Patents by Inventor Keith Graham

Keith Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE COMPOUNDS
    Publication number: 20250136599
    Abstract: Compounds of formula (I), formula (I), processes for their production and their use as pharmaceuticals.
    Type: Application
    Filed: November 15, 2024
    Publication date: May 1, 2025
    Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Stephan Siegel, Franziska Siegel, Volker Schulze, Markus Berger, Keith Graham, Detlev Sülzle, Ulf Bömer, Daniel Korr, Jens Schröder, Ursula Mönning, Michael Niehues, Matthew Meyerson, Heidi Greulich, Bethany Kaplan
  • Heat pump system and a method of operating a heat pump system
    Patent number: 12278546
    Abstract: A heat pump system includes a regenerative thermal machine (1*, 1**, 1***) in fluid communication with one or more heat reservoirs (21; 31), wherein the regenerative thermal machine (1, 1**, 1***) comprises working fluid compression (12) and expansion (11) spaces; and an electrical machine (130) that is electrically connectable via interconnector (3) to an electricity distribution grid (2); characterised in that the regenerative thermal machine (1*, 1**, 1***) further comprises a phase change means (160) operable to change the phase relationship between the said working fluid compression (12) and expansion spaces (11) of the regenerative thermal machine (1*, 1**, 1***).
    Type: Grant
    Filed: July 8, 2022
    Date of Patent: April 15, 2025
    Assignee: WHITAKER ENGINEERING (STONEHAVEN) LIMITED
    Inventors: Kenneth Whittaker, Keith Graham Watt, Matthias Graessner
  • HEAT PUMP SYSTEM AND A METHOD OF OPERATING A HEAT PUMP SYSTEM
    Publication number: 20240333096
    Abstract: A heat pump system includes a regenerative thermal machine (1*, 1**, 1***) in fluid communication with one or more heat reservoirs (21; 31), wherein the regenerative thermal machine (1, 1**, 1***) comprises working fluid compression (12) and expansion (11) spaces; and an electrical machine (130) that is electrically connectable via interconnector (3) to an electricity distribution grid (2); characterised in that the regenerative thermal machine (1*, 1**, 1***) further comprises a phase change means (160) operable to change the phase relationship between the said working fluid compression (12) and expansion spaces (11) of the regenerative thermal machine (1*, 1**, 1***).
    Type: Application
    Filed: July 8, 2022
    Publication date: October 3, 2024
    Inventors: KENNETH WHITTAKER, KEITH GRAHAM WATT, MATTHIAS GRAESSNER
  • STORAGE INLINE ENCRYPTION CIRCUIT
    Publication number: 20240330205
    Abstract: A processing system includes one or more storage encryption circuits (SIECs) interconnected with one or more input/output (I/O) devices and a system memory. Each SIEC is configured to encrypt and decrypt data as the data passes between the I/O devices and the system memory. To this end, an SIEC includes slots each associated with respective memory addresses of the system memory. Each slot provides an aperture to the associated memory addresses such that the I/O devices use these apertures to indirectly target the associated memory addresses. As the data targeting the memory addresses associated with an aperture passes through an SIEC, the SIEC encrypts or decrypts the data using cryptographic keys stored on the SIEC.
    Type: Application
    Filed: March 31, 2023
    Publication date: October 3, 2024
    Inventors: William A. Moyes, Carlos Javier Moreira, Kathirkamanathan Nadarajah, Keith Graham Shaw
  • 4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS
    Publication number: 20240307362
    Abstract: Compounds of formula (I), processes for their production and their use as pharmaceuticals are described herein.
    Type: Application
    Filed: April 22, 2020
    Publication date: September 19, 2024
    Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Stephan SIEGEL, Franziska SIEGEL, Volker SCHULZE, Markus BERGER, Keith GRAHAM, Stefan Nikolaus GRADL, Detlev SÜLZLE, Ulf BÖMER, Daniel KORR, Jens SCHRÖDER, Ursula MÖNNING, Michael NIEHUES, Matthew MEYERSON, Heidi GREULICH, Bethany KAPLAN, Hassan Youssef HARB, Phi Manh DINH
  • PHOSPHORUS DERIVATIVES AS NOVEL SOS1 INHIBITORS
    Publication number: 20240247015
    Abstract: The present invention covers phosphorus derivatives of general formula (I), in which R1, R2, R3, R4, R5, R6, X1, X2, X3, X4 and Y are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, especially diseases associated with SOS1, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: April 13, 2022
    Publication date: July 25, 2024
    Inventors: Felix PAPE, Steffen GRESSIES, Timo STELLFELD, Jeremie Xavier G MORTIER, Atanas Marinov KAMBUROV, Benjamin BADER, Keith GRAHAM, Roman HILLIG, Jens SCHRODER, Christoph Philipp HETHEY, Matthias ARLT, Gerhard SIEMEISTER, Katrin NOWAK-REPPEL, Michael ERKELENZ
  • N-[2-({4-[3-(ANILINO)-4-OXO-4,5,6,7-TETRAHYDRO-1H-PYRROLO[3,2-C]PYRIDIN-2-YL]PYRIDIN-3-YL)OXY)ETHYL]PROP-2-ENAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20230416249
    Abstract: Compounds of formula (I) processes for their production and their use as pharmaceuticals.
    Type: Application
    Filed: May 10, 2023
    Publication date: December 28, 2023
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Stephan SIEGEL, Franziska SIEGEL, Volker SCHULZE, Markus BERGER, Keith GRAHAM, Ulrich KLAR, Jeremie Xavier G. MORTIER, Detlev SÜLZLE, Ulf BÖMER, Daniel KORR, Jens SCHRÖDER, Matthew MEYERSON, Heidi GREULICH, Bethany KAPLAN
  • PYRIDO[2,3-D]PYRIMIDIN-4-AMINES AS SOS1 INHIBITORS
    Publication number: 20230357239
    Abstract: The present invention covers Pyrido[2,3-d]pyrimidin-4-amines compounds of general formula (I): in which R1, R2, R3, A, x and y are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: September 15, 2021
    Publication date: November 9, 2023
    Inventors: Keith GRAHAM, Benjamin BADER, Jens SCHROEDER, Roman HILLIG, Hans BRIEM, Jeremie Xavier G. MORTIER, Felix PAPE, Steffen GRESSIES, Timo STELLFELD
  • 2-METHYL-AZA-QUINAZOLINES
    Publication number: 20230029385
    Abstract: The present invention covers 2-methyl-aza-quinazoline compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: October 14, 2020
    Publication date: January 26, 2023
    Inventors: Lars WORTMANN, Keith GRAHAM, Benjamin BADER, Roman HILLIG, Jens SCHROEDER, Philip LIENAU, Hans BRIEM
  • 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE COMPOUNDS
    Publication number: 20220298157
    Abstract: Compounds of formula (I), formula (I), processes for their production and their R use as pharmaceuticals.
    Type: Application
    Filed: April 22, 2020
    Publication date: September 22, 2022
    Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Stephan SIEGEL, Franziska SIEGEL, Volker SCHULZE, Markus BERGER, Keith GRAHAM, Detlev SÜLZLE, Ulf BÖMER, Daniel KORR, Jens SCHRÖDER, Ursula MÖNNING, Michael NIEHUES, Matthew MEYERSON, Heidi GREULICH, Bethany KAPLAN
  • 4H-pyrrolo[3,2-c]pyridin-4-one derivatives
    Patent number: 11339157
    Abstract: Compounds of formula (I) processes for their production and their use as pharmaceuticals.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: May 24, 2022
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Dana-Farber Cancer Institute, Inc., The Broad Institute, Inc.
    Inventors: Stephan Siegel, Franziska Siegel, Volker Schulze, Markus Berger, Keith Graham, Ulrich Klar, Knut Eis, Detlev Sülzle, Ulf Bömer, Daniel Korr, Kirstin Petersen, Ursula Mönning, Uwe Eberspächer, Dieter Moosmayer, Matthew Meyerson, Heidi Greulich, Bethany Kaplan, Hassan Youssef Harb, Phi Manh Dinh
  • Sheet product roll holder with integrated flowable material dispensing mechanism
    Patent number: 10856707
    Abstract: A sheet product roll holder may include a support arm, a spindle, a flowable material container, and an automated flowable material dispensing mechanism. The support arm may define a first longitudinal axis. The spindle may be coupled to the support arm and define a second longitudinal axis extending transverse to the first longitudinal axis, and the spindle may be configured to rotatably support a roll of sheet product thereon. The flowable material container may be positioned at least partially within the spindle and define a third longitudinal axis extending coaxially with the second longitudinal axis, and the flowable material container may include a container body and a volume of a flowable material positioned within the container body. The automated flowable material dispensing mechanism may be positioned at least partially within the support arm and configured to dispense the flowable material from the flowable material container.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: December 8, 2020
    Assignee: GPCP IP HOLDINGS LLC
    Inventors: Eric Paul Peterson, Ryan Andersen, Jacob Edward Malesky, Jon Charles Alling, Gordon Keith Graham, III
  • HETERO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES
    Publication number: 20200216439
    Abstract: Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.
    Type: Application
    Filed: December 12, 2016
    Publication date: July 9, 2020
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Keith GRAHAM, Ulrich KLAR, Hans BRIEM, Gerhard SIEMEISTER, Ursula MÖNNING, Franz VON NUSSBAUM
  • Dried crumb manufacture
    Patent number: 10667548
    Abstract: A method of manufacture of a breadcrumb coating for a food product provides a crumb with an extremely low moisture content without the need for substantial energy input. The method achieves such very low moisture content without significant adverse effect on product quality.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: June 2, 2020
    Assignee: Crisp Sensation Holding S.A.
    Inventors: Keith Graham Pickford, Kees van Doorn, Carry Reichgelt
  • SHEET PRODUCT ROLL HOLDER WITH INTEGRATED FLOWABLE MATERIAL DISPENSING MECHANISM
    Publication number: 20200015638
    Abstract: A sheet product roll holder may include a support arm, a spindle, a flowable material container, and an automated flowable material dispensing mechanism. The support arm may define a first longitudinal axis. The spindle may be coupled to the support arm and define a second longitudinal axis extending transverse to the first longitudinal axis, and the spindle may be configured to rotatably support a roll of sheet product thereon. The flowable material container may be positioned at least partially within the spindle and define a third longitudinal axis extending coaxially with the second longitudinal axis, and the flowable material container may include a container body and a volume of a flowable material positioned within the container body. The automated flowable material dispensing mechanism may be positioned at least partially within the support arm and configured to dispense the flowable material from the flowable material container.
    Type: Application
    Filed: June 28, 2019
    Publication date: January 16, 2020
    Inventors: Eric Paul Peterson, Ryan Andersen, Jacob Edward Malesky, Jon Charles Alling, Gordon Keith Graham, III
  • Pyrazolopyridinamines as MKNK1 and MKNK2 inhibitors
    Patent number: 10487092
    Abstract: The present invention relates to substituted pyrazolopyridinamine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, inflammatory disease and disease associated with inflammatory pain, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: November 26, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Anja Giese, Ulrich Klar, Keith Graham, Georg Kettschau, Detlev Sülzle, Philip Lienau, Kirstin Petersen, Julien LeFranc, Nicole Schmidt
  • 3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones
    Patent number: 10428044
    Abstract: Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: October 1, 2019
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Keith Graham, Ulrich Klar, Hans Briem, Marion Hitchcock, Lars Bärfacker, Knut Eis, Volker Schulze, Gerhard Siemeister, Wilhelm Bone, Jens Schröder, Simon Holton, Philip Lienau, René Tempel, Helmut Sonnenschein, Jozsef Bálint, Heinz Graubaum
  • 4H-pyrrolo[3,2-C]pyridin-4-one derivatives
    Patent number: 10428063
    Abstract: Compound of formula (I), processes for their production and their use as pharmaceuticals.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: October 1, 2019
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Keith Graham, Ulrich Klar, Hans Briem, Volker Schulze, Gerhard Siemeister, Philip Lienau, René Tempel, Jozsef Bálint
  • Coated stabilized microwave heated foods
    Patent number: 10375983
    Abstract: A food product comprising a substrate of pieces of meat, poultry, fish, vegetable, fruit or dairy food and an aqueous composition coating the substrate provides improved performance, particularly for microwave cooking of reheating of the food product. The aqueous coating composition includes a mixture consisting of by dry weight: cellulose gum 15-35% modified starch 15-50% hydrocolloid ?20-30%, wherein the hydrocolloid is selected from the group consisting of xanthan gum, carrageenan gum, guar gum and mixtures thereof, and proteinaceous component 10-20%; wherein the percentages of the ingredients are selected from the ranges quoted to total 100%; and wherein the aqueous coating composition does not contain any substantial amount of polydextrose.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: August 13, 2019
    Assignee: Crisp Sensation Holding B.V.
    Inventor: Keith Graham Pickford
  • 1H-pyrrol-3-amines
    Patent number: 10308629
    Abstract: Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: June 4, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Keith Graham, Ulrich Klar, Hans Briem, Gerhard Siemeister, Ursula Mönning