Abstract: The present disclosure provides a class of Pyridopyrimidine compounds having a structure shown in Formula (I) or their pharmaceutically acceptable salts, or stereoisomers or prodrug molecules and applications thereof. The compounds in the present disclosure can efficiently and selectively degrade AKT3 protein in cells without affecting AKT1/2, thereby significantly inhibiting tumor cell proliferation mediated by high expression of AKT3 protein. It can be used to prepare therapeutic drugs for cancer and other diseases related to abnormal expression of AKT3 protein.

Abstract: Systems, apparatus, articles of manufacture, and methods are disclosed to preserve privacy in a user dataset including interface circuitry, machine readable instructions, and programmable circuitry to determine a data usage type for each one of a plurality of user data features in a first dataset, classify the data usage type associated with each user data feature of the plurality of user data feature into a feature category, apply at least one feature engineering mechanism to feature categories of the data usage types of the plurality of user data features, select, based on application of feature engineering, a subset of the plurality of user data features for a feature selection training model, and output a second dataset based on the subset of the plurality of user data for the feature selection training model, the second dataset to include fewer user data features than the first dataset.

Abstract: Systems, apparatus, articles of manufacture, and methods are disclosed that include interface circuitry, machine readable instructions, and programmable circuitry to at least one of instantiate or execute the machine readable instructions to associate first datapoints of a first feature with a first node, associate second datapoints of a second feature with a second node, construct a graph from the first datapoints and the second datapoints, and perform a comparison of a graph accuracy with a baseline accuracy.

Abstract: Provided are a display substrate, a preparation method thereof and a display apparatus. The display substrate includes a first semi-conductive layer, a first conductive layer, a second conductive layer, a second semi-conductive layer, a third conductive layer, an interlayer insulating layer and an organic layer stacked on a substrate. The first semi-conductive layer includes an active layer of a polysilicon transistor, the first conductive layer includes a gate electrode of a polysilicon transistor and a first electrode plate of a storage capacitor, the second conductive layer includes a second electrode plate of a storage capacitor, the second semi-conductive layer includes an active layer of an oxide transistor, and the third conductive layer includes a gate electrode of an oxide transistor.

Abstract: Disclosed is a control method for an audio device, the audio device includes a wireless charging module and a display screen, and the control method for the audio device includes the following steps: in response to detecting a mobile device is placed on the audio device, acquiring a screen placement state of the mobile device, the screen placement state includes at least one of a screen flat state, a screen horizontal state and a screen vertical state; and displaying display content of the display screen on a screen of the mobile device according to the screen placement state. This disclosure further provides an audio device and a computer-readable storage medium. The problem that the display effect of the display screen of the audio device will be affected when the audio device performs wireless charging for the mobile device has been solved.

Abstract: In a logging identification method for a small fault based on stress anisotropy and crustal stress types, a magnitude and direction of a current crustal stress are determined by means of logging calculation of the crustal stress, and a transformation location of a crustal stress type is determined; a development location of the small fault is determined according to the transformation location of the crustal stress type; and an included angle between the current crustal stress and the fault is determined according to an amplitude of variation of stress anisotropy. The present disclosure provides the logging identification method for a small fault based on stress anisotropy and crustal stress types. According to the method, prediction cost is low, operability is high, and a prediction result has a reference value for guiding exploration and development of a complex oil and gas reservoir and construction of a gas storage.

Abstract: The present disclosure relates to Alkynylphenylbenzamide compounds and the applications thereof. The said Alkynylphenylbenzamide compounds have the structure shown in Formula (I). The compounds can be used as protein kinase inhibitors, which can effectively inhibit the activity of TRK protein kinase and the proliferation, migration and invasion of various tumor cells. At the same time, it has the characteristics of good pharmacokinetics and low toxicity.

Abstract: The present disclosure provides a class of 2-aminopyrimidine compounds with a structure shown in Formula (I) or their pharmaceutically acceptable salts, isotope derivatives, solvates, or their stereoisomers, geometric isomers, tautomers, or prodrug molecules or metabolites and pharmaceutical compositions and application thereof. The compounds of the present disclosure can efficiently and selectively inhibit the kinase activity of Janus Kinase 3 (JAK3), and have strong signal inhibition and cell proliferation inhibition effects on various blood tumor cells (especially human acute myeloid leukemia cell U937 cells) and solid tumor cells. They can be used to prepare anti-tumor drugs and drugs for preventing and treating inflammatory diseases.

Abstract: Disclosed herein are major vault proteins having modified R8 flexible regions, vault particles comprising major vault proteins having modified R8 flexible regions, and methods of packaging passenger polypeptides in the modified R8 flexible regions.

Abstract: The present disclosure relates to Alkynylphenylbenzamide compounds and the applications thereof. The said Alkynylphenylbenzamide compounds have the structure shown in Formula (I). The compounds can be used as protein kinase inhibitors, which can effectively inhibit the activity of TRK protein kinase and the proliferation, migration and invasion of various tumor cells. At the same time, it has the characteristics of good pharmacokinetics and low toxicity.

Abstract: A thermally assisted magnetic head includes a slider, the slider includes a slider substrate and a magnetic head part. The magnetic head part includes a recording head, a reading head, a near field transducer and a medium-opposing surface. The medium-opposing surface includes a recording area and a reading area. The magnetic head part includes a record/read separately protective structure which an enhanced protective film is formed on the recording area and a reading head protective film is formed on the reading area. The enhanced protective film includes a plurality of films for effectively protecting the recording head and the near field transducer. The reading head protective film includes a thickness which is thinner than the enhanced protective film.

Abstract: The present application provides a display panel including a substrate, a thin film transistor layer, an electrode layer, a pixel definition layer, and a light-emitting function layer. layer. An orthographic projection area of the electrode on the substrate is D, an orthographic projection area of an area connecting the light-emitting function portion and the electrode on the substrate is P, and a reflection compensation parameter of the pixel is D/P. A display area comprises a first display area and a second display area. The reflection compensation parameter of the pixel in the first display area is less than the reflection compensation parameter of the pixel in the second display area.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to implement dual attention vision transformers for interactive image segmentation. In some examples, the apparatus includes memory, instructions, and processor circuitry to execute and/or instantiate the instructions to partition information in an input tensor into a plurality of tensor crops, the input tensor representing image data of an image. The processor circuitry is further to execute and/or instantiate the instructions to create a dual-attention tensor representation of the input tensor, including an inter-attention tensor representation describing a first correlation between the plurality of tensor crops and an intra-attention tensor representation describing a second correlation between a plurality of layers in a tensor crop of the plurality of tensor crops.

Abstract: A ceramic resin composite housing, including a ceramic member and a resin member that is molded on the ceramic member through injection molding. A surface that is of the ceramic member and that is bonded with the resin member includes a plurality of long-strip-shaped holes extending from the surface to the inside of the ceramic member. The long-strip-shaped holes have an open hole structure. The long-strip-shaped holes are filled with a resin material that constitutes the resin member. The composite housing has both a ceramic texture and appearance, and an internal fine structure formed by resin, the ceramic and the resin both are tightly bonded, and a bonding strength is high. The embodiments of the present invention further provide a preparation method of the ceramic resin composite housing, and a terminal including the composite housing.

Abstract: The present invention provides indazole derivatives or their pharmaceutically acceptable salts or stereoisomers having the structure shown in formula (I), and their pharmaceutical compositions and applications thereof. Such compounds can be used as protein kinase inhibitors, which can effectively inhibit the activity of tropomyosin receptor kinase (TRK) protein kinase and can inhibit the proliferation, migration and invasion of a variety of tumor cells.

Abstract: Disclosed is a method for preparing ?-phenylethanol. The method comprises the following steps: (1) reducing a catalyst in a reactor in advance; (2) introducing pre-heated hydrogen gas to warm the reactor to a predetermined temperature; and (3) introducing a raw material styrene oxide to perform a hydrogenation reaction so as to obtain the ?-phenylethanol. The catalyst is Ni—Cu/Al2O3 nanosized self-assembled catalyst. The reactor is an ultrasonic field micro-packed bed reactor. The method of the present invention enables the selectivity of the ?-phenylethanol to reach 99% or more.

Abstract: An organic electroluminescent device includes an anode, a cathode disposed opposite to the anode, and a light emitting functional layer disposed between the anode and the cathode. The light emitting functional layer includes a light emitting layer and a PN junction layer disposed on a side of the light emitting layer, and when a positive charge is applied to the anode and a negative charge is applied to the cathode, the PN junction layer forms an open circuit, so that the cathode and the anode evenly inject carriers into the light emitting layer.

Abstract: The present disclosure discloses an information processing method, a service providing system, and a computer storage medium. The method includes: assigning at least one first account for a multimedia device; assigning a plurality of second accounts associated with the first account for the multimedia device, each second account representing one user identifier; acquiring a voice instruction; determining a currently used second account according to the voice instruction; searching for user preference information associated with the currently used second account; and providing, based on the user preference information and service request information determined based on the voice instruction, a first service to the user identifier represented by the currently used second account.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for super-resolution rendering. An example apparatus includes a data handler to generate a multi-sample control surface (MCS) frame based on a color frame, a feature extractor to obtain features from the color frame, a depth frame, and the MCS frame, a network controller to generate spatial data and temporal data based on the features, and a reconstructor to generate a high-resolution image based on the features, the spatial data, and the temporal data.

Abstract: Compounds useful for treating or preventing diabetes and related conditions, and for preventing, inhibiting or reversing amylin-amyloid fibril formation, preventing islets of Langerhans (Beta)-cell death, preventing or reversing the transition from soluble human amylin to insoluble human amylin, preventing and inhibiting or reversing cytotoxic amylin fibril formation.