Abstract: The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.

Abstract: An upright machining center is characterized in being provided with: x-axis guides for moving and guiding a table in the left-right direction on a bed; a column provided on the bed and provided with an opening that straddles the x-axis guides in the front-back direction so that a moving body, on which the table is provided, can enter therein in the left-right direction; a saddle, which is disposed on the upper part of the column so as to be movable in the front-back direction and for which a first y-axis guide that extends in the front-back direction on the right side of the left-right direction and a left second y-axis guide that is located lower and parallel thereto are provided; and a main shaft head, which is disposed on the left side surface of the saddle and moves in the vertical direction.

Abstract: There is provided a medical apparatus, including medical vibration detection circuitry that is detachable from a medical instrument at an attachment position of the medical instrument in a longitudinal direction and that is configured to detect vibration generated in a distinct portion of the medical instrument, the distinct portion including at least a portion disposed toward a distal end of the medical instrument from the attachment position.

Abstract: According to one embodiment, a memory system includes a first memory, an interface circuit, and a processor. The interface circuit is configured to receive a first request from an external device. The processor is configured to select a mode among a plurality of modes in response to the first request, and perform, on data read from the first memory, error correction of the selected mode.

Abstract: [Object] To provide a haptic presentation apparatus capable of suppressing the transmission of vibration of a vibration actuator used to present tactile sensation to a force sensor. [Solution] A haptic presentation apparatus includes: a force sensor configured to detect force input to an operation portion that is operated by a user; a vibration generating source configured to present haptic sensation or tactile sensation to the user; and a vibration damping member configured to be interposed between the force sensor and the vibration generating source.

Abstract: The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.

Abstract: The application relates to a laminated porous film having a heat-resistant layer that is suitable for a separator for a non-aqueous electrolyte secondary battery having excellent cycle characteristics, and a coating liquid for forming the heat-resistant layer. A coating liquid containing a filler, a binder, and a solvent, wherein a hydrophilicity parameter A of the filler defined by formula (1) is 0.35 to 0.65: Hydrophilicity parameter A=BET1/BET2 ??(1) wherein, in formula (1), BET1: the specific surface area of the filler calculated using a BET method from a differential adsorption isotherm obtained by subtracting, from a first adsorption isotherm measured by adsorbing water vapor to the filler, a second adsorption isotherm; and BET2: the specific surface area of the filler calculated using a BET method from a differential adsorption isotherm measured by adsorbing nitrogen to the filler.

Abstract: The purpose of the present invention is to allow a silicon photonics modulator to be operated at high speed with high frequency by providing an electrode structure for the small multichannel high-density silicon photonics modulator. This electrode structure for a silicon photonics modulator includes, on the planar surface of a silicon substrate, a first layer for forming a plurality of bias electrical wirings, and a second layer formed by aligning each of a plurality of ground electrode portions and each electrical wiring in the first layer.

Abstract: [Object] To enable to detect a force acting on a surgical instrument with a simpler configuration. [Solution] Provided is an information processing device including an acting force calculation unit that calculates, on a basis of a first detected value by a first force sensor provided on one side of a rod-shaped member, at least one of acting forces on a first point of action and a second point of action that differ from each other on an other side of the rod-shaped member.

Abstract: The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.

Abstract: A sample measuring method of optically measuring a sample housed in a container in a sample measurement device, the method including: loading the container such that the container is shielded from light; starting to read information regarding a measurement to be performed on the sample in response to the loading the container; and measuring the sample based on the read information.

Abstract: Disclosed is a sequence analysis method for analyzing nucleic acid sequence, the sequence analysis method including: obtaining a plurality of read sequences read from the nucleic acid sequence; and determining each nucleic acid sequence by aligning each read sequence with reference to a single reference sequence, wherein the reference sequence includes at least a first rearrangement sequence and a second rearrangement sequence that is different from the first rearrangement sequence.

Abstract: According to one embodiment, a memory system includes a first memory, an interface circuit, and a processor. The interface circuit is configured to receive a first request from an external device. The processor is configured to select a mode among a plurality of modes in response to the first request, and perform, on data read from the first memory, error correction of the selected mode.

Abstract: Disclosed is a quality evaluation method performed in a genetic test for testing a gene in a sample collected from a subject, for a plurality of types of gene mutations that include a first type gene mutation and a second type gene mutation different from the first type gene mutation, and the quality evaluation method includes preparing a quality control sample that includes a first reference gene having the first type gene mutation, and a second reference gene having the second type gene mutation; obtaining sequence information of the genes included in the quality control sample; and outputting an index for evaluation of a quality of the genetic test, based on the sequence information having been obtained.

Abstract: A smooth shift is achieved between an operating region in which a first turbocharger is mainly operated and an operating region in which a second turbocharger is mainly operated. A PCM controls a throttle valve to use a first supercharging region in which a gas flow through an exhaust bypass passage is reduced and a second supercharging region in which the gas flow through the exhaust bypass passage is promoted differently based on the operating state of an engine. In an early stage of a shift from the first supercharging region to the second supercharging region, the PCM executes bridge control to allow the flow velocity of exhaust gas flowing into a large turbine to be higher than at a point in time at which the shift starts.

Abstract: In view of such problems, the present invention provides a sample processing apparatus, a sample processing system, and a method of calculating measurement time, which allow an operator to efficiently capture images of cells. This invention relates to a sample processing apparatus 10 for measuring and analyzing a measurement sample 22. The sample processing apparatus 10 includes a light source 121 that irradiates light to the measurement sample 22, an imaging unit 154 that images light generated from the measurement sample 22 by irradiation with light, concentration information of cells included in the measurement sample 22 And a processing unit 11 that calculates a time required for cell imaging. The required time includes the time required for the processing of the image captured by the imaging unit 154 and the time required for the analysis of the image processed by the imaging unit 154.

Abstract: Disclosed is a specimen processing chip installed in a liquid feeder, comprising a flow path into which a first liquid and a second liquid flow, a first well having a first injection port into which the first liquid is injected by an operator, and a first liquid feed port for feeding the first liquid injected from the first injection port to the flow path, that is smaller in diameter than the first injection port, a second well having a second injection port into which the second liquid fed from the liquid feeder is injected, and a second liquid feed port for feeding the second liquid injected from the second injection port to the flow path, that is smaller in diameter than the second injection port, and an identification section for distinguishing between the first injection port and the second injection port.

Abstract: An upright machining center is characterized in being provided with: x-axis guides for moving and guiding a table in the left-right direction on a bed; a column provided on the bed and provided with an opening that straddles the x-axis guides in the front-back direction so that a moving body, on which the table is provided, can enter therein in the left-right direction; a saddle, which is disposed on the upper part of the column so as to be movable in the front-back direction and for which a first y-axis guide that extends in the front-back direction on the right side of the left-right direction and a left second y-axis guide that is located lower and parallel thereto are provided; and a main shaft head, which is disposed on the left side surface of the saddle and moves in the vertical direction.

Abstract: A machine tool includes a trough which collects chips; a mobile unit which is located above the trough and moves in the longitudinal direction of the trough on a bed, is configured from a first beam member, a second beam member, and a connecting member connecting the first beam member and the second beam member, and is formed with a hollow that opens toward the trough from above; a first guide which supports the mobile unit in such a manner that the mobile unit is movable in the longitudinal direction of the trough; a second guide which faces the first guide across the trough, and supports the mobile unit in such a manner that the mobile unit is movable in the longitudinal direction of the trough; and a cradle, both ends of which are supported by the first beam member and the second beam member.

Abstract: A machine tool which causes a tool mounted on a main spindle and workpiece attached to a table to move relative to each other so as to machine the workpiece, said machine tool being equipped with: a column that has guides for guiding movements in the vertical direction, that is, the direction of gravity; and a moving body that supports a spindle head at the front and moves in the vertical direction along the guides. The guides comprise a pair of right and left first guides and at least one second guide that is provided on the inner side of and posterior to the pair of first guides.