Abstract: Early-induced genes by interleukin-2 (IL-2) have various DNA sequences. This patent describes a nucleotide segment encoding a polypeptide including amino acids 1-356 of SEQ. ID No: 6, antibody binding homologues thereof, antibody binding fragments, and fusion proteins thereof, alleles or naturally occurring mutants of the polyribonucleotides, and anti-sense polyribonucleotides thereof. Also provided are proteins, homologues, fragments, fusion proteins, vectors, transfected hosts, animal models, probes, and other related technology.

Abstract: A method of activating the immune system of a subject comprises the chronic administration of low doses of an agent such as IL-2, fusion proteins thereof and derivatives thereof that are pharmaceutically acceptable. The agent is provided as a dermal composition, transdermal delivery device and electrotransport device as well as in the form of a kit for self-administration.

Abstract: Early-induced genes by interleukin-2 (IL-2) have various DNA sequences. This patent describes a nucleotide segment, such as SEQ. ID No: 11, SEQ. ID No. 31, or encoding a polypeptide of amino acids 1-159 of SEQ. ID No: 12, antibody binding homologues thereof, antibody binding fragments, and fusion proteins thereof, alleles or naturally occurring mutants of the polyribonucleotides, and anti-sense polyribonucleotides thereof. Also provided are proteins, homologues, fragments, fusion proteins, vectors, transfected hosts, animal models, probes, and other related technology.

Abstract: A method for producing a complementary DNA (cDNA) library enriched in ligand-inducible genes of a cell is described. The method includes activating a cellular ligand receptor for a predetermined period of time in the presence of labelled RNA precursors and a substance which enhances the level of RNA in the cell. The RNA precursors are incorporated into the RNA synthesized by the cell in response to receptor activation. The labelled RNA is separated from unlabelled RNA and used to prepare cDNA. The cDNA is cloned into host cells to provide a cDNA library of cDNA-containing clones, which is then screened for clones containing ligand-induced genes. Also described are several novel ligand-induced genes identified using the method of the invention.

Abstract: Early-induced genes by interleukin-2 (IL-2) have various DNA sequences. This patent describes a polyribonucleotide with a nucleotide segment encoding amino acids 1-412 of SEQ. ID No: 14, antibody binding homologues thereof, antibody binding fragments thereof at least 5 amino acids long, and fusion proteins thereof, alleles or naturally occurring mutants of the polyribonucleotide, and anti-sense polyribonucleotides thereof. Also provided are proteins, homologues, fragments, fusion proteins, vectors, transfected hosts, animal models, probes, and other related technology.

Abstract: Early-induced genes by interleukin-2 (IL-2) have various DNA sequences. This patent describes a polyribonucleotide with a nucleotide segment encoding amino acids 1-60 of SEQ. ID No: 4, antibody binding homologues thereof, antibody binding fragments thereof at least 5 amino acids long, and fusion proteins thereof, alleles or naturally occurring mutants of the polyribonucleotide, and anti-sense polyribonucleotides thereof. Also provided are proteins, homologues, fragments, fusion proteins, vectors, transfected hosts, animal models, probes, and other related technology.

Abstract: Early-induced genes by interleukin-2 (IL-2) have various DNA sequences. This patent describes a nucleotide segment encoding a polypeptide including amino acids 1-258 of SEQ. ID No: 10, antibody binding homologues thereof, antibody binding fragments, and fusion proteins thereof, alleles or naturally occurring mutants of the polyribonucleotides, and anti-sense polyribonucleotides thereof. Also provided are proteins, homologues, fragments, fusion proteins, vectors, transfected hosts, animal models, probes, and other related technology.

Abstract: Disclosed is a method of producing a complementary DNA (cDNA) library enriched in ligand-inducible genes of a cell. The method includes activating a cellular ligand receptor for a predetermined period of time in the presence of labelled RNA precursors and a substance which enhances the level of RNA in said cell. The RNA presursors are incorporated into the RNA synthesized by said cell in response to receptor activation. The labelled RNA is separated from unlabelled RNA and used to prepare cDNA. The cDNA is cloned into host cells to provide a cDNA library of cDNA-containing clones. This library can then be screened for clones containing ligand-inducible genes.

Abstract: A new cellular protein produced by activated T cells and involved in the high affinity binding of interleukin-2 has been discovered. This protein has a molecular weight of about 75,000 (Mr) and is further characterized as having an affinity for IL-2 (in the absence of other receptor proteins) of about 10.sup.-9 molar and is substantially unreactive with anti-Tac antibodies. This new cellular protein, referred to herein as the ".alpha. chain," is believed to interact with the previously isolated 55,000 dalton receptor protein (referred to herein as the ".beta. chain") to form the high affinity interleukin-2 receptor which triggers the growth and mitosis of T cells during an immune response. Methods for isolating and purifying the .alpha. chain protein are disclosed herein as well as techniques for cloning and expressing the protein and related materials. Techniques for raising monoclonal antibodies to such proteins are also disclosed.

Abstract: Method and apparatus for increasing the effective data storage transfer rate in a system to permit the recording of a rapid sequence of high resolution images by eliminating and hence not transferring designated portions of each image in the sequence.

Abstract: A material distribution device is disclosed for spreading material such as grain during bin loading. A hopper, having a plurality of funnels therein acts in conjunction with the grain to automatically establish the path of the grain through the hopper according to flow rate of the grain passing through the hopper. Arms, rotated by a variable speed drive, receive the grain from the hopper and direct the grain into the bin with the speed of rotation, length and angle with respect to horizontal of the arms being selected and/or controlled to achieve uniform distribution of the grain throughout the bin without causing appreciable grain damage due to impact.

Abstract: A method of emission tomography using a gamma camera and a rotating collimator having an array of a large number of slanted, small diameter holes. A planar projection corresponding to each angular orientation assumed by the collimator is recorded. From these series of planar projections, a three-dimensional simulation model is reconstructed by an iterative algorithm which approximates the emitting object. The simulated model comprises multiple separable planes.

Abstract: A method of producing pigmented extrudates or mouldings from an unpigmented thermosetting moulding material, which comprises roughly blending a pigment component with an aminoplast moulding material substantially free from pigment and having an average particle size not greater than 150 microns, and completely dispersing the pigment compound through the aminoplast moulding material by progressing the rough blend through an extruder or injection moulding machine having a barrel grooved in accordance with German Offenlegungschrift No. 2514307, and extruding or injection moulding the resulting pigmented material.

Abstract: Cured thermoset plastics artefacts, (including extrusions) are made directly from a non-homogeneous blend of a filler and a solid particulate thermosetting material, by use of a screw injection moulding machine (or screw extruder) which is operated to cause the non-homogeneous blend to plasticize or flux so that a homogeneous intimate mixture of the filler and the thermosetting material is formed in the barrel of the machine. Thus, the moulding (or extrusion) sequence includes the provision or formation of the non-homogeneous blend in the barrel.

Abstract: A screw-housing for an extruder or injection moulding machine, having a longitudinal bore on the internal surface of which is defined grooving, preferably in the form of a number of equidistantly spaced grooves, extending longitudinally throughout substantially the whole length of the housing or alternatively throughout a major portion of the length of the housing downstream of the feed zone thereof.

Abstract: Aminoplastic moulding compositions include a filler which comprises or consists of a cured particulate aminoplast material having a water absorption (absorbency) of less than 2 milliliters of water per gram; the aminoplast filler material preferably is a hydrophobic ureaformaldehyde foam which has been disintegrated prior to incorporation in the resin component of the composition.