Abstract: The present invention provides a PIKfyve protein degradation agent and use thereof. Specifically, the present invention provides a compound having a structure represented by formula (I), or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a prodrug molecule thereof. The compound can target and degrade PIKfyve proteins through a ubiquitin-proteasome pathway, and therefore can be used for treating indications mediated by aberrant expression of the PIKfyve proteins.

Abstract: The present invention provides an EGFR inhibitor for use in the preparation of a medicament for treating diseases mediated by guanosine exchange factor (GEF) activity or co-mediated by guanosine nucleotide exchange factor (GEF) activity and EGFR tyrosine kinase activity, wherein the diseases are selected from the group consisting of: lung cancer, colon cancer, breast cancer, endometrial cancer, thyroid cancer, glioma, squamous cell carcinoma, prostate cancer, melanoma, leukemia, and glioblastoma. Specifically, the present invention has discovered that in addition to its conventional tyrosine kinase activity, EGFR also possesses a GEF function that promotes the activation of Ras homologous protein (Rheb), this function is independent of its tyrosine kinase activity and relies critically on the glutamate residue at position 804 on the EGFR molecule. The Rheb-GEF activity of EGFR induces allosteric activation of mammalian target of rapamycin complex 1 (mTORC1), ultimately promoting tumor growth.

Abstract: The present disclosure provides a class of 2-aminopyrimidine compounds with a structure shown in Formula (I) or their pharmaceutically acceptable salts, isotope derivatives, solvates, or their stereoisomers, geometric isomers, tautomers, or prodrug molecules or metabolites and pharmaceutical compositions and application thereof. The compounds of the present disclosure can efficiently and selectively inhibit the kinase activity of Janus Kinase 3 (JAK3), and have strong signal inhibition and cell proliferation inhibition effects on various blood tumor cells (especially human acute myeloid leukemia cell U937 cells) and solid tumor cells. They can be used to prepare anti-tumor drugs and drugs for preventing and treating inflammatory diseases.

Abstract: A display panel and a display device are provided. An organic light-emitting layer includes a doped region and an undoped region, and the undoped region is located between the doped region and the hole blocking layer. When the display panel is in a low grayscale display state, an exciton concentration distribution curve of the organic light-emitting layer includes a first peak located in the doped region and a second peak located in the undoped region, and a peak value of the second peak is less than a peak value of the first peak.

Abstract: The application relates to session-based recommendation. A method for session-based recommendation may include: generating a similarity graph comprising a plurality of nodes and one or more edges, each node corresponding to an individual session and an edge being generated to connect two nodes in the similarity graph, wherein a similarity score of a pair of sessions corresponding to the two nodes exceeds a preset similarity threshold; and loading the similarity graph into a Graph Neural Network (GNN) for the session-based recommendation.

Abstract: A system and method for LLM reinforcement learning with heterogeneous processors. An example system comprises: a first one or more processors to perform large language model (LLM) inference operations based on a current model version and to generate corresponding training data samples; a second one or more processors having a heterogeneous architecture relative to the first one or more processors, the second one or more processors configurable to perform reinforcement learning operations using the corresponding training data samples to update model weights for the current model version; and a weight transfer engine to provide point-to-point communication channels between the first one or more processors and the second one or more processors, the second one or more processors to transmit the model weights over the point-to-point communication channels to the first one or more processors.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to implement dual attention vision transformers for interactive image segmentation. In some examples, the apparatus includes memory, instructions, and processor circuitry to execute and/or instantiate the instructions to partition information in an input tensor into a plurality of tensor crops, the input tensor representing image data of an image. The processor circuitry is further to execute and/or instantiate the instructions to create a dual-attention tensor representation of the input tensor, including an inter-attention tensor representation describing a first correlation between the plurality of tensor crops and an intra-attention tensor representation describing a second correlation between a plurality of layers in a tensor crop of the plurality of tensor crops.

Abstract: Provided are a cyclic 2-aminopyrimidine compound having a structure as shown in formula (I), or a pharmaceutically acceptable salt, stereoisomer or prodrug molecule thereof, and a use thereof. The compound can effectively inhibit the activity of EGFR protein kinase drug-resistant mutants (such as EGFRT790M and EGFR19del/T790M/C797S), and can overcome the clinical drug resistance of patients suffering from tumors such as non-small cell lung cancer induced by existing third-generation selective EGFRT790M small molecule inhibitors Osimertinib (AZD9291), Olmutinib (HM6171), Rociletinib (CO-1686) and the like.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to implement dual attention vision transformers for interactive image segmentation. In some examples, the apparatus includes memory, instructions, and processor circuitry to execute and/or instantiate the instructions to partition information in an input tensor into a plurality of tensor crops, the input tensor representing image data of an image. The processor circuitry is further to execute and/or instantiate the instructions to create a dual-attention tensor representation of the input tensor, including an inter-attention tensor representation describing a first correlation between the plurality of tensor crops and an intra-attention tensor representation describing a second correlation between a plurality of layers in a tensor crop of the plurality of tensor crops.

Abstract: A liquid lens controlled by an interdigital electrode made of two insulated wires includes an inner core cavity body, the two insulated wires, a first transparent body, a second transparent body, a first fluid, and a second fluid. The insulated wires are arranged side by side and longitudinally winded on the inner core cavity body; the insulated wires are configured to form an interdigital electrode on a sidewall of the inner core cavity body; the first transparent body is disposed at an upper end of the inner core cavity body and the second transparent body is disposed at a lower end of the inner core cavity body; a lens cavity is defined among the inner core cavity body, the first transparent body, and the second transparent body; the first fluid and the second fluid are immiscible, and disposed in the lens cavity.

Abstract: Methods, apparatus, and systems are disclosed for semantic image segmentation using small datasets. An example apparatus includes at least one memory, machine readable instructions, and processor circuitry to at least one of instantiate or execute the machine readable instructions to identify a gradient vector flow associated with the input image, generate a spatial feature map based on pixels of the input image using a two-stream neural network architecture, generate a field feature map based on the gradient vector flow using the two-stream neural network architecture, fuse the spatial feature map and the field feature map, and output a segmented image of the input image based on the fused feature map.

Abstract: An electronic device and an electronic device assembly method. A through hole is provided in a rear cover. An inner wall of the through hole protrudes to form an annular flange. A camera decorative member is designed to include an inner decorative member and an outer decorative member. The outer decorative member is arranged on a side of the rear cover facing away from a middle frame and is connected to the annular flange by a bonding layer, and the inner decorative member is fastened to a side of the outer decorative member facing the middle frame, so that a gap between the outer decorative member and the annular flange can be blocked by the bonding layer, and the bonding layer is used for sealing to prevent water in an external environment from entering the electronic device through space between the outer decorative member and the rear cover.

Abstract: Techniques related to video coding include reinforcement-learning render-aware bitrate control.

Abstract: This invention discloses use of (3-((1H-pyrazol[3,4-b]pyridine-5-substituted)ethinyl)-4-methyl-N-(4-((4-methylpiperazine-1-substituted)methyl)-3-(trifluoromethyl)phenyl)benzamide) and a pharmaceutically acceptable salt thereof in the manufacture of a medicament for treating acute lymphoblastic leukemia in particular precursor B-cell lymphoblastic leukemia.

Abstract: A display panel and a display device are provided. An organic light-emitting layer includes a doped region and an undoped region, and the undoped region is located between the doped region and the hole blocking layer. When the display panel is in a low grayscale display state, an exciton concentration distribution curve of the organic light-emitting layer includes a first peak located in the doped region and a second peak located in the undoped region, and a peak value of the second peak is less than a peak value of the first peak.

Abstract: The present invention relates to a method for preparing a class of novel CDK12/13 covalent inhibitors or a pharmaceutical composition thereof, and use thereof. The class of novel CDK12/13 covalent inhibitors of the present invention have a structure shown in formula (I). Such compounds can serve as protein kinase inhibitors, can effectively and highly selectively inhibit the CDK12/13 protein kinase activity, and can inhibit the proliferation, migration, and invasion of various tumor cells.

Abstract: A liquid lens controlled by an interdigital electrode made of two insulated wires includes an inner core cavity body, the two insulated wires, a first transparent body, a second transparent body, a first fluid, and a second fluid. The insulated wires are arranged side by side and longitudinally winded on the inner core cavity body; the insulated wires are configured to form an interdigital electrode on a sidewall of the inner core cavity body; the first transparent body is disposed at an upper end of the inner core cavity body and the second transparent body is disposed at a lower end of the inner core cavity body; a lens cavity is defined among the inner core cavity body, the first transparent body, and the second transparent body; the first fluid and the second fluid are immiscible, and disposed in the lens cavity.

Abstract: An electronic device, including a battery cover. The battery cover includes a battery cover body. An inner surface of the battery cover body has an anti-shattering film. The anti-shattering film includes a plastic substrate. A back adhesive is provided on the plastic substrate. The back adhesive is adhered to the inner surface of the battery cover body. A surface of the back adhesive that is adhered to the inner surface of the battery cover body is provided with an exhaust groove grid. In this application, the anti-shattering film with the exhaust groove grid on its back adhesive is closely attached on the non-metallic battery cover body.

Abstract: A ceramic resin composite housing, including a ceramic member and a resin member that is molded on the ceramic member through injection molding. A surface that is of the ceramic member and that is bonded with the resin member includes a plurality of long-strip-shaped holes extending from the surface to the inside of the ceramic member. The long-strip-shaped holes have an open hole structure. The long-strip-shaped holes are filled with a resin material that constitutes the resin member. The composite housing has both a ceramic texture and appearance, and an internal fine structure formed by resin, the ceramic and the resin both are tightly bonded, and a bonding strength is high. The embodiments of the present invention further provide a preparation method of the ceramic resin composite housing, and a terminal including the composite housing.