Abstract: A method for producing a biodegradable polyoxyalkylene derivative, includes: reacting a biodegradable polyoxyalkylene compound represented by the formula (1) as defined herein with a compound represented by one of the formulae (I) to (IV) as defined herein in a presence of an alkaline solid salt, the biodegradable polyoxyalkylene derivative being represented by the formula (2) as defined herein.

Abstract: A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features: (1) having one or more aliphatic hydrocarbon groups at one end; (2) having one or more portions containing a hydrophilic group in a molecule; and (3) having one or more reactive functional groups which are capable of covalently binding with the substance to be modified at an end different from the end in the above (1).

Abstract: A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5?m?600, 1?n?45, 0?q?200, 10?m+n+q?600, 0.04?n/(m+n+q), and q/(m+n+q)?0.

Abstract: To provide a counter weight capable of forming an attaching part to a vehicle frame with high precision, capable of improving attaching precision to this vehicle frame, and further, capable of decreasing a manufacture cost thereof. The counter weight includes a base made of cast iron having an attaching part, whereby the counter weight is attached to a vehicle frame; and a weight part made of a slab material having a block body made of a slab material; wherein the weight part made of the slab material is attached on the above-described base made of cast iron. The outer surface of the above-described weight part made of the slab material is coated with the cover.

Abstract: A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1?k1?(k+2)/2, 0?k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.

Abstract: A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4?m?100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium

Abstract: A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3?m?200, 9?m×(k1+k2+k3)?1000, 1?k1?2, 0?k2?9 and 0?k3?9, and 3?k1+k2+k3?10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.

Abstract: A polyoxyalkylene derivative is represented by formula (I): wherein Z represents a residue of a compound having 2 to 8 hydroxyl groups; AO represents an oxyalkylene group having 2 to 18 carbon atoms; n and m each represent an integer of 0 to 2000 provided that both n and m do not represent 0; a and b each represent an integer satisfying the relationships: 2?a+b?8 and 1?b; R represents a hydrocarbon group having 1 to 30 carbon atoms; and X represents a divalent hydrocarbon group having 3 to 10 carbon atoms.

Abstract: To provide a counter weight capable of forming an attaching part to a vehicle frame with high precision, capable of improving attaching precision to this vehicle frame, and further, capable of decreasing a manufacture cost thereof. The counter weight includes a base made of cast iron having an attaching part, whereby the counter weight is attached to a vehicle frame; and a weight part made of a slab material having a block body made of a slab material; wherein the weight part made of the slab material is attached on the above-described base made of cast iron. The outer surface of the above-described weight part made of the slab material is coated with the cover.

Abstract: A polyalkylene oxide-modified phospholipid represented by formula (1) defined in the specification, has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight.

Abstract: A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features:

Abstract: A polyoxyalkylene derivative is represented by formula (I): 1

Abstract: A polyalkylene oxide-modified phospholipid represented by formula (1) defined in the specification, has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight.

Abstract: A bacterium belonging to Bacillus subtilis and having aflatoxin decomposing ability, as well as a fungal growth inhibitor, fermentation promoter and livestock fattening agent, all containing the bacterium as an active or effective ingredient. The Bacillus subtilis is strain FERM BP-3418. Also disclosed are methods for inhibiting or controlling a pathogenic fungus on a plant or animal.

Abstract: A bacterium belonging to Bacillus subtilis and having aflatoxin decomposing ability, as well as a fungal growth inhibitor, fermentation promoter and livestock fattening agent, all containing the bacterium as an active or effective ingredient.

Abstract: Novel xanthine compounds represented by the following formula: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 independently represents hydrogen or lower alkyl;each of X.sup.1 and X.sup.2 independently represents oxygen or sulfur; and Q represents: ##STR2## The compounds are useful as a diuretic, a renal-protecting agent and bronchodilator.

Abstract: Disclosed is a tricyclic compound represented by the formula (I): ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, amino, C1-6 alkylamino, halogenated C1-6 alkyl, halogenated C1-6 alkoxy, halogen, nitro, cyano, carboxy, C1-6 alkoxycarbonyl, hydroxymethyl, CR.sup.9 R.sup.10 CO.sub.2 R.sup.11 (wherein each of R.sup.9, R.sup.10 and R.sup.11 independently represents hydrogen or C1-6 alkyl) or CONR.sup.12 R.sup.13 (wherein each of R.sup.12 and R.sup.13 independently represents hydrogen or C1-6-alkyl); R.sup.5 represents hydrogen or C1-6 alkyl; each of R.sup.6, R.sup.7 and R.sup.8 independently represents hydrogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkanoyloxy, C1-6 alkylthio, thiocyanato or halogen; X represents CH or N; Y.sup.1 -Y.sup.2 represents CH.sub.2 -O, CH.sub.2 -S(O).sub.n, (wherein n represents 0, 1, or 2), CH.sub.2 CH.sub.2, CH.dbd.CH or CON(R.sup.14) (wherein R.sup.

Abstract: A bacterium belonging to Bacillus subtilis. The bacterium being identified as Bacillus subtilis FERM BP-3418. In addition the bacterium possesses the capability of decomposing aflatoxin. It is useful as an active ingredient in products such as a fungal growth inhibitor, fermentation promoter, and livestock fattening agent.

Abstract: Disclosed is a tricyclic compound represented by the formula (I): ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, amino, C1-6 alkylamino, halogenated C1-6 alkyl, halogenated C1-6 alkoxy, halogen, nitro, cyano, carboxy, C1-6 alkoxycarbonyl, hydroxymethyl, CR.sup.9 R.sup.10 CO.sub.2 R.sup.11 (wherein each of R.sup.9, R.sup.10 and R.sup.11 independently represents hydrogen or C1-6 alkyl) or CONR.sup.12 R.sup.13 (wherein each of R.sup.12 and R.sup.13 independently represents hydrogen or C1-6 alkyl); R.sup.5 represents hydrogen or C1-6 alkyl; each of R.sup.6, R.sup.7 and R.sup.8 independently represents hydrogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkanoyloxy, C1-6 alkylthio, thiocyanato or halogen; X represents CH or N; Y.sup.1 -Y.sup.2 represents CH.sub.2 --O, CH.sub.2 --(O).sub.n, (wherein n represents 0, 1, or 2), CH.sub.2 CH.sub.2, CH.dbd.CH or CON(R.sup.14) (wherein R.sup.

Abstract: Novel tricyclic compound represented by formula ##STR1## possess a TXA.sub.2 biosynthesis inhibiting activity and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.