Abstract: The present invention is directed to a therapeutic drug for cancer, containing, as an active ingredient, dendritic cells stimulated with an antigen derived from vascular endothelial cells which have been cultured in a medium containing a cancer cell culture supernatant.

Abstract: An oil-impregnated sintered sliding bearing formed of a porous iron-based sintered alloy with quenched structure and receiving a high surface pressure capable of reducing the number of finishing steps by cutting and grinding and providing a bearing performance equivalent to or higher than that of conventional bearings, wherein a plurality of ridge-and-groove lines having a height difference of 2 to 12.5 ?m and extending in circumferential direction are axially arranged in parallel with each other by boring the bearing surface thereof to form a wavy surface in axial direction, and the portion thereof deeper by 10 to 60 ?m from the outer layer of the bearing surface is formed dense to seal surface pores so as to reduce the pores opening to the outer surface to 1 to 10 percent by area, whereby the bearing can be used at a surface pressure of 6 kgf/mm2 (58.5 MPa) or higher and a sliding speed of 2 to 5 cm/s.

Abstract: A sliding bearing which is suitable for and durable in the use under high load of sliding in rocking motion, and the structure of bearing is not complicated so as to facilitate the manufacturing. The alloy used for making the bearing is composed of iron-based sintered alloy having quenched structure, and the bearing surface is provided with inclined grooves of an inclination angle of 10 to 40° relative to the direction perpendicular to the sliding direction and a width of 2 to 8 mm and the area of inclined grooves is 50% or less of the total inner bearing surface and an imaginary line perpendicular to the sliding direction crosses both the inclined groove and the bearing surface at any position of the inner surface of bearing. When the bearing is used, at least the inclined grooves are impregnated with a lubricant.

Abstract: An oil-impregnated sintered sliding bearing formed of a porous iron-based sintered alloy with quenched structure and receiving a high surface pressure capable of reducing the number of finishing steps by cutting and grinding and providing a bearing performance equivalent to or higher than that of conventional bearings, wherein a plurality of ridge-and-groove lines having a height difference of 2 to 12.5 ?m and extending in circumferential direction are axially arranged in parallel with each other by boring the bearing surface thereof to form a wavy surface in axial direction, and the portion thereof deeper by 10 to 60 ?m from the outer layer of the bearing surface is formed dense to seal surface pores so as to reduce the pores opening to the outer surface to 1 to 10 percent by area, whereby the bearing can be used at a surface pressure of 6 kgf/mm2 (58.5 MPa) or higher and a sliding speed of 2 to 5 cm/s.

Abstract: The present invention provides a liposome preparation containing oxaliplatin and derivatized with a hydrophilic polymer and a ligand. In one embodiment the hydrophilic polymer is polyethylene glycol and the ligand is transferrin. In accordance with the invention, the uptake of a pharmaceutical agent contained in the liposome into tumor cells can be enhanced through transferrin receptors expressed on the surface of the tumor cells. Also provided are pharmaceutical compositions containing the liposomes and methods of their use.

Abstract: The present invention provides a liposome preparation containing oxaliplatin and derivatized with a hydrophilic polymer, as well as a pharmaceutical composition for treatment of tumor comprising the liposome preparation. The liposome preparation according to the present invention is characterized in that it is derivatized with a ligand. The ligand is preferably transferrin. In accordance with the invention, the uptake of a pharmaceutical agent in the liposome into tumor cells can be enhanced through transferrin receptors expressed on the surface of the tumor cells.

Abstract: An image recording apparatus includes an image carrying part, a developing part and an image transferring part. The image carrying part has a surface on which an electrostatic latent image is formed. The developing part develops the electrostatic image into a toner image by selectively applying toner to the surface of the image carrying part. The image transferring part transfers the toner image onto a recording sheet or an intermediate image transferring part. Fine particles are uniformly formed on the surface of the image carrying part, and a portion of the fine particles is transferred from the image carrying part with the toner image. The fine particles are smaller in diameter than the toner particles.

Abstract: In an image recording apparatus, the surface of an image carrier is formed of a material having a high affinity to particulates the particle size of which is smaller than toner and the surfaces of which have been treated to be hydrophobic, so that a layer of the particulates treated to be hydrophobic is retained on the surface of the image carrier.

Abstract: In an image recording apparatus, the surface of an image carrier is formed of a material having a high affinity to particulates the particle size of which is smaller than toner and the surfaces of which have been treated to be hydrophobic, so that a layer of the particulates treated to be hydrophobic is retained on the surface of the image carrier.

Abstract: A toner for developing an electrostatic image is disclosed which has at least one endothermic peak in the temperature region of 120.degree. C. or below in differential thermal analysis and contains, in its particles having particle diameters of 3 .mu.m or larger, not less than 93% by number of particles having a circularity of at least 0.90 and less than 30% by number of particles having a circularity of at least 0.98. The toner does not cause the re-transfer under high transfer current conditions and can realize the formation of good images with high image density. Also, an image forming method using the toner is disclosed.

Abstract: A toner for forming an image has toner particles containing at least a colorant, a binder resin and a wax. The toner has (i) a circularity distribution in which the toner has an average circularity of 0.900 to less than 0.965, contains 20 to 60% by number of particles with a circularity of less than 0.95 and has a mode circularity of 0.90 or more; and (ii) a particle size distribution in which the toner has a circle-equivalent average diameter of 2.0 to 10.0 .mu.m and has at least one peak of frequency by number in the region of a circle-equivalent diameter of 0.6 to 3.0 .mu.m and at least one peak of frequency by number in the region of a circle-equivalent diameter of from more than 3.0 .mu.m to 10.0 .mu.m. The wax has an endothermic main peak as measured by DSC of 60 to 120.degree. C. The binder resin contains THF soluble matter and 0 to 5.0% by weight of THF insoluble matter.

Abstract: In an image forming apparatus, three or more (four in this case) cylindrical photosensitive members 1 to 4 on which latent images are formed and developed through use of toner to thereby produce toner images, are arranged so as to share a tangential line in common, and a cylindrical intermediate transfer member 51 is provided. Alternatively, a first unit containing one or more image carriers is positioned next to a first transfer member and a second unit containing one or more image carriers is positioned next to a second transfer member such that there is reflectional symmetry between the first and second units and the transfer members.

Abstract: A magnetic black toner for electrophotography, includes: (a) magnetic black toner particles containing a binder resin, a magnetic material in 30-200 wt. parts per 100 wt. parts of the binder resin, and a first solid wax, and (b) first inorganic fine powder. The first solid wax (ii) provides a DSC heat-absorption main peak in a range of 60.degree.-120.degree. C., and (iii) shows a molecular weight distribution factor Mw/Mn of 1.0-2.0. The binder resin (iv) has a THF (tetrahydrofuran)-insoluble content of at most 5 wt. %, and (v) contains a THF-soluble content showing a GPC molecular weight distribution including a content (M1) of 40-70% in molecular weights of below 5.times.10.sup.4, a content (M2.ltoreq.M1) of 20-45% in molecular weights of 5.times.10.sup.4 -5.times.10.sup.5, and a content (M3<M2) of 2-25% in molecular weights exceeding 5.times.10.sup.5. (vi) The magnetic black toner exhibits a tan .delta. of 0.5-3.0 in a range of 150.degree.-190.degree. C. and a tan .delta. at 150.degree. C.

Abstract: An ink transfer medium for toner is disclosed, comprising the following layers, in this order: a heat-generating resistive layer heated by input of electrical signal, a conductive layer, and an ink release layer having a toner layer on it, an adhesion from 0.2 g/mm to 40 g/mm as measured by the 90.degree. peeling off method and consisting of a viscoelastomer having a critical surface tension of 35 dyne/cm or less. It can be re-inked by attaching toner to the portions of the ink transfer medium from which the ink has been removed, using toner held in a toner holding means.

Abstract: An ink transfer medium for toner is disclosed, comprising the following layers, in this order: a heat-generating resistive layer heated by input of electrical signal, a conductive layer, and an ink release layer having a toner layer on it, an adhesion from 0.2 g/mm to 40 g/mm as measured by the 90.degree. peeling off method and consisting of a viscoelastomer having a critical surface tension of 35 dyne/cm or less. It can be re-inked by attaching toner to the portions of the ink transfer medium from which the ink has been removed, using toner held in a toner holding means.

Abstract: A reactive vesicle comprising, as a vesicle-forming component, a reactive phospholipid derivative represented by the following general formula (1) and a functional substance-fixed vesicle prepared by reacting the reactive vesicle with a functional substance: ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) each represent an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average number of moles of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r each being an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkli metal atom.

Abstract: A TAB-type lead automatic inspection system is provided to position with high accuracy at high speed for improving reliability and productivity of inspecting.A lead positioning method used for a TAB-type lead automatic inspection system or processing system, comprising fixing a product onto a table movable in an X-axis direction and two Y-axis directions in parallel to the product mounting surface, and positioning X-axis, Y-axis and rotational angle .theta. directions, and a lead positioning device used for a TAB-type lead automatic inspection system in a highly rigid translation mechanism provided with a pair of hinges in one sheet plate comprising microfeeding piezoelectric actuators for driving a translation mechanism of one axis in the X-axis direction and two axes in the Y-axis direction, and control means for feedbacking a lead positioning sensing signal, and driving each piezoelectric actuator, thereby positioning X, Y and .theta. directions with high accuracy at high speed.

Abstract: A multi-color image formation apparatus and method of its use prevent deterioration of stability due to a recharging process in one cycle of multi-color image formation and also effectively avoid color mixing in the toner image previously formed. The multi-color image formation apparatus includes an electrostatic latent image formation member, a first electrostatic latent image formation device for forming a first electrostatic latent image on the electrostatic latent image formation member, a first developer for developing the first electrostatic latent image with a first toner, a second electrostatic latent image formation device for forming a second electrostatic latent image on the electrostatic latent image formation member, and a second developer for developing the second electrostatic latent image with a second toner.