Abstract: Disclosed are compositions and methods for treating heart failure and cardiac damage that can lead to heart failure if left untreated comprising administering to a subject in need thereof a composition comprising an HSP60 derived peptide and an adjuvant.

Abstract: An aspect of the disclosure pertains to detecting a position of a blood pressure measurement device. An inflatable bladder of the blood pressure measurement device defines, at least in part, a pressurizable volume. The inflatable bladder may be inflated to pressurize a user's appendage and temporarily occlude blood flow in the user's appendage. A pump may initiate inflation of the inflatable bladder when one or more accelerometers and/or one or more proximity sensors determine that the blood pressure measurement device is within sufficient proximity or elevation to a user's heart and stationary.

Abstract: A valve assembly includes a valve body and an opening extending through the valve body along a longitudinal axis. The valve assembly also includes a valve member arranged within the opening, the valve member being movable, along the longitudinal axis, between an open position and a closed position. The valve assembly includes an upper seal positioned to seal against at least a first portion of the valve body. The valve assembly includes a lower seal positioned to seal against at least a second portion of the valve body, wherein both the upper seal and the lower seal travel with the valve member as the valve member moves between the open position and a closed position.

Abstract: A valve assembly includes a valve body and an opening extending through the valve body along a longitudinal axis. The valve assembly also includes a valve member arranged within the opening, the valve member being movable, along the longitudinal axis, between an open position and a closed position. The valve assembly includes an upper seal positioned to seal against at least a first portion of the valve body. The valve assembly includes a lower seal positioned to seal against at least a second portion of the valve body, wherein both the upper seal and the lower seal travel with the valve member as the valve member moves between the open position and a closed position.

Abstract: An apparatus for actuating an end-member is disclosed. The apparatus includes a housing, a spring within the housing, and a spring plate forming a restriction for the spring within the housing. A brake member is associated with the spring plate for retaining the spring plate in one or more positions. A drive rod is associated with a motor to enable a first movement of the drive rod and to enable a second movement of spring plate. The first movement or the second movement enables the actuating of the end-member in one or more different positions for the end-member. The brake member may be engaged or disengaged to control or decouple spring compression forces in the actuator when the spring is compressed.

Abstract: An aspect of the disclosure pertains to detecting a position of a blood pressure measurement device. An inflatable bladder of the blood pressure measurement device defines, at least in part, a pressurizable volume. The inflatable bladder may be inflated to pressurize a user's appendage and temporarily occlude blood flow in the user's appendage. A pump may initiate inflation of the inflatable bladder when one or more accelerometers and/or one or more proximity sensors determine that the blood pressure measurement device is within sufficient proximity or elevation to a user's heart and stationary.

Abstract: A well tool assembly can include a well barrier and a detachable sub connected to the well barrier. The detachable sub can include a sensor data receiver. A method of retrieving sensor data can include positioning a sensor on one side of a well barrier, connecting a detachable sub on an opposite side of the well barrier, the detachable sub including a sensor data receiver configured to receive sensor data from the sensor, and conveying the well barrier, the sensor and the detachable sub together into a well. A system can include a sensor, a detachable sub, and a well barrier positioned between the sensor and the detachable sub, the detachable sub including a sensor data receiver, a passage extending longitudinally through the detachable sub, and a closure that selectively opens and blocks the passage.

Abstract: Various embodiments are directed to group-based data storage systems configured for maintaining data exchanged between client devices within channel-specific shards each corresponding with one or more group-identifiers to provide group-based access to those channel-specific shards and for applying group-specific policies for data stored within those channel-specific shards. Membership of particular users within particular groups and within particular channels may be monitored such that access to particular channel shards may be controlled based on group-memberships of the users, and access to data stored within particular channel shards may be controlled based on channel-memberships of the users.

Abstract: A valve assembly includes a valve body and a valve member extending through at least a portion of the valve body. The valve assembly also includes a seat pocket forming an annular recess in the valve body and a seat arrangement positioned at least partially within the seat pocket. The seat arrangement includes a lower seat extending radially inward from the annular recess toward the valve cavity axis. The seat arrangement also includes an upper seat at least partially overlapping the lower seat, the upper seat extending radially inward toward the valve cavity axis to contact the valve member along a seat face. The seat arrangement further includes an interface seal positioned along an interface between the upper seat and the lower seat, the interface seal receiving a fluid pressure to drive the lower seat radially outward and into the annular recess.

Abstract: Various embodiments are directed to group-based data storage systems configured for maintaining data exchanged between client devices within channel-specific shards each corresponding with one or more group-identifiers to provide group-based access to those channel-specific shards and for applying group-specific policies for data stored within those channel-specific shards. Membership of particular users within particular groups and within particular channels may be monitored such that access to particular channel shards may be controlled based on group-memberships of the users, and access to data stored within particular channel shards may be controlled based on channel-memberships of the users.

Abstract: A tubular connection system includes a connector coupled to a tubular segment, the connector having a first bore with a first bore diameter and a mating connector coupled to the connector, the mating connector having a second bore with a second bore diameter. The connector includes a plurality of connector lugs extending into the first bore. The connector also includes a plurality of gaps, respective gaps of the plurality of gaps are arranged between adjacent connector lugs of the plurality of connector lugs in a first alternating pattern. The plurality of connectors lugs are arranged in connector lug rows. The mating connector includes a plurality of mating lugs radially outward. The mating connector also includes a plurality of openings, respective openings of the plurality of openings are arranged between adjacent mating lugs of the plurality of mating lugs. The plurality of mating lugs are arranged in mating lug rows.

Abstract: Techniques for committing back end computing resources to an online stream of requests for data from client devices are described herein. A polling schedule server (e.g., a reservation management system), may receive polling reservation requests from a plurality of client devices, may evaluate each client device's need for “fresh” data based on a number of input signals, and may assign the client device a polling slot (e.g., a reservation for a future polling time). The polling scheduler server may subsequently receive a polling request from a client device and, upon validating a token received from the client device as well as a difference between an assigned polling time and the polling request timestamp, may grant the polling request by transmitting a request to one or more communication system servers, receiving data from the communication system servers, and providing the data to the client device.

Abstract: A valve assembly includes a valve body and a valve member extending through at least a portion of the valve body. The valve assembly also includes a seat pocket forming an annular recess in the valve body and a seat arrangement positioned at least partially within the seat pocket. The seat arrangement includes a lower seat extending radially inward from the annular recess toward the valve cavity axis. The seat arrangement also includes an upper seat at least partially overlapping the lower seat, the upper seat extending radially inward toward the valve cavity axis to contact the valve member along a seat face. The seat arrangement further includes an interface seal positioned along an interface between the upper seat and the lower seat, the interface seal receiving a fluid pressure to drive the lower seat radially outward and into the annular recess.

Abstract: Methods, systems, and apparatuses are provided for reservation management for client-initiated polling requests in a communication system.

Abstract: A quick connect coupling mechanism joins an actuator to a bonnet. The quick connect coupling mechanism may utilize machined or otherwise prepared components including one or more specific features, such as slots or grooves, to facilitate a connection between the actuator and the bonnet. For example, the actuator housing may be machined or formed to include an opening to enable radial insertion of the bonnet into a slot formed circumferentially about at least a portion of the actuator housing. The opening may be secured to block radial movement of the bonnet within the housing. A rail system may also be utilized to couple the actuator housing to the bonnet. For example, pairs of grooves may be formed in the actuator housing and bonnet to facilitate insertion of rails. The rails may block both axial movement of the actuator housing and also block rotational movement.

Abstract: Low-profile latching mechanisms and related mechanical interfaces for allowing straps and other fastening accessories for limb-wearable devices are provided. The mechanisms in question allow for a very strong, yet easily releasable, connection to be made between a strap accessory and a device housing, with very little of the mechanism being visible.

Abstract: An aspect of the disclosure pertains to finger blood pressure cuff. The finger blood pressure cuff may include a housing having an opening sized to receive a human finger and an inflatable elastic bladder disposed about an inward-facing surface of the opening. The inflatable elastic bladder may be inflated to pressurize a user's finger and temporarily occlude blood flow in the user's finger. The finger blood pressure cuff may include a pressure sensor for obtaining blood pressure measurements.

Abstract: Various embodiments herein include at least one of devices, systems, methods, and software of communication and signaling devices. One device embodiment includes a visual signaling output, at least one radio transceiver, and a network interface device. This device further includes a processor and a memory device storing instructions executable by the processor to cause the device to perform data processing activities that may include receiving an identifier via the at least one radio transceiver, outputting a work in progress indicator from the visual signaling output, and transmitting the received identifier via the network interface device to a network service. These data processing activities further include receiving a payment success indicator via the network interface device indicating whether a payment was successfully processed with regard to the received identifier. The data processing activities may then output an indication of the received payment success indicator from the visual signaling output.

Abstract: Embodiments of the present disclosure include a system for coupling objects in a wellbore includes a unidirectional valve having a body. The body includes two or more body lugs extending radially outward, each body lug of the two or more body lugs extending at least a portion of a circumferential distance of the body. The system also includes a tubing hanger having a bore that receives the unidirectional valve. The bore includes an axial restraint system that receives the two or more body lugs and blocks axial movement of the unidirectional valve in a first position and enables axial movement of the unidirectional valve in a section position, the unidirectional valve being non-threadingly coupled to the tubing hanger.

Abstract: An apparatus (10) for downhole data acquisition and/or monitoring is configured to be disposed within a completion (12) and comprises a hanger (36) configured to latch into a control line spool (38), a retrofit valve (40) for location within the subsurface safety valve (16) of the completion (12), and a sensing arrangement (42) including an optical fiber line (44). In use, the apparatus (10) is configured to be run into the completion (12) and is operable to provide data acquisition and/or monitoring capability in the well, including up or near total depth and in particular but not exclusively in the region of the well subjected to an intervention operation, such as a chemical injection operation.