Patents by Inventor Keith Demarest

Keith Demarest has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
    Patent number: 7875744
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: January 25, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan DeAngelis, Keith Demarest, Patricia Pelton
  • SUBSTITUTED PYRROLINES AS KINASE INHIBITORS
    Publication number: 20100240650
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: May 25, 2010
    Publication date: September 23, 2010
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrroline kinase inhibitors
    Patent number: 7786135
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: August 31, 2010
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • Substituted pyrroline kinase inhibitors
    Patent number: 7781450
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: August 24, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • GPR40 agonists
    Patent number: 7750048
    Abstract: The invention is directed to compounds of Formula (I) useful as GPR40 agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, insulin resistance, hyperglycemia, obesity, diabetes such as NIDDM, and other disorders related to lipid metabolism, energy homeostasis, and complications thereof, using compounds of the invention are also described.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: July 6, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gee-Hong Kuo, Fengbin Song, Joseph Gunnet, Keith Demarest
  • 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS
    Publication number: 20090318332
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Application
    Filed: August 28, 2009
    Publication date: December 24, 2009
    Inventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan DeAngelis, Keith Demarest, Patricia Pelton
  • Substituted pyrrolines as kinase inhibitors
    Patent number: 7608634
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: October 27, 2009
    Assignee: Janssen Pharmaceutica NV
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
    Patent number: 7598416
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: October 6, 2009
    Assignee: Janssen Pharmaceutica N. V.
    Inventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan DeAngelis, Keith Demarest, Patricia Pelton
  • SUBSTITUTED PYRROLINE KINASE INHIBITORS
    Publication number: 20090181982
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: March 11, 2009
    Publication date: July 16, 2009
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • SUBSTITUTED PYRROLINE KINASE INHIBITORS
    Publication number: 20090176806
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: March 11, 2009
    Publication date: July 9, 2009
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS
    Publication number: 20080269336
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Application
    Filed: June 23, 2008
    Publication date: October 30, 2008
    Inventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan DeAngelis, Keith Demarest, Patricia Pelton
  • 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
    Patent number: 7425649
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: September 16, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan DeAngelis, Keith Demarest, Patricia Pelton
  • GPR40 AGONISTS
    Publication number: 20080176912
    Abstract: The invention is directed to compounds of Formula (I) useful as GPR40 agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, insulin resistance, hyperglycemia, obesity, diabetes such as NIDDM, and other disorders related to lipid metabolism, energy homeostasis, and complications thereof, using compounds of the invention are also described.
    Type: Application
    Filed: November 13, 2007
    Publication date: July 24, 2008
    Inventors: Gee-Hong Kuo, Fengbin Song, Joseph Gunnet, Keith Demarest
  • COMBINATION THERAPY COMPRISING GLUCOSE REABSORPTION INHIBITORS AND PPAR MODULATORS
    Publication number: 20080096802
    Abstract: Combination therapy comprising PPAR modulators and glucose reabsorption inhibitors useful for the treatment of diabetes and Syndrome X are disclosed.
    Type: Application
    Filed: October 24, 2007
    Publication date: April 24, 2008
    Inventors: JACQUELINE Bussolari, Xiaoli Chen, Bruce Conway, Keith Demarest, Hamish Ross, Rafael Severino
  • SUBSTITUTED SPIROHETEROCYCLES
    Publication number: 20080076753
    Abstract: The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal insufficiency, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Application
    Filed: September 19, 2007
    Publication date: March 27, 2008
    Inventors: Min Xiang, Mona Patel, Philip Rybczynski, Joseph Gunnet, Keith Demarest, Richard Look, Bruce Maryanoff, Michael Costanzo, Stephen Yabut
  • SUBSTITUTED SPIROHETEROCYCLES
    Publication number: 20080076754
    Abstract: The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Application
    Filed: September 19, 2007
    Publication date: March 27, 2008
    Inventors: Min Xiang, Mona Patel, Philip Rybczynski, Joseph Gunnet, Keith Demarest, Richard Look, Bruce Maryanoff, Michael Costanzo, Stephen Yabut
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20070213386
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: May 8, 2007
    Publication date: September 13, 2007
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, David McComsey, Kimberly White, Hong Ye, Leonard Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20070213387
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: May 8, 2007
    Publication date: September 13, 2007
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, David McComsey, Kimberly White, Hong Ye, Leonard Hecker, Bruce Conway, Keith Demarest
  • SUBSTITUTED DIPIPERIDINE CCR2 ANTAGONISTS
    Publication number: 20070197590
    Abstract: Substituted dipiperidine compounds of Formula (I) or a form thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.
    Type: Application
    Filed: January 31, 2007
    Publication date: August 23, 2007
    Inventors: Duane DeMong, Mingde Xia, Scott Pollack, Xiaoping Zheng, James Brackley, Michael Wachter, Druie Cavender, Keith Demarest
  • Substituted pyrrolines as kinase inhibitors
    Patent number: 7232906
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: June 19, 2007
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest