Patents by Inventor Keith Jones

Keith Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240254110
    Abstract: The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: September 5, 2023
    Publication date: August 1, 2024
    Inventors: Keith Jones, Carl Rye, Nicola Chessum, Matthew D. Cheeseman, Adele E. Pasqua, Kurt G. Pike, Paul F. Faulder
  • Publication number: 20240231014
    Abstract: A sealable connection system is provided. The system can include a connection assembly including a housing and at least one ferrule positioned within the housing. An inner surface of the housing can be arranged to mate with and secure to an outer surface of a sensor assembly. The at least one ferrule can be arranged to engage with the sensor assembly as the housing is secured to the sensor assembly. The system can also include a fiber optic cable assembly. The fiber optic cable assembly can include a fiber optic cable extending through the housing and the at least one ferrule. The fiber optic cable can also be surrounded, at least along a length of the fiber optic cable within the connection assembly, by a fiber optic cable cover. The sealable connection system is provided to hermetically connect the fiber optic cable assembly to a sensor assembly.
    Type: Application
    Filed: October 24, 2022
    Publication date: July 11, 2024
    Inventors: Keith Jones, Robin Desai, Kevin McKinny
  • Publication number: 20240134132
    Abstract: A sealable connection system is provided. The system can include a connection assembly including a housing and at least one ferrule positioned within the housing. An inner surface of the housing can be arranged to mate with and secure to an outer surface of a sensor assembly. The at least one ferrule can be arranged to engage with the sensor assembly as the housing is secured to the sensor assembly. The system can also include a fiber optic cable assembly. The fiber optic cable assembly can include a fiber optic cable extending through the housing and the at least one ferrule. The fiber optic cable can also be surrounded, at least along a length of the fiber optic cable within the connection assembly, by a fiber optic cable cover. The sealable connection system is provided to hermetically connect the fiber optic cable assembly to a sensor assembly.
    Type: Application
    Filed: October 23, 2022
    Publication date: April 25, 2024
    Inventors: Keith Jones, Robin Desai, Kevin McKinny
  • Patent number: 11814370
    Abstract: The present invention relates to N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-fluorophenyl)-2-((4-ethylpiperazin-1-yl)methyl)quinoline-6-carboxamide, or a pharmaceutically acceptable salt or solvate thereof, wherein at least one hydrogen atom has been substituted with a deuterium atom. Other aspects include pharmaceutical compositions comprising said compounds and medical uses and methods of treatment using said compounds.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: November 14, 2023
    Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Keith Jones, Matthew D. Cheeseman, A. Elisa Pasqua, Michael J. Tucker
  • Patent number: 11804082
    Abstract: Methods and apparatus are provided for diagnosing a vehicle. In one embodiment, a method includes: initiating, by a processor, a recording of a noise by at least one microphone based on user selection data from a user of the vehicle; receiving, by the processor, audio signal data based on the recording; generating, by the processor, vector data based on the audio signal data; processing, by the processor, the vector data with at least one trained machine, by the processor, learning model to determine a classification of the noise; predicting, by the processor, an action to be taken based on the classification; and storing, by the processor, the audio signal data, the classification, and the action in a datastore.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: October 31, 2023
    Assignee: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Gaurav Talwar, Kenneth Ray Booker, William L. Villaire, Jeffery J. Milton, Mathew Anthony Clifford Keith Jones
  • Patent number: 11787786
    Abstract: The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: October 17, 2023
    Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Keith Jones, Carl Rye, Nicola Chessum, Matthew D. Cheeseman, Adele E. Pasqua, Kurt G. Pike, Paul F. Faulder
  • Publication number: 20220406106
    Abstract: Methods and apparatus are provided for diagnosing a vehicle. In one embodiment, a method includes: initiating, by a processor, a recording of a noise by at least one microphone based on user selection data from a user of the vehicle; receiving, by the processor, audio signal data based on the recording; generating, by the processor, vector data based on the audio signal data; processing, by the processor, the vector data with at least one trained machine, by the processor, learning model to determine a classification of the noise; predicting, by the processor, an action to be taken based on the classification; and storing, by the processor, the audio signal data, the classification, and the action in a datastore.
    Type: Application
    Filed: June 17, 2021
    Publication date: December 22, 2022
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Gaurav Talwar, Kenneth Ray Booker, William L. Villaire, Jeffery J. Milton, Mathew Anthony Clifford Keith Jones
  • Publication number: 20220220097
    Abstract: The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: August 19, 2021
    Publication date: July 14, 2022
    Inventors: Keith Jones, Carl Rye, Nicola Chessum, Matthew D. Cheeseman, Adele E. Pasqua, Kurt G. Pike, Paul F. Faulder
  • Patent number: 11124501
    Abstract: The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: September 21, 2021
    Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Keith Jones, Carl Rye, Nicola Chessum, Matthew Cheeseman, Adele E. Pasqua, Kurt G. Pike, Paul F. Faulder
  • Publication number: 20210224276
    Abstract: Methods, systems, and devices for providing matching security between data stores are described. In a database system, an operational data store may store transactional datasets and an analytical data store may store analytics datasets generated based on the transactional datasets. For these analytics datasets to efficiently inherit the security configurations of the transactional datasets, security information may be embedded in datasets retrieved from the operational data store during a data acquisition procedure. This security information may be converted into an embedded multiple-value field for storage in the analytical data store. The analytical data store may receive a query for data in a dataset, and may determine security descriptors associated with the user sending the query. The analytical data store may then filter the data based on comparing these determined security descriptors with the security information in the multiple-value field, and may transmit a query response with the filtered data.
    Type: Application
    Filed: April 1, 2021
    Publication date: July 22, 2021
    Inventors: Donovan Schneider, Keith Jones Kelly, Nicholas Albert Bugajski
  • Patent number: 11003674
    Abstract: Systems and methods for automated aggregated content commenting are disclosed herein. Such a system can include a memory including a content database; an evaluation criteria database; and a comment database. The system can include at least one server. The at least one server can: receive a content identifier; receive a user identifier; provide a representation of the piece of content to the user; receive a comment from the user identifying a portion of the piece of content; generate a portion of the comment database linked to the user and the content; generate an entry in the portion of the comment database linked to the user and the content; and store the comment in the entry in the portion of the comment database.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: May 11, 2021
    Assignee: PEARSON EDUCATION, INC.
    Inventors: John P. Sadauskas, Erik R. Racho, Xindeling Pan, Lynn Chang, Anne Hong, Keith Jones, Miles T. Loring, Paul C. Grudnitski, Vishal Kapoor
  • Patent number: 10990593
    Abstract: Methods, systems, and devices for providing matching security between data stores are described. In a database system, an operational data store may store transactional datasets and an analytical data store may store analytics datasets generated based on the transactional datasets. For these analytics datasets to efficiently inherit the security configurations of the transactional datasets, security information may be embedded in datasets retrieved from the operational data store during a data acquisition procedure. This security information may be converted into an embedded multiple-value field for storage in the analytical data store. The analytical data store may receive a query for data in a dataset, and may determine security descriptors associated with the user sending the query. The analytical data store may then filter the data based on comparing these determined security descriptors with the security information in the multiple-value field, and may transmit a query response with the filtered data.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: April 27, 2021
    Assignee: saleforce.com, inc.
    Inventors: Donovan Schneider, Keith Jones Kelly, Nicholas Albert Bugajski
  • Patent number: 10806711
    Abstract: Described are inventions directed to methods of treating a cardiac dysfunction in a subject that includes administering an amount of probenecid effective to treat a symptom of cardiac dysfunction. The probenecid may be administered in at least one of an injection, orally, or transdermally. The amount of probenecid is sufficient to result in an improved performance on a standardized 6 minute walk test, an improved New York Heart Association (NYHA) classification, a lower diuretic dose requirement, a lower serum BNP levels, a normalization of serum sodium concentrations, and combinations thereof. In an embodiment, probenecid is administered over a period of about 8 hours to about 24 hours. Probenecid may be used for short term treatments, i.e., less than a week, or it may be administered in a long term manner, i.e., over a period of weeks, months, or even years.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: October 20, 2020
    Assignee: University of Cincinnati
    Inventors: Jack Rubinstein, W. Keith Jones
  • Publication number: 20200188297
    Abstract: A topical ophthalmic formulation of an LXR agonist that could be used for treating dry-eye disease. Examples of LXR agonists that could be used include naturally occurring oxysterol compounds, such as ouabagenin or hyodeoxycholic acid, or synthetic, non-sterol compounds such as IMB-151 or T0901317. The LXR agonist compound may be encapsulated within biodegradable nanoparticles, such as poly(lactic/glycolic) acid (PLGA) nanoparticles, micelles, or liposomes. Experimental work establishing proof-of-concept has been performed.
    Type: Application
    Filed: December 12, 2019
    Publication date: June 18, 2020
    Inventors: Simon Kaja, Anita Ghosh, Walter Keith Jones
  • Patent number: 10647678
    Abstract: The present invention relates to compounds of formula I wherein R, R4 and Q are each as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 pathway (HSF1 pathway). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: May 12, 2020
    Assignee: Cancer Research Technology Limited
    Inventors: Keith Jones, Matthew Cheeseman, Nicola Chessum, Elisa Pasqua, Lindsay Evans, Michael Tucker, Birgit Wilding, Ngai Yi Mok
  • Patent number: 10583103
    Abstract: Described herein are inventions directed to methods of treating a diastolic cardiac dysfunction and the symptoms thereof in a subject that includes administering an amount of a TRPV2 receptor agonist effective to treat the diastolic cardiac dysfunction. The TRPV2 receptor agonist may be administered in at least one of an injection, orally, or transdermally. The amount of TRPV2 receptor agonist is sufficient to result in an improved performance on quantitative diagnostic criteria. In an embodiment, the TRPV2 receptor agonist is administered over a period of about 8 hours to about 24 hours. The TRPV2 receptor agonist may be used for short term treatments, i.e., less than a week, or it may be administered in a long term manner, i.e., over a period of weeks, months, or even years. Exemplary TRPV2 receptor agonists include probenecid, 2-aminoethoxydiphenyl borate, cannabinol, cannabidiol, and combinations thereof.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 10, 2020
    Assignee: University of Cincinnati
    Inventors: Jack Rubinstein, W. Keith Jones
  • Publication number: 20200039965
    Abstract: The present invention relates to N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-fluorophenyl)-2-((4-ethylpiperazin-1-yl)methyl)quinoline-6-carboxamide, or a pharmaceutically acceptable salt or solvate thereof, wherein at least one hydrogen atom has been substituted with a deuterium atom. Other aspects include pharmaceutical compositions comprising said compounds and medical uses and methods of treatment using said compounds.
    Type: Application
    Filed: October 6, 2017
    Publication date: February 6, 2020
    Inventors: Keith Jones, Matthew D. Cheeseman, A. Elisa Pasqua, Michael J. Tucker
  • Publication number: 20190340283
    Abstract: Methods, systems, and devices for providing matching security between data stores are described. In a database system, an operational data store may store transactional datasets and an analytical data store may store analytics datasets generated based on the transactional datasets. For these analytics datasets to efficiently inherit the security configurations of the transactional datasets, security information may be embedded in datasets retrieved from the operational data store during a data acquisition procedure. This security information may be converted into an embedded multiple-value field for storage in the analytical data store. The analytical data store may receive a query for data in a dataset, and may determine security descriptors associated with the user sending the query. The analytical data store may then filter the data based on comparing these determined security descriptors with the security information in the multiple-value field, and may transmit a query response with the filtered data.
    Type: Application
    Filed: May 4, 2018
    Publication date: November 7, 2019
    Inventors: Donovan Schneider, Keith Jones Kelly, Nicholas Albert Bugajski
  • Patent number: 10417241
    Abstract: Systems and methods for automated aggregated content commenting are disclosed herein. Such a system can include a memory including a content database; an evaluation criteria database; and a comment database. The system can include at least one server. The at least one server can: receive a content identifier; receive a user identifier; provide a representation of the piece of content to the user; receive a comment from the user identifying a portion of the piece of content; generate a portion of the comment database linked to the user and the content; generate an entry in the portion of the comment database linked to the user and the content; and store the comment in the entry in the portion of the comment database.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: September 17, 2019
    Assignee: PEARSON EDUCATION, INC.
    Inventors: John P. Sadauskas, Jr., Erik R. Racho, Xindeling Pan, Lynn Chang, Anne Hong, Keith Jones
  • Publication number: 20190106413
    Abstract: The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 11, 2019
    Inventors: Keith Jones, Carl Rye, Nicola Chessum, Matthew Cheeseman, Adele E, Pasqua, Kurt G, Pike, Paul F. Faulder