Patents by Inventor Kazuyoshi Horii
Kazuyoshi Horii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230321657Abstract: Disclosed is a specimen analysis cartridge that includes: a first base having a micro flow path formed in at least one surface; a second base disposed so as to oppose a surface at which the micro flow path of the first base is formed; and a photocurable resin layer for adhering the first base and the second base to each other, and the first base and the second base each contain at least one of cycloolefin polymer and cycloolefin copolymer.Type: ApplicationFiled: April 7, 2023Publication date: October 12, 2023Applicants: SYSMEX CORPORATION, Creative Nanosystems Corporation, KYORITSU CHEMICAL & CO., LTD.Inventors: Kazuyoshi HORII, Shun NAKAMOTO, Koki HOSHIKAWA, Katsunori OSHIMA, Koji TSUJITA, Wataru KUZUTA, Tomoyuki HOSOYA, Yo TODA, Masahiro MORIMOTO
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Patent number: 11754491Abstract: A cartridge to be installed in a detection device for detecting light generated from a measurement sample containing a test substance is provided. The cartridge includes: a plurality of detection chambers fluidly isolated from each other and each receiving a measurement sample; and a transmission suppression unit provided between one detection chamber and another detection chamber of the plurality of detection chambers, and configured to suppress transmission of light generated from a measurement sample in the one detection chamber to the another detection chamber.Type: GrantFiled: March 17, 2020Date of Patent: September 12, 2023Assignee: SYSMEX CORPORATIONInventors: Kazuyoshi Horii, Kanako Nagaoka
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Patent number: 11674936Abstract: A thermal history detection label for detecting a thermal history over a temperature range to be monitored while suppressing an increase in label size is provided. The thermal history detection label is configured to detect a thermal history by the permeation of a molten permeating material into a permeation body, and the thermal history detection label includes a permeating material that integrally includes a first permeating material having a first melting point and a second permeating material having a second melting point higher than the first melting point, and a permeation body into which the permeating material permeates.Type: GrantFiled: September 29, 2020Date of Patent: June 13, 2023Assignee: SYSMEX CORPORATIONInventors: Kazuyoshi Horii, Shoichi Banno, Ken Odashiro
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Patent number: 11656223Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.Type: GrantFiled: June 24, 2021Date of Patent: May 23, 2023Assignee: SYSMEX CORPORATIONInventors: Kazuyoshi Horii, Tomoyuki Nose, Takao Fujiwara, Tatsuya Kosako
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Patent number: 11511246Abstract: The present invention provides a cartridge, a detection method, and a detection device capable of stabilizing the liquid level of a sample accommodated in a chamber in a predetermined state. A cartridge 20, that is rotated around a rotating shaft 42 for detecting a target substance, is provided with a chamber 100 in which a sample containing a target substance is stored. The chamber 100 includes a first region 110 in which a sample is stored, a second region 120 disposed at a position closer to the rotating shaft 42 than the first region 110, and a protrusion 130 protruding from a position between the first region 110 and the second region 120 to the inner side of the chamber 100.Type: GrantFiled: September 27, 2018Date of Patent: November 29, 2022Assignee: SYSMEX CORPORATIONInventors: Yongjian Yang, Tomoyuki Nose, Sayuri Tomoda, Kazuyoshi Horii
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Patent number: 11480525Abstract: Disclosed is a chemiluminescence measurement apparatus that includes: a support member configured to support a cartridge for measuring a test substance contained in a specimen by chemiluminescence measurement; a motor configured to rotate the support member so as to rotate the cartridge such that a process required for the chemiluminescence measurement proceeds in the cartridge; and a light receiver configured to receive light generated by chemiluminescence in the cartridge that is supported by the support member rotated by the motor. The cartridge supported by the support member and a light receiving surface of the light receiver are disposed inside a dark space surrounded by a light-shielding portion, and the motor is disposed outside the dark space.Type: GrantFiled: June 29, 2017Date of Patent: October 25, 2022Assignee: SYSMEX CORPORATIONInventors: Sayuri Tomoda, Tomoyuki Nose, Noriaki Sasaki, Kazuyoshi Horii
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Patent number: 11433680Abstract: Disclosed is a liquid-sealed cartridge that includes: a liquid storage portion configured to store liquid; a flow path in which the liquid stored in the liquid storage portion flows; and a liquid sealing portion configured to seal the liquid in the liquid storage portion, in which the liquid sealing portion has an outer circumferential portion and a center-side low strength portion disposed closer to a center than the outer circumferential portion, and the center-side low strength portion is broken when pressed, to allow the liquid in the liquid storage portion to flow in the flow path.Type: GrantFiled: September 25, 2020Date of Patent: September 6, 2022Assignees: SYSMEX CORPORATION, ASTI CORPORATIONInventors: Kazuyoshi Horii, Shun Nakamoto, Noriyuki Ogai, Yasuhiro Toda, Kimiaki Iwahori
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Patent number: 11327086Abstract: A sample measuring method of optically measuring a sample housed in a container in a sample measurement device, the method including: loading the container such that the container is shielded from light; starting to read information regarding a measurement to be performed on the sample in response to the loading the container; and measuring the sample based on the read information.Type: GrantFiled: November 30, 2018Date of Patent: May 10, 2022Assignee: SYSMEX CORPORATIONInventors: Tomoyuki Nose, Sayuri Tomoda, Yusuke Miida, Kazuyoshi Horii, Kenichiro Suzuki
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Patent number: 11266985Abstract: Disclosed is a liquid sealed cartridge in which a liquid injected through an inlet is previously sealed, and the liquid is transferred by a centrifugal force being applied by rotation, and the liquid sealed cartridge includes: a liquid storage portion configured to store the liquid; a bypass flow path having one end and the other end connected to the liquid storage portion, the bypass flow path having the inlet; and a transfer flow path into which the liquid is transferred from the liquid storage portion when the centrifugal force is applied.Type: GrantFiled: November 2, 2017Date of Patent: March 8, 2022Assignee: SYSMEX CORPORATIONInventors: Kazuyoshi Horii, Takao Fujiwara, Tomoyuki Nose
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Publication number: 20210318297Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.Type: ApplicationFiled: June 24, 2021Publication date: October 14, 2021Applicant: SYSMEX CORPORATIONInventors: Kazuyoshi HORII, Tomoyuki NOSE, Takao FUJIWARA, Tatsuya KOSAKO
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Patent number: 11117135Abstract: Disclosed is a liquid-sealed cartridge in which a liquid is transferred by a centrifugal force generated when the liquid-sealed cartridge is rotated around a rotation shaft, including: a liquid storage portion configured to store the liquid therein; a seal having an outer peripheral portion connected to the liquid storage portion, the seal being configured to seal the liquid storage portion; a flow path connected to the liquid storage portion via the seal, through which the liquid in the liquid storage portion is transferred by the centrifugal force in a direction away from the rotation shaft, wherein, when the seal receives a pressing force, the seal is inclined in a pressing direction, with one portion of the outer peripheral portion thereof remaining connected with the liquid storage portion, and the other portion of the outer peripheral portion being separated from the liquid storage portion.Type: GrantFiled: October 27, 2017Date of Patent: September 14, 2021Assignees: Sysmex Corporation, ASTI CorporationInventors: Kazuyoshi Horii, Takao Fujiwara, Tomoyuki Nose, Yasunori Maekawa, Noriyuki Ogai, Yasuhiro Toda
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Patent number: 11099182Abstract: Disclosed is a detection apparatus that transfers magnetic particles through a plurality of chambers in a cartridge which includes the plurality of chambers and a channel connecting between the plurality of chambers, and that causes the magnetic particles to carry a complex of a test substance and a labelling substance, to detect the test substance on the basis of the labelling substance in the complex. The detection apparatus includes: a rotation mechanism configured to rotate the cartridge about a rotation shaft; a magnet configured to collect the magnetic particles in the chambers; a movement mechanism configured to move the magnet in a direction different from a circumferential direction of a circle in which the rotation shaft is centered; a detector configured to detect the test substance; and a controller programmed to control the rotation mechanism and the movement mechanism so as to transfer the magnetic particles from one of the chambers to another one of the chambers.Type: GrantFiled: June 29, 2017Date of Patent: August 24, 2021Assignee: Sysmex CorporationInventors: Kazuyoshi Horii, Tomoyuki Nose, Takao Fujiwara, Sayuri Tomoda, Yusuke Miida, Yasunori Maekawa, Noriaki Sasaki
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Patent number: 11073514Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.Type: GrantFiled: September 19, 2019Date of Patent: July 27, 2021Assignee: SYSMEX CORPORATIONInventors: Kazuyoshi Horii, Tomoyuki Nose, Takao Fujiwara, Tatsuya Kosako
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Publication number: 20210148905Abstract: Disclosed is a detection apparatus that transfers magnetic particles through a plurality of chambers in a cartridge which includes the plurality of chambers and a channel connecting between the plurality of chambers, and that causes the magnetic particles to carry a complex of a test substance and a labelling substance, to detect the test substance on the basis of the labelling substance in the complex. The detection apparatus includes: a rotation mechanism configured to rotate the cartridge about a rotation shaft; a magnet configured to collect the magnetic particles in the chambers; a movement mechanism configured to move the magnet in a direction different from a circumferential direction of a circle in which the rotation shaft is centered; a detector configured to detect the test substance; and a controller programmed to control the rotation mechanism and the movement mechanism so as to transfer the magnetic particles from one of the chambers to another one of the chambers.Type: ApplicationFiled: January 29, 2021Publication date: May 20, 2021Inventors: Kazuyoshi HORII, Tomoyuki Nose, Takao Fujiwara, Sayuri Tomoda, Yusuke Miida, Yasunori Maekawa, Noriaki Sasaki
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Publication number: 20210094303Abstract: Disclosed is a liquid-sealed cartridge that includes: a liquid storage portion configured to store liquid; a flow path in which the liquid stored in the liquid storage portion flows; and a liquid sealing portion configured to seal the liquid in the liquid storage portion, in which the liquid sealing portion has an outer circumferential portion and a center-side low strength portion disposed closer to a center than the outer circumferential portion, and the center-side low strength portion is broken when pressed, to allow the liquid in the liquid storage portion to flow in the flow path.Type: ApplicationFiled: September 25, 2020Publication date: April 1, 2021Inventors: Kazuyoshi HORII, Shun NAKAMOTO, Noriyuki OGAI, Yasuhiro TODA, Kimiaki IWAHORI
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Publication number: 20210096114Abstract: A thermal history detection label for detecting a thermal history over a temperature range to be monitored while suppressing an increase in label size is provided. The thermal history detection label is configured to detect a thermal history by the permeation of a molten permeating material into a permeation body, and the thermal history detection label includes a permeating material that integrally includes a first permeating material having a first melting point and a second permeating material having a second melting point higher than the first melting point, and a permeation body into which the permeating material permeates.Type: ApplicationFiled: September 29, 2020Publication date: April 1, 2021Applicant: SYSMEX CORPORATIONInventors: Kazuyoshi HORII, Shoichi BANNO, Ken ODASHIRO
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Publication number: 20200300752Abstract: A cartridge to be installed in a detection device for detecting light generated from a measurement sample containing a test substance is provided. The cartridge includes: a plurality of detection chambers fluidly isolated from each other and each receiving a measurement sample; and a transmission suppression unit provided between one detection chamber and another detection chamber of the plurality of detection chambers, and configured to suppress transmission of light generated from a measurement sample in the one detection chamber to the another detection chamber.Type: ApplicationFiled: March 17, 2020Publication date: September 24, 2020Applicant: SYSMEX CORPORATIONInventors: Kazuyoshi HORII, Kanako NAGAOKA
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Patent number: 10697989Abstract: This liquid-sealed cartridge includes: a cartridge body including a plurality of liquid storage portions; a seal body configured to seal an opening of each of the plurality of liquid storage portions; and an elastic body disposed so as to be opposed to the plurality of liquid storage portions, the elastic body being configured to form a passage adjacent to the plurality of liquid storage portions. Each of the plurality of liquid storage portions and the passage are configured to be communicated with each other by the corresponding seal body being pushed to be opened through the elastic body.Type: GrantFiled: October 27, 2017Date of Patent: June 30, 2020Assignees: SYSMEX CORPORATION, ASTI CORPORATIONInventors: Kazuyoshi Horii, Takao Fujiwara, Noriyuki Ogai, Kenpei Onozuka, Yasuhiro Toda
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Publication number: 20200011861Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.Type: ApplicationFiled: September 19, 2019Publication date: January 9, 2020Applicant: SYSMEX CORPORATIONInventors: Kazuyoshi HORII, Tomoyuki NOSE, Takao FUJIWARA, Tatsuya KOSAKO
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Patent number: 10473652Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.Type: GrantFiled: March 25, 2016Date of Patent: November 12, 2019Assignee: SYSMEX CORPORATIONInventors: Kazuyoshi Horii, Tomoyuki Nose, Takao Fujiwara, Tatsuya Kosako