Abstract: The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Abstract: A sealable connection system is provided. The system can include a connection assembly including a housing and at least one ferrule positioned within the housing. An inner surface of the housing can be arranged to mate with and secure to an outer surface of a sensor assembly. The at least one ferrule can be arranged to engage with the sensor assembly as the housing is secured to the sensor assembly. The system can also include a fiber optic cable assembly. The fiber optic cable assembly can include a fiber optic cable extending through the housing and the at least one ferrule. The fiber optic cable can also be surrounded, at least along a length of the fiber optic cable within the connection assembly, by a fiber optic cable cover. The sealable connection system is provided to hermetically connect the fiber optic cable assembly to a sensor assembly.

Abstract: A sealable connection system is provided. The system can include a connection assembly including a housing and at least one ferrule positioned within the housing. An inner surface of the housing can be arranged to mate with and secure to an outer surface of a sensor assembly. The at least one ferrule can be arranged to engage with the sensor assembly as the housing is secured to the sensor assembly. The system can also include a fiber optic cable assembly. The fiber optic cable assembly can include a fiber optic cable extending through the housing and the at least one ferrule. The fiber optic cable can also be surrounded, at least along a length of the fiber optic cable within the connection assembly, by a fiber optic cable cover. The sealable connection system is provided to hermetically connect the fiber optic cable assembly to a sensor assembly.

Abstract: The present invention relates to N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-fluorophenyl)-2-((4-ethylpiperazin-1-yl)methyl)quinoline-6-carboxamide, or a pharmaceutically acceptable salt or solvate thereof, wherein at least one hydrogen atom has been substituted with a deuterium atom. Other aspects include pharmaceutical compositions comprising said compounds and medical uses and methods of treatment using said compounds.

Abstract: Methods and apparatus are provided for diagnosing a vehicle. In one embodiment, a method includes: initiating, by a processor, a recording of a noise by at least one microphone based on user selection data from a user of the vehicle; receiving, by the processor, audio signal data based on the recording; generating, by the processor, vector data based on the audio signal data; processing, by the processor, the vector data with at least one trained machine, by the processor, learning model to determine a classification of the noise; predicting, by the processor, an action to be taken based on the classification; and storing, by the processor, the audio signal data, the classification, and the action in a datastore.

Abstract: The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Abstract: Methods and apparatus are provided for diagnosing a vehicle. In one embodiment, a method includes: initiating, by a processor, a recording of a noise by at least one microphone based on user selection data from a user of the vehicle; receiving, by the processor, audio signal data based on the recording; generating, by the processor, vector data based on the audio signal data; processing, by the processor, the vector data with at least one trained machine, by the processor, learning model to determine a classification of the noise; predicting, by the processor, an action to be taken based on the classification; and storing, by the processor, the audio signal data, the classification, and the action in a datastore.

Abstract: The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Abstract: The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Abstract: Methods, systems, and devices for providing matching security between data stores are described. In a database system, an operational data store may store transactional datasets and an analytical data store may store analytics datasets generated based on the transactional datasets. For these analytics datasets to efficiently inherit the security configurations of the transactional datasets, security information may be embedded in datasets retrieved from the operational data store during a data acquisition procedure. This security information may be converted into an embedded multiple-value field for storage in the analytical data store. The analytical data store may receive a query for data in a dataset, and may determine security descriptors associated with the user sending the query. The analytical data store may then filter the data based on comparing these determined security descriptors with the security information in the multiple-value field, and may transmit a query response with the filtered data.

Abstract: Systems and methods for automated aggregated content commenting are disclosed herein. Such a system can include a memory including a content database; an evaluation criteria database; and a comment database. The system can include at least one server. The at least one server can: receive a content identifier; receive a user identifier; provide a representation of the piece of content to the user; receive a comment from the user identifying a portion of the piece of content; generate a portion of the comment database linked to the user and the content; generate an entry in the portion of the comment database linked to the user and the content; and store the comment in the entry in the portion of the comment database.

Abstract: Methods, systems, and devices for providing matching security between data stores are described. In a database system, an operational data store may store transactional datasets and an analytical data store may store analytics datasets generated based on the transactional datasets. For these analytics datasets to efficiently inherit the security configurations of the transactional datasets, security information may be embedded in datasets retrieved from the operational data store during a data acquisition procedure. This security information may be converted into an embedded multiple-value field for storage in the analytical data store. The analytical data store may receive a query for data in a dataset, and may determine security descriptors associated with the user sending the query. The analytical data store may then filter the data based on comparing these determined security descriptors with the security information in the multiple-value field, and may transmit a query response with the filtered data.

Abstract: Described are inventions directed to methods of treating a cardiac dysfunction in a subject that includes administering an amount of probenecid effective to treat a symptom of cardiac dysfunction. The probenecid may be administered in at least one of an injection, orally, or transdermally. The amount of probenecid is sufficient to result in an improved performance on a standardized 6 minute walk test, an improved New York Heart Association (NYHA) classification, a lower diuretic dose requirement, a lower serum BNP levels, a normalization of serum sodium concentrations, and combinations thereof. In an embodiment, probenecid is administered over a period of about 8 hours to about 24 hours. Probenecid may be used for short term treatments, i.e., less than a week, or it may be administered in a long term manner, i.e., over a period of weeks, months, or even years.

Abstract: A topical ophthalmic formulation of an LXR agonist that could be used for treating dry-eye disease. Examples of LXR agonists that could be used include naturally occurring oxysterol compounds, such as ouabagenin or hyodeoxycholic acid, or synthetic, non-sterol compounds such as IMB-151 or T0901317. The LXR agonist compound may be encapsulated within biodegradable nanoparticles, such as poly(lactic/glycolic) acid (PLGA) nanoparticles, micelles, or liposomes. Experimental work establishing proof-of-concept has been performed.

Abstract: The present invention relates to compounds of formula I wherein R, R4 and Q are each as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 pathway (HSF1 pathway). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Abstract: Described herein are inventions directed to methods of treating a diastolic cardiac dysfunction and the symptoms thereof in a subject that includes administering an amount of a TRPV2 receptor agonist effective to treat the diastolic cardiac dysfunction. The TRPV2 receptor agonist may be administered in at least one of an injection, orally, or transdermally. The amount of TRPV2 receptor agonist is sufficient to result in an improved performance on quantitative diagnostic criteria. In an embodiment, the TRPV2 receptor agonist is administered over a period of about 8 hours to about 24 hours. The TRPV2 receptor agonist may be used for short term treatments, i.e., less than a week, or it may be administered in a long term manner, i.e., over a period of weeks, months, or even years. Exemplary TRPV2 receptor agonists include probenecid, 2-aminoethoxydiphenyl borate, cannabinol, cannabidiol, and combinations thereof.

Abstract: The present invention relates to N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-fluorophenyl)-2-((4-ethylpiperazin-1-yl)methyl)quinoline-6-carboxamide, or a pharmaceutically acceptable salt or solvate thereof, wherein at least one hydrogen atom has been substituted with a deuterium atom. Other aspects include pharmaceutical compositions comprising said compounds and medical uses and methods of treatment using said compounds.

Abstract: Methods, systems, and devices for providing matching security between data stores are described. In a database system, an operational data store may store transactional datasets and an analytical data store may store analytics datasets generated based on the transactional datasets. For these analytics datasets to efficiently inherit the security configurations of the transactional datasets, security information may be embedded in datasets retrieved from the operational data store during a data acquisition procedure. This security information may be converted into an embedded multiple-value field for storage in the analytical data store. The analytical data store may receive a query for data in a dataset, and may determine security descriptors associated with the user sending the query. The analytical data store may then filter the data based on comparing these determined security descriptors with the security information in the multiple-value field, and may transmit a query response with the filtered data.

Abstract: Systems and methods for automated aggregated content commenting are disclosed herein. Such a system can include a memory including a content database; an evaluation criteria database; and a comment database. The system can include at least one server. The at least one server can: receive a content identifier; receive a user identifier; provide a representation of the piece of content to the user; receive a comment from the user identifying a portion of the piece of content; generate a portion of the comment database linked to the user and the content; generate an entry in the portion of the comment database linked to the user and the content; and store the comment in the entry in the portion of the comment database.

Abstract: The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.