Patents by Inventor Kazuhiro Ban
Kazuhiro Ban has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9086404Abstract: A method is provided by which a reagent is provided to a living sample, including contacting a thin-film containing a porous body with a living sample containing cells or tissues, and discharging a solution containing at least one or more reagents to a non-contact side of the thin-film by ink-jet to provide the solution to the specific area of the living sample through pores on the thin-film, wherein the smaller diameter of the pores on the porous body relative to the diameter of cells in the living sample enables the reagent to be provided to each individual cell separately. According to this method, the reagent and the reaction product can be fixed while maintaining positioning information of the target substance in the living sample, as a pretreatment for analyzing with high positioning accuracy the target substance in each individual cell in the living sample.Type: GrantFiled: October 4, 2007Date of Patent: July 21, 2015Assignee: CANON KABUSHIKI KAISHAInventors: Manabu Komatsu, Hiroyuki Hashimoto, Kazuhiro Ban, Yohei Murayama
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Patent number: 8986943Abstract: A pre-treatment method for analyzing a specified portion in a specimen composed of a biological tissue includes the steps of preparing a specimen to be analyzed, determining a specified portion in the specimen; and applying an analysis inhibitor to a portion except the specified portion of the specimen using a droplet spray method.Type: GrantFiled: March 14, 2013Date of Patent: March 24, 2015Assignee: Canon Kabushiki KaishaInventors: Yohei Murayama, Hiroyuki Hashimoto, Manabu Komatsu, Kazuhiro Ban
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Patent number: 8962302Abstract: A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of the proteins from the biological tissue, wherein the proteins or the degradation products obtained by the action of the enzyme are brought into contact with a member consisting of a metal.Type: GrantFiled: November 3, 2006Date of Patent: February 24, 2015Assignee: Canon Kabushiki KaishaInventors: Kazuhiro Ban, Miki Ogawa, Norihiko Utsunomiya, Hiroyuki Hashimoto, Manabu Komatsu, Yohei Murayama
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Patent number: 8486334Abstract: The invention is to provide a magnetic sensor capable of detecting magnetic particles over a wide range of number and of suppressing an increase in a detection area. The magnetic sensor includes a detection part, a selecting device connected electrically to an end of the detecting part, and a sensing amplifier for receiving a signal from the detecting part, wherein the detecting part includes at least two magnetoresistive films serially connected.Type: GrantFiled: January 30, 2006Date of Patent: July 16, 2013Assignee: Canon Kabushiki KaishaInventors: Takashi Ikeda, Kazuhiro Ban
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Patent number: 8436535Abstract: An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.Type: GrantFiled: February 24, 2010Date of Patent: May 7, 2013Assignee: Canon Kabushiki KaishaInventors: Hiroyuki Hashimoto, Katsuaki Kuge, Manabu Komatsu, Kumi Nakamura, Kazuhiro Ban, Takeshi Imamura, Shin Kobayashi, Tadashi Okamoto
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Patent number: 8415116Abstract: A pre-treatment method for analyzing a specified portion in a specimen composed of a biological tissue includes the steps of preparing a specimen to be analyzed, determining a specified portion in the specimen; and applying an analysis inhibitor to a portion except the specified portion of the specimen using a droplet spray method.Type: GrantFiled: May 1, 2008Date of Patent: April 9, 2013Assignee: Canon Kabushiki KaishaInventors: Yohei Murayama, Hiroyuki Hashimoto, Manabu Komatsu, Kazuhiro Ban
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Publication number: 20120283385Abstract: According to the present invention, there can be provided a structure preventing the nonspecific adsorption, and a target substance-detecting element and a target substance-detecting kit. A first aspect of the present invention is a structure including: a substrate; and a membrane, present on the surface of the substrate, having a polymer of a monomer represented by the following General Formula (1) or (2): (wherein R represents H or CH3; x represents an integer of 2 to 5, and y represents an integer of 1 to 7, with the proviso that x+y=an integer of 3 to 10), and (wherein R1?H or CH3, and R2 represents O or NH; a represents an integer of 2 to 5, and b represents an integer of 1 to 7, with the proviso that a+b=an integer of 3 to 10.Type: ApplicationFiled: June 28, 2012Publication date: November 8, 2012Applicant: CANON KABUSHIKI KAISHAInventors: Kazuhiro Ban, Masato Minami
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Patent number: 8232344Abstract: According to the present invention, there can be provided a structure preventing the nonspecific adsorption, and a target substance-detecting element and a target substance-detecting kit. A first aspect of the present invention is a structure including: a substrate; and a membrane, present on the surface of the substrate, having a polymer of a monomer represented by the following General Formula (1) or (2): (wherein R represents H or CH3; x represents an integer of 2 to 5, and y represents an integer of 1 to 7, with the proviso that x+y=an integer of 3 to 10), and (wherein R1?H or CH3, and R2 represents O or NH; a represents an integer of 2 to 5, and b represents an integer of 1 to 7, with the proviso that a+b=an integer of 3 to 10).Type: GrantFiled: June 24, 2008Date of Patent: July 31, 2012Assignee: Canon Kabushiki KaishaInventors: Kazuhiro Ban, Masato Minami
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Patent number: 7943370Abstract: A target substance detection element that can effectively prevent the nonspecific adsorption of a target substance or impurities and detects the target substance with high sensitivity, a target substance detection kit, and a structure constituting the target substance detection element. The structure has a substrate, polymers present on the substrate surface, and first target substance capturing molecules bonded to the polymers. The polymer is composed of a polymer of a carboxybetaine monomer represented by General Formula (1) below. The first target substance capturing molecules are bonded to some of the carboxyl groups of the polymers. A compound represented by General Formula (2) is bonded to at least some of the carboxyl groups, from among the carboxyl groups of the polymers, that are not bonded to the first target substance capturing molecules.Type: GrantFiled: August 7, 2008Date of Patent: May 17, 2011Assignee: Canon Kabushiki KaishaInventors: Masato Minami, Kazuhiro Ban
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Publication number: 20110065212Abstract: There is provided a graft polymer-containing substrate that reduces nonspecific adsorption of impurities onto a substrate surface and specifically captures a target substance. There is provided a graft polymer-containing substrate with a graft polymer formed on the surface thereof, characterized in that the graft polymer includes monomer units represented by the following general formulas (1) and (2): wherein R1, R2, and R3 represent one of a hydrogen atom and a methyl group, R4 represents a group including any of a carboxyl group, a succinimide group, an aldehyde group, an epoxy group, a bromo group, an amino group, and a maleimide group, X represents a hydrophilic crosslinking spacer having 15 or more atoms, and l, m, and n are an integer of 1 or greater.Type: ApplicationFiled: May 29, 2009Publication date: March 17, 2011Applicant: CANON KABUSHIKI KAISHAInventors: Kazuhiro Ban, Masato Minami, Mayuko Kishi
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Patent number: 7851749Abstract: A method for obtaining information on a mass of an object by time-of-flight mass spectrometry. This method includes placing colloidal metal particles for promoting ionization of the object inside the object at a depth ranging from 0.1 nm to 100 nm in opposition to a primary beam for the ionization; irradiating the object with the primary beam selected from the group of ions, neutral particles, and electrons, which can be focused, pulsed, and are capable of scanning, and laser beams, which can be focused, pulsed, and are capable of scanning to ionize a constituent of the object and to allow the ionized constituent to fly out of the object; and obtaining information on the mass of the flying constituent of the object by time-of-flight mass spectrometry.Type: GrantFiled: January 22, 2008Date of Patent: December 14, 2010Assignee: Canon Kabushiki KaishaInventors: Manabu Komatsu, Hiroyuki Hashimoto, Yohei Murayama, Kazuhiro Ban
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Publication number: 20100292427Abstract: The invention provides a structural member having an excellent ability to prevent the nonspecific adsorption of a biomolecule and a labeling substance to the surface of a substrate, and a method of producing the structural member. The structural member includes a substrate and a polymer present on a surface of the substrate, in which the polymer is formed from a polymer of a multi-vinyl monomer represented by the following general formula (I) or (II), and has a crosslinked structure: where R, R?, and R? are independently a hydrogen atom or a methyl group, and X represents a hydrophilic functional group in which fifteen or more atoms are linked in series.Type: ApplicationFiled: August 5, 2008Publication date: November 18, 2010Applicant: CANON KABUSHIKI KAISHAInventors: Kazuhiro Ban, Masato Minami, Mayuko Kishi
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Patent number: 7795579Abstract: An information obtaining method for obtaining information about a mass of a component of an analyte using a time of flight mass spectrometer and obtaining information about a distribution state of the component based on the obtained information about the mass includes the step of: (1) adding a self-reactive substance to the analyte on a base to facilitate ionization of the component; (2) irradiating the analyte with a primary beam in the presence of the self-reactive substance, thereby ionizing the components and allowing resulting ions to fly; (3) obtaining information about mass of the flying ions using the time of flight mass spectrometer; and (4) obtaining information about the distribution state of the component on the base based on the information about the mass.Type: GrantFiled: May 14, 2008Date of Patent: September 14, 2010Assignee: Canon Kabushiki KaishaInventors: Manabu Komatsu, Hiroyuki Hashimoto, Yohei Murayama, Kazuhiro Ban
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Publication number: 20100227308Abstract: An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.Type: ApplicationFiled: February 24, 2010Publication date: September 9, 2010Applicant: CANON KABUSHIKI KAISHAInventors: Hiroyuki Hashimoto, Katsuaki Kuge, Manabu Komatsu, Kumi Nakamura, Kazuhiro Ban, Takeshi Imamura, Shin Kobayashi, Tadashi Okamoto
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Patent number: 7701138Abstract: An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.Type: GrantFiled: December 28, 2005Date of Patent: April 20, 2010Assignee: Canon Kabushiki KaishaInventors: Hiroyuki Hashimoto, Katsuaki Kuge, Manabu Komatsu, Kumi Nakamura, Kazuhiro Ban, Takeshi Imamura, Shin Kobayashi, Tadashi Okamoto
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Patent number: 7622263Abstract: To provide an organic substance-immobilized structure employing a novel immobilizing technique and a manufacturing method thereof using the novel immobilizing technique, where, when an organic substance, particularly a biological substance is immobilized on the surface of a substrate, the organic substance, particularly the biological substance can be stably immobilized on the surface of the substrate through orientation of the organic substance, particularly the biological substance suitable for exerting physiological functions thereof. At least part of the substrate's surface is constructed of one or more substrates containing aluminum oxide. The immobilization of the organic substance to the surface of the substrate is carried out by binding at least part of the binding domain to the surface of the substrate through a binding domain containing a peptide having an affinity to aluminum oxide and composed of at least one or more amino acids, which is coupled with the organic substance.Type: GrantFiled: January 25, 2005Date of Patent: November 24, 2009Assignee: Canon Kabushiki KaishaInventors: Kazuhiro Ban, Hidenori Shiotsuka, Takeshi Imamura
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Patent number: 7560689Abstract: A sample is sliced obliquely with a blade provided with a metal thin film on the surface, and the slice of the sample adhering to the blade surface is subjected to mass spectrometry. As a result, the section of the sliced sample can be analyzed immediately by mass spectrometry with high sensitivity.Type: GrantFiled: March 6, 2007Date of Patent: July 14, 2009Assignee: Canon Kabushiki KaishaInventors: Kazuhiro Ban, Hiroyuki Hashimoto, Manabu Komatsu, Norihiko Utsunomiya, Yohei Murayama
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Publication number: 20090148346Abstract: A structural member having a binding functional group on a substrate for binding a capturing molecule capable of capturing a target substance, characterized in that the substrate binds to one end of a polymer which includes at the other end those to which the binding functional group is bound and those to which a suppressing functional group for suppressing adsorption of biological molecules to the structural member and that the suppressing functional group is also bound to a side chain of the polymer.Type: ApplicationFiled: October 3, 2006Publication date: June 11, 2009Applicant: CANON KABUSHIKI KAISHAInventors: Kazuhiro Ban, Kazumichi Nakahama, Miki Ogawa
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Publication number: 20090130776Abstract: A binding protein molecule, characterized in that it has a first domain having a binding site to an inhibitor of non-specific adsorption in which the domain comprises a part of the variable region of an antibody as the binding site and a second domain having a binding site to a target substance in which the domain comprises a part of the variable region of an antibody as the binding site, wherein the first and second domains are bound via a linker.Type: ApplicationFiled: September 1, 2006Publication date: May 21, 2009Applicant: CANON KABUSHIKI KAISHAInventors: Takeshi Imamura, Hidenori Shiotsuka, Kazuhiro Ban, Takahisa Ibii
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Publication number: 20090061533Abstract: A target substance detection element that can effectively prevent the nonspecific adsorption of a target substance or impurities and detects the target substance with high sensitivity, a target substance detection kit, and a structure constituting the target substance detection element. The structure has a substrate, polymers present on the substrate surface, and first target substance capturing molecules bonded to the polymers. The polymer is composed of a polymer of a carboxybetaine monomer represented by General Formula (1) below. The first target substance capturing molecules are bonded to some of the carboxyl groups of the polymers. A compound represented by General Formula (2) is bonded to at least some of the carboxyl groups, from among the carboxyl groups of the polymers, that are not bonded to the first target substance capturing molecules.Type: ApplicationFiled: August 7, 2008Publication date: March 5, 2009Applicant: CANON KABUSHIKI KAISHAInventors: Masato Minami, Kazuhiro Ban