Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.

Abstract: The present invention relates to a gutter mount which is particularly for use on outbuildings and temporary structures, such as sheds. The gutter mount comprises an adjustable retaining member for receiving the guttering, allowing the guttering to be retained in the correct position independent of roof angle, and a means of fastening the gutter mount to a structure. Additionally the gutter mount incorporates a design which can be affixed to a structure by hand, obviating the needs for tools and facilitating repositioning of the guttering during installation.

Abstract: The Scrape and Sweep Broom Handle Attachment is a scraping tool with special features that allow it to be quickly attached to the ends of broom and mop handles, so it doubles the effectiveness of brooms and mops as cleaning tools. Brooms and mops are some of the most commonly used cleaning tools in the world because they are highly effective at removing loose debris from floors; but when wet food and dirt dry and become stuck to floors, it often becomes necessary for people who are sweeping or mopping those floors to stop, then find other tools and get down on their hands and knees to scrape the stuck-on food and dirt loose, and then resume sweeping or mopping. When a person has a Scrape and Sweep Broom Handle Attachment on the end of their broom or mop handle though, it's not necessary for them to find another tool and get down on the floor; that person may simply turn their broom or mop around, remain standing, scrape off whatever is stuck, and then sweep or mop it away.

Abstract: A method for producing a barrier layer and a carrier body including such a barrier layer are disclosed. In an embodiment the method includes providing a carrier body including a polymer film having at least one polymer, drying the barrier interface, exposing the barrier interface to one reagent gas, or to a plurality of reagent gases which do not chemically react with each other, so that the at least one reagent gas chemically reacts with the at least one polymer at least inside the polymer film in at least one chemical reaction thereby forming the barrier layer, and removing at least one product gas of the at least one chemical reaction.

Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.

Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.

Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.

Abstract: A method of producing a jerky dog treat, comprising, tumbling, under vacuum, a mixture comprising diced chicken, salt, and water for about 5 minutes, tumbling, under vacuum, the mixture further comprising one or more additional ingredients for about 15 minutes, molding the mixture into one or more strips comprising the jerky dog treat that are placed on a screen, and cooking the one or more strips in an oven.

Abstract: A method of producing a jerky dog treat, comprising, tumbling, under vacuum, a mixture comprising diced chicken, salt, and water for about 5 minutes, tumbling, under vacuum, the mixture further comprising one or more additional ingredients for about 15 minutes, molding the mixture into one or more strips comprising the jerky dog treat that are placed on a screen, and cooking the one or more strips in an oven.

Abstract: A turbofan exhaust nozzle includes: a conical inner shell disposed coaxially inside a surrounding outer shell to define an annular flow duct therebetween terminating in an outlet at a trailing edge of the outer shell and the inner shell terminates in a trailing edge aft of the outlet; and a pylon interrupting circumferentially the duct, wherein at least a portion of the trailing edge of the outer shell is vertically non-coplanar.

Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.

Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.

Abstract: A medical instrument comprising: (a) a first joint comprising a first member and a second member, the first member configured to be repositionable with respect to the second member in a first degree of freedom; (b) a second joint operatively coupled to the first joint, the second joint comprising a third member and a fourth member, the third member configured to be repositionable with respect to the fourth member in a second degree of freedom; (c) a pair of repositionable jaws operatively coupled to the first joint and the second joint; (d) an open-ended occlusion clip detachably mounted to the pair of repositionable jaws; and, (e) a controller operatively coupled to the first joint, the second joint, and the pair of repositionable jaws, the controller including a first control configured to direct repositioning of at least one of the first member and the second member, and a second control configured to direct repositioning of at least one of the third member and the fourth member, and a third control config

Abstract: A medical instrument including a first joint including a first member and a second member, the first member configured to be repositionable with respect to the second member in a first degree of freedom, a second joint operatively coupled to the first joint, the second joint including a third member and a fourth member, the third member configured to be repositionable with respect to the fourth member in a second degree of freedom, a pair of repositionable jaws operatively coupled to the first joint and the second joint, an open-ended occlusion clip detachably mounted to the pair of repositionable jaws, and a controller operatively coupled to the first joint, the second joint, and the pair of repositionable jaws, the controller including a control with a line operatively coupled to the first and second jaws in at least a gun tackle pulley configuration.

Abstract: A medical instrument comprising: (a) a first joint comprising a first member and a second member, the first member configured to be repositionable with respect to the second member in a first degree of freedom; (b) a second joint operatively coupled to the first joint, the second joint comprising a third member and a fourth member, the third member configured to be repositionable with respect to the fourth member in a second degree of freedom; (c) a pair of repositionable jaws operatively coupled to the first joint and the second joint; (d) an occlusion clip detachably mounted to the pair of repositionable jaws; and, (e) a controller operatively coupled to the first joint, the second joint, and the pair of repositionable jaws, the controller including a first control configured to direct repositioning of at least one of the first member and the second member, and a second control configured to direct repositioning of at least one of the third member and the fourth member, and a third control configured to dir

Abstract: A medical instrument comprising: (a) a first joint comprising a first member and a second member, the first member configured to be repositionable with respect to the second member in a first degree of freedom; (b) a second joint operatively coupled to the first joint, the second joint comprising a third member and a fourth member, the third member configured to be repositionable with respect to the fourth member in a second degree of freedom; (c) a pair of repositionable jaws operatively coupled to the first joint and the second joint; (d) an occlusion clip detachably mounted to the pair of repositionable jaws; and, (e) a controller operatively coupled to the first joint, the second joint, and the pair of repositionable jaws, the controller including a first control configured to direct repositioning of at least one of the first member and the second member, and a second control configured to direct repositioning of at least one of the third member and the fourth member, and a third control configured to dir

Abstract: An super-resolution system for nano-patterning is disclosed, comprising an optical printing head that enables a super-resolution lithographic exposures compatible with conventional optical lithographic processes. The super-resolution exposures are carried out using light directed onto a medium using plasmonic structures, and in particular using plasmonic structures using specially designed super-resolution apertures, of which the “bow-tie” and “C-aperture” are examples. These specially designed apertures create small but bright images in the near-field transmission pattern. A printing head comprising an array of these apertures is held in close proximity to a medium for patterning. In some embodiments, a data processing system is provided to re-interpret the data to be patterned into a set of modulation signals used to drive the multiple individual channels and the multiple exposures.

Abstract: An electrosurgical device having a distal tip for creating a lesion on tissue includes a first electrode and a second electrode that are parallel for the delivery of RF energy to tissue. A sensor electrode is provided parallel to and spaced away from the first electrode a different distance than the second electrode. When the sensor electrode and at least one of the first and second electrodes are in contact with tissue. The electrosurgical device can perform at least one of the following: ablating tissue, and sensing at least one selected from the group of voltage, tissue impedance, electrical conduction, conduction time, conduction velocity, and signal phase angle.

Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.

Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.