Publication number: 20070219215
Abstract: To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions. A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO2 or C—CN; Hal is a halogen; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO2; M2 is amino, O, S or a single bond; R1 is a halogen, alkyl or the like; each of R2, R3, R4 and R5 is independently H, alkyl or the like; R6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.
Type:
Application
Filed:
February 16, 2005
Publication date:
September 20, 2007
Applicant:
Ishihara Sangyo Kaisha, Ltd
Inventors:
Fuminori Kato, Hirohiko Kimura, Kiyoshi Tamai, Kazuhiro Yamamoto, Mitsuo Sano, Shinya Mori, Takashi Okada, Toshihiko Ueki, Kumiko Azuma