Abstract: A super-resolution system for nano-patterning is disclosed, comprising an exposure head that enables a super-resolution patterning exposures. The super-resolution exposures are carried out using electromagnetic radiation and plasmonic structures, and in some embodiments, plasmonic structures having specially designed super-resolution apertures, of which the “bow-tie” and “C-aperture” are examples. These apertures create small but bright images in the near-field transmission pattern. A writing head comprising one or more of these apertures is held in close proximity to a medium for patterning. In some embodiments, a data processing system is provided to re-interpret the data to be patterned into a set of modulation signals used to drive the multiple individual channels and multiple exposures.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: The quality of service one may expect from a given network is often hard to determine in advance. Further, given agreements between network service providers and a variety of content providers, the complexity inherent in selecting a given available network is increasing for consumers. Embodiments described herein provide mechanisms for creating an augmented reality presentation of networks and the service quality of those networks. The presentation may display information regarding a variety of factors including content transit agreements with content providers, quality-of-service or prioritization guarantees for certain types of content, or low-level Wi-Fi signal quality. These presentations allow users to ascertain where in a given spatial area good quality is available for whichever services they intend to use.

Abstract: Systems and methods are provided for securing laminates to mandrels. One embodiment is a method for facilitating layup of preforms, the method including selecting a mandrel that includes at least one receptacle, disposing a first vacuum bag atop the mandrel that covers the receptacle, selecting a Ply Location Template (PLT) that includes a securement element, aligning a portion of the securement element with the receptacle, pressing the portion of the securement element downward into the first vacuum bag and driving the portion of the securement element into the receptacle, and abutting a preform against the PLT.

Abstract: Systems and methods are provided for securing laminates to mandrels. One embodiment is a method for facilitating layup of preforms, the method including selecting a mandrel that includes at least one receptacle, disposing a first vacuum bag atop the mandrel that covers the receptacle, selecting a Ply Location Template (PLT) that includes a securement element, aligning a portion of the securement element with the receptacle, pressing the portion of the securement element downward into the first vacuum bag and driving the portion of the securement element into the receptacle, and abutting a preform against the PLT.

Abstract: A medical instrument comprising: (A) a first joint comprising a first member and a second member, the first member configured to be repositionable with respect to the second member in an X-Y plane; (B) a second joint operatively coupled to the first joint, the second joint comprising a third member and a fourth member, the third member configured to be repositionable with respect to the fourth member in a Y-Z plane perpendicular to the X-Y plane; and, (C) a controller operatively coupled to the first joint and the second joint, the controller including a first control configured to direct repositioning of at least one of the first member and the second member, and a second control configured to direct repositioning of at least one of the third member and the fourth member.

Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 3, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound.

Abstract: There is provided the use of compounds of formula I wherein R1, R2, R3 and X have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula I per se.

Abstract: A method for producing a barrier layer and a carrier body including such a barrier layer are disclosed. In an embodiment the method includes providing a carrier body including a polymer film having at least one polymer, drying the barrier interface, exposing the barrier interface to one reagent gas, or to a plurality of reagent gases which do not chemically react with each other, so that the at least one reagent gas chemically reacts with the at least one polymer at least inside the polymer film in at least one chemical reaction thereby forming the barrier layer, and removing at least one product gas of the at least one chemical reaction.

Abstract: Systems and methods are provided in which a speaker profile-data inquiry is transmitted to a mobile device associated with a first speaker. In response to the speaker-profile-data inquiry, speaker profile data associated with the first speaker is received. Audio data representing a voice input is received. The first speaker is identified as providing the voice input, the identification being based on a comparison of characteristics of the received audio data with the speaker profile data of a plurality of speakers for whom speaker profile data is stored. An instruction, which includes a speaker-relative signifier, is determined from the received audio data, and determining the instruction includes determining a referent of the speaker-relative signifier based on the first speaker profile data. An action indicated by the instruction is performed.

Abstract: A medical instrument comprising: (A) a first joint comprising a first member and a second member, the first member configured to be repositionable with respect to the second member in an X-Y plane; (B) a second joint operatively coupled to the first joint, the second joint comprising a third member and a fourth member, the third member configured to be repositionable with respect to the fourth member in a Y-Z plane perpendicular to the X-Y plane; and, (C) a controller operatively coupled to the first joint and the second joint, the controller including a first control configured to direct repositioning of at least one of the first member and the second member, and a second control configured to direct repositioning of at least one of the third member and the fourth member.

Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.

Abstract: The quality of service one may expect from a given network is often hard to determine in advance. Further, given agreements between network service providers and a variety of content providers, the complexity inherent in selecting a given available network is increasing for consumers. Embodiments described herein provide mechanisms for creating an augmented reality presentation of networks and the service quality of those networks. The presentation may display information regarding a variety of factors including content transit agreements with content providers, quality-of-service or prioritization guarantees for certain types of content, or low-level Wi-Fi signal quality. These presentations allow users to ascertain where in a given spatial area good quality is available for whichever services they intend to use.

Abstract: Various methods and circuital arrangements for biasing one or more gates of stacked transistors of an amplifier are possible where the amplifier is configured to operate in at least an active mode and a standby mode. Circuital arrangements can reduce bias circuit and stacked transistors standby current during operation in the standby mode and to reduce impedance presented to the gates of the stacked transistors during operation in the active mode while maintaining voltage compliance of the stacked transistors during both modes of operation.

Abstract: Review systems and methods facilitate active reading by providing a flexible environment in which users can examine documents. A review system can comprise a virtual workspace, a document view region, a preview region, and optional document objects. The virtual workspace can simulate a desktop or other physical workspace. The document view region can display a portion of an open document at a magnification sufficient for reading. The preview region can display the document at a magnification sufficient to enable the general layout of the entire document to be determined. The document objects can be created from the document through tools of the review system. These document objects can be independently moveable throughout the virtual workspace as needed to facilitate the user's active reading process.

Abstract: An artificial disc to replace a damaged spinal disc in a spinal column includes a resilient core which is fixedly connected to first and second plates. The first and second plates engage upper and lower vertebra in the patient's spine. The inner side of at least one of the first and second plates has an array of recesses into which said resilient core extends. The array of recesses includes a plurality of recesses. Each of the recesses of the plurality of recesses has surfaces which are integrally formed as one piece with the plate.

Abstract: Systems and methods are presented for crowdsourcing generalized smart home automation scenes. One embodiment takes the form of a method comprising: receiving a first scene definition comprising a first plurality of destination states for a first plurality of home automation devices, the home automation devices being associated with a location in a first home; for each of the home automation devices: determining a location in the second home corresponding to the location in the first home; identifying an analogous home automation device at that location in the second home; and determining an analogous destination state for the analogous home automation device in second home; storing a second home automation scene comprising the analogous home automation devices and respective analogous destination states; and causing the analogous home automation devices in the second home to operate in the respective analogous destination state upon user selection of the second home automation scene.

Abstract: A laparoscopic device comprising: (a) a housing operatively coupled to a first control and a second control; (b) an end effector operatively coupled to the first control, the end effector comprising a first component and a second component selectively repositionable with respect to one another within an X-Y plane, the end effector also including a third component selectively repositionable with respect to the second component within an Y-Z plane; (c) a laparoscopic conduit extending between the housing and the end effector; and, (d) an occlusion clip deployment device operatively coupled to the end effector and the second control.

Abstract: The Scrape and Sweep Broom Handle Attachment is a scraping tool with special features that allow it to be quickly attached to the ends of broom and mop handles, so it doubles the effectiveness of brooms and mops as cleaning tools. Brooms and mops are some of the most commonly used cleaning tools in the world because they are highly effective at removing loose debris from floors; but when wet food and dirt dry and become stuck to floors, it often becomes necessary for people who are sweeping or mopping those floors to stop, then find other tools and get down on their hands and knees to scrape the stuck-on food and dirt loose, and then resume sweeping or mopping. When a person has a Scrape and Sweep Broom Handle Attachment on the end of their broom or mop handle though, it's not necessary for them to find another tool and get down on the floor; that person may simply turn their broom or mop around, remain standing, scrape off whatever is stuck, and then sweep or mop it away.

Abstract: The present disclosure provides a biodegradable drug delivery composition including a vehicle and an insoluble component comprising beneficial agent dispersed in the vehicle. Typically, the composition is not an emulsion, but has a low viscosity and further provides for minimized initial burst and sustained release of the beneficial agent over time. Also provided, are kits including the biodegradable drug delivery composition or components thereof, as well as methods of making and using the biodegradable drug delivery composition.