Abstract: The present invention belongs to the field of medicinal chemistry, and particularly relates to a pleuromutilin derivative with a thiazole side chain and preparation and application. The pleuromutilin derivative with the thiazole side chain is a compound of formula 2 or a pharmaceutically acceptable salt thereof, and a solvent compound, enantiomer, diastereoisomer, tautomer, or mixture of any proportion of the compound of formula 2 or the pharmaceutically acceptable salt thereof, comprising racemic mixtures: The pleuromutilin derivative has good antibacterial activity, is particularly suitable for use as a novel antibacterial drug for animal or human systemic infection, and has good water solubility.

Abstract: The present application relates to an antibody, kit, detection method, and sample analyzer for detecting thyroid stimulating hormone. Specifically, the present application relates to a monoclonal antibody or antigen-binding antibody fragment thereof that specifically binds to thyroid stimulating hormone (TSH), wherein the antibody can recognize TSH variant R55G and does not cross-react with an ?-subunit shared by human luteinizing hormone (LH), follicle stimulating hormone (FSH), human chorionic gonadotropin (hCG), and free glycoprotein hormones, and is particularly suitable for developing TSH detection kit with a functional sensitivity of ?0.0015 ?IU/ml. The present application also relates to a thyroid stimulating hormone detection kit, detection method, and sample analyzer.

Abstract: This application provides an antibody or antigen-binding fragment thereof that binds to thyroglobulin, including: a heavy chain variable region having: CDR-H1 having an amino acid sequence selected from SEQ ID NOs: 1, 7, 13, 19, 25, 31, and variants thereof, CDR-1-12 having an amino acid sequence selected from SEQ ID NOs: 2, 8, 14, 20, 26, 32, and variants thereof, and CDR-H3 having an amino acid sequence selected from SEQ ID NOs: 3, 9, 15, 21, 27, 33, and variants thereof; and a light chain variable region having: CDR-L1 having an amino acid sequence selected from SEQ ID NOs: 4, 10, 16, 22, 28, 34, and variants thereof, CDR-L2 having an amino acid sequence selected from SEQ ID NOs: 5, 11, 17, 23, 29, 35, and variants thereof, and CDR-L3 having an amino acid sequence selected from SEQ ID NOs: 6, 12, 18, 24, 30, 36, and variants thereof.

Abstract: The present disclosure relates to the technical field of medicines, and particularly relates to an immune preparation, a composition comprising the immune preparation and a use thereof, and a preparation method. an immune adjuvant provided by the present disclosure is an erythrocyte-derived vesicle, and the erythrocyte-derived vesicle has an erythrocyte content and a biofilm structured wrapped outside the erythrocyte content as a whole, and the two are matched with each other, so that the erythrocyte-derived vesicle serves as an endogenous substance of the body to activate an immune system of the body and effectively enhance a cellular immune response. Moreover, in this process, no toxic or side effect is caused to the body, and the method has the advantages of high biocompatibility, safe raw material source and simple preparation process.

Abstract: This application discloses a trip sharing method and apparatus, a device, a storage medium, and program product, and relates to the field of computer and the Internet technologies. The method includes displaying, shared information of a first trip created by a first user account in the mini program in a display interface of the social networking application, the first trip being a trip created by a car owner and waiting for participation by a passenger; displaying a trip detail interface of the mini program in a case that the mini program determines, after receiving the trip presentation instruction, that a second user account has permission to participate in the first trip; and displaying a trip confirmation interface in the mini program in response to an operation on the trip participation control, the trip confirmation interface displaying trip information of the participated first trip.

Abstract: An automatic leveling device of a 3D printer, and a 3D printer is provided. The automatic leveling device includes a photoelectric switch, an electromagnetic assembly and a probe assembly. The photoelectric switch is arranged in a housing and defines a photosensitive groove. The electromagnetic assembly is arranged in the housing and defines a sliding hole. The probe assembly is slidably engaged in the sliding hole, and an end of the probe assembly is engaged in the photosensitive groove. The electromagnetic assembly is capable of driving the probe assembly to make the end of the probe assembly move out of the photosensitive groove. The automatic leveling device has the advantages of simple structure, low manufacturing difficulty, low production cost, simple and stable leveling mode, high detection repetition accuracy and no complex circuit and software cooperation.

Abstract: A feed detection apparatus of a 3D printer, comprising a gear, a measurement device, a support, and a compression assembly. The gear is provided on the support to abut against a filament material, and rotates along with a movement of the filament material. The measurement device is placed on the support to measure a rotating speed of the gear, and determines a feeding status of the filament material according to a measurement result. The compression assembly comprises a connection member and an abutment member; the connection member is provided between the support and the abutment member; the abutment member is used for regulating a pressure of the connecting member applied on the support so as to enable the gear to abut against the filament material.

Abstract: Disclosed in the present invention are a method and apparatus for automatically improving printing effect, a device, and a storage medium. The method comprises: receiving an import request of a 3D model, and parsing a triangle patch comprised in the 3D model; acquiring all angular points of the 3D model according to the triangle patch, subtracting a minimum angular point from a maximum angular point to obtain a bounding box of the 3D model, creating an axis perpendicular to the bounding box; using the axis and a platform inclination angle to calculate a quaternion related to the rotation of the 3D model; multiplying a space matrix of the bounding box of the 3D model by the rotation matrix, enabling a printing path to be perpendicular to the bounding box. The model is imported to automatically keep the inclination angle consistent with a platform, thereby improving the printing effect.

Abstract: Embodiments of the disclosure disclose a method for a vehicle avoiding an obstacle, an electronic device, and a computer storage medium, and relates to a field of unmanned driving technologies. The detailed implementation includes: obtaining size information of a vehicle; obtaining a safe distance in a traveling direction of the vehicle; determining an obstacle screening area of the vehicle at least based on the size information and the safe distance; and determining an obstacle avoiding path of the vehicle in response to determining that the obstacle is located in the obstacle screening area. With the technical solution of the disclosure, higher efficiency obstacle avoiding can be realized.

Abstract: A method of logistics management based on QR code, the method includes: acquiring a video stream of a logistics box taken by a camera of a logistics box passing through an identification area, the logistics box having a corresponding QR code affixed to its surface; performing target detection on the video stream based on a predetermined neural network model to obtain a QR code image and a logistics box image, respectively; identifying the QR code image to generate QR code information; detecting and tracking the logistics box images in sequence to generate logistics box information; matching the QR code information and logistics box information, generating matching information, and updating logistics inventory information based on the matching information.

Abstract: Use of ginkgolide A in the treatment of autism. Specifically, the present invention relates to use of ginkgolide A, a stereoisomer thereof, a crystal form thereof, a pharmaceutically acceptable salt thereof, a derivative thereof, an extract comprising ginkgolide A, or a combination thereof in the preparation of a pharmaceutical composition for the treatment of autism. The experiments have demonstrated that ginkgolide A can significantly alleviate the behavioral defects of autism, and ginkgolide A has the advantages of small dosage and high safety when treating autism, and is very suitable as a common medicine for the treatment of autism.

Abstract: An automatic leveling device of a 3D printer, and a 3D printer is provided. The automatic leveling device includes a photoelectric switch, an electromagnetic assembly and a probe assembly. The photoelectric switch is arranged in a housing and defines a photosensitive groove. The electromagnetic assembly is arranged in the housing and defines a sliding hole. The probe assembly is slidably engaged in the sliding hole, and an end of the probe assembly is engaged in the photosensitive groove. The electromagnetic assembly is capable of driving the probe assembly to make the end of the probe assembly move out of the photosensitive groove. The automatic leveling device has the advantages of simple structure, low manufacturing difficulty, low production cost, simple and stable leveling mode, high detection repetition accuracy and no complex circuit and software cooperation.

Abstract: A method of logistics management based on QR code, the method includes: acquiring a video stream of a logistics box taken by a camera of a logistics box passing through an identification area, the logistics box having a corresponding QR code affixed to its surface; performing target detection on the video stream based on a predetermined neural network model to obtain a QR code image and a logistics box image, respectively; identifying the QR code image to generate QR code information; detecting and tracking the logistics box images in sequence to generate logistics box information; matching the QR code information and logistics box information, generating matching information, and updating logistics inventory information based on the matching information.

Abstract: A method and an apparatus for controlling a vehicle and a storage medium are disclosed. The method includes: controlling a vehicle to drive into a first parking space, the first parking space being a target parking space determined to be in an idle state; controlling the vehicle to stop driving into the first parking space in response to determining that the vehicle fails to drive into the first parking space while the vehicle is controlled to drive into the first parking space; determining a second parking space as the target parking space automatically; and controlling the vehicle to drive into the second parking space.

Abstract: The present disclosure provides a method and an apparatus for autonomously driving a vehicle. The method includes: recognizing a centerline of a lane on which a current vehicle is driving; acquiring a lateral distance between the current vehicle and the centerline of the lane, and a real-time speed and a real-time motion curvature of the current vehicle; calculating the lateral distance, the real-time speed, and the real-time motion curvature, based on a preset first spiral line equation, to acquire parameters of a reference spiral line; calculating the parameters, the real-time speed, and the real-time motion curvature, based on a preset second spiral line equation, to acquire a current spiral line; and determining an steering angle instruction of a steering wheel based on a first curvature of the current spiral line; and controlling the current vehicle for autonomous driving based on the steering angle instruction.

Abstract: The present disclosure provides a control method and apparatus for an autonomous vehicle, a computer device and a storage medium. The current steering wheel angle, vehicle speed and yaw rate are obtained, the current steering wheel angle is corrected based on the first correction deviation coefficient and the second correction deviation coefficient of the previous cycle, the corrected steering wheel angle and the current vehicle speed are input into the preset vehicle dynamic model to obtain the estimated yaw rate, the first yaw rate deviation value between the current yaw rate and the estimated yaw rate is obtained, and processed by the preset closed-loop algorithm to obtain the first correction deviation coefficient and the second correction deviation coefficient of the current cycle, and the target steering wheel angle is corrected, and the vehicle is driven based on the corrected target steering wheel angle.

Abstract: Embodiments of the disclosure disclose a method for a vehicle avoiding an obstacle, an electronic device, and a computer storage medium, and relates to a field of unmanned driving technologies. The detailed implementation includes: obtaining size information of a vehicle; obtaining a safe distance in a traveling direction of the vehicle; determining an obstacle screening area of the vehicle at least based on the size information and the safe distance; and determining an obstacle avoiding path of the vehicle in response to determining that the obstacle is located in the obstacle screening area. With the technical solution of the disclosure, higher efficiency obstacle avoiding can be realized.

Abstract: A method and an apparatus for controlling a vehicle and a storage medium are disclosed. The method includes: controlling a vehicle to drive into a first parking space, the first parking space being a target parking space determined to be in an idle state; controlling the vehicle to stop driving into the first parking space in response to determining that the vehicle fails to drive into the first parking space while the vehicle is controlled to drive into the first parking space; determining a second parking space as the target parking space automatically; and controlling the vehicle to drive into the second parking space.