Patents by Inventor Keiko Takahashi
Keiko Takahashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6469043Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof. In the formula, R1 represents hydrogen atom, a halogen atom or cyano group; R2 and R3 are the same as or different from and each represents hydrogen atom, a C1˜C4 lower alkyl group or a halogen atom; R4 represents hydrogen atom or a C1˜C4 lower alkyl group; and the ring A represents cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, a halopyridyl group or cyanothiophenyl group, provided that the case where all of R1, R2 and R3 are hydrogen atoms, where both R2 and R3 are hydrogen atoms or where the ring A is aminosulfonyl group and both R1 and R2 are halogen atoms is excluded.Type: GrantFiled: September 28, 2000Date of Patent: October 22, 2002Assignee: Eisai Co., Ltd.Inventors: Toru Haneda, Akihiko Tsuruoka, Junichi Kamata, Tadashi Okabe, Keiko Takahashi, Kazumasa Nara, Shinichi Hamaoka, Norihiro Ueda, Takashi Owa, Toshiaki Wakabayashi, Yasuhiro Funahashi, Taro Semba, Naoko Hata, Yuji Yamamoto, Yoichi Ozawa, Noako Tsukahara
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Publication number: 20020128480Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof.Type: ApplicationFiled: March 18, 2002Publication date: September 12, 2002Applicant: Eisai Co., Ltd.Inventors: Toru Haneda, Akihiko Tsuruoka, Junichi Kamata, Tadashi Okabe, Keiko Takahashi, Kazumasa Nara, Shinichi Hamaoka, Norihiro Ueda, Takashi Owa, Toshiaki Wakabayashi, Yasuhiro Funahashi, Taro Semba, Naoko Hata, Yuji Yamamoto, Yoichi Ozawa, Noako Tsukahara
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Publication number: 20020128483Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof.Type: ApplicationFiled: March 18, 2002Publication date: September 12, 2002Applicant: Eisai Co., Ltd.Inventors: Toru Haneda, Akihiko Tsuruoka, Junichi Kamata, Tadashi Okabe, Keiko Takahashi, Kazumasa Nara, Shinichi Hamaoka, Norihiro Ueda, Takashi Owa, Toshiaki Wakabayashi, Yasuhiro Funahashi, Taro Semba, Naoko Hata, Yuji Yamamoto, Yoichi Ozawa, Noako Tsukahara
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Patent number: 6448243Abstract: A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: (wherein A, B, C, D, T, Y and Z represent each methine or nitrogen; R1, R2, R3, R4 and R5 represent each a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3.) The compound has a serotonin antagonism and is clinically useful as medicament, in particular, for treating, ameliorating and preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.Type: GrantFiled: August 11, 1999Date of Patent: September 10, 2002Assignee: Eisai Co., Ltd.Inventors: Noritaka Kitazawa, Kohshi Ueno, Keiko Takahashi, Teiji Kimura, Atsushi Sasaki, Koki Kawano, Tadashi Okabe, Makoto Komatsu, Manabu Matsunaga, Atsuhiko Kubota
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Publication number: 20020086999Abstract: A novel 1,4-substituted cyclic amine derivative represented by the following formula: 1Type: ApplicationFiled: May 2, 2001Publication date: July 4, 2002Applicant: Eisai Co., Ltd.Inventors: Noritaka Kitazawa, Kohshi Ueno, Keiko Takahashi, Teiji Kimura, Atsushi Sasaki, Koki Kawano, Tadashi Okabe, Makoto Komatsu, Manabu Matsunaga, Atsuhiko Kubota
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Publication number: 20020019531Abstract: A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: 1Type: ApplicationFiled: May 18, 2001Publication date: February 14, 2002Applicant: Eisai Co., Ltd.Inventors: Noritaka Kitazawa, Kohshi Ueno, Keiko Takahashi, Teiji Kimura, Atsushi Sasaki, Koki Kawano, Tadashi Okabe, Makoto Komatsu, Manabu Matsunaga, Atsuhiko Kubota
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Publication number: 20020013460Abstract: The present provides a condensed pyridine compound (I) represented by the following formula: 1Type: ApplicationFiled: May 11, 2001Publication date: January 31, 2002Applicant: Eisai Co., LtdInventors: Kohshi Ueno, Atsushi Sasaki, Koki Kawano, Tadashi Okabe, Noritaka Kitazawa, Keiko Takahashi, Noboru Yamamoto, Yuichi Suzuki, Manabu Matsunaga, Atsuhiko Kubota
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Patent number: 6340759Abstract: The present provides a condensed pyridine compound (I) represented by the following formula: (wherein, R2 represents ring A represents benzene ring, pyridine ring, thiophene ring or furan ring; and B represents its pharmaceutically acceptable salt or hydrates thereof, which is a clinically useful medicament having a serotonin antagonism, in particular, that for treating, ameliorating or preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.Type: GrantFiled: March 31, 2000Date of Patent: January 22, 2002Assignee: Eisai Co., Ltd.Inventors: Kohshi Ueno, Atsushi Sasaki, Koki Kawano, Tadashi Okabe, Noritaka Kitazawa, Keiko Takahashi, Noboru Yamamoto, Yuichi Suzuki, Manabu Matsunaga, Atsuhiko Kubota
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Patent number: 5672712Abstract: Object: To provide compounds useful as inhibitors of blood platelet aggregation for intravenous administration.Constitution: A thiazoline derivative represented by the formula: ##STR1## ?wherein R.sup.1 is a hydroxyl group, an alkoxy group, a cycloalkoxy group or a group represented by the formula: R.sup.4 NH-- (wherein R.sup.4 is a cycloalkyl group), R.sup.2 is an alkyl group, a cycloalkyl group or a phenylalkyl group, R.sup.3 is a hydrogen atom or an alkyl group, and n is an integer of 2 to 9! or a salt thereof.Type: GrantFiled: December 12, 1996Date of Patent: September 30, 1997Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masakazu Sato, Akira Manaka, Keiko Takahashi, Yutaka Kawashima, Katsuo Hatayama
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Patent number: 5478945Abstract: A thiazoline derivative represented by the formula: ##STR1## [wherein R.sup.1 is cyano, carbamoyl, thiocarbamoyl, morpholinothiocarbonyl, alkylthioimidoyl, amidino, substituted amidino or imidazolin-2-yl, R.sup.2 is alkyl or aralkyl, R.sup.3 is hydrogen or alkyl, R.sup.4 is hydroxyl, alkoxy, substituted alkoxy or amino, l is an integer of 1 to 5] and salts thereof have fibrinogen receptor antagonism and cell adhesion factor antagonism, and are useful as therapeutic agents for ischemic diseases and atherosclerosis diseases, and metastasis inhibitory agents of tumors.Type: GrantFiled: January 11, 1995Date of Patent: December 26, 1995Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masakazu Sato, Akira Manaka, Keiko Takahashi, Yutaka Kawashima, Katsuo Hatayama
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Patent number: 4979212Abstract: In a speech recognition system which performs a frequency analysis of speech input and determines its spoken interval, a time-normalized pattern (matching pattern) is prepared for use in similarity calculations. In the time-normalization, the time axis is segmented in such a manner as to cancel the effects of differences in the length of syllables in the input speech. With such normalization, it is possible to achieve high performance in linear matching of the input speech pattern against reference patterns using simple processing and a small memory space even when there are variations in the speaking rate.Type: GrantFiled: October 20, 1989Date of Patent: December 18, 1990Assignee: OKI Electric Industry Co., Ltd.Inventors: Youichi Yamada, Keiko Takahashi
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Patent number: 4882755Abstract: In a speech recognition system using normalized spectrum matching, a second feature pattern is calculated and compared with reference patterns. The similarity obtained as a result of the comparison is used to determine overall similarity, from which the recognition is made. The second feature pattern can be a spectrum variation pattern, a level decrease pattern, or a spectrum relative value pattern.Type: GrantFiled: August 11, 1987Date of Patent: November 21, 1989Assignee: Oki Electric Industry Co., Ltd.Inventors: Youichi Yamada, Keiko Takahashi
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Patent number: 4868879Abstract: In a speech recognition system for effecting substantially linear matching, a start point of an input speech pattern is detected to start counting the frames of the input speech pattern for updating a speech frame number. Each time the speech frame number is updated, a plurality of frame numbers of reference templates are generated in substantially a linear relationship to the frame number, thus providing a plurality of matching paths between each of the reference templates and the input speech pattern. The distance between the input pattern data and the reference template data between the corresponding frames specified by each matching path is calculated each time the speech frame number is updated. An accumulated value of the distances along a matching path from the start point of the input speech until a desired speech frame is regarded as a dissimilarity, and the dissimilarity corresponding to each matching path in each reference template is calculated each time the speech frame is updated.Type: GrantFiled: March 26, 1985Date of Patent: September 19, 1989Assignee: Oki Electric Industry Co., Ltd.Inventors: Makoto Morito, Masao Takeuchi, Akihiko Fujisawa, Yukio Tabei, Keiko Takahashi
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Patent number: 4856067Abstract: In a speech-recognition system in which time-series patterns of characteristic quantities are extracted from an input utterance within a voiced interval, the local-peak patterns, which are the results obtained by stably extracting the characteristics of the steady vowel portions, and the consonantal patterns, which are the results obtained by stably extracting the characteristics of the consonantal portions, are recognized and identified. This makes it possible to perform accurate and stable speech-recognition including also the characteristics of the consonants.Type: GrantFiled: August 6, 1987Date of Patent: August 8, 1989Assignee: Oki Electric Industry Co., Ltd.Inventors: Youichi Yamada, Keiko Takahashi
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Patent number: 4794115Abstract: A method of treating or preventing hyperlipemia by administering ethanolamine derivatives. As preferable ethanolamine derivatives are mentioned N-(9,12,15,-octadecatrienoyl)-2-aminoethyl nicotinate, N-(5,8,11,14,17-eicosapentaenoyl)-2-aminoethyl nicotinate and the like. Hyperlipemia is effectively prevented or treated by administering 300-2000 mg per day of said ethanolamine derivative for adults.Type: GrantFiled: October 31, 1986Date of Patent: December 27, 1988Assignee: Terumo CorporationInventors: Keiko Takahashi, Toshio Wakabayashi
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Patent number: 4704393Abstract: 5-Fluorouracil derivatives represented by general; formula I: ##STR1## wherein R represents an acyl group derived from an unsaturated higher fatty acid selected from the group consisting of triene higher acids, pentaene higher acids, and hexaene higher fatty acids, can be used as for inhibiting platelet aggregation and an anticancer chemotherapeutic agent. They may be mixed with a pharmaceutically acceptable carrier or a diluent to form a medicinal preparation.Type: GrantFiled: June 17, 1985Date of Patent: November 3, 1987Assignee: Terumo Kabushiki KaishaInventors: Toshio Wakabayashi, Keiko Takahashi, Hajime Katayama
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Patent number: 4619938Abstract: Alkanolamine derivatives and platelet aggregation inhibitors containing the same as an active ingredient are disclosed. The alkanolamine derivatives are novel compounds which possess potent platelet aggregation inhibitory activities and effective in preventing diseases such as thrombosis. As typical compounds are mentioned N-5,8,11,14,17-eicosapentaenoyl-2-aminoethanol, N-nicotinoyl-2-aminoethyl-5,8,11,14,17-eicosapentaenoate, N-ethyl-N-5,8,11,14,17-eicosapentaenoyl-2-aminoethanol, N-butyl-N-5,8,11,14,17-eicosapentaenoyl-2-aminoethanol, N-5,8,11,14,17-3-aminopropylnicotinate, (N-ethyl-N-nicotinoyl-2-aminoethyl)-5,8,11,14,17-eicosapentaenoate and the like.Type: GrantFiled: March 19, 1985Date of Patent: October 28, 1986Assignee: Terumo Kabushiki KaishaInventors: Keiko Takahashi, Yasushi Suwabe, Toshio Wakabayashi