Abstract: An automobile vehicle compartment includes an octagonal frame having side sills that extend in the vehicle body fore-and-aft direction, a dashboard lower cross member and middle cross member that extend in the vehicle width direction, and four inclined members, and it is therefore possible to ensure that there is sufficient rigidity both for a collision load from the vehicle body fore-and-aft direction and from the side of the vehicle body, thereby minimizing deformation of the vehicle compartment. Furthermore, since front side frames and a front bumper beam form a U-shaped frame that curves in a U-shape toward the vehicle body fore-and-aft direction in front of the vehicle compartment, it is possible by crushing of the high rigidity U-shaped frame to absorb effectively a collision load from the vehicle body fore-and-aft direction, including an offset collision, thereby preventing more effectively deformation of the vehicle compartment.

Abstract: A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.

Abstract: A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.

Abstract: A vehicle front body structure includes a hollow front side frame of closed cross-sectional structure having a wheel relief portion having a horizontal width reducing to allow swivel movement of a front wheel of the vehicle. The wheel relief portion has a pair of reinforcement beads extending in a longitudinal direction of the vehicle and projecting from an outer sidewall and an inner sidewall, respectively, of the front side frame into an internal space of the hollow front side frame. The reinforcement beads have top surfaces being in abutment with each other and firmly fixed together.

Abstract: A vehicle front body structure includes an upper member extending from the lower end of a front pillar in a forward direction of a vehicle body and disposed outward a front side frame in a transverse direction of the vehicle body. The upper member has a substantially rectilinear configuration and is arranged to slope upward in a rearward direction of the vehicle body so that a load applied to a front end portion of the upper member can be born by the front pillar.

Abstract: A vehicle front body structure includes a hollow front side frame of closed cross-sectional structure having a wheel relief portion having a horizontal width reducing to allow swivel movement of a front wheel of the vehicle. The wheel relief portion has a pair of reinforcement beads extending in a longitudinal direction of the vehicle and projecting from an outer sidewall and an inner sidewall, respectively, of the front side frame into an internal space of the hollow front side frame. The reinforcement beads have top surfaces being in abutment with each other and firmly fixed together.

Abstract: In a front body structure including a bulk head 25 for supporting the tip 24 of a hood 16 covering an engine room 18 of a motor vehicle 11 and fenders 27, 27 covering the upper part of front wheels 26, 26, the left and right ends 33, 34 of the bulk head 25, after bent backward of a vehicle body, are connected to the fenders 27, 27 to adjust the shape of the front of the vehicle body by the bulk head 25, and when viewed in a plan, V-shape portions are formed at connecting portions between the ends of the bulk head and the fenders so that each of the V-shape portions is covered with each of eaves 36 extended from the fender and bulk head.

Abstract: A vehicle front body structure includes an upper member extending from the lower end of a front pillar in a forward direction of a vehicle body and disposed outward a front side frame in a transverse direction of the vehicle body. The upper member has a substantially rectilinear configuration and is arranged to slope upward in a rearward direction of the vehicle body so that a load applied to a front end portion of the upper member can be born by the front pillar.

Abstract: In a front body structure including a bulk head 25 for supporting the tip 24 of a hood 16 covering an engine room 18 of a motor vehicle 11 and fenders 27, 27 covering the upper part of front wheels 26, 26, the left and right ends 33, 34 of the bulk head 25, after bent backward of a vehicle body, are connected to the fenders 27, 27 to adjust the shape of the front of the vehicle body by the bulk head 25, and when viewed in a plan, V-shape portions are formed at connecting portions between the ends of the bulk head and the fenders so that each of the V-shape portions is covered with each of eaves 36 extended from the fender and bulk head.