Abstract: The present invention relates to a method for preparing glufosinate or an analogue and an intermediate thereof. The method comprises: a) reacting a compound of formula (II), an alcohol of formula (III) and a compound of formula (V); and b) hydrolyzing the product of the reaction above to obtain glufosinate of formula (IV) or an analogue thereof.

Abstract: The present invention relates to a method for preparing glufosinate or analogues thereof.

Abstract: The present disclosure provides compositions and methods relating to the use of exosomes derived from human dermal papilla (DP) cells. In particular, the present disclosure provides novel compositions and methods for generating and maintaining exosomes derived from DP spheroids, as well as compositions and methods for delivering exosomes to a subject for various therapeutic purposes, such as the treatment of diseases and conditions related to hair follicle development.

Abstract: The present disclosure provides compositions and methods related to antiviral therapeutics. In particular, the present disclosure provides novel compositions and methods for treating and/or preventing viral infections using vesicles derived from lung spheroid cells (LSCs). LSC-derived vesicles can be used as viral decoy nanoparticles for therapeutic applications, as virus-like particles (VLPs) for vaccine production, and as an antiviral drug delivery platform.

Abstract: Provided are compositions and methods useful in regenerating damaged tissue, especially cardiac tissue, by delivering to the site of injury an miRNA that can reduce, for example, the expression of phosphatase and tensin homolog (PTEN). The compositions and methods of the disclosure may be generally applied to deliver an miRNA to a cell or tissue such as, but not limited to, a neuron, a smooth muscle cell, or a tumor cell. The compositions comprise a transmembrane carrier peptide conjugated, optionally by a linker, to an oligonucleotide complementary to an miRNA. The carrier peptide facilitates the entry of the miRNA into cells and for delivery to a tissue of an animal or human may be mixed with an extracellular matrix-derived hydrogel carrier.

Abstract: A preparation method for glufosinate or a salt thereof, an enantiomer thereof, or mixtures of the enantiomer thereof in all ratios, comprising reacting a compound of formula (II) or a salt, an enantiomer, or mixtures of the enantiomer in all ratios with one or more compounds of formula (III) or mixtures thereof.

Abstract: An omnidirectional wheel includes a hub and a number of driven wheels. The hub defines a number of mounting grooves. Each mounting groove includes an axle provided therein. Each driven wheel includes a driven roller and a cover layer. Each of two ends of the driven roller defines a fixing hole. Each of the two holes receives the axle. The cover layer is sleeved on an outer side of the driven roller.

Abstract: Provided are a method for preparing L-glufosinate and the intermediate compounds of formula (V) and formula (III).

Abstract: A stem cell biomimetic microparticle and methods of manufacture are provided that comprise a core nanoparticle and an outer layer disposed on the core nanoparticle, the core nanoparticle comprising at least one stem cell-derived secreted factor or a population of stem-cell derived exosomes embedded in a biocompatible polymer core nanoparticle, and an outer layer obtained from a cell membrane. Also provided is a method of treating a pathological condition of a patient by delivering to the patient a composition comprising the stem cell biomimetic microparticle comprising at least one stem cell-derived secreted factor or population of stem cell-derived exosomes embedded in a biocompatible polymer core microparticle and an outer layer derived from red blood cell membranes or platelet membranes disposed on the biocompatible polymer core microparticle.

Abstract: The present disclosure provides compositions and methods relating to the use of platelet microparticles to deliver therapeutic antibodies. In particular, the present disclosure provides novel compositions and methods for treating cardiac injury using anti-IL-1? platelet microparticles (IL1-PMs) to promote cardiac detoxification and repair after cardiac injury (e.g., myocardial infarction).

Abstract: Provided are stem cell biomimetic microparticles comprised of at least one stem cell-derived paracrine polypeptide or growth factor embedded in a polymer core particle that further comprises an outer layer of at least one fragment of a cell membrane of a stem cell disposed on the core particle. The polymer core may be constituted of any biocompatible and biodegradable polymer or copolymer, or a combination thereof that allows the embedding of the paracrine factors and their prolonged release from the core. The core and hence the microparticles can be biodegradable, allowing eventual elimination from the recipient animal or human subject. The core particles are sized to allow both transport through blood vessels and extravasation from the blood vessels into the surrounding tissues. The core particle may further include at least one polypeptide or peptide growth factor to induce the generation and proliferation of a population of stem cells.

Abstract: A suction nozzle assembly used in manufacture for the gentlest handling of delicate components such as a camera lens includes a suction nozzle rod and a suction nozzle member. The suction nozzle rod includes a first through hole. The suction nozzle member includes a main body and a suction nozzle located on both sides of the main body. The main body includes a second through hole connected to the first through hole, and a third through hole connected to the second through hole. The suction nozzle includes at least one suction nozzle hole connected to the third through hole. The disclosure also provides a suction device having the suction nozzle assembly.

Abstract: An air-cooled carrier of heat-generating electronic components includes a frame, a plate, and baffles. The plate coupled to the frame divides airflow in the frame into two channels. Opposite sides of each channel along a first direction carry inlet and outlet. A pair of baffles is coupled to each channel, each baffle comprises a mounting part, an arc-shaped elastic part, and a blocking part. The mounting part is fixed to the frame and the arc-shaped elastic part. The blocking part is fixed to the arc-shaped elastic part and extends to middle of the airflow cavity in a second direction perpendicular to the first direction. In the absence of a mounted storage component, the elastic part bringing the blocking part to a first position and so blocking air flow from that outlet to that inlet.

Abstract: A warning structure includes a bracket and a warning member mounted on the bracket. The bracket includes a main body, rollers rotationally mounted to the main body, and a stopping assembly including a support member, a mounting member, and a resilient member. The support member is coupled to the main body. The mounting member is movably mounted to the support member. The rollers are mounted to the mounting member and the main body. The resilient member elastically resists the support member and the mounting member to bias the mounting member. When the support member is subjected to a downward force, the support member abuts against a ground to keep the bracket stationary.

Abstract: A carrier tray to allow rapid installment of additional modules or devices, without screws, into a computer includes a frame, two sliders, an elastic member, and a handle. A bracket of the frame has a unit cavity. The two sliders can slide along a first direction and the elastic member is compressible between the two sliders. The handle allows pushing and pulling of the tray along a second direction and is attached to the two sliders, the two sliders can move towards each other (to a first position) or apart (to a second position). The two sliders return to the unity cavity by pulling the handle from the first position to the second position along the second direction. Continued pulling of the handle in the second direction removes the carrier tray from the computer.

Abstract: Provided are a method for preparing L-glufosinate and the intermediate compounds of formula (V) and formula (III).

Abstract: A method of circulating tumor cells isolation, using an isolating cultural system of circulating tumor cells, comprises the following steps: (1) providing a sample; (2) adding a cell culture medium to the isolating cultural system of circulating tumor cells; (3) adding the sample to the isolating cultural system of circulating tumor cells to cultivate; and (4) collecting the suspended circulating tumor cells in the cell culture medium; wherein the isolating cultural system of circulating tumor cells comprises a container including a cell adhesion portion, and cellulose coated on the cell adhesion portion.

Abstract: A preparation method for glufosinate or a salt thereof, an enantiomer thereof, or mixtures of the enantiomer thereof in all ratios, comprising reacting a compound of formula (II) or a salt, an enantiomer, or mixtures of the enantiomer in all ratios with one or more compounds of formula (III) or mixtures thereof.

Abstract: Several embodiments relate to methods of repairing and/or regenerating damaged or diseased tissue comprising administering to the damaged or diseased tissues compositions comprising exosomes. In several embodiments, the exosomes comprise one or more microRNA that result in alterations in gene or protein expression, which in tum result in improved cell or tissue viability and/or function.

Abstract: A warning structure includes a bracket and a warning member mounted on the bracket. The bracket includes a main body, rollers rotationally mounted to the main body, and a stopping assembly including a rotating mechanism and a stopping member coupled to the rotating mechanism. The rotating mechanism is rotationally coupled to the main body. One of the rollers is mounted adjacent to the stopping member. When the rotating mechanism is rotated, the stopping member is engaged with a ground to prevent the bracket from moving.