Abstract: Flow rate measurement is performed with a propagation time by using a pair of ultrasonic wave oscillators which is provided in flow path through which a fluid to be measured flows, and is disposed so as to transmit and receive an ultrasonic wave signal by causing the ultrasonic wave signal to be reflected on an inner wall of flow path at least once. In addition, adjustment of an amplification rate is periodically performed by amplifier, which amplifies the ultrasonic wave signal received by each of the ultrasonic wave oscillators to a predetermined amplitude, and a difference between a previous amplification rate and a current amplification rate is a predetermined value or more, and the instantaneous flow rate calculated by flow rate calculation unit is a predetermined flow rate or less, the reference voltage is adjusted by reference voltage setting unit. With the configuration, the propagation time can be stably measured and deterioration of the maximum amplitude is prevented.

Abstract: A flow rate measurement device includes a turbulence reduction component having opening portions and disposed between a measurement channel and a pair of hole portions across which a pair of ultrasonic transceivers are disposed from the measurement channel. The pair of opening portions of the turbulence reduction component each have frame pieces which are substantially identical in width. This makes it possible to reduce, with small attenuation of ultrasound, the occurrence of turbulence that is attributable to entrained flows in the pair of hole portions and is a cause of measurement error, thereby ensuring measurement accuracy.

Abstract: A flow rate measurement device includes a turbulence reduction component having opening portions and disposed between a measurement channel and a pair of hole portions across which a pair of ultrasonic transceivers are disposed from the measurement channel. The pair of opening portions of the turbulence reduction component each have frame pieces which are substantially identical in width. This makes it possible to reduce, with small attenuation of ultrasound, the occurrence of turbulence that is attributable to entrained flows in the pair of hole portions and is a cause of measurement error, thereby ensuring measurement accuracy.

Abstract: A hatching egg inspection apparatus includes: a plurality of light emitter, the light emitter being disposed two dimensionally at prescribed positions; light receiver, which are provided in a one-to-one relationship with the light emitter and each of which receives light from the corresponding light emitter; and an egg container, which is for arraying in advance a hatching egg between each of the light emitter and the light receiver corresponding thereto. Each hatching egg is inspected by the corresponding light receiver that receives, among the lights from all the light emitter, transmitted light that transmitted through the interior of the hatching egg. When one light emitter of the plurality of light emitter is emitting light, other of the light emitter within a prescribed range centered on the one light emitter do not emit light.

Abstract: A flow meter device includes: an inlet portion, into which a fluid flows; an outlet portion, from which the fluid flows out; a plurality of measurement passage portions provided parallel to each other between the inlet portion and the outlet portion; and at least one flow rate measurement unit, each flow rate measurement unit being configured to measure a flow rate of the fluid that flows through a passage in a corresponding one of the measurement passage portions. Shapes of passages in the respective measurement passage portions coincide with each other. The plurality of measurement passage portions include: the one measurement passage portion(s), which is/are each provided with the flow rate measurement unit; and the other measurement passage portion(s), which is/are not provided with the flow rate measurement unit.

Abstract: In the present invention, a cardiomyocyte cluster is disposed on a transparent substrate, and the quality of the cardiomyocytes is evaluated from the response of the cells to a forced pulsation stimulus applied to the cardiomyocytes. The cardiomyocyte cluster is disposed on the transparent substrate, and is exposed to the flow of a liquid containing an agent in a manner so that the agent acts on the cells, which configure a network. The extent of cardiac toxicity resulting from the agent is evaluated from measuring the fluctuations obtained from a comparison of adjacent cardiomyocytes of the network.

Abstract: A hatching egg inspection apparatus includes: a plurality of light emitter, the light emitter being disposed two dimensionally at prescribed positions; light receiver, which are provided in a one-to-one relationship with the light emitter and each of which receives light from the corresponding light emitter; and an egg container, which is for arraying in advance a hatching egg between each of the light emitter and the light receiver corresponding thereto. Each hatching egg is inspected by the corresponding light receiver that receives, among the lights from all the light emitter, transmitted light that transmitted through the interior of the hatching egg. When one light emitter of the plurality of light emitter is emitting light, other of the light emitter within a prescribed range centered on the one light emitter do not emit light.

Abstract: A hatching egg inspection apparatus includes: a plurality of light emitter, the light emitter being disposed two dimensionally at prescribed positions; light receiver, which are provided in a one-to-one relationship with the light emitter and each of which receives light from the corresponding light emitter; and an egg container, which is for arraying in advance a hatching egg between each of the light emitter and the light receiver corresponding thereto. Each hatching egg is inspected by the corresponding light receiver that receives, among the lights from all the light emitter, transmitted light that transmitted through the interior of the hatching egg. When one light emitter of the plurality of light emitter is emitting light, other of the light emitter within a prescribed range centered on the one light emitter do not emit light.

Abstract: Regarding cardiomyocytes and fibroblasts, it is meaningful to develop a device or system whereby, upon the transmission of pulsation from an adjacent cardiomyocyte or fibroblast, cell potential and cell morphology can be accurately measured on a single cell basis and the toxicity of a drug on cardiomyocytes can be examined on the basis of accurately measured cell potential and cell morphology of a single cell. In the present invention, a mass of cardiomyocytes is disposed on a transparent substrate and the qualities of the cardiomyocytes are evaluated depending on the response of the cardiomyocytes to a forced pulsation stimulus that is applied to the pulsating cardiomyocytes. A mass of cardiomyocytes, said mass being disposed on the transparent substrate, is exposed to a flow of a drug-containing liquid so as to allow the drug to act on cells configuring a network.

Abstract: A hatching egg inspection apparatus includes: a plurality of light emitter, the light emitter being disposed two dimensionally at prescribed positions; light receiver, which are provided in a one-to-one relationship with the light emitter and each of which receives light from the corresponding light emitter; and an egg container, which is for arraying in advance a hatching egg between each of the light emitter and the light receiver corresponding thereto. Each hatching egg is inspected by the corresponding light receiver that receives, among the lights from all the light emitter, transmitted light that transmitted through the interior of the hatching egg. When one light emitter of the plurality of light emitter is emitting light, other of the light emitter within a prescribed range centered on the one light emitter do not emit light.

Abstract: The present invention provides a method for producing a microscopic object comprising locating a microscopic structure, formed of an organic substance, to be used as a mold on a substrate, depositing an intended element on a surface of the organic structure by a vacuum vapor deposition method or the like, and then decomposing and thus removing the organic structure as the mold by an ultraviolet-ozone process or the like to obtain the microscopic structure formed of only an intended element.

Abstract: A flow meter device includes: an inlet portion, into which a fluid flows; an outlet portion, from which the fluid flows out; a plurality of measurement passage portions provided parallel to each other between the inlet portion and the outlet portion; and at least one flow rate measurement unit, each flow rate measurement unit being configured to measure a flow rate of the fluid that flows through a passage in a corresponding one of the measurement passage portions. Shapes of passages in the respective measurement passage portions coincide with each other. The plurality of measurement passage portions include: the one measurement passage portion(s), which is/are each provided with the flow rate measurement unit; and the other measurement passage portion(s), which is/are not provided with the flow rate measurement unit.

Abstract: In labeling a cell, and separating and collecting the cell according to a degree of the labeling using a cell separator, effects on the cell is minimized and the use of the collected cell is facilitated, thereby, when labeling a cell, the cell is labeled in the state where interaction of each cell is retained. In the labeling, a specific labeling material present on a surface of a target cell is taken in the cell via a transporter, and the cell is dispersed one by one to separate the same with a cell separator. Immediately after the separation, the cell is put in a solution not containing the specific labeling substance to remove the specific labeling substance taken in the cell. This series of steps is continuously conducted with a cell separation chip.

Abstract: Provided is a device for concentrating and separating cells, which has a function for continuously concentrating cells; a function for then continuously arranging the concentrated cells in predetermined regions of a flow path; a function for simultaneously identifying shape and fluorescent emission in one-cell units on the basis of cell concentration and purification images, which serve to continuously separate and purify cells that have different properties in that they are either attracted to or repelled by an induction electrophoresis force of a predetermined frequency; and a function for identifying cells on the basis of this shape and fluorescent emission information and thereby separating and purifying the cells.

Abstract: The present invention provides a cell enrichment/purification device having a function of continuously enriching cells, a function of locating the cells in a particular area of a flow path in a continuous array after the cell enrichment, a function of recognizing the shape of the cells and fluorescence emission from the cells at the same time in units of one cell based on an image, and a function of recognizing the cells based on the information on the shape and fluorescence emission to separate/purify the cells.

Abstract: Provided is a cell concentration and purification device, having: a function of continuously concentrating cells; a function of then subsequently disposing the cells continuously in a specific region of a channel; a function of simultaneously recognizing, based on an image, the shape and fluorescence emission of each single cell; and a function of recognizing the cells and then separating and purifying the same based on the data relating to the shape and fluorescence emission thereof.

Abstract: The present invention provides a high-speed gene amplification device including an additional mechanism that allows more stable temperature control, a pre-treatment mechanism that performs pre-treatment including a pre-PCR reaction reverse transcription reaction process that allows RNA detection, a melting curve analysis function, chip technology optimal for holding liquid droplets and performing optical measurements and an optical measurement function for a PCR reaction.

Abstract: The present invention provides a liquid reflux reaction control device including an additional mechanism that allows more stable temperature control, a pre-treatment mechanism that performs pre-treatment including a pre-PCR reaction reverse transcription reaction process that allows RNA detection, a melting curve analysis function, chip technology optimal for holding liquid droplets and optical measurement and the optical measurement function for PCR, and a temperature gradient control mechanism using a quantitative infrared light irradiation/absorption control technique.

Abstract: The present invention provides a liquid reflux reaction control device comprising: a reaction vessel having one or a plurality of wells configured to accommodate a sample; a heat exchange vessel provided in contact with the reaction vessel so as to conduct heat to the reaction vessel, and comprising an inlet and an outlet respectively for introducing and draining a liquid of a predetermined temperature; a plurality of liquid reservoir tanks provided with a temperature-controllable heat source for maintaining liquids of predetermined temperatures; a tubular flow channel that connects the inlet and the outlet of the heat exchange vessel with the liquid reservoir tanks; a pump disposed on the tubular flow channel, and configured to circulate the liquid between the heat exchange vessel and the liquid reservoir tank; and a switching valve disposed on the tubular flow channel, and configured to control the flow of the circulating liquid, which controls the temperature of the reaction vessel to keep a desired tem