Abstract: The present invention generally relates to a process for transferring a graphitic thin film and a kit for the same.

Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.

Abstract: In some embodiments provided herein is a method of preparing cargo-loaded platelets, comprising: treating platelets with a cargo and with a loading buffer comprising a salt, a base, a loading agent, and optionally ethanol, to form the cargo-loaded platelets.

Abstract: Provided herein are RNA agent-loaded platelets, methods of preparing RNA agent-loaded platelets, and methods of using RNA agent-loaded platelets. In some embodiments, methods of loading RNA agents into platelets include treating platelets with a RNA agent, a cationic transfection reagent, and a loading buffer that can include a salt, a base, a loading agent, and optionally at least one organic solvent.

Abstract: In some embodiments provided herein is a method of preparing cargo-loaded platelets, comprising: treating platelets with a cargo and with a loading buffer comprising a salt, a base, a loading agent, and optionally ethanol, to form the cargo-loaded platelets.

Abstract: Provided herein are mRNA agent-loaded platelets, methods of preparing mRNA agent-loaded platelets, and methods of using mRNA agent-loaded platelets. In some embodiments, methods of loading mRNA agents into platelets include treating platelets with an mRNA agent, a transfection reagent, and a loading buffer that can include a salt, a base, a loading agent, and optionally at least one organic solvent.

Abstract: A handgun sear has a sear body extending between a proximal end portion to a distal end portion. The sear defines a first engagement surface adjacent the proximal end portion and a second engagement surface positioned distally of the first engagement surface. The sear can pivot about the distal end portion between a cocked position and a displaced position. The second engagement surface can be used to arrest forward movement of the striker in the event of an impulse that causes the striker to disengage from the first engagement surface. The sear may be incorporated into a fire control assembly of a semiautomatic handgun or other firearm.

Abstract: A propulsion system for an orbiting vehicle such as a low-Earth orbit (LEO) satellite includes a set of surfaces over which a gas passes during orbital flight, and a plurality of electrodes on the surfaces. The electrodes are configured to create an electric field having a spatial field pattern in response to field signals, experienced by passing gas molecules as an oscillating field having a frequency on the order of a polarization-resonance frequency of the molecules to impart a propulsive traveling-wave dielectrophoretic force to the passing molecules. The electrodes extend over sufficient area to impart sufficient traveling-wave dielectrophoretic force to the gas to overcome aerodynamic drag and thereby sustain orbital flight of the vehicle. A power source applies the field signals to the electrodes, providing sufficient power to overcome power lost to aerodynamic drag and thereby sustain orbital flight.

Abstract: Medical kits and methods for performing small incision DLEK include a corneal transplantation donor tissue graft formed into an implantable and compact rolled configuration using the flexible substrate.

Abstract: The present invention generally relates to a process for transferring a graphitic thin film and a kit for the same.

Abstract: An interactive system and method allow for broadcast of basic content data along with data that define graphical inserts that can be played with or super-imposed on screens of the decoded broadcast. Coordinated pages or screens may be transmitted to audience secondary devices, such as smart phones, tablet computers, and so forth. Audience members may participate in an interactive experience by selecting options provided on the secondary devices. Audience responses are received, aggregated, and rules applied in accordance with the desired experience. The graphical indicia are altered during the broadcast, and optionally during or just following a period for audience feedback.

Abstract: A first notification of a first action by a user with respect to a first content item may be received by a computer system, the first content item having a first relationship to the user. A second notification of a second notification by the user with respect to a second content item may be received by the computer system. The second content item may have a second relationship to the user, and at least a portion of the second content item may correspond to at least a portion of the first content item. A first property of the first relationship may be managed by the computer system based on the second notification.

Abstract: Medical kits and methods for performing small incision DLEK include a corneal transplantation donor tissue graft formed into an implantable and compact rolled configuration using the flexible substrate.

Abstract: A handgun sear has a sear body extending between a proximal end portion to a distal end portion. The sear defines a first engagement surface adjacent the proximal end portion and a second engagement surface positioned distally of the first engagement surface. The sear can pivot about the distal end portion between a cocked position and a displaced position. The second engagement surface can be used to arrest forward movement of the striker in the event of an impulse that causes the striker to disengage from the first engagement surface. The sear may be incorporated into a fire control assembly of a semiautomatic handgun or other firearm.

Abstract: There is a temperature activated spring hinge comprising hinge section comprising at least one door leaf and at least one hinge leaf. There is also a fuse which is configured to react in response to an elevated temperature. The fuse can be positioned inside one of the knuckles of the door leaf. There is also a biasing element configured to bias the hinge in a closed position. In at least one embodiment the biasing element is a spring. There is also at least one guide configured to guide a movement of the hinge when the hinge moves from an open position to a closed position.

Abstract: Devices and methods for cataract surgery include a tip with reciprocating door to chop, fragment or reduce size of large nuclear lens fragments and/or cortex fragments in a capsule bag to facilitate aspiration.

Abstract: Methods and systems for correcting presbyopia using a surgical excimer laser include activating the laser once and transmitting a pre-defined three dimensional ablation profile to treat presbyopia based on the single activating step.

Abstract: A wireless communication device includes a first circuit including a baseband circuit and a radio circuit, and at least one frontend module (FEM) remote from the first circuit and placed in close proximity to and coupled to at least one radio-frequency (RF) antenna. The FEM is coupled to the first circuit via interface circuitry. An FEM comprises a frontend (FE) circuit including one or more low-noise amplifiers (LNAs), one or more power amplifiers (PAs), and at least one of a multi-pole switch and a multiplexer. The multi-pole switch and the multiplexer being implemented on a first side of the FEM coupled to the interface circuitry. The interface circuitry includes at least some of filters, splitters, multi-pole switches, and multiplexers to reduce a count of interconnect routes to the at least one FEM.

Abstract: A propulsion system for an orbiting vehicle such as a low-Earth orbit (LEO) satellite includes a set of surfaces over which a gas passes during orbital flight, and a plurality of electrodes on the surfaces. The electrodes are configured to create an electric field having a spatial field pattern in response to field signals, experienced by passing gas molecules as an oscillating field having a frequency on the order of a polarization-resonance frequency of the molecules to impart a propulsive traveling-wave dielectrophoretic force to the passing molecules. The electrodes extend over sufficient area to impart sufficient traveling-wave dielectrophoretic force to the gas to overcome aerodynamic drag and thereby sustain orbital flight of the vehicle. A power source applies the field signals to the electrodes, providing sufficient power to overcome power lost to aerodynamic drag and thereby sustain orbital flight.