Patents by Inventor Keith Graham

Keith Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE COMPOUNDS
    Publication number: 20250136599
    Abstract: Compounds of formula (I), formula (I), processes for their production and their use as pharmaceuticals.
    Type: Application
    Filed: November 15, 2024
    Publication date: May 1, 2025
    Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Stephan Siegel, Franziska Siegel, Volker Schulze, Markus Berger, Keith Graham, Detlev Sülzle, Ulf Bömer, Daniel Korr, Jens Schröder, Ursula Mönning, Michael Niehues, Matthew Meyerson, Heidi Greulich, Bethany Kaplan
  • 4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS
    Publication number: 20240307362
    Abstract: Compounds of formula (I), processes for their production and their use as pharmaceuticals are described herein.
    Type: Application
    Filed: April 22, 2020
    Publication date: September 19, 2024
    Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Stephan SIEGEL, Franziska SIEGEL, Volker SCHULZE, Markus BERGER, Keith GRAHAM, Stefan Nikolaus GRADL, Detlev SÜLZLE, Ulf BÖMER, Daniel KORR, Jens SCHRÖDER, Ursula MÖNNING, Michael NIEHUES, Matthew MEYERSON, Heidi GREULICH, Bethany KAPLAN, Hassan Youssef HARB, Phi Manh DINH
  • PHOSPHORUS DERIVATIVES AS NOVEL SOS1 INHIBITORS
    Publication number: 20240247015
    Abstract: The present invention covers phosphorus derivatives of general formula (I), in which R1, R2, R3, R4, R5, R6, X1, X2, X3, X4 and Y are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, especially diseases associated with SOS1, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: April 13, 2022
    Publication date: July 25, 2024
    Inventors: Felix PAPE, Steffen GRESSIES, Timo STELLFELD, Jeremie Xavier G MORTIER, Atanas Marinov KAMBUROV, Benjamin BADER, Keith GRAHAM, Roman HILLIG, Jens SCHRODER, Christoph Philipp HETHEY, Matthias ARLT, Gerhard SIEMEISTER, Katrin NOWAK-REPPEL, Michael ERKELENZ
  • N-[2-({4-[3-(ANILINO)-4-OXO-4,5,6,7-TETRAHYDRO-1H-PYRROLO[3,2-C]PYRIDIN-2-YL]PYRIDIN-3-YL)OXY)ETHYL]PROP-2-ENAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20230416249
    Abstract: Compounds of formula (I) processes for their production and their use as pharmaceuticals.
    Type: Application
    Filed: May 10, 2023
    Publication date: December 28, 2023
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Stephan SIEGEL, Franziska SIEGEL, Volker SCHULZE, Markus BERGER, Keith GRAHAM, Ulrich KLAR, Jeremie Xavier G. MORTIER, Detlev SÜLZLE, Ulf BÖMER, Daniel KORR, Jens SCHRÖDER, Matthew MEYERSON, Heidi GREULICH, Bethany KAPLAN
  • PYRIDO[2,3-D]PYRIMIDIN-4-AMINES AS SOS1 INHIBITORS
    Publication number: 20230357239
    Abstract: The present invention covers Pyrido[2,3-d]pyrimidin-4-amines compounds of general formula (I): in which R1, R2, R3, A, x and y are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: September 15, 2021
    Publication date: November 9, 2023
    Inventors: Keith GRAHAM, Benjamin BADER, Jens SCHROEDER, Roman HILLIG, Hans BRIEM, Jeremie Xavier G. MORTIER, Felix PAPE, Steffen GRESSIES, Timo STELLFELD
  • 2-METHYL-AZA-QUINAZOLINES
    Publication number: 20230029385
    Abstract: The present invention covers 2-methyl-aza-quinazoline compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: October 14, 2020
    Publication date: January 26, 2023
    Inventors: Lars WORTMANN, Keith GRAHAM, Benjamin BADER, Roman HILLIG, Jens SCHROEDER, Philip LIENAU, Hans BRIEM
  • 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE COMPOUNDS
    Publication number: 20220298157
    Abstract: Compounds of formula (I), formula (I), processes for their production and their R use as pharmaceuticals.
    Type: Application
    Filed: April 22, 2020
    Publication date: September 22, 2022
    Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Stephan SIEGEL, Franziska SIEGEL, Volker SCHULZE, Markus BERGER, Keith GRAHAM, Detlev SÜLZLE, Ulf BÖMER, Daniel KORR, Jens SCHRÖDER, Ursula MÖNNING, Michael NIEHUES, Matthew MEYERSON, Heidi GREULICH, Bethany KAPLAN
  • 4H-pyrrolo[3,2-c]pyridin-4-one derivatives
    Patent number: 11339157
    Abstract: Compounds of formula (I) processes for their production and their use as pharmaceuticals.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: May 24, 2022
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Dana-Farber Cancer Institute, Inc., The Broad Institute, Inc.
    Inventors: Stephan Siegel, Franziska Siegel, Volker Schulze, Markus Berger, Keith Graham, Ulrich Klar, Knut Eis, Detlev Sülzle, Ulf Bömer, Daniel Korr, Kirstin Petersen, Ursula Mönning, Uwe Eberspächer, Dieter Moosmayer, Matthew Meyerson, Heidi Greulich, Bethany Kaplan, Hassan Youssef Harb, Phi Manh Dinh
  • HETERO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES
    Publication number: 20200216439
    Abstract: Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.
    Type: Application
    Filed: December 12, 2016
    Publication date: July 9, 2020
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Keith GRAHAM, Ulrich KLAR, Hans BRIEM, Gerhard SIEMEISTER, Ursula MÖNNING, Franz VON NUSSBAUM
  • Pyrazolopyridinamines as MKNK1 and MKNK2 inhibitors
    Patent number: 10487092
    Abstract: The present invention relates to substituted pyrazolopyridinamine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, inflammatory disease and disease associated with inflammatory pain, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: November 26, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Anja Giese, Ulrich Klar, Keith Graham, Georg Kettschau, Detlev Sülzle, Philip Lienau, Kirstin Petersen, Julien LeFranc, Nicole Schmidt
  • 4H-pyrrolo[3,2-C]pyridin-4-one derivatives
    Patent number: 10428063
    Abstract: Compound of formula (I), processes for their production and their use as pharmaceuticals.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: October 1, 2019
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Keith Graham, Ulrich Klar, Hans Briem, Volker Schulze, Gerhard Siemeister, Philip Lienau, René Tempel, Jozsef Bálint
  • 3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones
    Patent number: 10428044
    Abstract: Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: October 1, 2019
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Keith Graham, Ulrich Klar, Hans Briem, Marion Hitchcock, Lars Bärfacker, Knut Eis, Volker Schulze, Gerhard Siemeister, Wilhelm Bone, Jens Schröder, Simon Holton, Philip Lienau, René Tempel, Helmut Sonnenschein, Jozsef Bálint, Heinz Graubaum
  • 1H-pyrrol-3-amines
    Patent number: 10308629
    Abstract: Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: June 4, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Keith Graham, Ulrich Klar, Hans Briem, Gerhard Siemeister, Ursula Mönning
  • 3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones
    Patent number: 10227299
    Abstract: Compounds of formula (I) as described herein processes for their production and their use as anti-cancer agents.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: March 12, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Keith Graham, Ulrich Klar, Hans Briem, Gerhard Siemeister, Ursula Mönning, Jozsef Balint
  • 1H-PYRROL-3-AMINES
    Publication number: 20180222881
    Abstract: Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.
    Type: Application
    Filed: August 1, 2016
    Publication date: August 9, 2018
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Keith GRAHAM, Ulrich KLAR, Hans BRIEM, Gerhard SIEMEISTER, Ursula M?NNING
  • PYRAZOLOPYRIDINAMINES AS MKNK1 AND MKNK2 INHIBITORS
    Publication number: 20180162877
    Abstract: The present invention relates to substituted pyrazolopyridinamine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, inflammatory disease and disease associated with inflammatory pain, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: December 14, 2015
    Publication date: June 14, 2018
    Inventors: Anja GIESE, Ulrich KLAR, Keith GRAHAM, Georg KETTSCHAU, Detlev SÜLZLE, Philip LIENAU, Kirstin PETERSEN, Julien LEFRANC, Nicole SCHMIDT
  • 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES
    Publication number: 20180155285
    Abstract: Compounds of formula (I) as described hereinprocesses for their production and their use as anti-cancer agents.
    Type: Application
    Filed: June 14, 2016
    Publication date: June 7, 2018
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Keith GRAHAM, Ulrich KLAR, Hans BRIEM, Gerhard SIEMEISTER, Ursula MÕNNING, Jozsef BALINT
  • 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES
    Publication number: 20180016272
    Abstract: Compound of formula (I), processes for their production and their use as pharmaceuticals.
    Type: Application
    Filed: January 25, 2016
    Publication date: January 18, 2018
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Keith GRAHAM, Ulrich KLAR, Hans BRIEM, Volker SCHULZE, Gerhard SIEMEISTER, Philip LIENAU, René TEMPEL, Jozsef BÁLINT
  • Copolymers useful as rheology modifiers and home and personal care compositions comprising said copolymers
    Patent number: 9724288
    Abstract: The present invention relates to aqueous personal care, household care, and/or fabric care compositions comprising the instant copolymers. Also disclosed are methods for the rheological modification of aqueous personal care, household care, and/or fabric care compositions comprising the instant copolymers.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: August 8, 2017
    Assignee: BASF SE
    Inventors: Keith Graham, David Normington, Howard Roger Dungworth, John Mark Plonka
  • Substituted thiazolopyrimidines
    Patent number: 9675612
    Abstract: The present invention relates to substituted thiazolopyrimidine compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: June 13, 2017
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Ulrich Klar, Lars Wortmann, Keith Graham, Florian Puehler, Detlev Sülzle, Georg Kettschau, Philip Lienau