Abstract: A reliability calculation method according to one embodiment, executed by a computer, includes an input procedure designed to input a connected undirected graph G=(V, E), an operation probability pi of a link ei?E that constitutes the undirected graph G, and a predetermined set T?V of k-1 source nodes; a search procedure designed to generate a directed acyclic graph for calculating a reliability RG,p (T?{v}) representing the probability that each target node v?V\T is connected to each of the k-1 source nodes, based on the undirected graph G, the operation probability of operation pi, and the set T; and a probability calculation procedure designed to calculate the reliability RG,p (T?{v}) for each target node v based on the directed acyclic graph and a correspondence between each vertex of the directed acyclic graph and its adjacent vertex.

Abstract: A heat radiating fin part includes at least one protrusion protruding toward a first side in a first direction and being provided at an end of the heat radiating fin part on the first side in the first direction, the end allowing a refrigerant supplied through a liquid cooling jacket to flow into the end. The at least one protrusion is provided on at least one of a first side in the second direction with respect to a center position of the heat radiating fin part in the second direction. At least a part of a semiconductor element provided on a base part on a second side is disposed closer to a center position in the second direction than the protrusion provided closest to the center position in the second direction on the first side in the second direction.

Abstract: A cooling device includes a liquid cooling jacket and a heat dissipator including a plate-shaped base portion extending in a first direction along a direction in which a refrigerant flows and in a second direction perpendicular or substantially perpendicular to the first direction and has a thickness in a third direction, a fin protruding from the base portion toward, a top plate portion provided at the fin, and a bent portion bent toward the one side in the third direction at an end on one side in the first direction of the top plate portion, with the one side in the first direction being a downstream side. Between the liquid cooling jacket and the top plate portion, a gap in the third direction is provided, and the bent portion opposes the liquid cooling jacket.

Abstract: A cooling device includes a heat dissipator and a liquid cooling jacket. The heat dissipator includes a plate-shaped base portion that extends in a first direction along a direction where a refrigerant flows and in a second direction orthogonal to the first direction and has a thickness in a third direction, a fin that protrudes from the base portion to one side in the third direction, and a top plate portion provided to an end of the fin. The liquid cooling jacket includes a top surface located on one side of the top plate portion with a gap between the top surface and the top plate portion. Top surface recesses recessed from the top surface toward one side and located side by side in the first direction.

Abstract: A liquid cooling jacket includes, with a direction along a direction in which a refrigerant flows being defined as a first direction, and a direction perpendicular or substantially perpendicular to the first direction being defined as a second direction, a refrigerant flow path having a width in the second direction and including a heat radiator on one side in the third direction, a bottom surface portion located on the other side of the refrigerant flow path in the third direction, and protrusions protruding from the bottom surface portion toward one side in the third direction and arranged in the first direction. With one side in the first direction being defined as a downstream side, the protrusions include a convex portion extending in the second direction and protruding toward the other side in the first direction.

Abstract: A liquid cooling jacket includes a refrigerant flow path including a heat radiating portion on one side, a bottom surface located on the other side of the refrigerant flow path, and a protrusion protruding from the bottom surface toward one side. A first inclined portion is provided on the one side which is a downstream side of the protrusion. A first-direction length of the first inclined portion is longer than a height of the protrusion at a first-direction other end of the first inclined portion.

Abstract: An RNA methyltransferase inhibitor comprising sulfonamide-based compounds and/or pyrazoline-based compounds is provided

Abstract: A heat dissipator includes a first top plate at one side end of a third direction at a first fin(s). A second top plate is at one side end of a third direction at a second fin(s). The second fin(s) includes an opening open to one side in the third direction and located on the other side in the first direction relative to the second top plate. A liquid-cooled jacket includes a top surface that can oppose the first top plate and the second top plate in the third direction. A first gap between the top surface and the first top plate and a second gap between the top surface and the second top plate are narrower toward one side in the first direction.

Abstract: An object of the present invention is to provide a method for predicting a risk of developing cancer. DNA samples were prepared from blood and cancer tissues of 2480 cancer patients and analyzed for the nucleotide sequences of exon regions using NGS. As a result, among the cancer patients, 7 patients were confirmed to have D49H mutation or A159D mutation which is a germ cell mutation.

Abstract: A system of optimizing an activation degree of an occupant of a vehicle, the system including: a speaker configured to play music for the occupant; and a controller configured to: determine whether an activation degree detected by an detector is in an appropriate state set in advance; and actuate the speaker to play music when determined that the activation degree of the occupant is not in the appropriate state, the music being selected in advance, being unique to the occupant, arousing pleasant emotion of the occupant, and being high tempo music having a tempo equal to or higher than a predetermined tempo or low tempo music having a tempo equal to or lower than a predetermined tempo.

Abstract: An object of the present invention is to provide a method for predicting a risk of developing cancer. DNA samples were prepared from blood and cancer tissues of 2480 cancer patients and analyzed for the nucleotide sequences of exon regions using NGS. As a result, among the cancer patients, 7 patients were confirmed to have D49H mutation or A159D mutation which is a germ cell mutation.

Abstract: The object of the invention is to provide an anaerobic enterobacterium having a higher therapeutic effect on an anaerobic site such as a solid tumor tissue and an ischemic disease site. A bacterium of the genus Bifidobacterium, which is transformed with a plasmid co-expressing two types of heterologous polypeptides and comprising two types of secretory expression cassettes each sequentially comprising a promoter DNA functioning in the bacterium of the genus Bifidobacterium; a DNA encoding a secretory signal peptide; a DNA encoding a heterologous polypeptide; and a terminator DNA functioning in the bacterium of the genus Bifidobacterium, efficiently secretes the two types of heterologous peptides, i.e., two types of antibodies having anticancer effects, outside the bacterial cell.

Abstract: A system of optimizing an activation degree of an occupant of a vehicle, the system including: a speaker configured to play music for the occupant; and a controller configured to: determine whether an activation degree detected by an detector is in an appropriate state set in advance; and actuate the speaker to play music when determined that the activation degree of the occupant is not in the appropriate state, the music being selected in advance, being unique to the occupant, arousing pleasant emotion of the occupant, and being high tempo music having a tempo equal to or higher than a predetermined tempo or low tempo music having a tempo equal to or lower than a predetermined tempo.

Abstract: The object of the invention is to provide an anaerobic enterobacterium having a higher therapeutic effect on an anaerobic site such as a solid tumor tissue and an ischemic disease site. A bacterium of the genus Bifidobacterium, which is transformed with a plasmid co-expressing two types of heterologous polypeptides and comprising two types of secretory expression cassettes each sequentially comprising a promoter DNA functioning in the bacterium of the genus Bifidobacterium; a DNA encoding a secretory signal peptide; a DNA encoding a heterologous polypeptide; and a terminator DNA functioning in the bacterium of the genus Bifidobacterium, efficiently secretes the two types of heterologous peptides, i.e., two types of antibodies having anticancer effects, outside the bacterial cell.

Abstract: A semiconductor device manufacturing method includes: forming an element isolation insulating film in a semiconductor substrate; forming a first film on a surface of the semiconductor substrate; forming a second film on the element isolation insulating film and on the first film; forming a first resist pattern that includes a first open above the element isolation insulating film in a first region; removing the second film on the element isolation insulating film in the first region to separate the second film in the first region into a plurality of parts by performing first etching; forming a third film on the second film in the first region; forming a first gate electrode on the third film in the first region; and forming a first insulating film that includes the first to third films under the first gate electrode by patterning the first to third films.

Abstract: A semiconductor device manufacturing method includes: forming an element isolation insulating film in a semiconductor substrate; forming a first film on a surface of the semiconductor substrate; forming a second film on the element isolation insulating film and on the first film; forming a first resist pattern that includes a first open above the element isolation insulating film in a first region; removing the second film on the element isolation insulating film in the first region to separate the second film in the first region into a plurality of parts by performing first etching; forming a third film on the second film in the first region; forming a first gate electrode on the third film in the first region; and forming a first insulating film that includes the first to third films under the first gate electrode by patterning the first to third films.

Abstract: An object of the present invention is to provide a novel therapeutic agent for a patient with type 2 diabetes, a cause of which is the abnormal synthesis of insulin attributed to the abnormal modification of tRNALys (UUU) in pancreatic ? cells having Cdkal1 gene mutation. The present inventors have used (1) a screening system using E. coli in which correct translation into luciferase requires frameshift resulting from mistranslation during protein translation, (2) a screening system using the pancreatic islet of Langerhans isolated from a pancreatic ? cell-specific Cdkal1-deficient mouse, and (3) a screening system using a pancreatic ? cell-specific Cdkal1-deficient mouse, and found that a compound represented by any of the following formulas (I) to (III) can serve as a therapeutic agent for a patient with type 2 diabetes with Cdkal1 gene mutation resulting in the reduced ability to secrete insulin.

Abstract: A semiconductor device manufacturing method includes: forming an element isolation insulating film in a semiconductor substrate; forming a first film on a surface of the semiconductor substrate; forming a second film on the element isolation insulating film and on the first film; forming a first resist pattern that includes a first open above the element isolation insulating film in a first region; removing the second film on the element isolation insulating film in the first region to separate the second film in the first region into a plurality of parts by performing first etching; forming a third film on the second film in the first region; forming a first gate electrode on the third film in the first region; and forming a first insulating film that includes the first to third films under the first gate electrode by patterning the first to third films.

Abstract: A method of manufacturing a semiconductor device includes the steps of: preparing an underlying structure having a silicon carbide layer covering a copper wiring, and growing silicon oxycarbide on the underlying structure by vapor deposition using, as source gas, tetramethylcyclotetrasiloxane, carbon dioxide gas and oxygen gas, a flow rate of said oxygen gas being at most 3% of a flow rate of the carbon dioxide gas. The surface of the silicon carbide layer of the underlying structure may be treated with a plasma of weak oxidizing gas which contains oxygen and has a molecular weight larger than that of O2 to bring the surface more hydrophilic. Film peel-off and cracks in the interlayer insulating layer decrease.

Abstract: A method of manufacturing a semiconductor device includes the steps of: preparing an underlying structure having a silicon carbide layer covering a copper wiring, and growing silicon oxycarbide on the underlying structure by vapor deposition using, as source gas, tetramethylcyclotetrasiloxane, carbon dioxide gas and oxygen gas, a flow rate of said oxygen gas being at most 3% of a flow rate of the carbon dioxide gas. The surface of the silicon carbide layer of the underlying structure may be treated with a plasma of weak oxidizing gas which contains oxygen and has a molecular weight larger than that of O2 to bring the surface more hydrophilic. Film peel-off and cracks in the interlayer insulating layer decrease.