309
    Abstract: There is provided a vinyl alcohol-based polymer having an olefin in side chain, comprising 0.001 to 10 mol % of a structural unit represented by Formula (1) based on the total amount of structural units, wherein the total carbon number of X, R1, R2, R3 and R4 is 2 or more. The vinyl alcohol-based polymer having an olefin in side chain has excellent storage stability, good solubility in water or an organic solvent even after thermal treatment, and excellent reactivity to high energy beam.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: August 3, 2021
    Assignee: KURARAY CO., LTD.
    Inventors: Yuki Tachibana, Yusuke Amano, Kazuhiko Maekawa
  • Patent number: 11028200
    Abstract: The present invention relates to a vinyl alcohol-based polymer having an olefin in side chain, comprising a vinyl alcohol unit and a structural unit represented by Formula (I), wherein X represents a divalent saturated hydrocarbon group with 1 to 6 carbon atoms, optionally having a branched structure; Y represents a hydrogen atom or a saturated hydrocarbon group with 1 to 6 carbon atoms, optionally having a branched structure; and Z represents a hydrogen atom or a methyl group. Thus, there is provided a vinyl alcohol-based polymer having an olefin in side chain exhibiting higher water solubility even after thermal treatment, higher storage stability, and higher reactivity to high energy beam, and a method for producing it.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: June 8, 2021
    Assignee: KURARAY CO., LTD.
    Inventors: Yusuke Amano, Yuki Tachibana, Yuki Kosaka, Kazuhiko Maekawa
  • Publication number: 20200362078
    Abstract: The invention relates to particles with an average particle size of 300 to 1000 ?m, comprising a modified polyvinyl alcohol having vinyl alcohol units and structural units represented by formula (1), wherein a content of the vinyl alcohol units is 60 to 90 mol % based on the total structural units: wherein R1 represents a hydrogen atom or a methyl group. Thus, the present invention provides particles containing a modified polyvinyl alcohol having high water solubility and high affinity for a photosensitive monomer, which are highly photosensitive.
    Type: Application
    Filed: February 18, 2019
    Publication date: November 19, 2020
    Applicant: KURARAY CO., LTD.
    Inventors: Yusuke AMANO, Yuki TACHIBANA, Yuki SHIMIZU, Kazuhiko MAEKAWA
  • Publication number: 20200355486
    Abstract: A bend sensor comprising a sensor section in which a polymer electrolyte film is sandwiched between a pair of electrode films, wherein each of the electrode films contains: a block copolymer (Z) having a polymer block (S) composed of a structural unit derived from an aromatic vinyl compound, and containing an ion-conducting group, and an amorphous polymer block (T) composed of a structural unit derived from an unsaturated aliphatic hydrocarbon; and a conducting particle; which block copolymer (Z) forms a lamellar structure, which bend sensor therefore allows generation of enhanced voltage between the electrode films when deformation of the sensor occurs as it follows movement of an object, is provided.
    Type: Application
    Filed: May 26, 2020
    Publication date: November 12, 2020
    Applicant: NIPPON NEKTRON, LTD.T
    Inventors: Mikiya MATSUURA, Katsuei Takahashi, Naoki Chikugo, Kazuhiko Maekawa, Kenji Shachi
  • Patent number: 10766978
    Abstract: A polyvinyl alcohol is produced in a method comprising: a polymerization step comprising polymerizing vinyl ester monomers by controlled radical polymerization in the presence of a radical initiator and an organic cobalt complex to obtain a polymer solution containing a polyvinyl ester; an extraction step comprising extracting a cobalt complex from the polymer solution by contacting an aqueous solution containing a water-soluble ligand with the polymer solution; and a saponification step comprising saponifying the polyvinyl ester after the extraction step to obtain a polyvinyl alcohol. A method for producing a polyvinyl alcohol is thus provided that has a narrow molecular weight distribution and a high number-average molecular weight with good hue and further good solubility in water.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: September 8, 2020
    Assignees: KURARAY CO., LTD., UNIVERSITE DE LIEGE
    Inventors: Takumi Takayama, Yusuke Amano, Kazuhiko Maekawa, Christophe Detrembleur, Antoine Debuigne, Christine Jerome
  • Patent number: 10745491
    Abstract: Provided is a monoclonal antibody or a fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: August 18, 2020
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Shoichi Naito, Junji Onoda, Tasuku Tsukamoto, Katsutoshi Yamada, Shoji Yamane, Yoshito Numata, Kazuhiko Maekawa, Tatsuya Takahashi
  • Publication number: 20200216584
    Abstract: A polyvinyl alcohol has a number-average molecular weight (Mn) from 4,400 to 440,000, a molecular weight distribution (Mw/Mn) from 1.05 to 1.70, a degree of saponification from 80 to 99.99 mol %, wherein the polyvinyl alcohol contains an end group represented by a formula (I) below, and a molar ratio (X) of the end group based on total monomer units and the number-average molecular weight (Mn) satisfy a formula (1) below. Such a polyvinyl alcohol has a narrow molecular weight distribution and a high number-average molecular weight with hue good. (In the formula, R1 denotes an optionally substituted aromatic group having a carbon number from 6 to 20, and R2 denotes a hydrogen atom, an alkyl group having a carbon number from 1 to 20, or an optionally substituted aromatic group having a carbon number from 6 to 20.) X·Mn/44?0.
    Type: Application
    Filed: July 11, 2018
    Publication date: July 9, 2020
    Applicants: KURARAY CO., LTD., UNIVERSITE DE LIEGE
    Inventors: Takumi TAKAYAMA, Kazuhiko MAEKAWA, Christophe DETREMBLEUR, Antoine DEBUIGNE, Christine JEROME
  • Publication number: 20200157255
    Abstract: There is provided a vinyl alcohol-based polymer having an olefin in side chain, comprising 0.001 to 10 mol % of a structural unit represented by Formula (1) based on the total amount of structural units, wherein the total carbon number of X, R1, R2, R3 and R4 is 2 or more. The vinyl alcohol-based polymer having an olefin in side chain has excellent storage stability, good solubility in water or an organic solvent even after thermal treatment, and excellent reactivity to high energy beam.
    Type: Application
    Filed: June 5, 2018
    Publication date: May 21, 2020
    Applicant: KURARAYCO., LTD.
    Inventors: Yuki TACHIBANA, Yusuke AMANO, Kazuhiko MAEKAWA
  • Publication number: 20200123296
    Abstract: The present invention provides a resin composition satisfying both high crystallinity and excellent flexibility while ensuring desirable workability. The present invention relates to a resin composition comprising a vinyl alcohol polymer (A) and a copolymer (B), wherein the copolymer (B) comprises a vinyl alcohol polymer (B-1) and a diene polymer (B-2), and has a content ratio of 10 to 70 mass % with respect to a total mass of the vinyl alcohol polymer (A) and the copolymer (B), the resin composition having a powder or pellet form, and an average particle diameter of 50 to 4,000 ?m.
    Type: Application
    Filed: June 29, 2018
    Publication date: April 23, 2020
    Applicant: KURARAY CO., LTD.
    Inventors: Yusuke AMANO, Eiichi ISHIDA, Kazuhiko MAEKAWA
  • Publication number: 20190345279
    Abstract: The present invention relates to a vinyl alcohol-based polymer having an olefin in side chain, comprising a vinyl alcohol unit and a structural unit represented by Formula (I), wherein X represents a divalent saturated hydrocarbon group with 1 to 6 carbon atoms, optionally having a branched structure; Y represents a hydrogen atom or a saturated hydrocarbon group with 1 to 6 carbon atoms, optionally having a branched structure; and Z represents a hydrogen atom or a methyl group. Thus, there is provided a vinyl alcohol-based polymer having an olefin in side chain exhibiting higher water solubility even after thermal treatment, higher storage stability, and higher reactivity to high energy beam, and a method for producing it.
    Type: Application
    Filed: December 26, 2017
    Publication date: November 14, 2019
    Applicant: KURARAY CO., LTD.
    Inventors: Yusuke AMANO, Yuki TACHIBANA, Yuki KOSAKA, Kazuhiko MAEKAWA
  • Patent number: 10426712
    Abstract: The present invention provides a dental polymerizable composition that requires less discharging force, is easily formable, has low polymerization shrinkage stress during curing, and exhibits high stain resistance and surface gloss when cured. The present invention relates to a dental polymerizable composition including a (meth)acrylic block copolymer (A), a polymerizable monomer (B), and a polymerization initiator (C). The (meth)acrylic block copolymer (A) consists of a (meth)acrylic polymer block (a) having a curable functional group and a (meth)acrylic polymer block (b) having no curable functional group.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: October 1, 2019
    Assignee: KURARAY NORITAKE DENTAL INC.
    Inventors: Hirotsugu Ida, Kenji Suzuki, Seiya Shimizu, Kenji Shachi, Kazuhiko Maekawa
  • Publication number: 20190211114
    Abstract: Provided is a monoclonal antibody or a fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.
    Type: Application
    Filed: January 11, 2019
    Publication date: July 11, 2019
    Applicant: SHIONOGI & CO., LTD.
    Inventors: Shoichi NAITO, Junji ONODA, Tasuku TSUKAMOTO, Katsutoshi YAMADA, Shoji YAMANE, Yoshito NUMATA, Kazuhiko MAEKAWA, Tatsuya TAKAHASHI