Patents by Inventor Keith Demarest

Keith Demarest has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted tetralins and indanes
    Publication number: 20060247314
    Abstract: The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Application
    Filed: June 3, 2005
    Publication date: November 2, 2006
    Inventors: Xiaoli Chen, Keith Demarest, Jung Lee, Jay Matthews, Philip Rybczynski
  • Substituted pyrroline kinase inhibitors
    Patent number: 7125878
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: October 24, 2006
    Assignee: Janssen Pharmaceutica
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • Substituted pyrroline kinase inhibitors
    Publication number: 20060205763
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 17, 2006
    Publication date: September 14, 2006
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce Conway, David McComsey
  • Substituted pyrroline kinase inhibitors
    Publication number: 20060205762
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 17, 2006
    Publication date: September 14, 2006
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce Conway, David McComsey
  • Arylindenopyridines and related therapeutic and prophylactic methods
    Publication number: 20060154949
    Abstract: This invention provides novel arylindenopyridines of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing Adensine A2a receptors or reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
    Type: Application
    Filed: January 24, 2005
    Publication date: July 13, 2006
    Inventors: Geoffrey Heintzelman, Kristin Averill, John Dodd, Keith Demarest, Yuting Tang, Paul Jackson
  • Treating syndrome X with substituted tetralins and indanes
    Publication number: 20060094786
    Abstract: The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.
    Type: Application
    Filed: June 3, 2005
    Publication date: May 4, 2006
    Inventors: Xiaoli Chen, Keith Demarest, Jung Lee, Jay Matthews, Philip Rybczynski
  • Methods of using substituted tetralins and indanes
    Publication number: 20060074130
    Abstract: The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.
    Type: Application
    Filed: June 3, 2005
    Publication date: April 6, 2006
    Inventors: Xiaoli Chen, Keith Demarest, Jung Lee, Jay Matthews, Philip Rybczynski
  • 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
    Publication number: 20060058382
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Application
    Filed: September 14, 2005
    Publication date: March 16, 2006
    Inventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan DeAngelis, Keith Demarest, Patricia Pelton
  • 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
    Publication number: 20060058393
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Application
    Filed: September 14, 2005
    Publication date: March 16, 2006
    Inventors: Alan DeAngelis, Keith Demarest, Gee-Hong Kuo, Patricia Pelton, Aihua Wang, Rui Zhang
  • Substituted pyrrolines as kinase inhibitors
    Patent number: 6987110
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: January 17, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye, Bruce R. Conway, Keith Demarest
  • Arylindenopyridines and related therapeutic and prophylactic methods
    Publication number: 20050239782
    Abstract: This invention provides novel arylindenopyridines of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing Adensine A2a receptors or reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
    Type: Application
    Filed: June 8, 2005
    Publication date: October 27, 2005
    Inventors: Geoffrey Heintzelman, Kristin Averill, John Dodd, Keith Demarest, Yuting Tang, Paul Jackson
  • Methods of using peroxisome proliferator-activated receptor alpha target genes
    Publication number: 20050191668
    Abstract: This invention features the identification of novel target genes for peroxisome proliferator-activated receptors alpha (PPAR?) in human, and their use in treating or monitoring the treatment of metabolic abnormalities, as well as in identifying compounds useful for treating metabolic abnormalities.
    Type: Application
    Filed: January 14, 2005
    Publication date: September 1, 2005
    Inventors: Lubing Zhou, Ellen Cryan, Keith Demarest
  • Macroheterocylic compounds useful as kinase inhibitors
    Patent number: 6828327
    Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: December 7, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Gee-Hong Kuo, Han-Cheng Zhang, Catherine Prouty, Alan DeAngelis, Peter Connolly, William V. Murray, Lan Shen, Bruce Conway, Keith Demarest, Chandra R. Shah, Bruce E. Maryanoff, Kimberly B. White
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20040059113
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: June 4, 2003
    Publication date: March 25, 2004
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye, Bruce R. Conway, Keith Demarest
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20040054180
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: June 4, 2003
    Publication date: March 18, 2004
    Inventors: Han Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrroline kinase inhibitors
    Publication number: 20040006095
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 6, 2003
    Publication date: January 8, 2004
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • Macroheterocylic compounds useful as kinase inhibitors
    Publication number: 20030078280
    Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: December 6, 2001
    Publication date: April 24, 2003
    Inventors: Gee-Hong Kuo, Han-Cheng Zhang, Catherine Prouty, Alan DeAngelis, Peter Connolly, William V. Murray, Lan Shen, Bruce Conway, Keith Demarest, Chandra R. Shah, Bruce E. Maryanoff, Kimberly B. White
  • Trifluoromethybenzylphosphonates useful in treating osteoporosis
    Patent number: 5532226
    Abstract: Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.
    Type: Grant
    Filed: December 9, 1993
    Date of Patent: July 2, 1996
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Keith Demarest, Charles Schwender, David Wustrow
  • Trifluoromethylbenzylphosphonates useful in treating osteoporosis
    Patent number: 5300687
    Abstract: Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.
    Type: Grant
    Filed: July 18, 1991
    Date of Patent: April 5, 1994
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Charles Schwender, Keith Demarest, David Wustrow