Patents by Inventor Kenji Miki

Kenji Miki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210137078
    Abstract: Provided are a livestock sensor device, a livestock astasia inference method, a livestock astasia inference program, and a livestock management system that are capable of preventing damage to stockbreeders. According to an embodiment of the present technology, there is provided a livestock sensor device including a postural-state determination unit, a state inference unit, a transmission unit, and a casing. The postural-state determination unit determines in which of a prostrate state and a non-prostrate state a livestock animal has been on a basis of output values from an acceleration sensor. The state inference unit infers whether or not the livestock animal has developed astasia on a basis of a duration of the prostrate state. The transmission unit transmits, to a server, an astasia-notification data item indicating that an inference that the livestock animal has developed the astasia is made when the inference that the livestock animal has developed the astasia is made.
    Type: Application
    Filed: July 10, 2018
    Publication date: May 13, 2021
    Inventors: HIDETATSU YAMAMOTO, SEIJI OHISHI, HIDETOSHI ISAWA, KAZUHIKO TSUJI, NAOKI TAMAI, HIDEAKI KAMEI, YOSHINORI USAMI, TAKESHI NEGORO, KOICHI YAMAGUCHI, KAZUYA TERASAKI, OSAMU MIKI, KENJI SASAKI, TOMOYA IMAMURA, MAMI MAMIYA
  • Publication number: 20210054406
    Abstract: A production method comprising the step of forming an aggregate of cells under conditions that permit transfection of the cells with a substance in a non-cell-adhesive container is provided as a technique for producing cells having the desired substance introduced therein on a large scale at a commercial level.
    Type: Application
    Filed: March 28, 2019
    Publication date: February 25, 2021
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Yoshinori YOSHIDA, Kenji MIKI, Yasuharu KAMACHI
  • Publication number: 20210024512
    Abstract: The present invention provides a heterocyclic compound having an activity to promote the maturation of a cardiomyocyte. A compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof has an activity to promote the maturation of a cardiomyocyte, and is useful as a cardiomyocyte maturation promoter.
    Type: Application
    Filed: March 28, 2019
    Publication date: January 28, 2021
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Yoshinori YOSHIDA, Kenji MIKI, Akira KAIEDA, Shigeru KONDO, Hiroshi NARA, Yoshinori IKEURA
  • Publication number: 20210009956
    Abstract: The present invention provides a cardiomyocyte maturation promoter. The present invention provides a cardiomyocyte maturation promoter comprising one or more compounds selected from 2-methoxy-5-((Z)-2-(3,4,5-trimethoxyphenyl)vinyl)phenol, (1-ethyl-1H-benzotriazol-5-yl)methyl (2-(2-methoxy-4-methylphenyl)-4-methyl-1,3-thiazol-5-yl)carbamate, (2?beta)-22-oxovincaleukoblastine, 2-(2-(4-chlorophenyl)ethyl)-6-(2-furyl)-3H-imidazo[4,5-b]pyridine, 4,5-anhydro-1,2-dideoxy-4-methyl-2-((N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl)amino)-1-phenyl-L-threo-pent-3-ulose, 3-(3-methoxyphenyl)-N7,N7-dimethylisoquinoline-1,7-diamine, methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate, 2?-(4-aminophenyl)-1H,1?H-2,5?-bibenzimidazol-5-amine, and salts thereof.
    Type: Application
    Filed: March 28, 2019
    Publication date: January 14, 2021
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Yoshinori YOSHIDA, Kenji MIKI, Shigeru KONDO
  • Publication number: 20200056248
    Abstract: An object of the present invention is to provide a method for increasing the purity of a type of tissue cell such as an endothelial cell, a hepatocyte, or an insulin-producing cell. The present invention solves the problem by providing a method comprising a step of introducing, into a cell population, an mRNA comprising a nucleic acid sequence recognized by an miRNA specifically expressed in endothelial cells, hepatocytes, or insulin-producing cells.
    Type: Application
    Filed: October 22, 2019
    Publication date: February 20, 2020
    Inventors: Yoshinori Yoshida, Hirohide Saito, Kenji Miki, Kei Endo, Seiya Takahashi
  • Publication number: 20200040171
    Abstract: A non-crosslinked rubber laminate which is a rubber laminate includes a butyl rubber-containing layer stacked with an ethylene propylene diene rubber and/or ethylene propylene rubber-containing layer, wherein such non-crosslinked rubber laminate is characterized in that the ethylene propylene diene rubber and/or ethylene propylene rubber-containing layer is a rubber-containing layer that contains a low-molecular-weight polyolefin, a phenolic resin, and a crosslinking agent, where: the low-molecular-weight polyolefin is contained by 40 to 70 parts by weight, the phenolic resin is contained by 1 to 4 parts by weight, and the crosslinking agent is contained by at least 1 part by weight, relative to the ethylene propylene diene rubber and/or ethylene propylene rubber constituting a total of 100 parts by weight. An air conditioning hose made of the rubber laminate, for example, can accommodate POE-based lubricating oils and retain vibration absorption characteristics.
    Type: Application
    Filed: October 30, 2017
    Publication date: February 6, 2020
    Inventors: Kenji MIKI, Ryota KOJIMA, Yasushi TAKEO
  • Patent number: 10538740
    Abstract: An object of the present invention is to provide a novel method for sorting cardiomyocytes. Another object of the present invention is to provide a method for producing high-purity cardiomyocytes and a kit used therefor. The present invention provides a method for sorting cardiomyocytes, comprising a step of introducing miRNA-responsive mRNA into a cell group, wherein the miRNA-responsive mRNA consists of a sequence comprising the following (i) and (ii): (i) a nucleic acid specifically recognized by miRNA specifically expressed in cardiomyocytes, and (ii) a nucleic acid corresponding to the coding region of a gene, wherein translation of (ii) the nucleic acid corresponding to the coding region of a gene into protein is regulated by the nucleic acid sequence in (i) above, thereby achieving the aforementioned objects.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: January 21, 2020
    Assignee: Kyoto University
    Inventors: Yoshinori Yoshida, Hirohide Saito, Kenji Miki, Kei Endo, Seiya Takahashi
  • Patent number: 10501811
    Abstract: An object of the present invention is to provide a method for increasing the purity of a type of tissue cell such as an endothelial cell, a hepatocyte, or an insulin-producing cell. The present invention solves the problem by providing a method comprising a step of introducing, into a cell population, an mRNA comprising a nucleic acid sequence recognized by an miRNA specifically expressed in endothelial cells, hepatocytes, or insulin-producing cells.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: December 10, 2019
    Assignee: KYOTO UNIVERSITY
    Inventors: Yoshinori Yoshida, Hirohide Saito, Kenji Miki, Kei Endo, Seiya Takahashi
  • Publication number: 20180100203
    Abstract: An object of the present invention is to provide a method for increasing the purity of a type of tissue cell such as an endothelial cell, a hepatocyte, or an insulin-producing cell. The present invention solves the problem by providing a method comprising a step of introducing, into a cell population, an mRNA comprising a nucleic acid sequence recognized by an miRNA specifically expressed in endothelial cells, hepatocytes, or insulin-producing cells.
    Type: Application
    Filed: April 22, 2016
    Publication date: April 12, 2018
    Inventors: Yoshinori Yoshida, Hirohide Saito, Kenji Miki, Kei Endo, Seiya Takahashi
  • Publication number: 20170369846
    Abstract: An object of the present invention is to provide a novel method for sorting cardiomyocytes. Another object of the present invention is to provide a method for producing high-purity cardiomyocytes and a kit used therefor. The present invention provides a method for sorting cardiomyocytes, comprising a step of introducing miRNA-responsive mRNA into a cell group, wherein the miRNA-responsive mRNA consists of a sequence comprising the following (i) and (ii): (i) a nucleic acid specifically recognized by miRNA specifically expressed in cardiomyocytes, and (ii) a nucleic acid corresponding to the coding region of a gene, wherein translation of (ii) the nucleic acid corresponding to the coding region of a gene into protein is regulated by the nucleic acid sequence in (i) above, thereby achieving the aforementioned objects.
    Type: Application
    Filed: March 20, 2015
    Publication date: December 28, 2017
    Inventors: Yoshinori Yoshida, Hirohide Saito, Kenji Miki, Kei Endo, Seiya Takahashi
  • Patent number: 9822342
    Abstract: The present invention provides a method for efficiently producing cardiomyocytes from pluripotent stem cells, which method comprises the steps of dissociating embryoid bodies obtained during the production process, and allowing reaggregation of the resulting cells to allow formation of embryoid bodies.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: November 21, 2017
    Assignee: KYOTO UNIVERSITY
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Kenji Miki
  • Patent number: 9463381
    Abstract: A game apparatus includes a CPU, and the CPU executes game processing of a golf game, and displays a guide path of a circle a part of which is erased in a hitting operation. When the player performs a sliding operation in a clockwise direction so as to trace the guide path, and then inverts the sliding operation in a counterclockwise direction, the player character performs a swing motion according thereto. As to each of backswing, downswing and follow-through, precision, a speed, smoothness of the sliding operation are determined, and in accordance with the results, the movement of a ball is controlled.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: October 11, 2016
    Assignee: Nintendo Co., Ltd.
    Inventor: Kenji Miki
  • Publication number: 20160122716
    Abstract: The present invention provides a method for efficiently producing cardiomyocytes from pluripotent stem cells, which method comprises the steps of dissociating embryoid bodies obtained during the production process, and allowing reaggregation of the resulting cells to allow formation of embryoid bodies.
    Type: Application
    Filed: May 9, 2014
    Publication date: May 5, 2016
    Applicant: Kyoto University
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Kenji Miki
  • Patent number: 8672711
    Abstract: The invention provides a connector including a body having insulating properties, a conductive shield case surrounding the body, and a first terminal group arrayed in a line in the body. The first terminal group includes a first terminal and a second terminal. The second terminal is disposed adjacent to the first terminal and having a higher impedance than the first terminal. The shield case includes an adjacent portion that is adjacent to at least a portion of the second terminal and on an opposite side to the first terminal. At least one of the portion of the second terminal and the adjacent portion of the shield case is extended in width so as to shorten a distance between the portion of the second terminal and the adjacent portion of the shield case in accordance with an impedance difference between the first terminal and the second terminal.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: March 18, 2014
    Assignee: Hosiden Corporation
    Inventors: Hayato Kondo, Kenji Miki
  • Publication number: 20120077557
    Abstract: A game apparatus includes a CPU, and the CPU executes game processing of a golf game, and displays a guide path of a circle a part of which is erased in a hitting operation. When the player performs a sliding operation in a clockwise direction so as to trace the guide path, and then inverts the sliding operation in a counterclockwise direction, the player character performs a swing motion according thereto. As to each of backswing, downswing and follow-through, precision, a speed, smoothness of the sliding operation are determined, and in accordance with the results, the movement of a ball is controlled.
    Type: Application
    Filed: December 29, 2010
    Publication date: March 29, 2012
    Applicant: NINTENDO CO., LTD.
    Inventor: Kenji Miki
  • Publication number: 20110159732
    Abstract: The invention provides a connector including a body having insulating properties, a conductive shield case surrounding the body, and a first terminal group arrayed in a line in the body. The first terminal group includes a first terminal and a second terminal. The second terminal is disposed adjacent to the first terminal and having a higher impedance than the first terminal. The shield case includes an adjacent portion that is adjacent to at least a portion of the second terminal and on an opposite side to the first terminal. At least one of the portion of the second terminal and the adjacent portion of the shield case is extended in width so as to shorten a distance between the portion of the second terminal and the adjacent portion of the shield case in accordance with an impedance difference between the first terminal and the second terminal.
    Type: Application
    Filed: November 17, 2010
    Publication date: June 30, 2011
    Applicant: HOSIDEN CORPORATION
    Inventors: Hayato KONDO, Kenji MIKI
  • Patent number: 7824222
    Abstract: The invention provides a connector in which, in an over-mold process, it is possible to prevent a molten resin from flowing through inevitable gaps (88, 89) of a shell (80) into the inside of the shell, thereby preventing problems such as that movable portions of contacts (20) become immovable, from arising. The connector of the invention has a plug body (10) in which contacts (20) to be connected to a cable (70) are held by an insulative body (40), the body (40) is shielded by a shell (80) formed by a metal plate, and a part of the plug body (10) is over-molded. The body (40) has sealing portions (41, 42) which are fitted into gaps (88, 89) of the shell (80) to close the gaps (88, 89).
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: November 2, 2010
    Assignee: Hosiden Corporation
    Inventors: Toshiharu Miyoshi, Kenji Miki
  • Patent number: 7753712
    Abstract: The invention provides a connector plug in which a necessary and sufficient engaging force of a latch can be ensured irrespective of the thickness of a metal case. The connector plug of the invention has: a synthetic-resin made body (10) having a fitting portion (11) to which a counter connector socket is to be fitted, and which is projected from one end side; contacts (20) which are held by the body (10); and a metal case (40) which covers the body (10). A latch (30) which, when the fitting portion (11) of the body (10) is inserted into the counter connector socket, causes the fitting portion to be engaged with the counter connector socket, and which is formed by a metal plate is configured separately from the metal case (40). The latch (30) is held by the body (10).
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: July 13, 2010
    Assignee: Hosiden Corporation
    Inventor: Kenji Miki
  • Publication number: 20090004916
    Abstract: The invention provides a connector in which, in an over-mold process, it is possible to prevent a molten resin from flowing through inevitable gaps (88, 89) of a shell (80) into the inside of the shell, thereby preventing problems such as that movable portions of contacts (20) become immovable, from arising. The connector of the invention has a plug body (10) in which contacts (20) to be connected to a cable (70) are held by an insulative body (40), the body (40) is shielded by a shell (80) formed by a metal plate, and a part of the plug body (10) is over-molded. The body (40) has sealing portions (41, 42) which are fitted into gaps (88, 89) of the shell (80) to close the gaps (88, 89).
    Type: Application
    Filed: June 12, 2008
    Publication date: January 1, 2009
    Applicant: Hosiden Corporation
    Inventors: Toshiharu Miyoshi, Kenji Miki
  • Publication number: 20080311783
    Abstract: The invention provides a connector plug in which a necessary and sufficient engaging force of a latch can be ensured irrespective of the thickness of a metal case. The connector plug of the invention has: a synthetic-resin made body (10) having a fitting portion (11) to which a counter connector socket is to be fitted, and which is projected from one end side; contacts (20) which are held by the body (10); and a metal case (40) which covers the body (10). A latch (30) which, when the fitting portion (11) of the body (10) is inserted into the counter connector socket, causes the fitting portion to be engaged with the counter connector socket, and which is formed by a metal plate is configured separately from the metal case (40). The latch (30) is held by the body (10).
    Type: Application
    Filed: June 11, 2008
    Publication date: December 18, 2008
    Applicant: Hosiden Corporation
    Inventor: Kenji Miki