Abstract: A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.

Abstract: A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a, and R4b, is each independently a hydrogen atom, halogen, or hydroxyl etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt or a solvate thereof.

Abstract: Provided is a vehicle body bottom structure capable of restricting retraction of a front pillar by improving absorption performance for a collision load at a time of a narrow offset collision. The vehicle body bottom structure includes a dash lower for partitioning a vehicle compartment and a power mounted room as well as partitioning the vehicle compartment and a wheel house, a front pillar erected at a vehicle-widthwise end portion of the dash lower, and a gusset bridged between the dash lower and the front pillar, wherein the gusset is joined to the dash lower at one end thereof, and is spaced further from the dash lower the nearer to the front pillar, to be joined to the front pillar at the other end thereof, and wherein a crushing space is formed in a portion surrounded by the dash lower, the front pillar, and the gusset.

Abstract: A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.

Abstract: A front-end structure for a vehicle is provided with: front side frames, a subframe extending across a vehicle body floor front portion to support a suspension component and an electric power steering device, the subframe being supported at least at the front end portion and at the rear end portion and being formed in a subframe main body from a light alloy casting, and a pair of left and right extension arms that are fixed to the subframe main body and extend forward of the subframe main body, and that are formed from a light alloy or steel by press-molding. In the rear portion of the extension arms in the vicinity the subframe main body, provided is a recessed portion that serves as a point at which downward bending starts midway along the lengthwise direction of the subframe with an input load in the event of a vehicle frontal collision.

Abstract: A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.

Abstract: A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.

Abstract: A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.

Abstract: A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.

Abstract: A vehicle front part structure efficiently absorbs collision energy upon a narrow offset collision in which a collision object, such as an oncoming vehicle, makes a front collision with a vehicle outer side outer than a front side frame, and thereby inhibits the vehicle body front part from moving rearward to the vehicle interior side. The vehicle front part includes a pair of left/right front side frames extending along the longitudinal direction of the vehicle, and a power unit disposed at the longitudinal center between the left/right front side frames. The left/right front side frames beside the power unit include branch frames extending toward the vehicle laterally outer side. The rear end portions of the branch frames penetrate the outer surface of the left/right front side frames and extend along an inner wall. Connection members are provided at the front portions of the left/right front side frames.

Abstract: A vehicle includes a crush area disposed in front end part of each side sill, the crush area being crushable under a collision load upon collision in order to absorb the collision load. A bulkhead is disposed on the rear of the crush area inside the side sill. A reinforcing frame is attached to a side surface of the side sill facing a vehicle interior, one end of the reinforcing frame being joined to surface part of a portion, where the bulkhead is disposed, of the side sill such that the reinforcing frame extends rearwardly and inwardly in a vehicle width direction, the other end thereof being joined to a floor frame.

Abstract: An automobile vehicle compartment includes an octagonal frame having side sills that extend in the vehicle body fore-and-aft direction, a dashboard lower cross member and middle cross member that extend in the vehicle width direction, and four inclined members, and it is therefore possible to ensure that there is sufficient rigidity both for a collision load from the vehicle body fore-and-aft direction and from the side of the vehicle body, thereby minimizing deformation of the vehicle compartment. Furthermore, since front side frames and a front bumper beam form a U-shaped frame that curves in a U-shape toward the vehicle body fore-and-aft direction in front of the vehicle compartment, it is possible by crushing of the high rigidity U-shaped frame to absorb effectively a collision load from the vehicle body fore-and-aft direction, including an offset collision, thereby preventing more effectively deformation of the vehicle compartment.

Abstract: A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.

Abstract: A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group; E is lower alkylene; X is S; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; or its pharmaceutically acceptable salt thereof.

Abstract: A vehicle body body includes: left and right floor frames for supporting a floor panel; left and right side-frames extending from the vicinities of ends of the left and right floor frames in the front-rear direction so as to be separated in the front-rear direction of the vehicle body from the left and right floor frames; and a subframe provided below the left and right side-frames. Left and right bulkheads and left and right collar sections of a hollow shape, which are provided to the left and right bulkheads, are provided within the left and right floor frames. The subframe has left and right subframe end sections extending toward end sections of the left and right floor frames. The left and right subframe end sections are connected to the left and right collar sections by left and right connection members so as to be able to swing vertically.

Abstract: A vehicle includes a crush area disposed in front end part of each side sill, the crush area being crushable under a collision load upon collision in order to absorb the collision load. A bulkhead is disposed on the rear of the crush area inside the side sill. A reinforcing frame is attached to a side surface of the side sill facing a vehicle interior, one end of the reinforcing frame being joined to surface part of a portion, where the bulkhead is disposed, of the side sill such that the reinforcing frame extends rearwardly and inwardly in a vehicle width direction, the other end thereof being joined to a floor frame.

Abstract: A vehicle front part structure efficiently absorbs collision energy upon a narrow offset collision in which a collision object, such as an oncoming vehicle, makes a front collision with a vehicle outer side outer than a front side frame, and thereby inhibits the vehicle body front part from moving rearward to the vehicle interior side. The vehicle front part includes a pair of left/right front side frames extending along the longitudinal direction of the vehicle, and a power unit disposed at the longitudinal center between the left/right front side frames. The left/right front side frames beside the power unit include branch frames extending toward the vehicle laterally outer side. The rear end portions of the branch frames penetrate the outer surface of the left/right front side frames and extend along an inner wall. Connection members are provided at the front portions of the left/right front side frames.

Abstract: A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.

Abstract: A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.

Abstract: A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.