Abstract: An interchangeable chromatic range sensor (CRS) probe for a coordinate measuring machine (CMM). The CRS probe is capable of being automatically connected to a CMM under program control. In one embodiment, in order to make the CRS probe compatible with a standard CMM auto exchange joint, all CRS measurement light transmitting and receiving elements (e.g., the light source, wavelength detector, optical pen, etc.) are included in the CRS probe assembly. The CRS probe assembly also includes an auto exchange joint element that is attachable through a standard auto exchange joint connection to a CMM. In one embodiment, in order to provide the required signals through the limited number of connections of the standard CMM auto exchange joint (e.g., 13 pins), a low voltage differential signaling (LVDS) serializer may be utilized for providing additional control and data signals on two signal lines.

Abstract: An optical pen for use in a chromatic range sensor (CRS) may be used in a probe system for a coordinate measuring machine (CMM). The optical pen includes a confocal optical path, an interchangeable optics element, an optical pen base member, and a repeatable fast exchange mount. The confocal optical path includes a confocal aperture and a chromatically dispersive optics portion. The interchangeable optics element includes the chromatically dispersive optics portion. The optical pen base member includes an external mounting surface for mounting to an external reference frame. The repeatable fast exchange mount includes a first mating half located on the base member and a second mating half located on the interchangeable optics element. The repeatable fast exchange mount is configured to allow the base member to receive and hold the interchangeable optics element in a fixed relationship relative to the base member and the external reference frame.

Abstract: A micrometer drive configuration for a handheld micrometer comprises: a frame; a spindle; a linear displacement sensor that senses a displacement of the spindle; a threaded spindle drive having a relatively coarse thread pitch, wherein the threaded spindle drive is attached to a spindle drive gear; a planetary drive gear that mates to the spindle drive gear; a ring gear surrounding and mating to the planetary drive gear; and a thimble generally surrounding the spindle drive gear, the planetary drive gear, and the ring gear. The thimble is coupled to drive the spindle drive gear through the planetary drive gear, and the planetary drive gear is sized and mounted such that the spindle drive gear turns faster than the thimble.

Abstract: Compositions, methods and kits are disclosed for synthesizing and amplifying pools of probes using precursor oligonucleotides. In some aspects the precursor is amplified and nicking enzymes are used to separate the full length probes from the amplification products. The methods enable the preparation of single stranded DNA probes of defined sequence and length that are suitable for use in target detection assays.

Abstract: Described herein are inventions is directed to methods of treating a cardiac dysfunction and symptoms of cardiac dysfunction in a subject that includes administering an amount of probenecid effective to treat a symptom of cardiac dysfunction. The probenecid may be administered in at least one of an injection, orally, or transdermally. The amount of probenecid is sufficient to result in an improved performance on a standardized 6 minute walk test, an improved New York Heart Association (NYHA) classification, a lower diuretic dose requirement, a lower serum BNP levels, a normalization of serum sodium concentrations, and combinations thereof In an embodiment, probenecid is administered over a period of about 8 hours to about 24 hours. Probenecid may be used for short term treatments, i.e., less than a week, or it may be administered in a long term manner, i.e., over a period of weeks, months, or even years. Probenecid may be administered in an amount sufficient to treat the symptoms of cardiac dysfunction.

Abstract: The present invention describes reagents and methods for using a concatemerized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end repeated copies of a short (more than 5, 10, 15, 20, 2, 3035, 40, 45, 50, 75, 100, or more by but generally less than about 3 kb) dsDNA containing a sequence or sequences that act as transcription factor decoys. The present invention also provides for the use of the polymers for CODN/polymer complexes to a specific cell type; thus the agent can be made organ, tissue and/or cell-type specific. In another embodiment, the present invention provides for use of the CODN's in vitro or in vivo, in isolated cells or intact animals in which specific blockade of transcription factors or delivery of DNA or other biological effector is desirable.

Abstract: A system and method bringing video to commercial FM and video to Sub-Carrier Authorization programming, the system would make use of a Double Sideband Suppress Carrier SCA frequency at 67 kHz, modulated by a Slow San Video Converter for providing minute by minute snap shots of video related to the audio program on the main FM channel such as if the main FM channel being listened to is 87.5 MHz then the related video channel would be 87.567 MHz, also, an additional audio/slow scan video FM station would be available as well and will be known as fm2, the audio portion of fm2 is an Independent Sideband Suppressed Carrier for providing audio in stereo at the SCA frequency at 114 kHz the slow scan video portion of the station is again another Double Sideband Suppress Carrier SCA at the frequency of 92 kHz.

Abstract: The present invention describes reagents and methods for using concatermized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end copies of a short dsDNA containing a sequence or sequences that act as transcription factor decoys.

Abstract: A software architecture that can sense and respond to context and state information is disclosed. The software architecture includes a semantic filter to correlate individual events in an event stream to make the event stream consistent with an ontology. Events in the event stream are substituted with higher order events, resulting in an actionable event stream containing recognizable patterns. Patterns in the actionable event stream are detected and matched with event processing policies to generate an action stream indicating actions to be taken in the real world.

Abstract: A correlation function peak finding method for an image correlation displacement sensing system is provided. The method may include capturing a reference image and a displaced image, and searching for an initial peak correlation function value point (CFVP) with pixel-level resolution based on correlating the reference image and displaced images at a plurality of offset positions. Then a complete set of CFVPs may be determined at each offset position in an analysis region surrounding the initial peak CFVP. Then a preliminary correlation function peak location is estimated with sub-pixel resolution, based on CFVPs included in the analysis region. Finally, curve-fitting operations are performed to estimate a final correlation function peak location with sub-pixel accuracy, wherein the curve-fitting operations apply a windowing function and/or a set of weighting factors that is/are located with sub-pixel resolution based on the preliminary sub-pixel correlation function peak location.

Abstract: The invention concerns a method of providing a seal within a pipe or aperture in a vessel and preventing fluid flow therethrough, the method comprising: (a) providing a non-porous, expandable, flexible container within said pipe or aperture; (b) introducing an expandable polymeric material into said container so as to expand said container, thereby forcing said container to fill the cross-sectional area of said pipe or aperture and displacing any fluid in said pipe or aperture in order to provide an engineered blockage within said pipe or aperture; (c) applying a bonding resin between the external surfaces of said container and the internal surfaces of the walls of said pipe or aperture; and (d) curing said expandable polymeric material and bonding resin so as to bond the expanded container to the pipe or aperture and create a seal between the outer surfaces of said container and the internal surfaces of the walls of said pipe or aperture.

Abstract: Methods of inhibiting ischemia-related and ischemia-reperfusion-related injury are provided. Remote administration of a C-fiber activator or TRPV1 agonist or remote electrical stimulation and activation of TRPV1 reduces ischemia-related tissue damage in subjects at risk for ischemia-related tissue damage. In aspects of the invention, remote application of a TRPV1 agonist inhibits ischemia-related cardiac tissue damage. Methods of inhibiting cardiac tissue damage by topically administering the TRPV1 agonist, capsaicin are provided.

Abstract: Methods of inhibiting ischemia-related and ischemia-reperfusion-related injury are provided. Remote administration of a C-fiber activator or TRPV1 agonist or remote electrical stimulation and activation of TRPV1 reduces ischemia-related tissue damage in subjects at risk for ischemia-related tissue damage. In aspects of the invention, remote application of a TRPV1 agonist inhibits ischemia-related cardiac tissue damage. Methods of inhibiting cardiac tissue damage by topically administering the TRPV1 agonist, capsaicin are provided.

Abstract: A road base made from an existing roadbed material and a coal-combustion by-product comprises: a tilled roadbed soil, a coal-combustion fly ash blended into the tilled roadbed soil at 5 to 50 percent by weight, and a site-specific quantity of an emulsion blended into the tilled roadbed soil after the coal-combustion fly ash. The emulsion includes a resin base, and the site-specific quantity ranges from 0.5 to 2.5 gallons per square yard, depending on a type of the tilled roadbed soil, and further depending on a type of the coal-combustion fly ash.

Abstract: A system and method bringing video to commercial FM and video to Sub-Carrier Authorization programming, the system would make use of a Double Sideband Suppress Carrier SCA frequency at 67 kHz, modulated by a Slow San Video Converter for providing minute by minute snap shots of video related to the audio program on the main FM channel such as if the main FM channel being listened to is 87.7 MHz then the related video channel would be 87.767 MHz, also, an additional audio/slow scan video FM station would be available as well and will be known as fm2, the audio portion of fm2 is an Independent Sideband Suppressed Carrier for providing audio in stereo at the SCA frequency at 92 kHz and the slow scan video portion of the station is again another Double Sideband Suppress Carrier SCA at the frequency of 114 kHz.

Abstract: A mixture, comprising of fly ash and an emulsion, where said emulsion is mixed with said fly ash in a range of 5% to 50% of fly ash per an area of a square yard and 0.5 gallons to 2.5 gallons per square yard of the emulsion to said area.

Abstract: A system for AM broadcasting, and listing to audio, as well as, viewing slow scan pictures, by using an ordinary AM receiver and a slow scan video converter. The slow scan can be an AM picture, such as, robot 36, or a FM picture in the AM band, using the FAST FM MODE of a slow scan converter, like the KENWOOD VC-H1. A transmitter, like the AM-88 NORTH COUNTRY RADIO, can broadcast in AM or FM mode on the AM band. Because of frequency differences between the audio and video, and if desired, modulation differences between the audio and video, there is no interference between the audio and video on the AM service. A diplexer and an antenna tuner enable both signals to be sent out from the same antenna.

Abstract: The present invention pertains to certain 2-[3H-thiazol-2-ylidinemethyl]pyridine compounds and analogs thereof, which, inter alia, inhibit cell proliferation, treat cancer, etc., and more specifically to compounds of the following formula, wherein RA1, RA2, RA3, RA4, RB1, RB2, RNA, RNB, and X? are as defined herein: The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative conditions such as cancer, etc.

Abstract: The present invention describes reagents and methods for using concatermized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end copies of a short dsDNA containing a sequence or sequences that act as transcription factor decoys.

Abstract: A radiation detector assembly is provided. The radiation detector assembly includes a radiation detector element and a light detection element operationally connected to the radiation detector element. The radiation detector element is seated within a housing. The assembly also includes a plurality of continuous wave formed springs located along the outer periphery of the radiation detector element, radially between the housing and the radiation detector element.