Abstract: Embodiments of the present invention improve the accuracy of measurements and/or in vivo calibrations of a biosensor by (1) using more than one sensor signal value and/or more than one directly sampled and measured value, such as a capillary blood glucose value, and/or by (2) delaying the acquisition of a sensor output value that is compared with a directly sampled and measured value, such as a capillary blood glucose value, during a calibration. In an embodiment of the present invention, the median of a series of measured values, or a median or mean of the medians, may be utilized to provide more consistent and accurate measurement data and/or to compensate for error or artifact.

Abstract: Embodiments of the present invention provide for raising a background current setting for a biosensor above the actual (measured) background current present (i.e., overestimating the background current), particularly in the hypoglycemic range, to improve sensor accuracy and decrease the chance of glucose value overestimation by the sensor.

Abstract: A liquid dispensing device (10) having a drop ejection device (12) including an orifice (18) adapted for ejecting drops (20) therefrom above a particular turn-on-energy, a turn-on-energy detection device (28) positioned to receive turn-on-energy information from said ejected drops as a function of energy applied to the drop ejection device, and a controller (40) that receives the turn-on-energy information and conducts a mathematical operation on the turn-on-energy information to determine a drop volume of the drops ejected.

Abstract: One aspect is a drop detection arrangement including a light source for projecting a light beam for scattering light off of an ejected drop. The arrangement includes a light collector configured to collect the scattered light off the ejected drop and configured to process scattered light into an output signal. The arrangement includes a controller configured to receive the output signal from the light collector, to calculate the velocity of the ejected drop and to determine the volume of the ejected drop using the output signal and the velocity of the ejected drop.

Abstract: Embodiments provide a method and related systems that take into account the difference between a measured glucose value and the calibration level and the amount of elapsed time since the prior calibration. As one or both of these determined differences increases, the desirability of an additional calibration also increases. The methodology described herein thus analyzes the combination of change in glucose level as well as the time since the prior calibration. If the combination exceeds a predetermined value, the system recommends, but does not require, that the subject user perform an additional calibration.

Abstract: Electrochemical systems for measuring an analyte concentration, and correcting any surplus or deficiency in the measured concentration. More specifically, systems for measuring an analyte level in a fluid with an implantable sensor, processing the measurements with a front-loaded delivery algorithm having a fluid delivery period and a refractory period, and determining an appropriate fluid infusion rate in response to the measurements.

Abstract: A multiple use analyte sensing assembly that includes a long, thin conductor. A plurality of sensing sites are spaced along the conductor and each sensing site includes a membrane system adapted to create a current when placed into contact with body fluid containing the analyte. The assembly also includes a housing, having an aperture, an uptake spool and a payout spool, the conductor being wrapped about the payout spool before the sensing assembly is used. A sensor positioning actuator turns the uptake spool to move each sensing site, in sequence, to the housing aperture and then to the uptake spool. The assembly also includes a skin broaching assembly, having a multiplicity of lancets and a lancet positioning actuator adapted to move each lancet to the aperture. In addition, a lancet use actuator is adapted to move each lancet at least partially through the aperture and then back again.

Abstract: The present invention is embodied in an image reconstruction method for analyzing unordered microwell plates, including acquiring a digital image of a microwell plate showing unordered visible compound concentration effects, creating a dispensing log listing the dispensing log information for an unordered microwell plate, establishing one or more rules to govern the reorganization of the unordered visible digital image, creating a reordered log with well input locations reordered by test compound identity and quantity levels dispensed order corresponding reordered log well output locations, assigning ordered output locations to reordered input compound and concentration levels order and copying test well digital image pixels from well input locations to reordered output locations in a reconstructed digital image for visualization of visible compound effects in the microwell plates in ordered compound concentrations.

Abstract: The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has endometriosis or is at risk of developing endometriosis and the use of such risk information in selectively administering a treatment that at least partially prevents or compensates for an endometriosis related symptom.

Abstract: In one embodiment, a drop ejector assembly includes a printhead, a drop zone immediately downstream from the printhead, an array of optical fibers exposed to the drop zone such that light scattered off drops in the drop zone illuminates at least some of the optical fibers in the array, and a photo detector operatively connected to the array of optical fibers for converting light from the optical fibers into an electrical signal. In another embodiment, a drop detector includes a light source for illuminating drops passing through a drop zone and a light sensor for sensing light scattered off drops in the drop zone. The length of drop zone is 3 mm or less and the light sensor has a cross sectional dimension less than the length of the drop zone.

Abstract: Described is a search technology in which a search engine constructs a results page for a query that integrates suggested queries with the individual query results (e.g., displayed URLs). When rendered, the proximity of the suggested queries to their corresponding individual query result provides context as to the specific URL to which the suggested query is related. Suggested queries may appear alongside their associated search result, e.g., a displayed URL, and/or in an expandable panel proximate that individual search result. Suggested queries may appear within text accompanying a URL, and/or in a drop down menu following interaction with such text or the like. Related queries may be found by using a search result URL to find a query, by analyzing a search result's text snippet, by accessing historical data, and/or by accessing current user session data.

Abstract: Embodiments of the present invention provide for raising a background current setting for a biosensor above the actual (measured) background current present (i.e., overestimating the background current), particularly in the hypoglycemic range, to improve sensor accuracy and decrease the chance of glucose value overestimation by the sensor.

Abstract: Embodiments of the present invention provide for raising a background current setting for a biosensor above the actual (measured) background current present (i.e., overestimating the background current), particularly in the hypoglycemic range, to improve sensor accuracy and decrease the chance of glucose value overestimation by the sensor.

Abstract: An improved data compression method and apparatus is provided, particularly with regard to the compression of data in tabular form such as database records. The present invention achieves improved compression ratios by utilizing metadata to transform the data in a manner that optimizes known compression techniques. In one embodiment of the invention, a schema is generated which is utilized to reorder and partition the data into low entropy and high entropy portions which are separately compressed by conventional compression methods. The high entropy portion is further reordered and partitioned to take advantage of row and column dependencies in the data. The present invention enables not only much greater compression ratios but increased speed than is achieved by compressing the untransformed data.

Abstract: Embodiments of the present invention provide various multipolymers and permselective membranes for use with biosensors and other implantable medical devices and prostheses. Embodiments of the present invention may provide structural strength and integrity, and further may control the influx of glucose, oxygen and/or water. Embodiments of the present invention may, for example, minimize or reduce the influx of glucose by minimizing the percentage of hydrophilic segments, which in turn minimizes the percentage of water uptake and the degree of glucose transport.

Abstract: The present invention relates to novel genetic markers associated with degenerative disc disease (DDD), risk of developing DDD and risk of DDD progression, and methods and materials for determining whether a human subject has DDD, is at risk of developing DDD or is at risk of DDD progression.

Abstract: A system that facilitates selecting advertisements that match a search query is described herein. The system includes a search query receiver component that receives a search query including keywords. The system also includes a match component that uses an associative data structure to identify in the associative data structure one or more data nodes that are associated in the associative data structure with respective unique keys corresponding to respective one or more hashes of combinations of the keywords in the search query. For each identified data node, the match component selects advertisements associated with bid phrases stored in the identified data node that respectively only include keywords included in the search query.

Abstract: Systems and methods that enhance estimate(s) of features (e.g., word associations), via employing a sampling component (e.g., sketches) that facilitates computations of sample contingency tables, and designates occurrences (or absence) of features in data (e.g., words in document lists). The sampling component can further include a contingency table generator and an estimation that employs a likelihood argument (e.g., partial likelihood, maximum likelihood, and the like) to estimate features/word pair(s) associations in the contingency tables.

Abstract: A method of creating an analyte sensor. The method starts with the step of providing an electrochemically active surface. Then, at least one nub made of dielectric material and extending transversely outwardly from the electrochemically active surface is created. A curable liquid is applied to the electrochemically active surface and the nub and is then cured. In this process, the nub, which could be one of several nubs, serves to support the liquid before and during the curing.

Abstract: Embodiments of the present invention provide a device and method for treating animal skin to produce tautness in the skin during the insertion of an analyte sensor. A device in accordance with embodiments of the present invention includes a housing that partially encloses a cavity and is adapted for mounting onto animal skin and a sensor insertion module adapted to insert an analyte sensor through animal skin.