Patents by Inventor Kazuko Matsuda

Kazuko Matsuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of amyotrophic lateral sclerosis (ALS) with ibudilast
    Patent number: 9314452
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: April 19, 2016
    Assignee: MediciNova, Inc.
    Inventors: Michael E. Kalafer, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • COMBINATION OF GERANYLGERANYLACETONE AND IBUDILAST AND METHODS OF USING SAME
    Publication number: 20150366847
    Abstract: The present invention relates generally to methods for treating progressive neurodegenerative diseases, including their progressive forms. In particular, the present invention pertains to methods of treating or preventing progressive neurodegenerative diseases and its associated symptoms by administration of a combination of geranylgeranylacetone (teprenone) and ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine), or pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 17, 2015
    Publication date: December 24, 2015
    Applicant: MediciNova, Inc.
    Inventors: Kazuko MATSUDA, Yuichi IWAKI
  • METHOD OF INHIBITING OR TREATING FIBROSIS
    Publication number: 20150342913
    Abstract: A compound of Formula (I) or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein Formula (I), m, n, X1 and X2 are as defined herein, is useful for inhibiting, reducing, or treating fibrosis, conditions leading to or arising from it, and/or negative effects of each thereof.
    Type: Application
    Filed: June 1, 2015
    Publication date: December 3, 2015
    Inventors: Kazuko MATSUDA, Yuichi IWAKI
  • METHOD OF TREATING IDIOPATHIC PULMONARY FIBROSIS
    Publication number: 20150321989
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for inhibiting or treating idiopathic pulmonary fibrosis, conditions leading to or arising from it, and/or negative effects of each thereof.
    Type: Application
    Filed: September 18, 2014
    Publication date: November 12, 2015
    Applicant: MediciNova, Inc.
    Inventors: Kazuko MATSUDA, Yuichi Iwaki
  • METHOD OF TREATING ADVANCED NON-ALCOHOLIC STEATOHEPATITIS
    Publication number: 20150322004
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for inhibiting or treating advanced nonalcoholic steatohepatitis, conditions leading to or arising from it, and/or negative effects of each thereof.
    Type: Application
    Filed: September 18, 2014
    Publication date: November 12, 2015
    Applicant: MediciNova, Inc.
    Inventors: Kazuko MATSUDA, Yuichi IWAKI
  • METHOD OF INHIBITING OR TREATING AMYOTROPHIC LATERAL SCLEROSIS WITH PHENOXYALKYLCARBOXYLIC ACIDS
    Publication number: 20150320705
    Abstract: A compound of Formula (I), or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof wherein: m is an integer from 2 to 5 inclusive; and n is an integer from 3 to 8 inclusive; and X1 and X2 are each independently sulfur, oxygen, a sulfinyl group or a sulfonyl group, provided that X1 and X2 are not simultaneously oxygen. Such a compound may be useful for treating, inhibiting, or preventing the progression of amyotrophic lateral sclerosis, primary lateral sclerosis, or familial amyotrophic lateral sclerosis, or a symptom of each thereof.
    Type: Application
    Filed: May 6, 2015
    Publication date: November 12, 2015
    Applicant: MediciNova, Inc.
    Inventors: Kazuko MATSUDA, Yuichi IWAKI
  • Treatment of progressive neurodegenerative disease with ibudilast
    Patent number: 9114136
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: August 25, 2015
    Assignee: MEDICINOVA, INC.
    Inventors: Michael E. Kalafer, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • METHOD OF TREATING LIVER DISORDERS
    Publication number: 20150209314
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for inhibiting liver steatosis, lobular inflammation, hepatic ballooning and hepatic scarring.
    Type: Application
    Filed: February 3, 2015
    Publication date: July 30, 2015
    Applicant: MediciNova, Inc.
    Inventor: Kazuko MATSUDA
  • Method of treating non-alcoholic steatohepatitis
    Patent number: 9012509
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for treating non-alcoholic steatohepatitis (NASH) and/or reducing one or more of hepatic fibrosis, lobular inflammation, and hepatocellular ballooning.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: April 21, 2015
    Assignee: MedicNova, Inc.
    Inventor: Kazuko Matsuda
  • METHODS FOR REDUCING TRIGLYCERIDE, TOTAL CHOLESTEROL AND LOW DENSITY LIPOPROTEIN BLOOD LEVELS
    Publication number: 20150080471
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for reducing blood levels of one or more of triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL) in human subjects.
    Type: Application
    Filed: November 13, 2014
    Publication date: March 19, 2015
    Applicant: MEDICINOVA, INC.
    Inventor: Kazuko MATSUDA
  • Method of treating liver disorders
    Patent number: 8962687
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for inhibiting liver steatosis, lobular inflammation, hepatic ballooning and hepatic scarring.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: February 24, 2015
    Assignee: MediciNova, Inc.
    Inventor: Kazuko Matsuda
  • METHODS FOR REDUCING TRIGLYCERIDE, TOTAL CHOLESTEROL AND LOW DENSITY LIPOPROTEIN BLOOD LEVELS
    Publication number: 20150031769
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for reducing blood levels of one or more of triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL) in human subjects.
    Type: Application
    Filed: July 23, 2014
    Publication date: January 29, 2015
    Applicant: MEDICINOVA, INC.
    Inventor: Kazuko MATSUDA
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20150011581
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: September 19, 2014
    Publication date: January 8, 2015
    Applicant: MediciNova, Inc.
    Inventors: Michael E. KALAFER, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • METHOD OF TREATING NON-ALCOHOLIC FATTY LIVER DISEASE AND STEATOHEPATITIS
    Publication number: 20150005385
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for treating non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).
    Type: Application
    Filed: September 15, 2014
    Publication date: January 1, 2015
    Applicant: MediciNova, Inc.
    Inventor: Kazuko MATSUDA
  • Method of treating non-alcoholic fatty liver disease and steatohepatitis
    Patent number: 8835499
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for treating non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: September 16, 2014
    Assignee: MediciNova, Inc.
    Inventor: Kazuko Matsuda
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20140171463
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: February 24, 2014
    Publication date: June 19, 2014
    Applicant: MediciNova, Inc.
    Inventors: Michael E. KALAFER, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • METHOD OF TREATING LIVER DISORDERS
    Publication number: 20140155484
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for inhibiting liver steatosis, lobular inflammation, hepatic ballooning and hepatic scarring.
    Type: Application
    Filed: January 10, 2014
    Publication date: June 5, 2014
    Applicant: MediciNova, Inc.
    Inventor: Kazuko MATSUDA
  • METHOD OF TREATING NON-ALCOHOLIC STEATOHEPATITIS
    Publication number: 20140128473
    Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for treating non-alcoholic steatohepatitis (NASH) and/or reducing one or more of hepatic fibrosis, lobular inflammation, and hepatocellular ballooning.
    Type: Application
    Filed: January 10, 2014
    Publication date: May 8, 2014
    Applicant: MediciNova, Inc.
    Inventor: Kazuko MATSUDA
  • METHODS FOR COMPOSITIONS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME
    Publication number: 20140066513
    Abstract: A method for a prevention and/or treatment of irritable bowel syndrome or amelioration of a symptom thereof in a subject, comprises administering to said subject an effective amount of a compound of formula I:
    Type: Application
    Filed: August 26, 2013
    Publication date: March 6, 2014
    Applicant: MediciNova, Inc.
    Inventors: Kazuko MATSUDA, Yuichi Iwaki, Kale Ruby
  • Methods and compositions for the treatment of irritable bowel syndrome
    Patent number: 8518995
    Abstract: A method for a prevention and/or treatment of irritable bowel syndrome or amelioration of a symptom thereof in a subject, comprises administering to said subject an effective amount of a compound of formula I:
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: August 27, 2013
    Assignee: MediciNova, Inc.
    Inventors: Kazuko Matsuda, Yuichi Iwaki, Kale Ruby