Patents by Inventor Kazuhiro Kubo

Kazuhiro Kubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7531604
    Abstract: A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4?m?100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: May 12, 2009
    Assignees: NOF Corporation, Daiichi Pharmaceutical Co., Ltd.
    Inventors: Syunsuke Ohhashi, Kazuhiro Kubo, Chika Itoh, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Kurosawa, Hitoshi Yamauchi
  • Patent number: 7524981
    Abstract: A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1?k1?(k+2)/2, 0?k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: April 28, 2009
    Assignees: NOF Corporation, DAIICHI Pharmaceutical Co., Ltd.
    Inventors: Kazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi, Yusuke Ohkawa, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Patent number: 7495116
    Abstract: A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3?m?200, 9?m×(k1+k2+k3)?1000, 1?k1?2, 0?k2?9 and 0?k3?9, and 3?k1+k2+k3?10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: February 24, 2009
    Assignees: NOF Corporation, Daiichi Pharmaceutical Co., Ltd.
    Inventors: Chika Itoh, Kazuhiro Kubo, Syunsuke Ohhashi, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Patent number: 7399877
    Abstract: A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5?m?600, 1?n?45, 0?q?200, 10?m+n+q?600, 0.04?n/(m+n+q), and q/(m+n+q)?0.
    Type: Grant
    Filed: March 19, 2004
    Date of Patent: July 15, 2008
    Assignees: NOF Corporation, Daiichi Pharmaceutical Co., Ltd.
    Inventors: Chika Itoh, Syunsuke Ohhashi, Kazuhiro Kubo, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Publication number: 20080081888
    Abstract: A method for producing a biodegradable polyoxyalkylene derivative, includes: reacting a biodegradable polyoxyalkylene compound represented by the formula (1) as defined herein with a compound represented by one of the formulae (I) to (IV) as defined herein in a presence of an alkaline solid salt, the biodegradable polyoxyalkylene derivative being represented by the formula (2) as defined herein.
    Type: Application
    Filed: September 28, 2007
    Publication date: April 3, 2008
    Applicant: NOF CORPORATION
    Inventors: Kazuhiro KUBO, Shigeru KITANO, Chika ITO
  • Patent number: 7198945
    Abstract: A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features: (1) having one or more aliphatic hydrocarbon groups at one end; (2) having one or more portions containing a hydrophilic group in a molecule; and (3) having one or more reactive functional groups which are capable of covalently binding with the substance to be modified at an end different from the end in the above (1).
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: April 3, 2007
    Assignees: Teruyuki Nagamune, NOF Corporation
    Inventors: Teruyuki Nagamune, Chika Itoh, Tohru Yasukohchi, Syunsuke Ohhashi, Kazuhiro Kubo
  • Publication number: 20070031481
    Abstract: A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5?m?600, 1?n?45, 0?q?200, 10?m+n+q?600, 0.04?n/(m+n+q), and q/(m+n+q)?0.
    Type: Application
    Filed: March 19, 2004
    Publication date: February 8, 2007
    Inventors: Chika Itoh, Syunsuke Ohhashi, Kazuhiro Kubo, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Patent number: 7147250
    Abstract: To provide a counter weight capable of forming an attaching part to a vehicle frame with high precision, capable of improving attaching precision to this vehicle frame, and further, capable of decreasing a manufacture cost thereof. The counter weight includes a base made of cast iron having an attaching part, whereby the counter weight is attached to a vehicle frame; and a weight part made of a slab material having a block body made of a slab material; wherein the weight part made of the slab material is attached on the above-described base made of cast iron. The outer surface of the above-described weight part made of the slab material is coated with the cover.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: December 12, 2006
    Assignee: Komatsu Ltd.
    Inventors: Kazuhiro Kubo, Masatoshi Kajiya, Morihiko Kawahashi
  • Publication number: 20060210618
    Abstract: A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1?k1?(k+2)/2, 0?k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.
    Type: Application
    Filed: December 12, 2003
    Publication date: September 21, 2006
    Inventors: Kazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi, Yusuke Ohkawa, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Publication number: 20060110436
    Abstract: A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4?m?100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium
    Type: Application
    Filed: September 30, 2003
    Publication date: May 25, 2006
    Inventors: Syunsuke Ohhashi, Kazuhiro Kubo, Chika Itoh, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Kurosawa, Hitoshi Yamauchi
  • Publication number: 20050220856
    Abstract: A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3?m?200, 9?m×(k1+k2+k3)?1000, 1?k1?2, 0?k2?9 and 0?k3?9, and 3?k1+k2+k3?10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.
    Type: Application
    Filed: March 28, 2003
    Publication date: October 6, 2005
    Inventors: Chika Itoh, Kazuhiro Kubo, Syunsuke Ohhashi, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Kurosawa, Hitoshi Yamauchi
  • Patent number: 6875841
    Abstract: A polyoxyalkylene derivative is represented by formula (I): wherein Z represents a residue of a compound having 2 to 8 hydroxyl groups; AO represents an oxyalkylene group having 2 to 18 carbon atoms; n and m each represent an integer of 0 to 2000 provided that both n and m do not represent 0; a and b each represent an integer satisfying the relationships: 2?a+b?8 and 1?b; R represents a hydrocarbon group having 1 to 30 carbon atoms; and X represents a divalent hydrocarbon group having 3 to 10 carbon atoms.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: April 5, 2005
    Assignee: NOF Corporation
    Inventors: Kenji Sakanoue, Kazuhiro Kubo, Syunsuke Ohashi, Chika Itoh
  • Publication number: 20050012314
    Abstract: To provide a counter weight capable of forming an attaching part to a vehicle frame with high precision, capable of improving attaching precision to this vehicle frame, and further, capable of decreasing a manufacture cost thereof. The counter weight includes a base made of cast iron having an attaching part, whereby the counter weight is attached to a vehicle frame; and a weight part made of a slab material having a block body made of a slab material; wherein the weight part made of the slab material is attached on the above-described base made of cast iron. The outer surface of the above-described weight part made of the slab material is coated with the cover.
    Type: Application
    Filed: February 3, 2004
    Publication date: January 20, 2005
    Applicant: KOMATSU LTD.
    Inventors: Kazuhiro Kubo, Masatoshi Kajiya, Morihiko Kawahashi
  • Patent number: 6679822
    Abstract: A polyalkylene oxide-modified phospholipid represented by formula (1) defined in the specification, has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: January 20, 2004
    Assignee: NOF Corporation
    Inventors: Kazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi
  • Publication number: 20030114523
    Abstract: A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features:
    Type: Application
    Filed: August 5, 2002
    Publication date: June 19, 2003
    Applicant: NOF Corporation
    Inventors: Teruyuki Nagamune, Chika Itoh, Tohru Yasukohchi, Syunsuke Ohhashi, Kazuhiro Kubo
  • Publication number: 20030065134
    Abstract: A polyoxyalkylene derivative is represented by formula (I): 1
    Type: Application
    Filed: July 30, 2002
    Publication date: April 3, 2003
    Applicant: NOF CORPORATION
    Inventors: Kenji Sakanoue, Kazuhiro Kubo, Syunsuke Ohashi, Chika Itoh
  • Publication number: 20020165205
    Abstract: A polyalkylene oxide-modified phospholipid represented by formula (1) defined in the specification, has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight.
    Type: Application
    Filed: March 4, 2002
    Publication date: November 7, 2002
    Applicant: NOF CORPORATION
    Inventors: Kazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi
  • Patent number: 5667779
    Abstract: A bacterium belonging to Bacillus subtilis and having aflatoxin decomposing ability, as well as a fungal growth inhibitor, fermentation promoter and livestock fattening agent, all containing the bacterium as an active or effective ingredient. The Bacillus subtilis is strain FERM BP-3418. Also disclosed are methods for inhibiting or controlling a pathogenic fungus on a plant or animal.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: September 16, 1997
    Assignee: AHC Inc.
    Inventor: Kazuhiro Kubo
  • Patent number: 5549890
    Abstract: A bacterium belonging to Bacillus subtilis and having aflatoxin decomposing ability, as well as a fungal growth inhibitor, fermentation promoter and livestock fattening agent, all containing the bacterium as an active or effective ingredient.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: August 27, 1996
    Assignee: AHC, Inc.
    Inventor: Kazuhiro Kubo
  • Patent number: 5525607
    Abstract: Novel xanthine compounds represented by the following formula: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 independently represents hydrogen or lower alkyl;each of X.sup.1 and X.sup.2 independently represents oxygen or sulfur; and Q represents: ##STR2## The compounds are useful as a diuretic, a renal-protecting agent and bronchodilator.
    Type: Grant
    Filed: May 20, 1993
    Date of Patent: June 11, 1996
    Assignee: Kyowa Hakko Kogyo Co., Ltd
    Inventors: Fumio Suzuki, Junichi Shimada, Akio Ishii, Tetsuji Ohno, Akira Karasawa, Kazuhiro Kubo, Hiromi Nonaka, Fumio Suzuki, Junichi Shimada, Akio Ishii, Tetsuji Ohno, Akira Karasawa, Kazuhiro Kubo, Hiromi Nonaka