Abstract: A water treatment system, such as a water softener, is remotely operated and a method of remotely controlling a water treatment system. In a first embodiment, a method of detecting abnormal water usage within a water system associated with a water treatment system is provided. The method includes the steps of monitoring water usage associated with the water treatment system, determining whether the current water usage is above an alarm value, and sending an alarm notice in the event the current water usage is above the alarm value, and automatically taking predetermined action.

Abstract: An agricultural cutting blade has top and bottom surfaces and mounting apertures extending through top and bottom surfaces. A cutting edge support surface (e.g. that may be a flat, pointed or rounded) is formed on the cutting blade body with the cutting edge support extending along a side of the cutting blade body transversely between the top and bottom surfaces. A clad material deposited upon the cutting edge support such as by laser cladding process. The clad material can be built up, that is layered in partial or full overlapping relation to provide at least 2 and often more than 4 layers of clad material at one or more locations. A cutting edge provided by the clad material that may be a ground surface into a laser clad bead.

Abstract: A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.

Abstract: A female coupling device includes: a main body, and a clip member coupled to the main body, the clip member having a plurality of arms extending perpendicularly therefrom, with the plurality of arms forming at least one pair of arms, with the pair of arms including a first distance therebetween and a second distance therebetween, with the first distance being sized to engage a clip groove of a mating male coupling device, and with the second distance being sized to disengage the mating male coupling device. In a locked position, the pair of arms is positioned so that the first distance is adjacent to the mating male coupling device. In an unlocked position, the pair of arms is positioned so that the second distance is adjacent to the mating male coupling device.

Abstract: A laser cladded agricultural blade is provided. The blade includes a blade body. The blade body is of a first hardness. The blade body is additionally provided with a cladding material of a second hardness, wherein the cladding material comprises an amorphous metal. The cladding material is applied by a laser cladding process.

Abstract: A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.

Abstract: A system for storing an implantable device prior to a surgical implant procedure, comprising a sealable container and housed therein: a volume of solution, the solution comprising water/saline, and calcium chloride or sodium bicarbonate; and said implantable device suspended in the solution.

Abstract: A drive roll for driving and engaging a belt is disclosed as well as a hay baler incorporating such a drive roll. The drive roll includes at least one set and typically many sets of drive ribs, which project from the outer cylindrical surface of the drive roll. The drive roll may be made from steel material while the drive ribs may comprise laser cladding such as tungsten carbide or other high hardness particles. The drive rib may have a tapering profile or other centering structure that corresponds to a belt having end regions with overlay or overlap ends of the drive ribs.

Abstract: Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.

Abstract: Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.

Abstract: A blade for a mower disc body is provided. The blade includes a cutting blade body of a first base material, top and bottom surfaces and an outer surface that extends around the cutting blade body vertically between the top and bottom surfaces. The blade further includes a cutting edge formed along the outer surface and a plurality of clad beads extending along one of the top and bottom surfaces transversely away from the non-serrated cutting edge.

Abstract: A blade for a mower disc body is provided. The blade defines a central axis of rotation. The blade includes a blade body. The blade body is of a first hardness. The blade body has opposed top and bottom surfaces. An outer surface extends around the blade body vertically between the top and bottom surfaces. The blade body comprises first and second apertures or retainer structures in spaced apart relation. A cutting edge extends along an outer surface of the blade.

Abstract: Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM -utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.

Abstract: Provided herein are methods for treating, preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.

Abstract: One of first and second beams (28) of corresponding first and second light (13) are projected into an atmosphere (20) and at least one physical property of the atmosphere (20) is detected from the interference pattern (47) generated from the resulting scattered light (30). The first and second beams (20) are selected responsive to either a detected signal-to-noise ratio (SNR) or a detected aerosol-to-molecular ratio (AMR). The wavelength (740) of the first light (13) provides for either molecular or aerosol scattering, whereas the wavelength (738) of the second light (13) provides for primarily only aerosol scattering. In accordance with a second aspect, scattered light (30) from one or more beams (28) of substantially monochromatic light (13) projected into the atmosphere (20) and received from a plurality of interaction regions (17) or measurement volumes (52) provides for determining wind power (P*) within a region of the atmosphere (20).

Abstract: Compositions are provided comprising recombinant variants of the human clotting Factor Xa. Such compositions include a wide variety of isoforms and post-translational modifications of FXa and are useful for treating subjects in need of hemostasis.

Abstract: Systems, methods and computer-readable media for incident queue assignment and prioritization are disclosed. An incident handling system may receive a request for a next highest priority incident. An incident requiring resolution may be identified. The incident may be associated with an incident queue based at least in part on a queue assignment rule. The incident queue may comprise one or more incidents. The incident queue may be processed based at least in part on a prioritization rule to identify, from the one or more incidents associated with the incident queue, the next highest priority incident. The incident handling system may transmit the next highest priority incident associated with the incident queue.

Abstract: Provided herein are methods for treating, preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.

Abstract: An agricultural auger for conveying grain material is provided. The agricultural auger includes a shaft that is adapted to rotate about a central axis. A flight extends and spirals about the shaft. The flight further includes a base material of a first hardness. A laser treated material is formed on or into the base material along a portion of the flight. The laser treated material comprises a second hardness greater than the first hardness.