Abstract: Various embodiments of an apparatus and method for lifting an imaging head are disclosed.

Abstract: This application discloses a novel process for the preparation of phosphonate esters useful as intermediates in the preparation of himbacine analogs, themselves useful as thrombin receptor antagonists. The chemistry taught herein can be exemplified by the following scheme: wherein R9 is selected from alkyl, aryl heteroaryl and arylalkyl groups having 1 to 10 carbon atoms, and R11 is selected independently for each occurrence from alkyl, aryl heteroaryl and arylalkyl groups having 1 to 10 carbon atoms and hydrogen, X2 is Cl, Br, or I; X3 is selected from Cl and Br; and PdLn is a supported palladium metal catalyst or a soluble heterogeneous palladium catalyst. The L-derivatizing reagent is a moiety which converts the alcohol functional group of compound 137D to any leaving group which can be displaced by a triorgano-phosphite phosphonating agent.

Abstract: A data processing system is described that reduces read latency of requested memory data, thereby resulting in improved system performance. An exemplary system includes a bus, a processor, and a controller associated with the processor. The controller is configured to send a request for data to a memory storage unit, receive, from the memory storage unit, an early response indicating that the controller will later receive the requested data, and upon receipt of the early response indicator, start a timer to wait a period of time. The controller is further configured to, after expiration of the timer but prior to receipt of the requested data, send an arbitration request to initiate a transaction on the bus to communicate the requested data from the controller to the processor when the requested data is later received by the controller.

Abstract: An internal hinge (34) for a fire-resistant enclosure is provided. The internal hinge includes a cabinet end (36) and a door end (38). The cabinet end is pivotally coupled with a bracket (64) mounted on the enclosure and the door end is fixedly coupled with a door (32) of the enclosure. The hinge includes first, second, third, and fourth segments (72, 74, 76, 78). The first segment extends linearly from the cabinet end of the hinge. The second segment extends from the first segment in a generally curved path wrapping around the cabinet end approximately 90 degrees. The third segment extends linearly from the second segment and at an angle relative to the first segment. The fourth segment extends linearly from the third segment to the door end of the hinge and is perpendicular to the first segment. The internal hinge of the present invention allows the door of the enclosure to open approximately 147 degrees.

Abstract: Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

Abstract: A vehicle chassis assembly includes a frame assembly having a plurality of frame members connected together, a drivetrain, a suspension system, and an exhaust system. The connection of the frame members provides a low-profile configuration for reduced step height and a kick-up portion to allow ascent of steeper inclines. The frame further includes an exhaust pipe supported within a frame member and two castings bolted to removable wheel arches. The exhaust pipe has a circular cross-section that changes to a rectangular cross-section near the back of the chassis assembly.

Abstract: A cylindrical illumination confocal spectroscopy system has a fluidic device having a fluid channel defined therein, an objective lens unit arranged proximate the fluidic device, an illumination system in optical communication with the objective lens unit to provide light to illuminate a sample through the objective lens unit, and a detection system in optical communication with the objective lens unit to receive at least a portion of light that passes through the objective lens unit from the sample. The illumination system includes a beam-shaping lens unit constructed and arranged to provide a substantially planar illumination beam that subtends across, and is longer than, a lateral dimension of the fluid channel, the substantially planar illumination beam having a diffraction limited thickness in a direction substantially orthogonal to the lateral dimension of the fluid channel.

Abstract: Methods and devices for point of care determination of heparin concentration in blood are described. Cartridges including protamine ion sensitive electrodes (ISEs) and reference electrodes and systems for automatically determining heparin concentration in the cartridges are provided. Some systems add blood to a protamine bolus sufficient to bind all heparin, leaving excess protamine. The excess protamine concentration can be determined by measuring the initial slope of the electrode potential rate of change, and comparing the slope to known protamine concentration slope values In some cartridges, an oscillating pressure source moves the blood-protamine mixture back and forth across the protamine ISE. Some systems also use a second blood sample having the heparin removed or degraded to create a blank reference sample. Protamine ISEs can include polyurethane polymer, DNNS ionophore, and NPOE plasticizer.

Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

Abstract: Systems and methods for creating user generated content incorporating content from a content catalog are described. One embodiment of the invention includes a user generated content creation system, which includes a database, and is connected to a network, and a plurality of user devices that are connected to the network. In addition, the database contains a content catalog, the user generated content creation system is configured to dynamically create a user interface accessible via a user device, where the user interface enables a user device to create user generated content incorporating at least one piece of content from the content catalog, the user generated content creation system is configured to store a file containing user generated content created via the user interface on a storage device, and the user generated content creation system is configured to record information concerning content from the content catalog incorporated within the stored user generated content.

Abstract: A resource management system for an intelligent communications network having one or more distributed service nodes, each service node for providing services relating to an event received at a network resource associated with a service node. The system comprising a first processing tier comprising one or more local execution environments located at a node, each execution environment including a mechanism for instantiating one or more service objects capable of performing event services at a first local execution environment, and, for generating status information relating to executing service objects; and, a second processing tier associated with a service node and including a system processor for tracking status and availability of service objects and local execution environments.

Abstract: The present invention relates to a bone fixation device having a fixation member using a shape memory effect to secure bone fractures, including but not limited to, femur, tibia and humerus fractures. The fixation member can be malleable at a room temperature, but become rigid at a body temperature because of the shape memory effect, such as derived from a super-elastic property found in such as a nickel titanium alloy. The fixation member can be formed on one or more of the shaft portion and the two end portions of a nail member for securing bone fractures, such as by providing translational and rotational stabilities. The fixation member is also capable of providing a continuous and controllable compression force over the fractured bone, if needed.

Abstract: This application discloses a novel process for the preparation of phosphonate esters useful as intermediates in the preparation of himbacine analogs, themselves useful as thrombin receptor antagonists. The chemistry taught herein can be exemplified by the following scheme: wherein R9 is selected from alkyl, aryl heteroaryl and arylalkyl groups having 1 to 10 carbon atoms, and R11 is selected independently for each occurrence from alkyl, aryl heteroaryl and arylalkyl groups having 1 to 10 carbon atoms and hydrogen, X2 is Cl, Br, or I; X3 is selected from Cl and Br; and PdLn is a supported palladium metal catalyst or a soluble heterogeneous palladium catalyst. The L-derivatizing reagent is a moiety which converts the alcohol functional group of compound 137D to any leaving group which can be displaced by a triorgano-phosphite phosphonating agent.

Abstract: An electrochromic device including a first substantially transparent substrate having an electrically conductive material associated therewith, a second substrate having an electrically conductive material associated therewith, and an electrochromic medium including at least one solvent, at least one anodic electroactive material, at least one cathodic electroactive material, wherein at least one of the anodic and cathodic electroactive materials is electrochromic, and one or more ultraviolet light stabilizing compounds including a substituted diaroyl or unsubstituted diaroyl resorcinol.

Abstract: An interactive device with local area time synchronization is contemplated. The device includes a communications module linkable to a corresponding communications module of one or more other interactive devices. There is also memory for storing a set of clock values including a time component, a date component, a daylight savings component, and an event component. A computer processor connected to the communications module and the memory is also included, and is programmed to actively maintain an actively maintained real-time clock based upon the set of clock values stored in the memory. The set of clock values stored in the memory is transferrable by the communications module to a corresponding clock of one or more other interactive devices.

Abstract: A system and method for operating an engine having at least two spark plugs per cylinder include controlling at least one actuator to alter combustion within a selected cylinder such that the combustion burn rate determined by ion sense current signals associated with the at least two spark plugs of the selected cylinder approaches a desired combustion burn rate. A desired combustion burn rate is determined based on current engine/vehicle operating and ambient conditions with ion sense signals from each spark plug analyzed to determine combustion timing relative to corresponding ignition timing. Ignition timing and/or other actuators are controlled in response to provide a desired combustion burn rate.

Abstract: An internal hinge for a fire-resistant enclosure is provided. The internal hinge includes a cabinet end and a door end. The cabinet end is pivotally coupled with a bracket mounted on the enclosure and the door end is fixedly coupled with a door of the enclosure. The hinge includes first, second, third, and fourth segments. The first segment extends linearly from the cabinet end of the hinge. The second segment extends from the first segment in a generally curved path wrapping around the cabinet end approximately 90 degrees. The third segment extends linearly from the second segment and at an angle relative to the first segment. The fourth segment extends linearly from the third segment to the door end of the hinge and is perpendicular to the first segment. The internal hinge of the present invention allows the door of the enclosure to open approximately 147 degrees.

Abstract: The present invention relates to methods for prognosis, diagnosis, and treatment of malignant tumors that were treatment resistant. The present invention provides methods of prognosis and diagnosis of multidrug resistant tumors through detection of the expression levels of nuclear co-repressor 2 (“N-CoR2”), histone deacetylases 3 (“HDAC3”), and their associated gene expression biomarkers. The present invention also provides methods of sensitizing tumors to anti-tumor therapeutics by disrupting HDAC3 activation, abrogating the N-CoR2-HDAC3 interaction, inhibiting the activity of either protein, or by down-regulating the expression of either protein.

Abstract: A method of scheduling transmission from radios having multiple radios is provided, where the number of radios is smaller than then number of neighbours to which transmission needs to occur. Scheduling blocks are identified consisting of sets of neighbours that can be transmitted to simultaneously without interference. Then, the scheduling blocks are used for scheduling purposes.

Abstract: Methods and systems for on-the-fly chip verification method for tracking non-contiguous events. A method includes comparing a first search marker associated with a first check vector to search key associated with an output vector of a design under test (DUT). The method also includes performing either: verifying a validity of the output vector when the first search marker equals the search key, or comparing a second search marker associated with a second check vector to the search key when the first search marker does not equal the search key.