Abstract: The present disclosure relates to novel compounds that inhibit glucose-induced degradation-deficient (GID) E3 ligase, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.

Abstract: The present disclosure provides a class of Pyridopyrimidine compounds having a structure shown in Formula (I) or their pharmaceutically acceptable salts, or stereoisomers or prodrug molecules and applications thereof. The compounds in the present disclosure can efficiently and selectively degrade AKT3 protein in cells without affecting AKT1/2, thereby significantly inhibiting tumor cell proliferation mediated by high expression of AKT3 protein. It can be used to prepare therapeutic drugs for cancer and other diseases related to abnormal expression of AKT3 protein.

Abstract: Provided is a method for coupling flavonoid-containing compounds to provide flavonoid dimers, trimers and oligomers. The method comprises contacting a flavonoid-containing compound with base in the presence of air. Flavonoid dimers, trimers and oligomers may also be useful in the treatment of diseases, such as fungal infections and diseases associated with starch hydrolase.

Abstract: A regulating device for regulating water consumption of a concealed water tank includes a water tank, a hinged base is fixedly arranged on the inner wall of the water tank, a water separator is hinged on the hinged base. A regulating mechanism is arranged between the hinged base and the water separator, and the regulating mechanism can drive the water separator to rotate and fix to divide the accommodation space of the water tank. Compared with the prior art, the regulating device realizes the variable volume of the water tank by regulating the rotation of the water separator through the regulating mechanism. The structure is simple and convenient for the later repair and maintenance of the water tank.

Abstract: Provided are a display substrate, a preparation method thereof and a display apparatus. The display substrate includes a first semi-conductive layer, a first conductive layer, a second conductive layer, a second semi-conductive layer, a third conductive layer, an interlayer insulating layer and an organic layer stacked on a substrate. The first semi-conductive layer includes an active layer of a polysilicon transistor, the first conductive layer includes a gate electrode of a polysilicon transistor and a first electrode plate of a storage capacitor, the second conductive layer includes a second electrode plate of a storage capacitor, the second semi-conductive layer includes an active layer of an oxide transistor, and the third conductive layer includes a gate electrode of an oxide transistor.

Abstract: An image pre-processing method and an image processing apparatus for a fundoscopic image are provided. A region of interest (ROI) is obtained from a fundoscopic image to generate a first image. The ROI is focused on an eyeball in the fundoscopic image. A smoothing process is performed on the first image to generate a second image. A value difference between neighboring pixels in the second image is increased to generate a third image.

Abstract: Disclosed are devices, systems and methods for capturing an image. In one aspect an electronic camera apparatus includes an image sensor with a plurality of pixel regions. The apparatus further includes an exposure controller. The exposure controller determines, for each of the plurality of pixel regions, a corresponding exposure duration and a corresponding exposure start time. Each pixel region begins to integrate incident light starting at the corresponding exposure start time and continues to integrate light for the corresponding exposure duration. In some example embodiments, at least two of the corresponding exposure durations or at least two of the corresponding exposure start times are different in the image.

Abstract: Disclosed are a system and a method for detecting a centroid of a complementary single pixel. The system includes a lens group, a single-pixel detector assembly, a Digital Micromirror Device (DMD) and an acquisition and processing unit. The acquisition and processing unit generates two-dimensional modulation matrices A and B which are loaded into the DMD; the lens group processes light reflected or transmitted from a target object, such that an image of the target object is imaged on the DMD; and the acquisition and processing unit is connected with data output ends of two single-pixel detectors in respective, to calculate the centroid of the target object. The DMD modulates an image signal of the target object according to modulation information A and B; the single-pixel detector assembly includes a first single-pixel detector and a second single-pixel detector.

Abstract: Disclosed are a system and a method for detecting a centroid of a complementary single pixel. The system includes a lens group, a single-pixel detector assembly, a Digital Micromirror Device (DMD) and an acquisition and processing unit. The acquisition and processing unit generates two-dimensional modulation matrices A and B which are loaded into the DMD; the lens group processes light reflected or transmitted from a target object, such that an image of the target object is imaged on the DMD; and the acquisition and processing unit is connected with data output ends of two single-pixel detectors in respective, to calculate the centroid of the target object. The DMID modulates an image signal of the target object according to modulation information A and B; the single-pixel detector assembly includes a first single-pixel detector and a second single-pixel detector.

Abstract: Techniques for determining a vehicle trajectory that causes a vehicle to navigate in an environment relative to one or more objects are described herein. For example, the techniques may include a computing device determining a decision tree having nodes to represent different object intents and/or nodes to represent vehicle actions at a future time. A tree search algorithm can search the decision tree to evaluate potential interactions between the vehicle and the one or more objects over a time period, and output a vehicle trajectory for the vehicle. The vehicle trajectory can be sent to a vehicle computing device for consideration during vehicle planning, which may include simulation.

Abstract: A low-oxygen heating-type cigarette assembly, comprising a low-oxygen heating-type smoking set (B) and a low-oxygen heating-type cigarette (A). The low-oxygen heating-type smoking set (B) comprises a heating section (4) and a smoke extracting member (2) detachably arranged with the heating section (4), wherein the heating section (4) is provided with a cigarette receiving chamber (4-1), and the smoke extracting member (2) comprises a hollow smoke extracting cone (2-1) and a smoke transmission tube (2-2).

Abstract: Techniques are described herein that are capable of generating a machine learning model based on constrained decision trees using a judgmental sample and feature ranking. A judgmental sample including observations, which include respective subsets of features, is generated. The observations are selected using multivariate stratified sampling. Important subsets of the features are determined based on each important subset being designated as more important than the other features by a respective individual. A score is determined for each feature, indicating a proportion of the important subsets that includes the respective feature. A highest scored feature is identified. Constrained decision trees having respective first splits are generated, based on respective subsets of the observations. A proportion of the first splits corresponding to the highest scored feature is based at least on the score of the highest scored feature.

Abstract: A capsule endoscope, an endoscope system, and an image correction method are provided. The capsule endoscope includes an image sensor and a posture sensor. The image sensor is coupled to a processor and obtains a sensed image. The posture sensor is coupled to the processor and obtains three-axis data. The processor calculates a screen rotation angle according to the three-axis data and corrects the sensed image according to the screen rotation angle. A first axis and a second axis of the corrected sensed image rotate toward an actual vertical axis and an actual horizontal axis.

Abstract: A method of forming an electro-optical modulator including forming a lithium-niobate (LN) wafer including an optical waveguide situated within and proximate a first side of the LN wafer; bonding the LN wafer to a substrate such that the first side of the LN wafer faces the substrate; thinning the LN wafer; and forming coplanar transmission lines over and/or on a second side of the LN wafer, wherein the coplanar transmission lines extend parallel with and are laterally on either side of the optical waveguide.

Abstract: The present disclosure belongs to the technical field of gene therapy, and specifically relates to a series of lipid compounds as well as lipid vectors, nucleic acid lipid nanoparticle compositions, and pharmaceutical preparations containing the same. The compound having the structure of formula (I) provided by the present disclosure may be used in combination with other lipid compounds to prepare a lipid vector, which exhibits pH responsiveness, has high encapsulation efficiency for nucleic acid drugs, and greatly enhances the in-vivo delivery efficiency of nucleic acid drugs. Moreover, it is possible to select lipid compounds with different structures as lipid vectors to adjust the enrichment of nucleic acid drugs in different organs, thereby having good market application prospect.

Abstract: The method and system disclosed herein presents a method and system for capturing, by a camera disposed on a device moving in an environment, a plurality of image frames recorded in a first coordinate reference frame at respective locations within a portion of the environment in a first time period; capturing, by an inertial measurement unit disposed on the device, sets of inertial odometry data recorded in a second coordinate reference frame; determining a rotational transformation matrix that corresponds to a relative rotation between the first reference frame and the second reference frame; and determining a scale factor from the matching pairs of image frames. The rotational transformation matrix defines an orientation of the device, and the scale factor and the rotational transformation matrix calibrate the plurality of image frames captured by the camera.

Abstract: The invention relates to methods for increasing plant yield, and in particular grain yield by reducing or abolishing the expression and/or activity of OTUB1 in a plant. Also described are genetically altered plants characterised by the above phenotype and methods of producing such plants.

Abstract: The present invention belongs to the technical field of gene therapy, and particularly relates to a series of lipid compounds as well as a lipid carrier, nucleic acid lipid nanoparticle composition and pharmaceutical preparation containing the same. A compound having a structure of a formula (I) provided by the present invention can be used for preparing a lipid carrier together with other lipid compounds, and exhibits pH response, and the entrapment efficiency to a nucleic acid drug is high, which greatly improves in-vivo delivery efficiency of the nucleic acid drug; and furthermore, a lipid compound with a specific structure can be chosen as a lipid carrier based on an organ in which the nucleic acid drug needs to be enriched, having a good market application prospect.

Abstract: The method and system disclosed herein presents a method and system for capturing, by a depth-perception device on a mobile robot moving in an environment, depth-perception information at a first location within a portion of the environment. The method includes capturing, by a camera device on the mobile robot, an image frame at the first location within the portion of the environment, generating a three-dimensional point cloud representing the portion of the environment based on the depth-perception information and the image frame, extracting semantic information by providing the frame and the point cloud to a neural network model configured to perform semantic segmentation, associating the semantic information to the three-dimensional point cloud, projecting the three-dimensional point cloud onto a two-dimensional plane to form a first two-dimensional map; and demarcating the first two-dimensional map with a plurality of different regions based on the semantic information.

Abstract: Provided is a parent phytase variant, which relates to the technical field of protein engineering. The variant, relative to the parent phytase thereof, has one or more amino acid substitutions at positions corresponding to positions 295, 349, and 374 of SEQ ID NO: 1. Compared to the parent phytase, the variant has increased thermal stability.