Patents by Inventor Kazuko Matsuda

Kazuko Matsuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION OF IBUDILAST AND RILUZOLE AND METHODS OF USING SAME
    Publication number: 20210000804
    Abstract: The present disclosure relates generally to methods for treating neurodegenerative diseases, including their progressive forms. In particular, the present disclosure pertains to methods of treating or preventing neurodegenerative diseases, including their progressive forms and their associated symptoms by administering a combination of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) and riluzole, or pharmaceutically acceptable salts of one or both thereof.
    Type: Application
    Filed: June 18, 2020
    Publication date: January 7, 2021
    Applicant: MEDICINOVA, INC.
    Inventors: Kazuko Matsuda, Yuichi Iwaki
  • Methods and dosing regimens using ibudilast and a second agent for cancer therapy
    Patent number: 10744123
    Abstract: Methods and dosing regimens for treating glioblastoma or recurrent glioblastoma and its associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) or a pharmaceutically acceptable salt thereof and at least one or more other therapeutic agent.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: August 18, 2020
    Assignee: MediciNova, Inc.
    Inventors: Kazuko Matsuda, Kerrie McDonald
  • METHODS OF TREATING OPHTHALMIC DISEASE/DISORDER OR INJURY WITH IBUDILAST
    Publication number: 20200121659
    Abstract: This disclosure is directed to methods of treating ophthalmic disease/disorder or injury associated with neurodegenerative disease/disorder, such as progressive multiple sclerosis, or a neuro-ophthalmologic disorder in human patients using ibudilast.
    Type: Application
    Filed: October 18, 2019
    Publication date: April 23, 2020
    Applicant: MediciNova, Inc.
    Inventor: Kazuko Matsuda
  • COMBINATION OF IBUDILAST AND INTERFERON-BETA AND METHODS OF USING SAME
    Publication number: 20200108123
    Abstract: This disclosure is directed to methods of alleviating the negative effects of, treating, or slowing the progression of progressive multiple sclerosis in human patients using ibudilast and interferon-beta.
    Type: Application
    Filed: October 8, 2019
    Publication date: April 9, 2020
    Applicant: MediciNova, Inc.
    Inventor: Kazuko MATSUDA
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20200093805
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: May 1, 2019
    Publication date: March 26, 2020
    Applicant: MediciNova, Inc.
    Inventors: Michael E. KALAFER, Kenneth W. LOCKE, Kazuko MATSUDA, Richard E. GAMMANS
  • METHODS OF TREATING GLIOBLASTOMA MULTIFORME USING IBUDILAST
    Publication number: 20200038382
    Abstract: Compositions and methods for treating glioblastoma or recurrent glioblastoma and its associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 9, 2019
    Publication date: February 6, 2020
    Applicant: MediciNova, Inc.
    Inventors: Kazuko Matsuda, Kerrie McDonald
  • COMBINATION OF IBUDILAST AND RILUZOLE AND METHODS OF USING SAME
    Publication number: 20200030301
    Abstract: The present disclosure relates generally to methods for treating neurodegenerative diseases, including their progressive forms. In particular, the present disclosure pertains to methods of treating or preventing neurodegenerative diseases, including their progressive forms and their associated symptoms by administering a combination of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) and riluzole, or pharmaceutically acceptable salts of one or both thereof.
    Type: Application
    Filed: February 28, 2019
    Publication date: January 30, 2020
    Applicant: MEDICINOVA, INC.
    Inventors: Kazuko Matsuda, Yuichi Iwaki
  • Methods of treating glioblastoma multiforme using ibudilast
    Patent number: 10391085
    Abstract: Compositions and methods for treating glioblastoma or recurrent glioblastoma and its associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: August 27, 2019
    Assignee: MediciNova, Inc.
    Inventors: Kazuko Matsuda, Kerrie McDonald
  • METHODS AND DOSING REGIMENS USING IBUDILAST AND A SECOND AGENT FOR CANCER THERAPY
    Publication number: 20190247370
    Abstract: Methods and dosing regimens for treating glioblastoma or recurrent glioblastoma and its associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) or a pharmaceutically acceptable salt thereof and at least one or more other therapeutic agent.
    Type: Application
    Filed: February 11, 2019
    Publication date: August 15, 2019
    Applicant: MediciNova, Inc.
    Inventors: Kazuko Matsuda, Kerrie McDonald
  • METHODS OF SUPPRESSING MYELOID-DERIVED SUPPRESSOR CELLS IN PATIENTS
    Publication number: 20190247369
    Abstract: Methods of suppressing myeloid-derived suppressor cells (MDSCs), reducing immune suppression, reducing regulatory T-cell count and increasing CD4+ T-cell count in cancer patients using ibudilast.
    Type: Application
    Filed: February 11, 2019
    Publication date: August 15, 2019
    Applicant: MediciNova, Inc.
    Inventor: Kazuko Matsuda
  • Combination of ibudilast and riluzole and methods of using same
    Patent number: 10258611
    Abstract: The present disclosure relates generally to methods for treating neurodegenerative diseases, including their progressive forms. In particular, the present disclosure pertains to methods of treating or preventing neurodegenerative diseases, including their progressive forms and their associated symptoms by administering a combination of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) and riluzole, or pharmaceutically acceptable salts of one or both thereof.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: April 16, 2019
    Assignee: MediciNova, Inc.
    Inventors: Kazuko Matsuda, Yuichi Iwaki
  • METHODS OF TREATING GLIOBLASTOMA MULTIFORME USING IBUDILAST
    Publication number: 20180177772
    Abstract: Compositions and methods for treating glioblastoma or recurrent glioblastoma and its associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 28, 2018
    Applicant: MediciNova, Inc.
    Inventors: Kazuko Matsuda, Kerrie McDonald
  • METHOD OF TREATING IDIOPATHIC PULMONARY FIBROSIS
    Publication number: 20180021275
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for inhibiting or treating idiopathic pulmonary fibrosis, conditions leading to or arising from it, and/or negative effects of each thereof.
    Type: Application
    Filed: July 5, 2017
    Publication date: January 25, 2018
    Applicant: MediciNova, Inc.
    Inventors: Kazuko MATSUDA, Yuichi IWAKI
  • COMBINATION OF IBUDILAST AND RILUZOLE AND METHODS OF USING SAME
    Publication number: 20170360762
    Abstract: The present disclosure relates generally to methods for treating neurodegenerative diseases, including their progressive forms. In particular, the present disclosure pertains to methods of treating or preventing neurodegenerative diseases, including their progressive forms and their associated symptoms by administering a combination of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) and riluzole, or pharmaceutically acceptable salts of one or both thereof.
    Type: Application
    Filed: November 24, 2015
    Publication date: December 21, 2017
    Applicant: MEDICINOVA, INC.
    Inventors: Kazuko Matsuda, Yuichi Iwaki
  • METHOD OF TREATING IDIOPATHIC PULMONARY FIBROSIS
    Publication number: 20170065544
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for inhibiting or treating idiopathic pulmonary fibrosis, conditions leading to or arising from it, and/or negative effects of each thereof.
    Type: Application
    Filed: April 21, 2016
    Publication date: March 9, 2017
    Applicant: MediciNova, Inc.
    Inventors: Kazuko MATSUDA, Yuichi IWAKI
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20170020851
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: October 7, 2016
    Publication date: January 26, 2017
    Applicant: MediciNova, Inc.
    Inventors: Michael E. KALAFER, Kenneth W. LOCKE, Kazuko MATSUDA, Richard E. GAMMANS
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20170014390
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: March 23, 2016
    Publication date: January 19, 2017
    Applicant: MediciNova, Inc.
    Inventors: Michael E. KALAFER, Kenneth W. LOCKE, Kazuko MATSUDA, Richard E. GAMMANS
  • Method of inhibiting or treating fibrosis
    Patent number: 9498458
    Abstract: A compound of Formula (I) or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein Formula (I), m, n, X1 and X2 are as defined herein, is useful for inhibiting, reducing, or treating fibrosis, conditions leading to or arising from it, and/or negative effects of each thereof.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: November 22, 2016
    Assignee: MediciNova, Inc.
    Inventors: Kazuko Matsuda, Yuichi Iwaki
  • Methods for reducing triglyceride, total cholesterol and low density lipoprotein blood levels
    Patent number: 9358217
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for reducing blood levels of one or more of triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL) in human subjects.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: June 7, 2016
    Assignee: MediciNova, Inc.
    Inventor: Kazuko Matsuda
  • Method of treating advanced non-alcoholic steatohepatitis
    Patent number: 9346754
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for inhibiting or treating advanced nonalcoholic steatohepatitis, conditions leading to or arising from it, and/or negative effects of each thereof.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: May 24, 2016
    Assignee: MediciNova, Inc.
    Inventors: Kazuko Matsuda, Yuichi Iwaki