Patents by Inventor Kazuo Nakanishi
Kazuo Nakanishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11220704Abstract: Provided is a method of avoiding the influence of a coexisting substance in the measurement of HbA1c % for a whole blood sample by an enzymatic method. Specifically, provided is a method of measuring a ratio of a hemoglobin A1c concentration to a hemoglobin concentration in a sample by an enzymatic method, the method including: a first step of optically measuring the hemoglobin concentration; and a second step of optically measuring the hemoglobin A1c concentration, wherein, when HbA1c % is calculated by dividing the hemoglobin A1c concentration measured in the second step by the hemoglobin concentration measured in the first step, the hemoglobin concentration serving as a denominator, which is measured at a first wavelength, is corrected using a result measured at a second wavelength.Type: GrantFiled: August 10, 2017Date of Patent: January 11, 2022Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Satoshi Machida, Tomohisa Nishio, Kazuo Nakanishi
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Publication number: 20190169674Abstract: Provided is a method of avoiding the influence of a coexisting substance in the measurement of HbA1c % for a whole blood sample by an enzymatic method. Specifically, provided is a method of measuring a ratio of a hemoglobin A1c concentration to a hemoglobin concentration in a sample by an enzymatic method, the method including: a first step of optically measuring the hemoglobin concentration; and a second step of optically measuring the hemoglobin A1c concentration, wherein, when HbA1c % is calculated by dividing the hemoglobin A1c concentration measured in the second step by the hemoglobin concentration measured in the first step, the hemoglobin concentration serving as a denominator, which is measured at a first wavelength, is corrected using a result measured at a second wavelength.Type: ApplicationFiled: August 10, 2017Publication date: June 6, 2019Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Satoshi MACHIDA, Tomohisa NISHIO, Kazuo NAKANISHI
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Publication number: 20140045219Abstract: In a method for producing a target substance utilizing a microorganism comprising culturing the microorganism in a medium to produce and accumulate the target substance in the medium and collecting the target substance, microorganism is employed, which is a mutant strain or a genetic recombinant strain constructed from a parent strain of the microorganism having a respiratory chain pathway of high energy efficiency and a respiratory chain pathway of low energy efficiency as respiratory chain pathways, and having either one or both of the following characteristics: (A) the respiratory chain pathway of high energy efficiency is enhanced, (B) the respiratory chain pathway of low energy efficiency is deficient.Type: ApplicationFiled: October 16, 2013Publication date: February 13, 2014Applicant: AJINOMOTO CO., INC.Inventors: Yuta Nakai, Kazuo Nakanishi, Yoshio Kawahara, Hisao Ito, Osamu Kurahashi
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Patent number: 8586334Abstract: In a method for producing a target substance utilizing a microorganism comprising culturing the microorganism in a medium to produce and cause accumulation of the target substance in the medium and collecting the target substance, there is used, as the microorganism, a mutant strain or a genetic recombinant strain constructed from a parent strain of the microorganism having a respiratory chain pathway of high energy efficiency and a respiratory chain pathway of low energy efficiency as respiratory chain pathways, and having either one or both of the following characteristics: (A) the respiratory chain pathway of high energy efficiency is enhanced, (B) the respiratory chain pathway of low energy efficiency is deficient.Type: GrantFiled: July 5, 2001Date of Patent: November 19, 2013Assignee: Ajinomoto Co., Inc.Inventors: Yuta Nakai, Kazuo Nakanishi, Yoshio Kawahara, Hisao Ito, Osamu Kurahashi
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Publication number: 20130078659Abstract: A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene tribenzylphenyl ethers and a cholesterol-assaying enzyme reagent so as to preferentially react cholestrols in high density- and very low density-cholesterols among lipoproteins, and subsequently determining the amount of cholesterol that reacts thereafter. This method can eliminate the necessity for pretreatments such as centrifugation and electrophoresis, enables the quantitative determination to be conducted in an efficient, simple manner, and can be applied to various automatic analyzers.Type: ApplicationFiled: November 16, 2012Publication date: March 28, 2013Inventors: Mitsuhiro NAKAMURA, Kazuo NAKANISHI, Koichi HINO, Mitsuhisa MANABE
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Publication number: 20120149047Abstract: A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene tribenzylphenyl ethers and a cholesterol-assaying enzyme reagent so as to preferentially react cholestrols in high density- and very low density-cholesterols among lipoproteins, and subsequently determining the amount of cholesterol that reacts thereafter. This method can eliminate the necessity for pretreatments such as centrifugation and electrophoresis, enables the quantitative determination to be conducted in an efficient, simple manner, and can be applied to various automatic analyzers.Type: ApplicationFiled: July 11, 2011Publication date: June 14, 2012Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Mitsuhiro Nakamura, Kazuo Nakanishi, Koichi Hino, Mitsuhisa Manabe
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Patent number: 8062869Abstract: An Escherichia bacterium having dihydrodipicolinate synthase and aspartokinase, both of which are desensitized to feedback inhibition by L-lysine. The intracellular activity of dihydrodipicolinate reductase in this bacterium can also be enhanced. Furthermore, a diaminopimelate dehydrogenase gene can be introduced into this bacterium, or intracellular activities of tetrahydrodipicolinate succinylase and succinyl diaminopimelate deacylase can be enhanced. Finally, the intracellular activities of aspartate-semialdehyde dehydrogenase or phosphoenolpyruvate carboxylase can be enhanced in this bacterium. The bacterium can be cultured in a suitable medium to produce and accumulate L-lysine in culture, and the L-lysine is collected from the culture.Type: GrantFiled: March 11, 2010Date of Patent: November 22, 2011Assignee: Ajinomoto Co., Inc.Inventors: Kazuo Nakanishi, Yoshimi Kikuchi, Junichiro Kojima, Tomoko Suzuki, Yasushi Nishimura, Hiroyuki Kojima
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Publication number: 20110091917Abstract: A method of measuring a lipid in a specific lipoprotein characterized by using a polycyclic polyoxyalkylene derivative at least in the step of determining the specificity of the measurement of the target lipid.Type: ApplicationFiled: December 30, 2010Publication date: April 21, 2011Applicant: DAIICHI PURE CHEMICALS CO., LTD.Inventors: Shoko YAMAMOTO, Mitsuaki YAMAMOTO, Kazuo NAKANISHI, Kazunori SAITO
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Publication number: 20100227309Abstract: A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene tribenzylphenyl ethers and a cholesterol-assaying enzyme reagent so as to preferentially react cholestrols in high density- and very low density-cholesterols among lipoproteins, and subsequently determining the amount of cholesterol that reacts thereafter. This method can eliminate the necessity for pretreatments such as centrifugation and electrophoresis, enables the quantitative determination to be conducted in an efficient, simple manner, and can be applied to various automatic analyzers.Type: ApplicationFiled: May 18, 2010Publication date: September 9, 2010Applicant: DAIICHI PURE CHEMICALS CO., LTD.Inventors: Mitsuhiro Nakamura, Kazuo Nakanishi, Koichi Hino, Mitsuhisa Manabe
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Publication number: 20100173368Abstract: An Escherichia bacterium having dihydrodipicolinate synthase and aspartokinase, both of which are desensitized to feedback inhibition by L-lysine. The intracellular activity of dihydrodipicolinate reductase in this bacterium can also be enhanced. Furthermore, a diaminopimelate dehydrogenase gene can be introduced into this bacterium, or intracellular activities of tetrahydrodipicolinate succinylase and succinyl diaminopimelate deacylase can be enhanced. Finally, the intracellular activities of aspartate-semialdehyde dehydrogenase or phosphoenolpyruvate carboxylase can be enhanced in this bacterium. The bacterium can be cultured in a suitable medium to produce and accumulate L-lysine in culture, and the L-lysine is collected from the culture.Type: ApplicationFiled: March 11, 2010Publication date: July 8, 2010Inventors: Kazuo Nakanishi, Yoshimi Kikuchi, Junichiro Kojima, Tomoko Suzuki, Yasushi Nishimura, Hiroyuki Kojima
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Publication number: 20100136591Abstract: A method of measuring a lipid in a specific lipoprotein characterized by using a polycyclic polyoxyalkylene derivative at least in the step of determining the specificity of the measurement of the target lipid.Type: ApplicationFiled: January 29, 2010Publication date: June 3, 2010Applicant: DAIICHI PURE CHEMICALS CO., LTD.Inventors: Shoko YAMAMOTO, Mitsuaki Yamamoto, Kazuo Nakanishi, Kazunori Saito
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Patent number: 7723081Abstract: An Escherichia bacterium (1) which harbors dihydrodipicolinate synthase of which feedback inhibition by L-lysine is desensitized and aspartokinase of which feedback inhibition by L-lysine is desensitized, (2) in which intracellular activity of dihydrodipicolinate reductase is enhanced, and (3) in which a diaminopimelate dehydrogenase gene is introduced or intracellular activities of tetrahydrodipicolinate succinylase and succinyl diaminopimelate deacylase are enhanced, wherein intracellular activity of aspartate-semialdehyde dehydrogenase or phosphoenolpyruvate carboxylase is enhanced, is cultured in a suitable medium to produce and accumulate L-lysine in culture, and the L-lysine is collected from the culture.Type: GrantFiled: January 21, 2000Date of Patent: May 25, 2010Assignee: Ajinomoto Co., Inc.Inventors: Kazuo Nakanishi, Yoshimi Kikuchi, Junichiro Kojima, Tomoko Suzuki, Yasushi Nishimura, Hiroyuki Kojima
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Patent number: 7682831Abstract: A method of measuring a lipid in a specific lipoprotein characterized by using a polycyclic polyoxyalkylene derivative at least in the step of determining the specificity of the measurement of the target lipid.Type: GrantFiled: November 26, 2003Date of Patent: March 23, 2010Assignee: Sekisui Medical Co., Ltd.Inventors: Shoko Yamamoto, Mitsuaki Yamamoto, Kazuo Nakanishi, Kazunori Saito
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Patent number: 7527950Abstract: A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of the yfiK gene is described. A method for producing the L-amino acid using the bacterium is also described.Type: GrantFiled: September 13, 2007Date of Patent: May 5, 2009Assignee: Ajinomoto Co., Inc.Inventors: Vitaliy Arkadievich Livshits, Natalia Pavlovna Zakataeva, Kazuo Nakanishi, Vladimir Veniaminovich Aleshin, Petr Vladimirovich Troshin, Irina Lyvovna Tokhmakova
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Patent number: 7524656Abstract: A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of the yggA gene is described. A method for producing the L-amino acid using the bacterium is also described.Type: GrantFiled: September 13, 2007Date of Patent: April 28, 2009Assignee: Ajinomoto Co., Inc.Inventors: Vitaliy Arkadievich Livshits, Natalia Pavlovna Zakataeva, Kazuo Nakanishi, Vladimir Veniaminovich Aleshin, Petr Vladimirovich Troshin, Irina Lyvovna Tokhmakova
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Publication number: 20090075310Abstract: A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene tribenzylphenyl ethers and a cholesterol-assaying enzyme reagent so as to preferentially react cholesterols in high density- and very low density-cholesterols among lipoproteins, and subsequently determining the amount of cholesterol that reacts thereafter. This method can eliminate the necessity for pretreatments such as centrifugation and electrophoresis, enables the quantitative determination to be conducted in an efficient, simple manner, and can be applied to various automatic analyzers.Type: ApplicationFiled: November 5, 2008Publication date: March 19, 2009Applicant: DAIICHI PURE CHEMICALS CO., LTD.Inventors: Mitsuhiro NAKAMURA, Kazuo NAKANISHI, Koichi HINO, Mitsuhisa MANABE
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Patent number: 7399617Abstract: A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the L-amino acid using the bacterium is also described.Type: GrantFiled: March 3, 2006Date of Patent: July 15, 2008Assignee: Ajinomoto Co., Inc.Inventors: Vitaliy Arkadievich Livshits, Natalia Pavlovna Zakataeva, Kazuo Nakanishi, Vladimir Veniaminovich Aleshin, Petr Vladimirovich Troshin, Irina Lyvovna Tokhmakova
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Publication number: 20080131911Abstract: A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene tribenzylphenyl ethers and a cholesterol-assaying enzyme reagent so as to preferentially react cholesterols in high density- and very low density-cholesterols among lipoproteins, and subsequently determining the amount of cholesterol that reacts thereafter. This method can eliminate the necessity for pretreatments such as centrifugation and electrophoresis, enables the quantitative determination to be conducted in an efficient, simple manner, and can be applied to various automatic analyzers.Type: ApplicationFiled: February 4, 2008Publication date: June 5, 2008Applicant: DAIICHI PURE CHEMICALS CO., LTD.Inventors: Mitsuhiro NAKAMURA, Kazuo Nakanishi, Koichi Hino, Mitsuhisa Manabe
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Publication number: 20080050784Abstract: A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the L-amino acid using the bacterium is also described.Type: ApplicationFiled: September 13, 2007Publication date: February 28, 2008Inventors: Vitaliy Livshits, Natalia Zakataeva, Kazuo Nakanishi, Vladimir Aleshin, Petr Troshin, Irina Tokhmakova
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Publication number: 20080050785Abstract: A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the L-amino acid using the bacterium is also described.Type: ApplicationFiled: September 13, 2007Publication date: February 28, 2008Inventors: Vitaliy Livshits, Natalia Zakataeva, Kazuo Nakanishi, Vladimir Aleshin, Petr Troshin, Irina Tokhmakova