Abstract: An object of present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles and pharmaceutical composition using the compound or a salt thereof, which can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, each symbol has a meaning defined in the present specification.

Abstract: An object of the present invention is to provide an anti-tumor agent that exhibits a remarkably excellent anti-tumor effect. According to the present invention, there is provided an anti-tumor agent for curing cancer, the anti-tumor agent having a liposome which has an inner water phase and having an aqueous solution which is an outer water phase and disperses the liposome, in which the liposome encompasses topotecan or a salt thereof, a lipid constituting the liposome contains a lipid modified with polyethylene glycol, dihydrosphingomyelin, and cholesterol, the inner water phase contains an ammonium salt, and the topotecan or the salt thereof encompassed in the liposome is administered at a dose rate of 0.1 mg/m2 body surface area to 10 mg/m2 body surface area, in terms of topotecan per administration.

Abstract: In a power conversion device for performing conversion from DC to AC, a positive-side capacitor and a negative-side capacitor with their connection point serving as a neutral point are provided between the positive and negative sides of the inputted DC power, and a switching pattern for specifying switching phases which are timings of ON/OFF driving switching elements of an inverter which outputs AC voltage having at least a positive-side potential, a negative-side potential, and a neutral point potential, is calculated so as to satisfy conditions for ensuring a modulation factor, eliminating harmonic components for respective orders of output voltage, ensuring a predetermined value for a phase difference between adjacent switching phases, and balancing voltage of the positive-side capacitor and voltage of the negative-side capacitor.

Abstract: An object of the present invention is to provide a lipid composition capable of achieving excellent nucleic acid delivery. According to the present invention, there is provided a lipid composition containing a lipid represented by Formula (1) or a salt thereof, a nucleic acid, at least one non-cationic lipid, and a lipid represented by R51-L-(OCH2CH2)n—O-R52 (in the formula, R51 represents a hydrocarbon group having 6 to 30 carbon atoms, L represents —CO— or a single bond, R52 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and n represents an integer of 10 to 150). In the formula, each symbol means the definition described in the description.

Abstract: An information providing device for a trip to multiple users including a first user and a second user is provided. The information providing device includes circuitry configured to determine a destination of the trip based on a degree of interest of the first user, provide the second user with a first trip proposal to the destination when a degree of interest of the second user in the destination is greater than or equal to a predetermined degree-of-interest threshold value, and provide the second user with a second trip proposal to the destination when the degree of interest of the second user in the destination is less than the predetermined degree-of-interest threshold value. In the second trip proposal, a degree of recommendation of the trip proposal is increased from the first trip proposal.

Abstract: An information processor includes a generation section that generates a specified character string on the basis of at least one of voice information corresponding to a content of speech detected by a voice detection section and vehicle information acquired from a vehicle. With this configuration, a user can input the specified character string, which is a hashtag, without an operation. Thus, compared to the related art in which the hashtag is generated on the basis of the operation (manual input) by the user, a burden on the user can significantly be reduced, and an input error can be prevented.

Abstract: The present invention relates generally to maqui berry for use in the treatment or prevention of bone injuries, diseases or defects, the promotion of healing of bone injuries, and the promotion of bone formation. Particular embodiments as disclosed herein find application in, inter alia, the treatment of bone fractures and in bone formation and regeneration. In particular, the present invention relates to the use of maqui berry extract in the manufacture of a medicament or dietary supplement for use in treating or preventing of bone injury or diseases or defects selected from the group of congenital bone defects, bone or spinal deformation, osteosarcoma, bone dysplasia, osteomalacia (rickets), osteogenesis imperfecta (brittle bone disorder), Paget's disease of the bone, osteoarthritis.

Abstract: A server device includes an acquisition unit configured to acquire vehicle information including at least positional information of a vehicle and related time information from a plurality of vehicles; and a congestion identification unit configured to acquire a speed of the vehicle obtained from the vehicle information and information of a road of multiple lanes in one direction based on map information, and identify that there are a congested lane and a non-congested lane among the multiple lanes in one direction based on speeds of a plurality of vehicles traveling on the same road of the multiple lanes in one direction.

Abstract: A server apparatus includes circuitry configured to acquire utterance information on a traveling location point, the utterance information being provided by occupants of a plurality of vehicles and derive a reason for danger near the traveling location point based on the acquired utterance information.

Abstract: A clothing information acquisition device includes an image acquisition unit that acquires a captured image obtained by capturing an image of the outside of a vehicle by an in-vehicle camera and location information on a location at which the image is captured, a specifying unit that specifies clothing information of a person included in the captured image, and a storage unit that stores the specified clothing information in association with the location information.

Abstract: An information determination device includes an occupant identification unit configured to identify a plurality of occupants in a vehicle, a group specification unit configured to specify, based on an identification result of the occupants, a group composed of the occupants, a storage unit configured to store group behavior information of the group and individual behavior information of the occupants, a derivation unit configured to derive group preference information based on the individual behavior information of the occupants identified by the occupant identification unit and the group behavior information of the group composed by the occupants, and a determination unit configured to determine, based on the group preference information that is derived, suggestion information to be provided to the occupants.

Abstract: A resin composition including the following components (a) and (b). (a) A polyimide precursor having a structural unit represented by the following general formula (1); and (b) a compound represented by the following general formula (2): wherein in the formula R1 is a tetravalent organic group, R2 is a divalent organic group and R3 and R4 are independently a hydrogen atom, an alkyl group, a cycloalkyl group or a monovalent organic group having a carbon-carbon unsaturated double bond.

Abstract: An information providing device includes a receiving unit configured to receive identification information of a first user and a character string from a terminal, an extracting unit configured to extract place information associated with the character string from action histories of a plurality of persons, a first identification unit configured to identify a second user that the first user follows by consulting information that represents a relationship between users on social media, an adjusting unit configured to, of the extracted place information, raise a priority of the place information contained in the action history of the second user as compared to the other place information; and a sending unit configured to send the extracted place information and the priority of the place information to the terminal.

Abstract: An information processor includes a generation section that generates a specified character string on the basis of at least one of voice information corresponding to a content of speech detected by a voice detection section and vehicle information acquired from a vehicle. With this configuration, a user can input the specified character string, which is a hashtag, without an operation. Thus, compared to the related art in which the hashtag is generated on the basis of the operation (manual input) by the user, a burden on the user can significantly be reduced, and an input error can be prevented.

Abstract: An information providing device for a trip to multiple users including a first user and a second user is provided. The information providing device includes circuitry configured to determine a destination of the trip based on a degree of interest of the first user, provide the second user with a first trip proposal to the destination when a degree of interest of the second user in the destination is greater than or equal to a predetermined degree-of-interest threshold value, and provide the second user with a second trip proposal to the destination when the degree of interest of the second user in the destination is less than the predetermined degree-of-interest threshold value. In the second trip proposal, a degree of recommendation of the trip proposal is increased from the first trip proposal.

Abstract: A navigation system which performs route guidance from a vehicle departure location to a target location. After a vehicle has arrived at the target location and completed the route guidance, if the vehicle has moved away from the target location and thereafter has approached the target location again, the navigation system: determines that the vehicle is disorientated and unable to arrive at the target location; and resumes the route guidance.

Abstract: An information processor includes: a purpose estimation portion configured to estimate a moving purpose of a user to a destination based on destination information that is information indicative of the destination set by the user; and a candidate facility proposing portion configured to determine a candidate drop-in facility where the user drops in between a departure place and the destination by use of at least the moving purpose and to propose the candidate drop-in facility thus determined to the user.

Abstract: An information providing device includes a receiving unit configured to receive identification information of a first user and a character string from a terminal, an extracting unit configured to extract place information associated with the character string from action histories of a plurality of persons, a first identification unit configured to identify a second user that the first user follows by consulting information that represents a relationship between users on social media, an adjusting unit configured to, of the extracted place information, raise a priority of the place information contained in the action history of the second user as compared to the other place information; and a sending unit configured to send the extracted place information and the priority of the place information to the terminal.

Abstract: A voice recognition supporting device includes a light emitting unit, a sound detecting unit, and an emission control unit configured to determine whether an environment around the sound detecting unit is suitable for recognition of a voice based on a voice level, a noise level, and a threshold value, to change an emission state of the light emitting unit to a first state when it is determined that the environment around the sound detecting unit is suitable for recognition of a voice, and to change the emission state of the light emitting unit to a second state which is different from the first state when it is determined that the environment around the sound detecting unit is not suitable for recognition of a voice.

Abstract: An information processing apparatus includes a first acquisition unit configured to acquire a value of a stress index measured for a user of a vehicle shared by a plurality of persons during use of the vehicle, a storage processing unit configured to store the value to be associated with the user and the vehicle into a storage unit, and a selection unit configured to select a vehicle recommended to the user based on the value stored to be associated with the user in the storage unit in response to a vehicle use request from the user.