Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

Abstract: A method and apparatus for generating a signal. The method includes: by taking a reference signal as a standard, cyclically performing isoprobabilistic processing and isospectral processing, or cyclically perform isoprobabilistic processing, perturbation processing and isospectral processing, on an input signal, until an obtained signal satisfies both a requirement on a target probability distribution and a requirement on a target spectrum, where a probability distribution of the reference signal satisfying the requirement on a target probability distribution, the isoprobabilistic processing referring to processing that makes the probability distribution of an output signal identical to the probability distribution of the reference signal. Therefore, a signal that satisfies both the requirement on the specific probability distribution and the requirement on the spectrum can be generated, and the degree of compliance is higher.

Abstract: A memory device including an array of memory cells arranged in a plurality of word lines is provided. A control circuitry is configured to program the memory cells of a selected word line to a plurality of leading data states in a plurality of programming loops that include programming and verify pulses. The control circuitry is also configured to count a total number of programming loops during programming of the selected word line. The control circuitry is also configured to program at least one memory cell of the selected word line to a last data state in at least one last data state programming loop. In response to both the total number of programming loops being less than a first predetermined threshold and the number of last data state programming loops being equal to a second predetermined threshold, the control circuitry automatically skips verify in a final programming loop.

Abstract: The present disclosure provides an apparatus and method for measuring a nonlinear signal-to-noise ratio, and a test instrument. The method for measuring a nonlinear signal-to-noise ratio may include performing notch operation on at least one frequency point in a spectrum of an input signal in a symbol domain or a bit domain; performing spectrum measurement on an output signal after passing through a nonlinear system; and estimating a nonlinear signal-to-noise ratio of at least one frequency point of the nonlinear system according to a spectrum of the output signal. According to the embodiments of the present disclosure, when the notch operation is performed, internal structures of symbols or bits of the input signal may be retained, and an accuracy of the measurement of the nonlinear signal-to-noise ratio may be improved.

Abstract: The present disclosure provides a method and apparatus for generating equivalent nonlinear noise. The method includes randomly generating white noise obeying zero-mean Chi-square distribution; and filtering the input white noise by using an equivalent nonlinear noise spectrum as an equivalent nonlinear filter to obtain the equivalent nonlinear noise. According to the embodiments of the present application, equivalent nonlinear noise may be generated based on zero-mean Chi-square distribution random variables combined with equivalent nonlinear noise spectrum filtering, and more accurate equivalent nonlinear noise than the related art may be generated, thus accurately evaluating an influence of nonlinearity of devices on Bit Error Rate (BER).

Abstract: Techniques disclosed for managing video captured by an imaging device. Methods disclosed capture a video in response to a capture command received at the imaging device. Following a video capture, techniques for classifying the captured video based on feature(s) extracted therefrom, for marking the captured video based on the classification, and for generating a media item from the captured video according to the marking are disclosed. Accordingly, the captured video may be classified as representing a static event, and, as a result, a media item of a still image may be generated. Otherwise, the captured video may be classified as representing a dynamic event, and, as a result, a media item of a video may be generated.

Abstract: In accordance with one or more embodiments of the present disclosure, a multi-stage process for upgrading pyrolysis oil comprising polyaromatic compounds to benzene, toluene, ethylbenzene, and xylenes (BTEX) includes upgrading the pyrolysis oil in a slurry-phase reactor zone to produce intermediate products, wherein the slurry-phase reactor zone comprises a mixed metal oxide catalyst; and hydrocracking the intermediate products in a fixed-bed reactor zone to produce the BTEX, wherein the fixed-bed reactor zone comprises a mesoporous zeolite-supported metal catalyst.

Abstract: Provided herein are methods for the diagnosis, or management of liver diseases, e.g.. hepatocellular carcinoma, using profiles of the miRNAs determined from cellular or acellular body fluids.

Abstract: An SOI lateral homogenization field high voltage power semiconductor device, and a manufacturing method and application thereof are provided. The device includes a type I conductive semiconductor substrate, a type II conductive drift region, a type I field clamped layer, type I and type II conductive well regions, the first dielectric oxide layer forming a field oxide layer, the second dielectric oxide layer forming a gate oxide layer, a type II conductive buried dielectric layer, a type II conductive source heavily doped region, a type II conductive drain heavily doped region. The first dielectric oxide layer and the floating field plate polysilicon electrodes form a vertical floating field plate distributed throughout the type II conductive drift region to form a vertical floating equipotential field plate array. When the device is in on-state, high doping concentration can be realized by the full-region depletion effect form the vertical field plate arrays.

Abstract: A runoff yield calculation method and device based on double free reservoirs, and a storage medium are provided, the method includes: forming a four-layer vadose zone structure by making a tension water storage layer be located under a deep vadose zone based on a three-layer vadose zone structure of a Xin'anjiang model; dividing a space occupied by free water in the four-layer vadose zone structure into an upper free reservoir and a lower free reservoir; calculating a time interval runoff yield by using a saturation excess runoff method; and dividing, based on a runoff yield structure of the double free reservoirs, the time interval runoff yield into a surface runoff, an interflow and a subsurface runoff. The method proposes a runoff yield structure of double free reservoirs, which can be well applied to semi-arid and semi humid watersheds with deeper buried depth of shallow groundwater.

Abstract: Apparatuses and techniques are described for detecting latent defects in a memory device by considering both physical segment and logical segment fail bits in an erase operation. The erase operation involves performing a series of erase loops until the memory cells pass an erase-verify test. The passing of the erase-verify test is based on counting memory cells in different logical segments which fail the verify test and determining that the count is less than a logical segment threshold for each logical segment. Subsequently, the technique involves counting memory cells in each physical segment which fail the erase-verify test and determining whether the count is less than a physical segment threshold. If the count is equal to or greater than the physical segment threshold for one or more of the physical segments, the block of memory cells is marked as being bad.

Abstract: In accordance with one or more embodiments of the present disclosure, a multi-stage process for upgrading pyrolysis oil comprising polyaromatic compounds to benzene, toluene, ethylbenzene, and xylenes (BTEX) includes upgrading the pyrolysis oil in a slurry-phase reactor zone to produce intermediate products, wherein the slurry-phase reactor zone comprises a mixed metal oxide catalyst; and hydrocracking the intermediate products in a fixed-bed reactor zone to produce the BTEX, wherein the fixed-bed reactor zone comprises a mesoporous zeolite-supported metal catalyst.

Abstract: Provided in the present disclosure are an electrical impedance tomography based method and device for generating a three-dimensional blood perfusion image. The method (100) comprises: using an electrode array distributed in a three-dimensional space to perform electrical impedance measurement on a human body region to be measured so as to obtain an electrical impedance measurement signal (110); and on the basis of a blood perfusion signal in the electrical impedance measurement signal, reconstructing a three-dimensional blood perfusion image by means of an image reconstruction algorithm (120). Therefore, a three-dimensional image of electrical impedance variations caused by blood perfusion can be generated; and compared with a two-dimensional image in the prior art, the three-dimensional image can more intuitively reflect the blood perfusion condition of a volume area in the three-dimensional space of a human body region, and facilitates image analysis and comparison and disease detection and diagnosis.

Abstract: A voice awakening method and apparatus, a device, and a medium are provided. The voice awakening method includes: collecting a voice signal by using a microphone array (S201); separately performing denoising processing on the voice signal by using N beamforming denoising algorithms to obtain N denoising signals, where each beamforming denoising algorithm corresponds to one of N areas, different beamforming denoising algorithms correspond to different areas, a union set of the N areas covers a signal collection area of the microphone array, and N is a positive integer greater than 1 (S202); and performing voice awakening by using an awakening engine based on at least one of the N denoising signals (S203). The method can maximize denoising performance of the denoising algorithms and can cancel an echo outside a beam to enhance echo cancellation performance, featuring a relatively high awakening rate and recognition rate. In addition, the method is easy to implement and popularize.

Abstract: Apparatuses and techniques are described for detecting and isolating defective blocks of memory cells in a multi-plane operation such as program or erase. In one aspect, a program operation begins in a multi-plane mode, for one block in each plane. If fewer than all blocks complete programming by the time a trigger number of program loops have been performed, one or more unpassed blocks are programmed further, one at a time, in a single plane mode. If the one or more unpassed blocks do not complete programming when a maximum allowable number of program loops have been performed, they are marked as bad blocks and disabled from further operations. In another aspect, when a trigger number of program loops have been performed, one or more unpassed blocks are subject to a word line leakage detection operation.

Abstract: A method for producing a hierarchical mesoporous beta includes mixing a beta zeolite with an aqueous metal hydroxide solution and heating the beta zeolite and the aqueous metal hydroxide mixture to produce a desilicated beta zeolite, contacting the desilicated beta zeolite with an ammonium salt solution to produce an intermediate hierarchical mesoporous beta zeolite, and treating the intermediate hierarchical mesoporous beta zeolite with an acidic solution to produce the hierarchical mesoporous beta zeolite. The hierarchical mesoporous beta zeolite includes a molar ratio of silicon to aluminum of greater than 12.5, a total pore volume of greater than or equal to the total pore volume of the intermediate hierarchical mesoporous beta zeolite, and an average mesopore size of greater than or equal to the average mesopore size of the hierarchical mesoporous beta zeolite. The method may also include calcining the intermediate hierarchical mesoporous beta zeolite.

Abstract: A distorter coefficient updating apparatus, a distorter coefficient updating method, and a digital predistortion apparatus. The distorter coefficient updating apparatus is configured at an optical receiver side, and comprises a processor configured to: perform re-distortion processing on a signal after decision according to a first distorter coefficient to generate a first reference signal; and calculate a second distorter coefficient according to the first reference signal and a signal before decision, or according to the first reference signal, the signal after decision, and the signal before decision The second distorter coefficient is fed back to the processor as the first distorter coefficient of the processor in a next update, and the second distorter coefficient is fed back to a predistorter on an optical transmitter side as a predistortion coefficient for the predistorter to perform a predistortion processing on a signal input to the predistorter.

Abstract: A method for updating a non-linear look-up table, an apparatus for updating a non-linear look-up table, and an optical receiver. The method for updating a non-linear look-up table includes: performing suppression processing on residual linear ISI contained in an input look-up table in an iterative update process of a look-up table to obtain a processed look-up table. The method eliminates adverse effects of a residual linear ISI in real time during an iterative update process of a LUT, so that a generated LUT coefficient does not continue to diverge along an iteration process, which ensures stable operation of pre-compensating on nonlinearity of an optical transmitter device.

Abstract: Use of ginkgolide A in the treatment of autism. Specifically, the present invention relates to use of ginkgolide A, a stereoisomer thereof, a crystal form thereof, a pharmaceutically acceptable salt thereof, a derivative thereof, an extract comprising ginkgolide A, or a combination thereof in the preparation of a pharmaceutical composition for the treatment of autism. The experiments have demonstrated that ginkgolide A can significantly alleviate the behavioral defects of autism, and ginkgolide A has the advantages of small dosage and high safety when treating autism, and is very suitable as a common medicine for the treatment of autism.