Abstract: A cell culture container includes: an insert member having a membrane on which a cell is seeded, the insert member defining a first inner space that functions as an anaerobic chamber; a container having an attachment/detachment portion to and from which the insert member is attachable and detachable, the container defining a second inner space that functions as an aerobic chamber; a sealing member that closes an opening of the aerobic chamber between the attachment/detachment portion and the insert member with the insert member being attached to the attachment/detachment portion; and a transfer mechanism that transfers force to the sealing member. The sealing member closes the opening in response to an input of the force from the transfer mechanism.

Abstract: A tire state determination system (100) acquires, from a vehicle (50), state data that includes various types of information that may exert influence on deterioration of a base body portion of a tire (1), and calculates an evaluation value S that indicates a state of the base body portion of the tire (1), based on the acquired state data. This allows an inspector who inspects an applicability to a base tire, to preliminarily grasp, as a material for determining whether it can be used as the base tire, the state of the base body portion of the tire.

Abstract: A tire air pressure management system (100) includes: an acquisition processing portion (61) that acquires an air pressure and an air temperature of a tire (11) attached to a vehicle (1); a correction processing portion (62) that corrects the air pressure that has been acquired by the acquisition processing portion (61) together with the air temperature, based on a difference between the air temperature and a predetermined reference temperature; and a first output processing portion (63) that outputs determination information that is generated based on the air pressure after correction by the correction processing portion (62) and is used to determine whether or not the tire (11) needs air pressure adjustment.

Abstract: A tire management system (100) includes: an acquisition processing portion (62) that acquires state information regarding a state of a pneumatic tire (11) attached to a vehicle (1); a detection processing portion (63) that detects an abnormality of the pneumatic tire (11) based on the state information acquired by the acquisition processing portion (62); and a first output processing portion (64) that, when the detection processing portion (63) has detected the abnormality, outputs first route information to a display portion of a vehicle-mounted communication apparatus (13) of the vehicle (1), wherein the first route information includes a first route that is a route to, among a plurality of predetermined stop spots, a specific stop spot that has a stop space corresponding to a size of the vehicle (1).

Abstract: A tire management system (100) includes: a first communication apparatus (2) that acquires state information regarding a state of a tire (11) that is transmitted from an air pressure detection device (12) provided in a vehicle (1) when the vehicle (1) is located in a communication range of a predetermined wireless communication standard; and a management server (4) including a storage processing portion (70) that stores, into a storage portion (43), the state information acquired by the first communication apparatus (2).

Abstract: To continue a series of cell treatments even in a case where a treatment has become impossible in any isolator, a cell treatment system is provided with at least two isolators that perform different treatments, such that a sequential series of cell treatments is performed in each of the isolators. The cell treatment system is provided with a first isolator that performs a first treatment, a second isolator that performs a second treatment different from the first treatment, and a common isolator capable of performing the first treatment and the second treatment.

Abstract: A genetically modified cell that can be mass-produced efficiently. The genetically modified cell production system includes a cell-processing isolator for seeding a T cell in a well plate (culture vessel) a cell culture incubator (cell storage) for holding the culture vessel in which the T cell has been seeded and culturing the T cell a virus-processing isolator (nucleic acid preparation isolator) for providing, to the well plate, a virus having a nucleic acid containing a gene to be introduced into a cell a virus storage (nucleic acid storage) for holding the well plate from the virus-processing isolator and a virus infection isolator (nucleic acid introduction isolator) for introducing the nucleic acid into the T cell by infecting the T cell with the virus.

Abstract: The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compound, a method for producing the compound, and the like. Specifically, the present invention provides a compound represented by the following general formula (I): [wherein: A1 and A2 each independently represent an inhibitor residue having at least one activity selected from an enteropeptidase inhibitory activity and a trypsin inhibitory activity; and Z represents a spacer that links A1 to A2] or a pharmaceutically acceptable salt thereof.

Abstract: A dentin regenerative cell culture that can bring about a rapid regeneration of dentin in a deficit region. In the treatment of a tooth using the dentin regenerative cell culture, a root canal where a pulpectomy has been performed is filled with a root canal filler containing dental pulp stem cells. The dentin regenerative cell culture is then implanted in the deficit region of dentin, and temporary sealing with a packing is carried out. The dentin regenerative cell culture is formed three-dimensionally in conformity with the shape of the deficit region with the coalescence of cell masses of a plurality of odontoblasts, and thus the dentin regeneration is well promoted. In addition, gaps between the dentin regenerative cell culture and biological tissue can be rapidly filled. Infection due to bacterial infiltration can thereby be prevented.

Abstract: For a hybrid vehicle including an engine, a motor generator, and a belt-type continuously variable transmission, a controller performs a low speed position return expediting control in response to a downshift request accompanying deceleration. During the low speed position return expediting control, the controller increases a differential pressure between a primary pressure and a secondary pressure and cause a downshift toward a lowest speed position transmission ratio by reducing the primary pressure, and further reduces the primary pressure when the secondary pressure becomes greater than or equal to a trigger threshold value during the downshift; and terminates the low speed position return expediting control when an actual secondary pressure decreases to a secondary pressure minimum level. The controller further sets a secondary pressure lower limit higher than the secondary pressure minimum level during the low speed position return expediting control.

Abstract: To continue a series of cell treatments even in a case where a treatment has become impossible in any isolator, a cell treatment system is provided with at least two isolators that perform different treatments, such that a sequential series of cell treatments is performed in each of the isolators. The cell treatment system is provided with a first isolator that performs a first treatment, a second isolator that performs a second treatment different from the first treatment, and a common isolator capable of performing the first treatment and the second treatment.

Abstract: The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compound, a method for producing the compound, and the like. Specifically, the present invention provides a compound represented by the following general formula (I): [wherein: A1 and A2 each independently represent an inhibitor residue having at least one activity selected from an enteropeptidase inhibitory activity and a trypsin inhibitory activity; and Z represents a spacer that links A1 to A2] or a pharmaceutically acceptable salt thereof.

Abstract: A schedule management system 1 having isolators 3 (production facilities) and a main control device 4 for managing a production schedules of all the isolators 3. The production process of each isolator constituting the production schedule has a plurality of sub-processes, the production status being determined in the sub-process. The main control device 4 adds a new separating operation to the passage process and performs an update when the main control device 4 obtains a determination result that the separation of cells in a separation state confirmation operation (sub-process) in the passage process is insufficient while a passage process for cells A is being carried out in the isolators. The main control device 4 alters the start time of a culture medium exchange process for other cells B different from the updated passage operation, and updates the production schedule.

Abstract: A method for evaluating the activity level of mesenchymal stem cells, and a method for culturing mesenchymal stem cells using the evaluation method in the field of culturing mesenchymal stem cells for regenerative medicine, and further, a method for producing a therapeutic agent for liver dysfunction and a therapeutic agent for liver dysfunction. This method for evaluating mesenchymal stem cell activity has an assay step for assaying the amount of adenylate kinase 4 (AK4) in the mesenchymal stem cells; and a determination step for determining the activity level of the mesenchymal stem cells from the assayed amount of adenylate kinase 4.

Abstract: For a hybrid vehicle including an engine, a motor generator, and a belt-type continuously variable transmission, a controller performs a low speed position return expediting control in response to a downshift request accompanying deceleration. During the low speed position return expediting control, the controller increases a differential pressure between a primary pressure and a secondary pressure and cause a downshift toward a lowest speed position transmission ratio by reducing the primary pressure, and further reduces the primary pressure when the secondary pressure becomes greater than or equal to a trigger threshold value during the downshift; and terminates the low speed position return expediting control when an actual secondary pressure decreases to a secondary pressure minimum level. The controller further sets a secondary pressure lower limit higher than the secondary pressure minimum level during the low speed position return expediting control.

Abstract: A sterile work can be applied by a worker 29 to cells or the like through a glove 28 provided in an isolator 15. A work headset 31 outputting a work procedure of the sterile work vocally is prepared for the worker, and a check input device 39 is prepared for a checker 36. A management device 12 outputs the work procedure of the sterile work this time vocally to the work headset. When the fact that the worker has normally performed the sterile work this time is checked by the checker, and when the fact is input from the check input device to the management device, the management device performs the subsequent work procedure. Since the sterile work by the worker 29 can be monitored by the checker 36, a wrong work can be prevented from being performed.

Abstract: A bone marrow fluid of a patient is sampled, housed in a collection tube 11 and conveyed into an isolator in a sterile state. In the isolator, the bone marrow fluid in the collection tube is pipetted into test tubes and culture tube, etc. To the bone marrow fluid in the tubes, an erythrocyte sedimentation agent is added. After precipitating erythrocytes, the supernatant is collected. From the collected supernatant, a bone marrow cell-containing fraction for liver regeneration is concentrated and pipetted into flasks which are conveyed into an incubator to start the cell-culture. From the isolator system, test tubes are taken out. The bone marrow fluid in the test tubes and the concentrate are subjected to a safety test, etc.

Abstract: A toner is provided. The toner includes toner particles each including a mother particle and external additive particles covering the mother particle. In a SEM image of the toner, toner particles having a ratio Sd/St of from 5% to 50% are present at a frequency of 15% or more, where Sd representing an area of a largest recessed portion D of each toner particle and St representing whole area of the toner particle, Sd and St determined from the SEM image magnified and binarized to discriminate recessed portions and projected portions of the toner particle from each other. An external additive coverage rate Ca at the largest recessed portion D is from 30% to 100%.

Abstract: A schedule management system 1 having isolators 3 (production facilities) and a main control device 4 for managing a production schedules of all the isolators 3. The production process of each isolator constituting the production schedule has a plurality of sub-processes, the production status being determined in the sub-process. The main control device 4 adds a new separating operation to the passage process and performs an update when the main control device 4 obtains a determination result that the separation of cells in a separation state confirmation operation (sub-process) in the passage process is insufficient while a passage process for cells A is being carried out in the isolators. The main control device 4 alters the start time of a culture medium exchange process for other cells B different from the updated passage operation, and updates the production schedule.

Abstract: A toner is provided. The toner includes toner particles each including a mother particle and external additive particles covering the mother particle. In a SEM image of the toner, toner particles having a ratio Sd/St of from 5% to 50% are present at a frequency of 15% or more, where Sd representing an area of a largest recessed portion D of each toner particle and St representing whole area of the toner particle, Sd and St determined from the SEM image magnified and binarized to discriminate recessed portions and projected portions of the toner particle from each other. An external additive coverage rate Ca at the largest recessed portion D is from 30% to 100%.