Abstract: Geofence crossing-based control systems and techniques are described herein. For example, a geofence crossing control technique may include receiving a location signal indicative of a range of locations in which a mobile computing device is located; receiving a velocity signal indicative of a speed and direction of the mobile computing device; generating, for each of a plurality of candidate geofence crossing times, a performance indicator based on the location signal, the velocity signal, and a boundary of the geofence; selecting a geofence crossing time from the plurality of candidate geofence crossing times based on the performance indicators; and transmitting a control signal representative of the geofence crossing time. Other embodiments may be disclosed and/or claimed.

Abstract: Technologies for location privacy management include a mobile computing device to determine whether an application is authorized to obtain the location of the mobile computing device based on a determined location and location access policy of the mobile computing device. The location access policy includes policy rules that identify whether the application is authorized to obtain the location of the mobile computing device. If the mobile computing device determines that the application is not authorized to obtain the location of the mobile computing device, the mobile computing device blocks the application from obtaining the location.

Abstract: The present invention discloses coupling compounds of a structure as shown in Formula I, II or III formed by connecting NSAID anti-inflammatory and analgesic drugs and EGFR inhibitors by ester bonds or pharmaceutically acceptable salts or stereoisomers thereof or prodrug molecules thereof: where R is a NSAID anti-inflammatory and analgesic drug. In the present invention, the coupling compounds obtained by coupling NSAID anti-inflammatory and analgesic drugs with EGFR inhibitors have excellent therapeutic effects of tumors and provide new drugs for clinic treatment options.

Abstract: A high-conductivity thin-film structure for reducing metal contact resistance is disposed between a substrate and at least a metal electrode of a photoelectric component, characterized in that the thin-film structure has a first conductive layer and a second conductive layer, wherein the first conductive layer is a non-crystalline transparent conductive thin-film deposited on a lateral surface of the substrate, and the second conductive layer is a crystalline transparent conductive thin-film deposited on a lateral surface of the first conductive layer, wherein another surface of the second conductive layer is in contact with the metal electrode to serve as a conduction medium between the first conductive layer and the metal electrode. Therefore, the thin-film structure exhibits high conductivity, high transmittance, low contact resistance toward the metal electrode, and insusceptibility to unfavorable effects of coarseness of the surface of the substrate.

Abstract: The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.

Abstract: A system, method, and computer-readable medium for providing a user interface. The system includes circuitry configured to generate chatter information based on sensor data collected from a machining operation of a machine performed at a previously selected tool speed setting. The chatter information includes a chatter level value and a chatter frequency value. A plurality of different candidate tool speed settings is determined based on the generated chatter frequency value from the machining operation. The circuitry generates the user interface that includes a plurality of different tool speed settings, including the previously selected tool speed setting and the plurality of different candidate tool speed settings for selection by a user. The user interface is configured to indicate the chatter level value for the previously selected.

Abstract: Techniques for predicting a future location of a mobile device are included herein in which a previous location of the mobile device can be detected. Additionally, a current location of the mobile device can be detected. Furthermore, the future location of the mobile device can be predicted based at least in part on the previous location of the mobile device, the current location of the mobile device, and a location history.

Abstract: In one embodiment a controller comprises logic configured to receive, in the controller, a geofencing definition and input from at least one location information device, update a location of the controller using one or more location parameters from one or more location information devices, and generate a notification signal when the location of the controller indicates that the controller has crossed a threshold. Other embodiments may be described.

Abstract: A method and system for context sensing is described herein. The method includes determining if sensor data obtained via a number of sensors exceed a predetermined threshold. The method also includes increasing a sampling rate of any of the sensors to obtain context data corresponding to a computing device if the sensor data exceed the threshold. The method further includes analyzing the context data to classify a context of the computing device.

Abstract: System and methods are provided for dynamic performance adjustment of a media playing pipeline. For example, the media playing pipeline includes one or more components synchronized for media playing. A reference component in the media playing pipeline is selected, the reference component having a component performance level. A pipeline performance level of the media playing pipeline is determined. When the pipeline performance level is higher than a threshold, the component performance level of the reference component is adjusted to decrease the pipeline performance level. When the pipeline performance level is lower than the threshold, the component performance level of the reference component is adjusted to increase the pipeline performance level.

Abstract: Techniques for predicting a future location of a mobile device are included herein in which a previous location of the mobile device can be detected. Additionally, a current location of the mobile device can be detected. Furthermore, the future location of the mobile device can be predicted based at least in part on the previous location of the mobile device, the current location of the mobile device, and a location history.

Abstract: In one embodiment a controller comprises logic configured to receive, in the controller, a geofencing definition and input from at least one location information device, update a location of the controller using one or more location parameters from one or more location information devices, and generate a notification signal when the location of the controller indicates that the controller has crossed a threshold. Other embodiments may be described.

Abstract: The compounds according to formula (VIII), their pharmaceutically acceptable acid or base addition salts, and the uses thereof. These compounds and their pharmaceutically acceptable acid or base addition salts can be used for preparing medicaments for modulating estrogen related receptors (ERR), and treating metabolic diseases, such as high blood fat, fatty liver, hyperglycemia, diabetes, obesity. The substituents of the formula are defined in the description.

Abstract: A user device including a haptic feedback system configured to receive and process data captured by one or more sensors and determine contextual characteristics of the user device and a surrounding environment based on the captured data. The contextual characteristics may include, but are not limited to, ambient noise level and ambient light level of the surrounding environment, as well as user possession, movement and/or use and interaction with the device. The haptic feedback system is further configured to adjust haptic feedback effects of the user device based, at least in part, on the contextual characteristics of the user device and surrounding environment so as to provide an optimized haptic feedback effect to the user.

Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

Abstract: The compounds according to formula (VIII), their pharmaceutically acceptable acid or base addition salts, and the uses thereof. These compounds and their pharmaceutically acceptable acid or base addition salts can be used for preparing medicaments for modulating estrogen related receptors (ERR), and treating metabolic diseases, such as high blood fat, fatty liver, hyperglycemia, diabetes, obesity. The substituents of the formula are defined in the description.

Abstract: A compound of formula (I) or (II) and use of the compound in the preparation of drugs for treating cancer are disclosed. The study shows that the compounds can inhibit the growth of many kinds of tumor cells, can be used for targeting epidermal growth factor receptor (EGFR), and particularly can inhibit tumor cells with single or multiple mutations of EGFR (T790M). Therefore, the compound can be used as EGFR inhibitor to treat cancer and has a relatively large application value.

Abstract: The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.

Abstract: The heterocyclic alkynyl benzene compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in preparing drugs for preventing or treating tumors. The compounds can overcome the clinically induced resistance against Gleevec.

Abstract: An efficient approach for estimating scalefactors for use in the quantization of audio signal spectrum values is described. The scalefactor estimation approach can be implemented in multiple stages. A first stage estimates a distortion level for a selected scalefactor band spectrum value based on a received maximum tolerant distortion threshold and the spectrum values in the scalefactor band. A second stage determines an interim process value based on the previously estimated distortion level and generates a scalefactor for a selected scalefactor band spectrum value based on the generated interim process value and a statistically predetermined fraction. A third stage generates a scalefactor that applies to the whole scalefactor band based on the scalefactor generated for the selected scalefactor band spectrum value. The approach provides a performance gain of 40% over previous techniques, thereby reducing device power requirements and audio encoder bottlenecks.